CR20140495A - 5-amino[1,4]thiazines como inhibidores de bace1 - Google Patents
5-amino[1,4]thiazines como inhibidores de bace1Info
- Publication number
- CR20140495A CR20140495A CR20140495A CR20140495A CR20140495A CR 20140495 A CR20140495 A CR 20140495A CR 20140495 A CR20140495 A CR 20140495A CR 20140495 A CR20140495 A CR 20140495A CR 20140495 A CR20140495 A CR 20140495A
- Authority
- CR
- Costa Rica
- Prior art keywords
- thiazines
- bace1
- inhibitors
- amino
- compound
- Prior art date
Links
- 102100021257 Beta-secretase 1 Human genes 0.000 title 1
- 101000894895 Homo sapiens Beta-secretase 1 Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 150000004897 thiazines Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
La presente invención proporciona un compuesto de fórmula I
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12169353 | 2012-05-24 | ||
| PCT/EP2013/060352 WO2013174781A1 (en) | 2012-05-24 | 2013-05-21 | 5-amino[1,4]thiazines as bace 1 inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CR20140495A true CR20140495A (es) | 2014-12-01 |
Family
ID=48534350
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CR20140495A CR20140495A (es) | 2012-05-24 | 2014-10-27 | 5-amino[1,4]thiazines como inhibidores de bace1 |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US9273042B2 (es) |
| EP (1) | EP2855469B1 (es) |
| JP (1) | JP6251249B2 (es) |
| KR (1) | KR20150014934A (es) |
| CN (1) | CN104334554B (es) |
| AU (1) | AU2013265376B2 (es) |
| BR (1) | BR112014028813A2 (es) |
| CA (1) | CA2872179A1 (es) |
| CL (1) | CL2014003123A1 (es) |
| CO (1) | CO7131369A2 (es) |
| CR (1) | CR20140495A (es) |
| EA (1) | EA026004B1 (es) |
| IL (1) | IL235681A (es) |
| MA (1) | MA37691B1 (es) |
| MX (1) | MX2014013839A (es) |
| NZ (1) | NZ702254A (es) |
| PE (1) | PE20150021A1 (es) |
| PH (1) | PH12014502541B1 (es) |
| SG (1) | SG11201407575PA (es) |
| UA (1) | UA113438C2 (es) |
| WO (1) | WO2013174781A1 (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20140054295A (ko) * | 2011-08-22 | 2014-05-08 | 머크 샤프 앤드 돔 코포레이션 | Bace 억제제로서의 2-스피로-치환된 이미노티아진 및 그의 모노- 및 디옥시드, 조성물 및 그의 용도 |
| US9556135B2 (en) | 2012-10-12 | 2017-01-31 | Amgen, Inc. | Amino-dihydrothiazine and amino-dioxido dihydrothiazine compounds as beta-secretase antagonists and methods of use |
| WO2015017407A1 (en) | 2013-07-30 | 2015-02-05 | Amgen Inc. | Bridged bicyclic amino thiazine dioxide compounds as inhibitors of beta- secretase |
| US9725468B2 (en) | 2013-09-13 | 2017-08-08 | Merck Sharp & Dohme Corp. | C5-spiro iminothiazine dioxides as BACE inhibitors, compositions, and their use |
| WO2016071211A1 (en) * | 2014-11-03 | 2016-05-12 | F. Hoffmann-La Roche Ag | Bace1 inhibitors |
| AU2016236402B2 (en) | 2015-03-20 | 2019-08-01 | F. Hoffmann-La Roche Ag | BACE1 inhibitors |
| JP6895424B2 (ja) * | 2015-08-12 | 2021-06-30 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | Ｂａｃｅ１阻害剤 |
| US11629154B2 (en) | 2018-04-27 | 2023-04-18 | Shionogi & Co., Ltd. | Tetrahydropyranooxazine derivatives having selective BACE1 inhibitory activity |
| CN110467611B (zh) * | 2018-05-11 | 2022-09-27 | 广东东阳光药业有限公司 | 亚氨基噻二嗪二氧化物衍生物及其用途 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090221579A1 (en) * | 2004-10-15 | 2009-09-03 | Jeffrey Scott Albert | Substituted Amino-Compounds and Uses Thereof |
| US8461160B2 (en) * | 2009-05-08 | 2013-06-11 | Hoffmann-La Roche, Inc. | Dihydropyrimidinones |
| US8188079B2 (en) * | 2009-08-19 | 2012-05-29 | Hoffman-La Roche Inc. | 3-amino-5-phenyl-5,6-dihydro-2H-[1,4]oxazines |
| US20110065695A1 (en) * | 2009-09-11 | 2011-03-17 | Jeremy Beauchamp | Use of aminodihydrothiazines for the treatment or prevention of diabetes |
| UA103272C2 (uk) * | 2009-12-11 | 2013-09-25 | Ф. Хоффманн-Ля Рош Аг | 2-аміно-5,5-дифтор-5,6-дигідро-4h-оксазини як інгібітори bace1 і/або bace2 |
| MX2013011947A (es) | 2011-04-13 | 2014-01-16 | Merck Sharp & Dohme | Iminotiazinas 5-sustituidas y sus monoxidos y dioxidos como inhibidores de la enzima que encinde la proteina precursora amiloide en el sitio beta, composiciones y su uso. |
| KR20140054295A (ko) * | 2011-08-22 | 2014-05-08 | 머크 샤프 앤드 돔 코포레이션 | Bace 억제제로서의 2-스피로-치환된 이미노티아진 및 그의 모노- 및 디옥시드, 조성물 및 그의 용도 |
-
2013
- 2013-05-21 AU AU2013265376A patent/AU2013265376B2/en not_active Ceased
- 2013-05-21 SG SG11201407575PA patent/SG11201407575PA/en unknown
- 2013-05-21 EA EA201492097A patent/EA026004B1/ru not_active IP Right Cessation
- 2013-05-21 UA UAA201413535A patent/UA113438C2/uk unknown
- 2013-05-21 JP JP2015513132A patent/JP6251249B2/ja not_active Expired - Fee Related
- 2013-05-21 US US14/400,448 patent/US9273042B2/en not_active Expired - Fee Related
- 2013-05-21 EP EP13725321.7A patent/EP2855469B1/en active Active
- 2013-05-21 CN CN201380026707.3A patent/CN104334554B/zh not_active Expired - Fee Related
- 2013-05-21 MX MX2014013839A patent/MX2014013839A/es unknown
- 2013-05-21 PE PE2014002013A patent/PE20150021A1/es not_active Application Discontinuation
- 2013-05-21 CA CA2872179A patent/CA2872179A1/en not_active Abandoned
- 2013-05-21 KR KR1020147032555A patent/KR20150014934A/ko not_active Withdrawn
- 2013-05-21 WO PCT/EP2013/060352 patent/WO2013174781A1/en not_active Ceased
- 2013-05-21 NZ NZ702254A patent/NZ702254A/en not_active IP Right Cessation
- 2013-05-21 BR BR112014028813A patent/BR112014028813A2/pt not_active IP Right Cessation
-
2014
- 2014-10-27 CR CR20140495A patent/CR20140495A/es unknown
- 2014-11-11 CO CO14249385A patent/CO7131369A2/es unknown
- 2014-11-13 IL IL235681A patent/IL235681A/en not_active IP Right Cessation
- 2014-11-14 PH PH12014502541A patent/PH12014502541B1/en unknown
- 2014-11-18 CL CL2014003123A patent/CL2014003123A1/es unknown
- 2014-12-24 MA MA37691A patent/MA37691B1/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CO7131369A2 (es) | 2014-12-01 |
| IL235681A (en) | 2017-10-31 |
| JP2015517548A (ja) | 2015-06-22 |
| US20150141413A1 (en) | 2015-05-21 |
| EP2855469A1 (en) | 2015-04-08 |
| UA113438C2 (xx) | 2017-01-25 |
| CA2872179A1 (en) | 2013-11-28 |
| PH12014502541A1 (en) | 2015-01-21 |
| EA026004B1 (ru) | 2017-02-28 |
| US9273042B2 (en) | 2016-03-01 |
| KR20150014934A (ko) | 2015-02-09 |
| MA37691B1 (fr) | 2016-11-30 |
| IL235681A0 (en) | 2015-02-01 |
| BR112014028813A2 (pt) | 2017-06-27 |
| MA37691A1 (fr) | 2016-03-31 |
| CN104334554B (zh) | 2017-10-31 |
| HK1201261A1 (en) | 2015-08-28 |
| MX2014013839A (es) | 2015-02-04 |
| AU2013265376B2 (en) | 2017-07-20 |
| SG11201407575PA (en) | 2014-12-30 |
| AU2013265376A1 (en) | 2014-11-13 |
| PE20150021A1 (es) | 2015-01-28 |
| EP2855469B1 (en) | 2019-06-19 |
| PH12014502541B1 (en) | 2015-01-21 |
| JP6251249B2 (ja) | 2017-12-20 |
| CL2014003123A1 (es) | 2015-02-27 |
| NZ702254A (en) | 2016-08-26 |
| EA201492097A1 (ru) | 2015-04-30 |
| CN104334554A (zh) | 2015-02-04 |
| WO2013174781A1 (en) | 2013-11-28 |
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