CR20140495A - 5-amino[1,4]thiazines como inhibidores de bace1 - Google Patents
5-amino[1,4]thiazines como inhibidores de bace1Info
- Publication number
- CR20140495A CR20140495A CR20140495A CR20140495A CR20140495A CR 20140495 A CR20140495 A CR 20140495A CR 20140495 A CR20140495 A CR 20140495A CR 20140495 A CR20140495 A CR 20140495A CR 20140495 A CR20140495 A CR 20140495A
- Authority
- CR
- Costa Rica
- Prior art keywords
- thiazines
- bace1
- inhibitors
- amino
- compound
- Prior art date
Links
- 102100021257 Beta-secretase 1 Human genes 0.000 title 1
- 101000894895 Homo sapiens Beta-secretase 1 Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 150000004897 thiazines Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
La presente invención proporciona un compuesto de fórmula I
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12169353 | 2012-05-24 | ||
| PCT/EP2013/060352 WO2013174781A1 (en) | 2012-05-24 | 2013-05-21 | 5-amino[1,4]thiazines as bace 1 inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CR20140495A true CR20140495A (es) | 2014-12-01 |
Family
ID=48534350
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CR20140495A CR20140495A (es) | 2012-05-24 | 2014-10-27 | 5-amino[1,4]thiazines como inhibidores de bace1 |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US9273042B2 (es) |
| EP (1) | EP2855469B1 (es) |
| JP (1) | JP6251249B2 (es) |
| KR (1) | KR20150014934A (es) |
| CN (1) | CN104334554B (es) |
| AU (1) | AU2013265376B2 (es) |
| BR (1) | BR112014028813A2 (es) |
| CA (1) | CA2872179A1 (es) |
| CL (1) | CL2014003123A1 (es) |
| CO (1) | CO7131369A2 (es) |
| CR (1) | CR20140495A (es) |
| EA (1) | EA026004B1 (es) |
| IL (1) | IL235681A (es) |
| MA (1) | MA37691B1 (es) |
| MX (1) | MX2014013839A (es) |
| NZ (1) | NZ702254A (es) |
| PE (1) | PE20150021A1 (es) |
| PH (1) | PH12014502541B1 (es) |
| SG (1) | SG11201407575PA (es) |
| UA (1) | UA113438C2 (es) |
| WO (1) | WO2013174781A1 (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2014111055A (ru) * | 2011-08-22 | 2015-09-27 | Мерк Шарп И Доум Корп. | 2-спирозамещенные иминотиазины и их моно- и диоксиды в качестве ингибиторов bace, композиции и их применение |
| WO2014059185A1 (en) | 2012-10-12 | 2014-04-17 | Amgen Inc. | Amino - dihydrothiazine and amino - dioxido dihydrothiazine compounds as beta-secretase antagonists and methods of use |
| WO2015017407A1 (en) | 2013-07-30 | 2015-02-05 | Amgen Inc. | Bridged bicyclic amino thiazine dioxide compounds as inhibitors of beta- secretase |
| WO2015038446A1 (en) * | 2013-09-13 | 2015-03-19 | Merck Sharp & Dohme Corp. | C5-spiro iminothiazine dioxides as bace inhibitors, compositions, and their use |
| JP6554547B2 (ja) * | 2014-11-03 | 2019-07-31 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | Ｂａｃｅ１阻害剤 |
| CR20170426A (es) | 2015-03-20 | 2017-10-23 | Hoffmann La Roche | Inhibidores de bace 1 |
| WO2017025491A1 (en) * | 2015-08-12 | 2017-02-16 | F. Hoffmann-La Roche Ag | Bace1 inhibitors |
| TW202014191A (zh) | 2018-04-27 | 2020-04-16 | 日商鹽野義製藥股份有限公司 | 具有選擇性ｂａｃｅ１抑制活性的四氫哌喃并衍生物 |
| CN110467611B (zh) * | 2018-05-11 | 2022-09-27 | 广东东阳光药业有限公司 | 亚氨基噻二嗪二氧化物衍生物及其用途 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1802587A4 (en) * | 2004-10-15 | 2010-02-17 | Astrazeneca Ab | SUBSTITUTED AMINO BINDINGS AND THEIR APPLICATIONS |
| US8461160B2 (en) * | 2009-05-08 | 2013-06-11 | Hoffmann-La Roche, Inc. | Dihydropyrimidinones |
| US8188079B2 (en) | 2009-08-19 | 2012-05-29 | Hoffman-La Roche Inc. | 3-amino-5-phenyl-5,6-dihydro-2H-[1,4]oxazines |
| US20110065695A1 (en) | 2009-09-11 | 2011-03-17 | Jeremy Beauchamp | Use of aminodihydrothiazines for the treatment or prevention of diabetes |
| UA103272C2 (uk) * | 2009-12-11 | 2013-09-25 | Ф. Хоффманн-Ля Рош Аг | 2-аміно-5,5-дифтор-5,6-дигідро-4h-оксазини як інгібітори bace1 і/або bace2 |
| JP2014514302A (ja) * | 2011-04-13 | 2014-06-19 | メルク・シャープ・アンド・ドーム・コーポレーション | Ｂａｃｅ阻害薬としての５−置換されたイミノチアジン類およびそれのモノおよびジオキシド、組成物およびそれらの使用 |
| RU2014111055A (ru) * | 2011-08-22 | 2015-09-27 | Мерк Шарп И Доум Корп. | 2-спирозамещенные иминотиазины и их моно- и диоксиды в качестве ингибиторов bace, композиции и их применение |
-
2013
- 2013-05-21 PE PE2014002013A patent/PE20150021A1/es not_active Application Discontinuation
- 2013-05-21 SG SG11201407575PA patent/SG11201407575PA/en unknown
- 2013-05-21 EA EA201492097A patent/EA026004B1/ru not_active IP Right Cessation
- 2013-05-21 CA CA2872179A patent/CA2872179A1/en not_active Abandoned
- 2013-05-21 AU AU2013265376A patent/AU2013265376B2/en not_active Ceased
- 2013-05-21 MX MX2014013839A patent/MX2014013839A/es unknown
- 2013-05-21 KR KR1020147032555A patent/KR20150014934A/ko not_active Withdrawn
- 2013-05-21 US US14/400,448 patent/US9273042B2/en not_active Expired - Fee Related
- 2013-05-21 UA UAA201413535A patent/UA113438C2/uk unknown
- 2013-05-21 EP EP13725321.7A patent/EP2855469B1/en active Active
- 2013-05-21 NZ NZ702254A patent/NZ702254A/en not_active IP Right Cessation
- 2013-05-21 CN CN201380026707.3A patent/CN104334554B/zh not_active Expired - Fee Related
- 2013-05-21 JP JP2015513132A patent/JP6251249B2/ja not_active Expired - Fee Related
- 2013-05-21 BR BR112014028813A patent/BR112014028813A2/pt not_active IP Right Cessation
- 2013-05-21 WO PCT/EP2013/060352 patent/WO2013174781A1/en not_active Ceased
-
2014
- 2014-10-27 CR CR20140495A patent/CR20140495A/es unknown
- 2014-11-11 CO CO14249385A patent/CO7131369A2/es unknown
- 2014-11-13 IL IL235681A patent/IL235681A/en not_active IP Right Cessation
- 2014-11-14 PH PH12014502541A patent/PH12014502541B1/en unknown
- 2014-11-18 CL CL2014003123A patent/CL2014003123A1/es unknown
- 2014-12-24 MA MA37691A patent/MA37691B1/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2015517548A (ja) | 2015-06-22 |
| HK1201261A1 (en) | 2015-08-28 |
| MA37691B1 (fr) | 2016-11-30 |
| JP6251249B2 (ja) | 2017-12-20 |
| US9273042B2 (en) | 2016-03-01 |
| BR112014028813A2 (pt) | 2017-06-27 |
| AU2013265376B2 (en) | 2017-07-20 |
| KR20150014934A (ko) | 2015-02-09 |
| EA201492097A1 (ru) | 2015-04-30 |
| PE20150021A1 (es) | 2015-01-28 |
| UA113438C2 (xx) | 2017-01-25 |
| MX2014013839A (es) | 2015-02-04 |
| SG11201407575PA (en) | 2014-12-30 |
| EP2855469B1 (en) | 2019-06-19 |
| EP2855469A1 (en) | 2015-04-08 |
| CL2014003123A1 (es) | 2015-02-27 |
| AU2013265376A1 (en) | 2014-11-13 |
| CN104334554B (zh) | 2017-10-31 |
| PH12014502541A1 (en) | 2015-01-21 |
| EA026004B1 (ru) | 2017-02-28 |
| IL235681A0 (en) | 2015-02-01 |
| IL235681A (en) | 2017-10-31 |
| CO7131369A2 (es) | 2014-12-01 |
| PH12014502541B1 (en) | 2015-01-21 |
| NZ702254A (en) | 2016-08-26 |
| CN104334554A (zh) | 2015-02-04 |
| US20150141413A1 (en) | 2015-05-21 |
| MA37691A1 (fr) | 2016-03-31 |
| CA2872179A1 (en) | 2013-11-28 |
| WO2013174781A1 (en) | 2013-11-28 |
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