CR20150662A - OLIGÓMEROS ANTISENTIDO AND CONJUGADOS WITH DIANA IN PCSK9 - Google Patents

OLIGÓMEROS ANTISENTIDO AND CONJUGADOS WITH DIANA IN PCSK9

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Publication number
CR20150662A
CR20150662A CR20150662A CR20150662A CR20150662A CR 20150662 A CR20150662 A CR 20150662A CR 20150662 A CR20150662 A CR 20150662A CR 20150662 A CR20150662 A CR 20150662A CR 20150662 A CR20150662 A CR 20150662A
Authority
CR
Costa Rica
Prior art keywords
pcsk9
oligómeros
conjugados
antisentido
diana
Prior art date
Application number
CR20150662A
Other languages
Spanish (es)
Inventor
Nanna Albæk
Maj Hedtjärn
Marie Lindholm
Niels Fisker Nielsen
Andreas Petri
Jacob Ravn
Original Assignee
Roche Innovation Ct Copenhagen As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/EP2014/063757 external-priority patent/WO2014207232A1/en
Application filed by Roche Innovation Ct Copenhagen As filed Critical Roche Innovation Ct Copenhagen As
Publication of CR20150662A publication Critical patent/CR20150662A/en

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Abstract

La presente invención se refiere a compuestos oligoméricos y conjugados de los mismos con diana en el ARNm de la proproteína-convertasa subtilisina/kexina tipo 9 (PCSK9) en una célula, que conducen a una expresión reducida de PCSK9. La reducción de la expresión de PCSK9 resulta beneficiosa para un abanico de trastornos médicos, tales como la hipercolesterolemia y trastornos relacionados.The present invention relates to oligomeric compounds and conjugates thereof with target in the mRNA of proprotein-convertase subtilisin / kexin type 9 (PCSK9) in a cell, which lead to reduced expression of PCSK9. The reduction of PCSK9 expression is beneficial for a range of medical disorders, such as hypercholesterolemia and related disorders.

CR20150662A 2013-06-27 2015-12-14 OLIGÓMEROS ANTISENTIDO AND CONJUGADOS WITH DIANA IN PCSK9 CR20150662A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP13174092 2013-06-27
EP13192930 2013-11-14
EP13192938 2013-11-14
PCT/EP2014/063757 WO2014207232A1 (en) 2013-06-27 2014-06-27 Antisense oligomers and conjugates targeting pcsk9

Publications (1)

Publication Number Publication Date
CR20150662A true CR20150662A (en) 2016-03-09

Family

ID=55859771

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20150662A CR20150662A (en) 2013-06-27 2015-12-14 OLIGÓMEROS ANTISENTIDO AND CONJUGADOS WITH DIANA IN PCSK9

Country Status (1)

Country Link
CR (1) CR20150662A (en)

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