CR20160142A - Pirido [4,3-b]pirazín-2-carboxamidas como agentes neurogénicos para el tratamiento de trastornos neurodegenerativos - Google Patents

Pirido [4,3-b]pirazín-2-carboxamidas como agentes neurogénicos para el tratamiento de trastornos neurodegenerativos

Info

Publication number
CR20160142A
CR20160142A CR20160142A CR20160142A CR20160142A CR 20160142 A CR20160142 A CR 20160142A CR 20160142 A CR20160142 A CR 20160142A CR 20160142 A CR20160142 A CR 20160142A CR 20160142 A CR20160142 A CR 20160142A
Authority
CR
Costa Rica
Prior art keywords
pirazín
carboxamids
pirido
treatment
neurodegenerative disorders
Prior art date
Application number
CR20160142A
Other languages
English (en)
Inventor
Ravi Jagasia
Roland Jakob-Roetne
Jens-Uwe Peters
Juergen Wichmann
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CR20160142A publication Critical patent/CR20160142A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Epidemiology (AREA)

Abstract

La presente invención se refiere a compuestos de la fórmula general: en la que R1 es hidrógeno, R2es hidrógeno, alquilo inferior, bencilo, alquilo inferior sustituido con hidroxi o es cicloalquilo sustituido opcionalmente con ciano, o R1 y R2 forman, conjuntamente con el átomo de N al que se encuentran unidos, un grupo heterocicloalquilo, que opcionalmente contiene un átomo anular adicional de N, O o S, y que se encuentra sustituido opcionalmente con hidroxi, R3 es halógeno.
CR20160142A 2013-11-12 2016-03-29 Pirido [4,3-b]pirazín-2-carboxamidas como agentes neurogénicos para el tratamiento de trastornos neurodegenerativos CR20160142A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13192406 2013-11-12
PCT/EP2014/073988 WO2015071178A1 (en) 2013-11-12 2014-11-07 Pyrido[4,3-b]pyrazine-2-carboxamides as neurogenic agents for the treatment of neurodegenerative disorders

Publications (1)

Publication Number Publication Date
CR20160142A true CR20160142A (es) 2016-05-04

Family

ID=49552255

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20160142A CR20160142A (es) 2013-11-12 2016-03-29 Pirido [4,3-b]pirazín-2-carboxamidas como agentes neurogénicos para el tratamiento de trastornos neurodegenerativos

Country Status (17)

Country Link
US (1) US9670206B2 (es)
EP (1) EP3068781B1 (es)
JP (1) JP6229056B2 (es)
KR (1) KR101861937B1 (es)
CN (1) CN105764901B (es)
AU (1) AU2014350371B2 (es)
CA (1) CA2929461A1 (es)
CL (1) CL2016001024A1 (es)
CR (1) CR20160142A (es)
EA (1) EA028940B1 (es)
IL (1) IL244619A0 (es)
MA (1) MA39027B1 (es)
MX (1) MX2016006052A (es)
PE (1) PE20160692A1 (es)
PH (1) PH12016500605A1 (es)
UA (1) UA117041C2 (es)
WO (1) WO2015071178A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20181198A1 (es) 2015-10-26 2018-07-23 Bayer Cropscience Ag Derivados de heterociclos biciclicos condensados como agentes de control de plagas
CA3108099A1 (en) * 2018-07-31 2020-02-06 Merck Patent Gmbh Tlr7/8 antagonists and uses thereof
PY2012000A (es) 2019-02-26 2023-07-25 Bayer Ag Derivados de heterociclos bicíclicos fusionados como pesticidas
PY2011993A (es) 2019-02-26 2021-07-05 Bayer Ag Derivados heterocíclos bicíclicos condensados como plaguicida

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7282506B2 (en) * 2004-08-03 2007-10-16 Serenex, Inc. 2,8-disubstituted naphthyridine derivatives
CN101356173B (zh) * 2005-11-11 2012-10-31 阿特纳赞塔里斯有限公司 新的吡啶并吡嗪和它们作为激酶调节剂的用途
AU2010221417A1 (en) * 2009-03-02 2011-09-22 Sirtris Pharmaceuticals, Inc. 8-substituted quinolines and related analogs as sirtuin modulators
JP2012524800A (ja) * 2009-04-22 2012-10-18 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ モノアシルグリセロールリパーゼ阻害剤としてのアゼチジニルジアミド
CA2804161A1 (en) * 2010-07-07 2012-01-12 Board Of Regents Of The University Of Texas System Pro-neurogenic compounds
CN105163727B (zh) * 2013-05-03 2018-08-17 豪夫迈·罗氏有限公司 刺激神经发生的异喹啉衍生物
TWI529171B (zh) * 2013-07-29 2016-04-11 赫孚孟拉羅股份公司 １，７－萘啶衍生物

Also Published As

Publication number Publication date
WO2015071178A1 (en) 2015-05-21
MX2016006052A (es) 2016-07-18
PE20160692A1 (es) 2016-07-28
AU2014350371B2 (en) 2018-02-15
JP6229056B2 (ja) 2017-11-08
PH12016500605A1 (en) 2016-06-13
EA028940B1 (ru) 2018-01-31
JP2016536320A (ja) 2016-11-24
US9670206B2 (en) 2017-06-06
EP3068781B1 (en) 2017-12-20
IL244619A0 (en) 2016-04-21
CN105764901A (zh) 2016-07-13
CN105764901B (zh) 2018-06-22
UA117041C2 (uk) 2018-06-11
MA39027A1 (fr) 2018-05-31
HK1223916A1 (zh) 2017-08-11
CA2929461A1 (en) 2015-05-21
KR101861937B1 (ko) 2018-05-28
EP3068781A1 (en) 2016-09-21
US20160251355A1 (en) 2016-09-01
KR20160061427A (ko) 2016-05-31
EA201690971A1 (ru) 2016-08-31
CL2016001024A1 (es) 2016-11-18
MA39027B1 (fr) 2018-10-31

Similar Documents

Publication Publication Date Title
BR112016028773A2 (pt) processos para preparação de compostos antivirais
BR112016014020A8 (pt) moduladores de tetra-hidropiridopirazinas de gpr6.
GT201400195A (es) Compuestos de heterociclilo como inhibidores de mek
DOP2015000289A (es) Compuestos de 3,4-dihidroisoquinolin-2(1h)-ilo
DOP2017000066A (es) Compuestos y composiciones como inhibidores de quinasa raf
MX378186B (es) Cristales novedosos de 9-etil-6,6-dimetil-8-(4-morfolin-4-il-piperidin-1-il)-11-oxo-6,11-dihidro-5h-benzo[b]carbazol-3-carbonitrilo.
ECSP14013339A (es) Compuestos con actividad nematicida
MX2018002986A (es) Compuestos de heteroarilo como inhibidores de cinasas asociadas al receptor de interleucina 1 (irak) y sus usos.
MX2017006266A (es) Compuestos de heteroarilo como inhibidores de cinasas asociadas al receptor de interleucina 1(irak) y sus usos.
CR20200276A (es) Sulfamoilarilamidas y su uso como medicamentos para el tratamientos de la hepatitis b (divisional exp. 2015-0059)
PE20210548A1 (es) Derivado de amino-fluoropiperidina como inhibidor de quinasa
BR112014019909A8 (pt) Processo para produção de compostos úteis como antagonistas do receptor de orexina-2
AR093184A1 (es) Compuesto de pirimidina sustituida como inhibidor de quinurenina-3-monooxigenasa y composicion farmaceutica que lo comprenden
CR20150378A (es) Compuestos tetracíclicos sustituidos con heterociclo y métodos de uso de los mismos para el tratamiento de enfermedades víricas
CR20140183A (es) Compuestos con actividad nematicida
CL2020001589A1 (es) Proceso para la preparación de derivados de quinolina.
MA38982A1 (fr) Nouvel octahydro-cyclobuta [1,2-c; 3,4-c'] dipyrrol-2-yl
MX2016007128A (es) Compuestos del receptor 6 de quimiocina (ccr6).
DOP2015000059A (es) Amino-quinolinas como inhibidores de cinasa
ECSP15004780A (es) Antagonistas del receptor de 5–ht3
BR112014030474A2 (pt) novos compostos bicíclicos de tiofenilamida
CR20140495A (es) 5-amino[1,4]thiazines como inhibidores de bace1
MX340816B (es) Compuestos que inhiben el glioblastoma y su uso.
BR112016029510A2 (pt) métodos para a preparação de um composto, e, composto intermediário.
MX2017011650A (es) Inhibidores de kv1.3 y su aplicacion medica.