CR20170585A - Linea de producción para la producción de medicamentos y planta de producción que comprende una tal línea de producción - Google Patents

Linea de producción para la producción de medicamentos y planta de producción que comprende una tal línea de producción

Info

Publication number
CR20170585A
CR20170585A CR20170585A CR20170585A CR20170585A CR 20170585 A CR20170585 A CR 20170585A CR 20170585 A CR20170585 A CR 20170585A CR 20170585 A CR20170585 A CR 20170585A CR 20170585 A CR20170585 A CR 20170585A
Authority
CR
Costa Rica
Prior art keywords
production
production line
active ingredient
line
cylinder
Prior art date
Application number
CR20170585A
Other languages
English (en)
Inventor
Donatien Bruggeman
Margerie Victoire De
Hans Mayer
Original Assignee
Rondol Ind
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rondol Ind filed Critical Rondol Ind
Publication of CR20170585A publication Critical patent/CR20170585A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
    • B29C48/25—Component parts, details or accessories; Auxiliary operations
    • B29C48/36—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die
    • B29C48/395—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die using screws surrounded by a cooperating barrel, e.g. single screw extruders
    • B29C48/40—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die using screws surrounded by a cooperating barrel, e.g. single screw extruders using two or more parallel screws or at least two parallel non-intermeshing screws, e.g. twin screw extruders
    • B29C48/402—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die using screws surrounded by a cooperating barrel, e.g. single screw extruders using two or more parallel screws or at least two parallel non-intermeshing screws, e.g. twin screw extruders the screws having intermeshing parts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/06—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of pills, lozenges or dragees
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/08—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of suppositories or sticks
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
    • B29C48/022—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor characterised by the choice of material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
    • B29C48/14—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor characterised by the particular extruding conditions, e.g. in a modified atmosphere or by using vibration
    • B29C48/141—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor characterised by the particular extruding conditions, e.g. in a modified atmosphere or by using vibration extruding in a clean room
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
    • B29C48/25—Component parts, details or accessories; Auxiliary operations
    • B29C48/36—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die
    • B29C48/395—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die using screws surrounded by a cooperating barrel, e.g. single screw extruders
    • B29C48/40—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die using screws surrounded by a cooperating barrel, e.g. single screw extruders using two or more parallel screws or at least two parallel non-intermeshing screws, e.g. twin screw extruders
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
    • B29C48/25—Component parts, details or accessories; Auxiliary operations
    • B29C48/88—Thermal treatment of the stream of extruded material, e.g. cooling
    • B29C48/911—Cooling
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
    • B29C48/25—Component parts, details or accessories; Auxiliary operations
    • B29C48/92—Measuring, controlling or regulating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J2200/00—General characteristics or adaptations
    • A61J2200/20—Extrusion means, e.g. for producing pharmaceutical forms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J2200/00—General characteristics or adaptations
    • A61J2200/40—Heating or cooling means; Combinations thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J2200/00—General characteristics or adaptations
    • A61J2200/40—Heating or cooling means; Combinations thereof
    • A61J2200/42—Heating means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J2200/00—General characteristics or adaptations
    • A61J2200/40—Heating or cooling means; Combinations thereof
    • A61J2200/44—Cooling means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C2791/00—Shaping characteristics in general
    • B29C2791/004—Shaping under special conditions
    • B29C2791/005—Using a particular environment, e.g. sterile fluids other than air
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
    • B29C48/14—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor characterised by the particular extruding conditions, e.g. in a modified atmosphere or by using vibration
    • B29C48/142—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor characterised by the particular extruding conditions, e.g. in a modified atmosphere or by using vibration using force fields, e.g. gravity or electrical fields

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Thermal Sciences (AREA)
  • Extrusion Moulding Of Plastics Or The Like (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Glanulating (AREA)
  • Medicinal Preparation (AREA)

Abstract

Esta línea de producción (12), adaptada para la producción de medicamentos que comprende al menos un ingrediente activo, contiene un extrusor (20) para la producción de un extruido a partir del ingrediente activo y de al menos un excipiente destinado a formar una matriz encapsulante de ingrediente activo y un miembro de enfriamiento (24) del extruido a la salida del extrusor (20). El extrusor (20) comprende un cilindro (30) u al menos dos tornillos (32) paralelos alojados en el cilindro (30) y que se interpenetran entre sí para la mezcla del o de cada ingrediente activo con el o cada excipiente. El cilindro (30) está orientado sensiblemente verticalmente y la superficie del suelo ocupada por la línea de producción (12) es inferior a 0.5 m2.
CR20170585A 2015-06-23 2016-06-23 Linea de producción para la producción de medicamentos y planta de producción que comprende una tal línea de producción CR20170585A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR1555783A FR3037789A1 (fr) 2015-06-23 2015-06-23 Ligne de production pour la production de medicaments, et installation de production comprenant une telle ligne de production
PCT/EP2016/064539 WO2016207279A1 (fr) 2015-06-23 2016-06-23 Ligne de production pour la production de médicaments, et installation de production comprenant une telle ligne de production

Publications (1)

Publication Number Publication Date
CR20170585A true CR20170585A (es) 2018-08-06

Family

ID=53776869

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20170585A CR20170585A (es) 2015-06-23 2016-06-23 Linea de producción para la producción de medicamentos y planta de producción que comprende una tal línea de producción

Country Status (17)

Country Link
US (1) US10945923B2 (es)
EP (1) EP3313353B1 (es)
JP (1) JP2018527044A (es)
KR (1) KR20180055760A (es)
CN (1) CN108200765A (es)
CA (1) CA2987913C (es)
CR (1) CR20170585A (es)
DK (1) DK3313353T3 (es)
ES (1) ES2740198T3 (es)
FR (1) FR3037789A1 (es)
HR (1) HRP20191394T1 (es)
HU (1) HUE045470T2 (es)
IL (1) IL256429B (es)
MX (1) MX373632B (es)
PL (1) PL3313353T3 (es)
PT (1) PT3313353T (es)
WO (1) WO2016207279A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3954526A3 (en) * 2018-06-11 2022-06-15 I.M.A. Industria Macchine Automatiche S.p.A. System for molding and coating of pharmaceutical tablets
EP3656530B2 (de) * 2018-11-21 2026-04-01 Coperion GmbH Verbindungsvorrichtung zum verbinden einer schneckenmaschine mit einem getriebe und verfahren zur reinigung einer derartigen verbindungsvorrichtung

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3645659A (en) * 1969-03-13 1972-02-29 Gloucester Eng Co Inc Extruding plastic
US3696061A (en) * 1970-04-13 1972-10-03 Amerace Esna Corp Method for forming flowable powder processable into microporous object
IT941066B (it) * 1971-06-19 1973-03-01 Jenne S R L Cella modulare per la filatura di fibre sintetiche
US4092089A (en) * 1974-04-06 1978-05-30 Bayer Aktiengesellschaft Apparatus for the preparation of melt-sprayed spherical phenacetin granules
JPS5780036A (en) 1980-11-06 1982-05-19 Toshiba Mach Co Ltd Extruder for molding plastics material
JP2546880B2 (ja) * 1987-08-06 1996-10-23 株式会社神戸製鋼所 スクリュー押出機
US5432250A (en) * 1991-03-13 1995-07-11 Daicel Chemical Industries, Ltd. Process for producing polycarbonate
JPH0857289A (ja) * 1994-08-22 1996-03-05 Freunt Ind Co Ltd スプレーユニット、洗浄ユニット、搬送ユニット、パンコーティング制御システム、およびこれらから成るパンコーティングシステム
US5686632A (en) * 1996-08-14 1997-11-11 Henkel Corporation Method of producing a tocopherol product
US6139872A (en) * 1996-08-14 2000-10-31 Henkel Corporation Method of producing a vitamin product
JP3763648B2 (ja) * 1996-11-07 2006-04-05 東芝機械株式会社 ２軸押出機の駆動伝達装置
PT1009387E (pt) * 1997-07-02 2006-08-31 Euro Celtique Sa Formulacoes estabilizadas de libertacao controlada de tramadol
US6093009A (en) * 1999-02-17 2000-07-25 Jacks, Jr.; Morris G. Apparatus and method for controlling angular relation between two rotating shafts
US6593053B1 (en) * 2000-10-23 2003-07-15 Xerox Corporation Method for controlling melt rheology of resin mixtures
GB0113841D0 (en) * 2001-06-07 2001-08-01 Boots Co Plc Therapeutic agents
DE10258261A1 (de) * 2002-12-13 2004-06-24 Saurer Gmbh & Co. Kg Spinnbalken
CA2685118C (en) * 2007-04-26 2016-11-01 Sigmoid Pharma Limited Manufacture of multiple minicapsules
WO2009057107A2 (en) 2007-10-29 2009-05-07 Yaron Elyasi A system and method for producing customized items
EP2240167B1 (en) * 2007-12-21 2013-11-13 Ludwig-Maximilians-Universität Extruded rod-shaped devices for controlled release of biological substances in humans and animals
ES2607814T3 (es) * 2008-02-28 2017-04-04 Abbvie Inc. Preparación de tabletas
CN101559023A (zh) 2008-04-18 2009-10-21 孙国强 新型滴丸机
US9132119B2 (en) * 2008-04-18 2015-09-15 Medtronic, Inc. Clonidine formulation in a polyorthoester carrier
MX2010011962A (es) * 2008-04-30 2010-11-30 Novartis Ag Proceso continuo para hacer composiciones farmaceuticas.
US20100099696A1 (en) * 2008-10-16 2010-04-22 Anthony Edward Soscia Tamper resistant oral dosage forms containing an embolizing agent
CN201350217Y (zh) * 2008-12-03 2009-11-25 天津天士力制药股份有限公司 滴盘、滴制蓄料器单元、冷凝单元及其组成的装置单元和系统
US20100316821A1 (en) * 2009-06-12 2010-12-16 Sunny General International Co., Ltd. Multi-layer films, sheets, and hollow articles with thermal management function for uses as casings of secondary batteries and supercapacitors, and sleeves of secondary battery and supercapacitor packs
DE102010007497A1 (de) * 2010-02-09 2011-08-11 Thüringisches Institut für Textil- und Kunststoff-Forschung e.V., 07407 Wärmespeichernde Formkörper
JP5462034B2 (ja) 2010-03-12 2014-04-02 東芝機械株式会社 押出機のスクリュ軸固定用分割式カラーおよび押出機
CN201676290U (zh) * 2010-04-02 2010-12-22 江世元 立式旋转挤出机
WO2012061780A1 (en) * 2010-11-04 2012-05-10 Abbott Gmbh & Co. Kg Method for producing monolithic tablets
JP2014500359A (ja) * 2010-11-24 2014-01-09 ビーエーエスエフ ソシエタス・ヨーロピア マイクロカプセル化潜熱蓄熱材料を含む熱可塑性成形組成物
WO2013030226A2 (en) * 2011-08-29 2013-03-07 Dsm Ip Assets B.V. Laboratory extruder
DE102011114577A1 (de) * 2011-09-30 2013-04-04 Thermo Electron (Karlsruhe) Gmbh Extruder
DE102011114576A1 (de) * 2011-09-30 2013-04-04 Thermo Electron (Karlsruhe) Gmbh Extruder
US8871125B2 (en) * 2011-12-19 2014-10-28 Exxonmobil Chemical Patents Inc. Laminates of partially scorched adhesive and DVA film
JP5165809B1 (ja) * 2012-09-10 2013-03-21 株式会社シーエンジ 立体網状構造体製造装置及び立体網状構造体製造方法
US9364995B2 (en) * 2013-03-15 2016-06-14 Matterrise, Inc. Three-dimensional printing and scanning system and method
US10945488B2 (en) * 2013-08-09 2021-03-16 Reebok International Limited Article of footwear with extruded components
CA3042642A1 (en) * 2013-08-12 2015-02-19 Pharmaceutical Manufacturing Research Services, Inc. Extruded immediate release abuse deterrent pill
US10195778B2 (en) * 2013-10-15 2019-02-05 Wolf & Associates, Inc. Three-dimensional printer systems and methods
CN203637129U (zh) * 2013-12-20 2014-06-11 上海玉城灿星塑料材料有限公司 一种高效双螺杆垂直塑料挤出机
JP6483443B2 (ja) * 2014-01-14 2019-03-13 日本合成化学工業株式会社 エチレンービニルエステル系共重合体ケン化物を用いた成形材料
US9539305B1 (en) * 2014-03-14 2017-01-10 Fleurir Abx Llc Pristinamycin compositions, LpxC compositions, their improvements, and combinations thereof
US9713902B2 (en) * 2015-05-01 2017-07-25 Thermwood Corporation Additive manufacturing apparatus

Also Published As

Publication number Publication date
MX2017016698A (es) 2018-11-09
PL3313353T3 (pl) 2019-11-29
IL256429A (en) 2018-02-28
CA2987913C (fr) 2023-10-17
DK3313353T3 (da) 2019-08-12
US10945923B2 (en) 2021-03-16
CA2987913A1 (fr) 2016-12-29
ES2740198T3 (es) 2020-02-05
IL256429B (en) 2021-01-31
EP3313353A1 (fr) 2018-05-02
HUE045470T2 (hu) 2019-12-30
KR20180055760A (ko) 2018-05-25
HRP20191394T1 (hr) 2019-11-01
EP3313353B1 (fr) 2019-05-01
CN108200765A (zh) 2018-06-22
WO2016207279A1 (fr) 2016-12-29
FR3037789A1 (fr) 2016-12-30
MX373632B (es) 2020-05-20
JP2018527044A (ja) 2018-09-20
PT3313353T (pt) 2019-08-19
US20180185244A1 (en) 2018-07-05

Similar Documents

Publication Publication Date Title
CO2019008364A2 (es) Composiciones farmacéuticas que comprenden meloxicam
MX2018003388A (es) Agonistas del receptor farnesoide x y usos de los mismos.
MX377649B (es) Composición que contiene una mezcla de extractos vegetales o una mezcla de moléculas contenidas en dichas plantas y uso para controlar el metabolismo de glúcidos y/o lípidos.
MX2018001721A (es) 5-bromo-2,6-di-(1h-pirazol-1-il) pirimidin-4-amina-para su uso en el tratamiento del cancer.
CR20140557A (es) Evento de maíz mon 87411
BR112015015891A8 (pt) Composição farmacêutica de solução sólida, e, uso de uma composição farmacêutica
ECSP11010960A (es) Formulación farmacéutica 514
BR112017015310A2 (pt) uso de pgr4 como um agente anti-inflamatório
MX2018004175A (es) Derivado oxa espiro, su metodo de preparacion, y sus aplicaciones en medicinas.
MX2018007301A (es) Aparato de expansion palatal.
CR20190394A (es) Compuestos de inhibidores de autotaxina
CL2018000739A1 (es) Terapia adjuntiva con 25-hidroxi vitamina d y artículos de la misma.
BR112016025876A8 (pt) composição, processos para preparar uma microcápsula e uma forma de dosagem unitária, forma de dosagem unitária, microcápsula, produto, uso de uma composição, e, método para tratar uma condição associada à vitamina k1 ou k2
BR112017001192A2 (pt) composições de açúcar para preparação de tabletes por meio de compressão direta
DOP2015000006A (es) Formulaciones de etanercept que muestran una marcada reducción de la cantidad de partículas subvisibles
CO2017002472A2 (es) Formulación de acetato de abiraterona
NI201600070A (es) Inhibidores tetracíclicos de autotaxina
CL2016001094A1 (es) Silicato de zirconio microporoso para el tratamiento de hipercalemia.
MX2017000676A (es) Oritavancina de alta pureza y metodo para producir la misma.
BR112017028137A2 (pt) agente terapêutico para fibrose
AR103609A1 (es) Transparencia para tarjeta de medicación
CR20170585A (es) Linea de producción para la producción de medicamentos y planta de producción que comprende una tal línea de producción
BR112018011476A2 (pt) formulação de vitamina
PH12019500992A1 (en) Directly tablettable matrix for producing tablets with extended active substance delivery
MX2016014701A (es) (r)-pirlindol y sus sales farmaceuticamente aceptables para uso en medicina.