CR20180328A - Compuestos de isoindol - Google Patents

Compuestos de isoindol

Info

Publication number
CR20180328A
CR20180328A CR20180328A CR20180328A CR20180328A CR 20180328 A CR20180328 A CR 20180328A CR 20180328 A CR20180328 A CR 20180328A CR 20180328 A CR20180328 A CR 20180328A CR 20180328 A CR20180328 A CR 20180328A
Authority
CR
Costa Rica
Prior art keywords
isoindol
compounds
compound
ror
prepare
Prior art date
Application number
CR20180328A
Other languages
English (en)
Inventor
Sarah LEVER
Berg Stefan; Von
Roine Ingemar Olsson
Frank Narjes
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of CR20180328A publication Critical patent/CR20180328A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/4035—Isoindoles, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/12—Mucolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente memoria descriptiva proporciona un compuesto de fórmula (I): o una sal farmacéuticamente aceptable del mismo; un proceso para preparar tal compuesto; y al uso de tal compuesto en el tratamiento de una patología mediada por ROR¿ y/o ROR¿t.
CR20180328A 2015-12-15 2016-12-14 Compuestos de isoindol CR20180328A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562267391P 2015-12-15 2015-12-15
PCT/EP2016/080885 WO2017102784A1 (en) 2015-12-15 2016-12-14 Isoindole compounds

Publications (1)

Publication Number Publication Date
CR20180328A true CR20180328A (es) 2018-08-09

Family

ID=57708552

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20180328A CR20180328A (es) 2015-12-15 2016-12-14 Compuestos de isoindol

Country Status (27)

Country Link
US (4) US10011566B2 (es)
EP (1) EP3390396B1 (es)
JP (1) JP6448867B2 (es)
KR (1) KR101947976B1 (es)
CN (1) CN109071516B (es)
AR (1) AR107054A1 (es)
AU (1) AU2016374294B2 (es)
BR (1) BR112018011851A2 (es)
CA (1) CA3007893A1 (es)
CL (1) CL2018001573A1 (es)
CO (1) CO2018005983A2 (es)
CR (1) CR20180328A (es)
DO (1) DOP2018000148A (es)
EA (1) EA034514B1 (es)
ES (1) ES2927631T3 (es)
IL (1) IL259818B (es)
MX (1) MX376029B (es)
MY (1) MY196276A (es)
NI (1) NI201800071A (es)
PE (1) PE20181319A1 (es)
PH (1) PH12018501237A1 (es)
SG (1) SG11201804587QA (es)
SV (1) SV2018005713A (es)
TN (1) TN2018000188A1 (es)
TW (1) TWI728017B (es)
WO (1) WO2017102784A1 (es)
ZA (1) ZA201804618B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109071516B (zh) 2015-12-15 2021-08-31 阿斯利康(瑞典)有限公司 新颖的化合物
WO2018229155A1 (en) * 2017-06-14 2018-12-20 Astrazeneca Ab 2,3-dihydroisoindole-1-carboxamides useful as ror-gamma modulators
WO2020035557A1 (en) 2018-08-17 2020-02-20 Leo Pharma A/S Novel heteroaromatic modulators of the retinoid-related orphan receptor gamma
WO2020035556A1 (en) 2018-08-17 2020-02-20 Leo Pharma A/S Novel heteroaromatic modulators of the retinoid-related orphan receptor gamma
CA3178650A1 (en) * 2020-05-15 2021-11-18 Yaobang CHENG Aniline compound used as ror.gamma. regulator
WO2021228216A1 (zh) * 2020-05-15 2021-11-18 上海辉启生物医药科技有限公司 可用作RORγ调节剂的联芳基类化合物
KR102422891B1 (ko) 2022-01-26 2022-07-20 (주)셀시스템 Ai기반 우선순위 제어기능을 구비한 일체형 태양광 온수 및 배터리 충전장치 및 이를 이용한 충전 방법
WO2023232870A1 (en) 2022-05-31 2023-12-07 Immunic Ag Rorg/rorgt modulators for the treatment of virus infections like covid-19

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Also Published As

Publication number Publication date
US20190084934A1 (en) 2019-03-21
PH12018501237A1 (en) 2019-02-18
KR20180086269A (ko) 2018-07-30
JP2018537485A (ja) 2018-12-20
PE20181319A1 (es) 2018-08-14
EA201891342A1 (ru) 2019-01-31
WO2017102784A1 (en) 2017-06-22
BR112018011851A2 (pt) 2018-12-04
ES2927631T3 (es) 2022-11-08
CA3007893A1 (en) 2017-06-22
JP6448867B2 (ja) 2019-01-09
EP3390396A1 (en) 2018-10-24
EA034514B1 (ru) 2020-02-14
KR101947976B1 (ko) 2019-02-13
AU2016374294B2 (en) 2019-06-27
US10526286B2 (en) 2020-01-07
AR107054A1 (es) 2018-03-14
MX376029B (es) 2025-03-07
CO2018005983A2 (es) 2018-06-20
US10011566B2 (en) 2018-07-03
CN109071516A (zh) 2018-12-21
MX2018007296A (es) 2019-01-10
TN2018000188A1 (en) 2019-10-04
ZA201804618B (en) 2020-09-30
EP3390396B1 (en) 2022-07-06
IL259818A (en) 2018-07-31
DOP2018000148A (es) 2018-07-15
US11453644B1 (en) 2022-09-27
CL2018001573A1 (es) 2018-07-27
US20200181084A1 (en) 2020-06-11
AU2016374294A1 (en) 2018-07-19
SG11201804587QA (en) 2018-06-28
IL259818B (en) 2021-05-31
MY196276A (en) 2023-03-24
CN109071516B (zh) 2021-08-31
US20170166527A1 (en) 2017-06-15
WO2017102784A9 (en) 2018-04-05
TW201738210A (zh) 2017-11-01
TWI728017B (zh) 2021-05-21
US10988445B2 (en) 2021-04-27
SV2018005713A (es) 2018-08-08
NI201800071A (es) 2018-10-18

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