CR20190542A - Compuestos - Google Patents
CompuestosInfo
- Publication number
- CR20190542A CR20190542A CR20190542A CR20190542A CR20190542A CR 20190542 A CR20190542 A CR 20190542A CR 20190542 A CR20190542 A CR 20190542A CR 20190542 A CR20190542 A CR 20190542A CR 20190542 A CR20190542 A CR 20190542A
- Authority
- CR
- Costa Rica
- Prior art keywords
- compounds
- tmlrcs
- tmlr
- lrcs
- manufacture
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 239000013543 active substance Substances 0.000 abstract 1
- 230000003281 allosteric effect Effects 0.000 abstract 1
- 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 abstract 1
- 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
La presente invención proporciona compuestos que son inhibidores alostéricos selectivos de mutantes de receptor del factor de crecimiento epidérmico (RFCE) que contienen TMLR, TMLCRS, LR, LRCS, su preparación, composiciones farmacéuticas que los contienen y su utilización como sustancias terapéuticamente activas.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762514244P | 2017-06-02 | 2017-06-02 | |
| EP17174334 | 2017-06-02 | ||
| US201762543438P | 2017-08-10 | 2017-08-10 | |
| PCT/EP2018/064399 WO2018220149A1 (en) | 2017-06-02 | 2018-06-01 | Compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CR20190542A true CR20190542A (es) | 2020-01-14 |
Family
ID=62495802
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CR20190542A CR20190542A (es) | 2017-06-02 | 2018-06-01 | Compuestos |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US11117890B2 (es) |
| EP (1) | EP3630754B8 (es) |
| JP (1) | JP7191045B2 (es) |
| KR (1) | KR20200015595A (es) |
| CN (1) | CN110753691B (es) |
| AU (1) | AU2018276441B2 (es) |
| BR (1) | BR112019025370A2 (es) |
| CA (1) | CA3065874A1 (es) |
| CL (1) | CL2019003501A1 (es) |
| CO (1) | CO2019013557A2 (es) |
| CR (1) | CR20190542A (es) |
| ES (1) | ES2927480T3 (es) |
| IL (1) | IL271013B2 (es) |
| MA (1) | MA48946A (es) |
| MX (1) | MX390898B (es) |
| MY (1) | MY201976A (es) |
| PE (1) | PE20200718A1 (es) |
| PH (1) | PH12019502662A1 (es) |
| PL (1) | PL3630754T3 (es) |
| TW (1) | TWI774780B (es) |
| UA (1) | UA126452C2 (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2961187T3 (es) | 2019-06-21 | 2024-03-08 | Hoffmann La Roche | Inhibidor de EGFR para el tratamiento del cáncer |
| CN116507328A (zh) | 2020-12-01 | 2023-07-28 | 豪夫迈·罗氏有限公司 | 新的吲唑衍生物 |
| IL303064A (en) | 2020-12-01 | 2023-07-01 | Hoffmann La Roche | NEW INDAZOLE ACETYLENE DERIVATIVES |
| CN118525018A (zh) * | 2021-12-21 | 2024-08-20 | 上海艾力斯医药科技股份有限公司 | 一种联炔类化合物及其应用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2049518B1 (en) | 2006-05-31 | 2011-08-31 | Takeda San Diego, Inc. | Indazole and isoindole derivatives as glucokinase activating agents. |
| EP2148944A1 (en) * | 2007-05-25 | 2010-02-03 | Burnham Institute for Medical Research | Inhibitors of thapsigargin-induced cell death |
| US20110212078A1 (en) * | 2008-06-25 | 2011-09-01 | Reddy Panduranga Adulla P | Synthesis and use of heterocyclic antibacterial agents |
| US8420661B2 (en) * | 2010-04-13 | 2013-04-16 | Hoffmann-La Roche Inc. | Arylethynyl derivatives |
| CN102060848B (zh) | 2010-12-09 | 2013-09-18 | 天津药物研究院 | 芳香胺取代的嘧啶衍生物的制备及用途 |
| CN102093339B (zh) | 2010-12-09 | 2013-06-12 | 天津药物研究院 | 一类嘧啶衍生物的制备及用途 |
| CN103421005A (zh) * | 2012-05-16 | 2013-12-04 | 上海医药集团股份有限公司 | 具有抗肿瘤活性的乙炔衍生物 |
| WO2016008411A1 (en) * | 2014-07-18 | 2016-01-21 | Beigene, Ltd. | 5-amino-4-carbamoyl-pyrazole compounds as selective and irreversible t790m over wt-egfr kinase inhibitors and use thereof |
| EP3205650B1 (en) * | 2014-10-11 | 2021-08-04 | Shanghai Hansoh Biomedical Co., Ltd. | Egfr inhibitor, and preparation and application thereof |
| KR102616818B1 (ko) * | 2015-05-14 | 2023-12-22 | 더 위스타 인스티튜트 오브 아나토미 앤드 바이올로지 | Ebna1 억제제 및 그의 사용 방법 |
| HK1252693A1 (zh) * | 2015-06-30 | 2019-05-31 | Dana Farber Cancer Institute, Inc. | Egfr抑制剂及其使用方法 |
| TW201834651A (zh) * | 2016-12-22 | 2018-10-01 | 瑞士商赫孚孟拉羅股份公司 | 化合物 |
-
2018
- 2018-06-01 ES ES18728875T patent/ES2927480T3/es active Active
- 2018-06-01 UA UAA202000003A patent/UA126452C2/uk unknown
- 2018-06-01 MY MYPI2019007060A patent/MY201976A/en unknown
- 2018-06-01 AU AU2018276441A patent/AU2018276441B2/en not_active Ceased
- 2018-06-01 BR BR112019025370-0A patent/BR112019025370A2/pt not_active IP Right Cessation
- 2018-06-01 PE PE2019002464A patent/PE20200718A1/es unknown
- 2018-06-01 MX MX2019014332A patent/MX390898B/es unknown
- 2018-06-01 MA MA048946A patent/MA48946A/fr unknown
- 2018-06-01 EP EP18728875.8A patent/EP3630754B8/en active Active
- 2018-06-01 CN CN201880036589.7A patent/CN110753691B/zh active Active
- 2018-06-01 KR KR1020197038496A patent/KR20200015595A/ko not_active Ceased
- 2018-06-01 JP JP2019566634A patent/JP7191045B2/ja active Active
- 2018-06-01 TW TW107118846A patent/TWI774780B/zh not_active IP Right Cessation
- 2018-06-01 CR CR20190542A patent/CR20190542A/es unknown
- 2018-06-01 PL PL18728875.8T patent/PL3630754T3/pl unknown
- 2018-06-01 CA CA3065874A patent/CA3065874A1/en active Pending
-
2019
- 2019-11-25 PH PH12019502662A patent/PH12019502662A1/en unknown
- 2019-11-28 IL IL271013A patent/IL271013B2/en unknown
- 2019-11-29 CO CONC2019/0013557A patent/CO2019013557A2/es unknown
- 2019-11-29 CL CL2019003501A patent/CL2019003501A1/es unknown
- 2019-12-02 US US16/700,900 patent/US11117890B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| KR20200015595A (ko) | 2020-02-12 |
| PE20200718A1 (es) | 2020-07-21 |
| IL271013B (en) | 2022-10-01 |
| CN110753691B (zh) | 2024-02-02 |
| TW201902892A (zh) | 2019-01-16 |
| JP2020524659A (ja) | 2020-08-20 |
| RU2019143647A (ru) | 2021-07-09 |
| RU2019143647A3 (es) | 2021-09-28 |
| CO2019013557A2 (es) | 2020-01-17 |
| IL271013B2 (en) | 2023-02-01 |
| MY201976A (en) | 2024-03-27 |
| UA126452C2 (uk) | 2022-10-05 |
| US20200102299A1 (en) | 2020-04-02 |
| CL2019003501A1 (es) | 2020-06-05 |
| EP3630754A1 (en) | 2020-04-08 |
| AU2018276441A1 (en) | 2019-12-12 |
| TWI774780B (zh) | 2022-08-21 |
| CA3065874A1 (en) | 2018-12-06 |
| US11117890B2 (en) | 2021-09-14 |
| ES2927480T3 (es) | 2022-11-07 |
| EP3630754B1 (en) | 2022-07-27 |
| BR112019025370A2 (pt) | 2020-06-23 |
| IL271013A (en) | 2020-01-30 |
| EP3630754B8 (en) | 2022-08-31 |
| MA48946A (fr) | 2020-04-08 |
| MX390898B (es) | 2025-03-21 |
| MX2019014332A (es) | 2022-03-24 |
| AU2018276441B2 (en) | 2022-04-28 |
| PL3630754T3 (pl) | 2022-10-24 |
| JP7191045B2 (ja) | 2022-12-16 |
| PH12019502662A1 (en) | 2020-06-08 |
| CN110753691A (zh) | 2020-02-04 |
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