CR20200042A - Anticuerpos anti-cd137 - Google Patents

Anticuerpos anti-cd137

Info

Publication number
CR20200042A
CR20200042A CR20200042A CR20200042A CR20200042A CR 20200042 A CR20200042 A CR 20200042A CR 20200042 A CR20200042 A CR 20200042A CR 20200042 A CR20200042 A CR 20200042A CR 20200042 A CR20200042 A CR 20200042A
Authority
CR
Costa Rica
Prior art keywords
antibodies
chemotherapy
bind
human
useful
Prior art date
Application number
CR20200042A
Other languages
English (en)
Inventor
Helen Kotanides
Christopher Carl Frye
Stephanie Lynn Sandefur
Michael Dewain Kalos
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of CR20200042A publication Critical patent/CR20200042A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • H—ELECTRICITY
    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04L—TRANSMISSION OF DIGITAL INFORMATION, e.g. TELEGRAPHIC COMMUNICATION
    • H04L7/00—Arrangements for synchronising receiver with transmitter
    • H04L7/04—Speed or phase control by synchronisation signals
    • H04L7/10—Arrangements for initial synchronisation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/524—CH2 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • H—ELECTRICITY
    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04B—TRANSMISSION
    • H04B10/00—Transmission systems employing electromagnetic waves other than radio-waves, e.g. infrared, visible or ultraviolet light, or employing corpuscular radiation, e.g. quantum communication
    • H04B10/25—Arrangements specific to fibre transmission
    • H04B10/2575—Radio-over-fibre, e.g. radio frequency signal modulated onto an optical carrier
    • H04B10/25752—Optical arrangements for wireless networks
    • H04B10/25753—Distribution optical network, e.g. between a base station and a plurality of remote units

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Signal Processing (AREA)
  • Computer Networks & Wireless Communication (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La presente invención se refiere a anticuerpos que se fijan a CD137 humano y muestran actividad agonista, y pueden ser útiles para tratar tumores sólidos y hematológicos solos y en combinación con quimioterapia y radiación ionizante.
CR20200042A 2017-08-01 2018-07-25 Anticuerpos anti-cd137 CR20200042A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762539687P 2017-08-01 2017-08-01
PCT/US2018/043632 WO2019027754A1 (en) 2017-08-01 2018-07-25 ANTI-CD137 ANTIBODIES

Publications (1)

Publication Number Publication Date
CR20200042A true CR20200042A (es) 2020-03-03

Family

ID=63165504

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20200042A CR20200042A (es) 2017-08-01 2018-07-25 Anticuerpos anti-cd137

Country Status (25)

Country Link
US (2) US10906983B2 (es)
EP (2) EP4070811A1 (es)
JP (2) JP6743320B1 (es)
KR (2) KR20210158420A (es)
CN (1) CN111182919B (es)
AU (2) AU2018311804B2 (es)
BR (1) BR112020001441A2 (es)
CA (2) CA3146758A1 (es)
CL (1) CL2020000233A1 (es)
CO (1) CO2020001050A2 (es)
CR (1) CR20200042A (es)
DO (1) DOP2020000020A (es)
EA (1) EA202090204A1 (es)
EC (1) ECSP20007663A (es)
ES (1) ES2912651T3 (es)
IL (1) IL272349B2 (es)
JO (1) JOP20200016B1 (es)
MA (1) MA49749A (es)
MX (1) MX2020001351A (es)
PE (1) PE20200839A1 (es)
PH (1) PH12020500225A1 (es)
SA (1) SA520411186B1 (es)
SG (1) SG11202000747VA (es)
UA (1) UA128388C2 (es)
WO (1) WO2019027754A1 (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112020000719A2 (pt) 2017-07-11 2020-07-14 Compass Therapeutics Llc anticorpos agonistas que ligam o cd137 humano e seus usos
PE20200839A1 (es) 2017-08-01 2020-08-13 Lilly Co Eli Anticuerpos anti-cd137
US11512134B2 (en) 2017-08-01 2022-11-29 Eli Lilly And Company Anti-CD137 antibodies
US11718679B2 (en) 2017-10-31 2023-08-08 Compass Therapeutics Llc CD137 antibodies and PD-1 antagonists and uses thereof
WO2019100052A2 (en) 2017-11-20 2019-05-23 Compass Therapeutics Llc Cd137 antibodies and tumor antigen-targeting antibodies and uses thereof
CN112020517B (zh) * 2018-03-23 2024-10-29 伊莱利利公司 用于与抗pd-l1抗体组合的抗cd137抗体
KR20250038810A (ko) * 2018-03-23 2025-03-19 일라이 릴리 앤드 캄파니 항-pd-1 항체와의 조합을 위한 항-cd137 항체
EP3823988A1 (en) * 2018-07-19 2021-05-26 Eli Lilly and Company Bispecific antibodies targeting immune checkpoints
JP7598312B2 (ja) 2018-07-23 2024-12-11 ハイデルベルク ファーマ リサーチ ゲーエムベーハー 同種異系の細胞療法における抗－ｃｄ１３７抗体薬物コンジュゲート（ａｄｃ）の使用
KR102697702B1 (ko) 2018-08-10 2024-08-22 추가이 세이야쿠 가부시키가이샤 항cd137 항원 결합 분자 및 그의 사용
SG11202110287QA (en) 2019-04-24 2021-10-28 Heidelberg Pharma Res Gmbh Amatoxin antibody-drug conjugates and uses thereof
CN118791614A (zh) * 2019-06-26 2024-10-18 圆祥生技股份有限公司 T细胞活化抗体
TWI895351B (zh) * 2020-02-12 2025-09-01 日商中外製藥股份有限公司 用於癌症之治療的抗cd137抗原結合分子
EP4253530A4 (en) 2020-11-25 2024-10-30 Shanghai Juncell Therapeutics Co., Ltd. TUMOR INFILTRATION LYMPHOCYTE CULTURE MEDIUM AND ITS APPLICATION
EP4674954A1 (en) 2023-02-27 2026-01-07 Shanghai Juncell Therapeutics Co., Ltd. Tumor infiltrating lymphocyte expressing membrane-bound cytokine
KR20250104669A (ko) 2023-12-29 2025-07-08 쿠팡 주식회사 옵션 선택 가이드 정보 제공 방법 및 그 장치
KR20250104655A (ko) 2023-12-29 2025-07-08 쿠팡 주식회사 옵션 피커 화면 제공 방법 및 그 장치
KR20250132789A (ko) 2024-02-29 2025-09-05 쿠팡 주식회사 옵션 피커 화면 제공 방법 및 그 장치

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6303121B1 (en) 1992-07-30 2001-10-16 Advanced Research And Technology Method of using human receptor protein 4-1BB
US6362325B1 (en) 1988-11-07 2002-03-26 Advanced Research And Technology Institute, Inc. Murine 4-1BB gene
US7211259B1 (en) 1993-05-07 2007-05-01 Immunex Corporation 4-1BB polypeptides and DNA encoding 4-1BB polypeptides
HUP9904697A3 (en) 1996-10-11 2001-06-28 Bristol Myers Squibb Company P Methods and compositions for immunomodulation
EP1434596B1 (en) 2001-10-09 2009-07-08 Mayo Foundation For Medical Education And Research Enhancement of immune responses by agonist 4-1bb-antibodies
US7288638B2 (en) * 2003-10-10 2007-10-30 Bristol-Myers Squibb Company Fully human antibodies against human 4-1BB
WO2010042433A1 (en) 2008-10-06 2010-04-15 Bristol-Myers Squibb Company Combination of cd137 antibody and ctla-4 antibody for the treatment of proliferative diseases
CN103221428B (zh) * 2010-09-09 2016-02-10 辉瑞公司 4-1bb结合分子
ES2716685T3 (es) 2014-01-24 2019-06-14 Dana Farber Cancer Inst Inc Moléculas de anticuerpo para PD-1 y usos de las mismas
EP3686219A1 (en) 2014-02-04 2020-07-29 Pfizer Inc Combination of a pd-1 antagonist and a 4-1bb agonist for treating cancer
US20170247455A1 (en) 2014-08-22 2017-08-31 Bristol-Myers Squibb Company Treatment of cancer using a combination of an anti-pd-1 antibody and an anti-cd137 antibody
TW201632559A (zh) * 2015-02-22 2016-09-16 索倫多醫療公司 結合ｃｄ１３７之抗體治療劑
WO2017024465A1 (en) 2015-08-10 2017-02-16 Innovent Biologics (Suzhou) Co., Ltd. Pd-1 antibodies
AR105654A1 (es) 2015-08-24 2017-10-25 Lilly Co Eli Anticuerpos pd-l1 (ligando 1 de muerte celular programada)
GB201619648D0 (en) * 2016-11-21 2017-01-04 Alligator Bioscience Ab Novel antibodies and uses thereof
PE20200839A1 (es) * 2017-08-01 2020-08-13 Lilly Co Eli Anticuerpos anti-cd137

Also Published As

Publication number Publication date
CO2020001050A2 (es) 2020-02-18
SG11202000747VA (en) 2020-02-27
UA128388C2 (uk) 2024-07-03
MA49749A (fr) 2021-03-24
BR112020001441A2 (pt) 2020-08-04
JP2020527356A (ja) 2020-09-10
CA3071383A1 (en) 2019-02-07
KR20200023439A (ko) 2020-03-04
NZ761548A (en) 2024-07-05
IL272349B1 (en) 2024-05-01
EP3661544A1 (en) 2020-06-10
AU2018311804A1 (en) 2020-02-13
CL2020000233A1 (es) 2020-07-31
JP6743320B1 (ja) 2020-08-19
CN111182919B (zh) 2023-07-07
SA520411186B1 (ar) 2025-06-29
AU2018311804B2 (en) 2021-09-02
KR102344620B1 (ko) 2022-01-03
US20230279134A1 (en) 2023-09-07
CA3071383C (en) 2022-04-12
CN111182919A (zh) 2020-05-19
AU2021277707A1 (en) 2021-12-23
ECSP20007663A (es) 2020-06-30
CA3146758A1 (en) 2019-02-07
WO2019027754A1 (en) 2019-02-07
MX2020001351A (es) 2020-03-09
JOP20200016B1 (ar) 2022-10-30
KR20210158420A (ko) 2021-12-30
JOP20200016A1 (ar) 2020-01-28
IL272349B2 (en) 2024-09-01
ES2912651T3 (es) 2022-05-26
PE20200839A1 (es) 2020-08-13
EP4070811A1 (en) 2022-10-12
JP7257364B2 (ja) 2023-04-13
US20200377607A1 (en) 2020-12-03
EP3661544B1 (en) 2022-04-13
US12453771B2 (en) 2025-10-28
PH12020500225A1 (en) 2020-11-09
EA202090204A1 (ru) 2020-05-22
DOP2020000020A (es) 2020-02-28
JP2020182492A (ja) 2020-11-12
US10906983B2 (en) 2021-02-02
IL272349A (en) 2020-03-31

Similar Documents

Publication Publication Date Title
JOP20200016B1 (ar) أجسام مضادة لـ cd137
PH12019500369A1 (en) Anti-tim-3 antibodies
PH12019502875A1 (en) Antibody molecules to cd73 and uses thereof
PH12019501253A1 (en) Anti-tim-3 antibodies for combination with anti-pd-1 antibodies
MX2020006668A (es) Anticuerpos para lilrb2.
MY199019A (en) Pd-1 antibodies
MX2019004834A (es) Anticuerpos de pd-1 y usos de estos.
PH12018500815A1 (en) Antibody conjugates comprising toll-like receptor agonist
PH12021552158A1 (en) Antibodies to icos
TN2018000044A1 (en) Pd-l1 ("programmed death-ligand 1") antibodies
CR20190576A (es) Anticuerpos biespecíficos inhibidores de punto de control
PH12016500137A1 (en) Afucosylated anti-fgfr2iiib antibodies
MX375221B (es) Composiciones que comprenden anticuerpos anti-molécula de adhesión celular relacionada con antígeno carcinoembrionario 1 y anti-muerte celular programada para la terapia contra el cáncer.
JOP20210314A1 (ar) Tigit وجزيئات ربط pd-1/tigit
MX2020009864A (es) Anticuerpos anti-cd137 para combinacion con anticuerpos anti-pd-1.
MX2020009863A (es) Anticuerpos anti-cd137 para combinacion con anticuerpos anti-pd-l1.