CR20210364A - Compuestos de quinolina como inhibidores de quinasas tam y met - Google Patents
Compuestos de quinolina como inhibidores de quinasas tam y metInfo
- Publication number
- CR20210364A CR20210364A CR20210364A CR20210364A CR20210364A CR 20210364 A CR20210364 A CR 20210364A CR 20210364 A CR20210364 A CR 20210364A CR 20210364 A CR20210364 A CR 20210364A CR 20210364 A CR20210364 A CR 20210364A
- Authority
- CR
- Costa Rica
- Prior art keywords
- tam
- inhibitors
- quinoline compounds
- met kinases
- strong
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
En la presente, se proporcionan compuestos de la Fórmula <strong>I</strong>: <img height="284" src="data:image/png;base64,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 (***)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962787965P | 2019-01-03 | 2019-01-03 | |
| US201962858819P | 2019-06-07 | 2019-06-07 | |
| US201962947720P | 2019-12-13 | 2019-12-13 | |
| PCT/IB2020/050009 WO2020141470A1 (en) | 2019-01-03 | 2020-01-02 | Quinoline compounds as inhibitors of tam and met kinases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CR20210364A true CR20210364A (es) | 2021-08-18 |
Family
ID=69185648
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CR20210364A CR20210364A (es) | 2019-01-03 | 2020-01-02 | Compuestos de quinolina como inhibidores de quinasas tam y met |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US20200216416A1 (es) |
| EP (1) | EP3906234A1 (es) |
| JP (1) | JP2022515880A (es) |
| KR (1) | KR20210110664A (es) |
| CN (1) | CN113302188A (es) |
| AU (1) | AU2020205035A1 (es) |
| BR (1) | BR112021012956A2 (es) |
| CA (1) | CA3125559A1 (es) |
| CO (1) | CO2021008535A2 (es) |
| CR (1) | CR20210364A (es) |
| IL (1) | IL284570A (es) |
| MA (1) | MA54656A (es) |
| MX (1) | MX2021008136A (es) |
| PH (1) | PH12021551590A1 (es) |
| PY (1) | PY2000386A (es) |
| SG (1) | SG11202106897XA (es) |
| TW (1) | TWI745824B (es) |
| UY (1) | UY38536A (es) |
| WO (1) | WO2020141470A1 (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2985569T3 (es) * | 2018-08-24 | 2024-11-06 | Transthera Sciences Nanjing Inc | Nuevo inhibidor de derivado de quinolina |
| CN112625026B (zh) * | 2019-09-24 | 2022-09-09 | 药捷安康(南京)科技股份有限公司 | Tam家族激酶抑制剂的喹啉衍生物 |
| WO2022161447A1 (zh) * | 2021-02-01 | 2022-08-04 | 江苏恒瑞医药股份有限公司 | 二甲酰胺类化合物、其制备方法及其在医药上的应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7732613B2 (en) * | 2005-09-14 | 2010-06-08 | Bristol-Myers Squibb Company | Met kinase inhibitors |
| US20110053931A1 (en) * | 2006-06-08 | 2011-03-03 | John Gaudino | Quinoline compounds and methods of use |
| SI2235002T1 (sl) * | 2008-01-23 | 2013-06-28 | Bristol-Myers Squibb Company | Spojine 4-piridinona in njihova uporaba za zdravljenje raka |
| KR20170036037A (ko) | 2014-07-31 | 2017-03-31 | 노파르티스 아게 | 조합 요법 |
| JP6708130B2 (ja) * | 2014-12-25 | 2020-06-10 | 小野薬品工業株式会社 | キノリン誘導体 |
| KR101829998B1 (ko) | 2015-11-04 | 2018-02-19 | 롬엔드하스전자재료코리아유한회사 | 착색 감광성 수지 조성물 및 이를 이용한 차광성 스페이서 |
| BR102018007822A2 (pt) | 2017-04-20 | 2018-11-06 | Gilead Sciences, Inc. | composto, métodos para inibir pd-1, pd-l1 e/ou interação de pd-1/pd-l1 e para tratamento de câncer, composição farmacêutica, e, kit para tratamento de ou prevenção de câncer ou uma doença ou condição |
| US20210177828A1 (en) * | 2018-01-17 | 2021-06-17 | Nanjing Transthera Biosciences Co., Ltd. | Tam family kinase /and csf1r kinase inhibitor and use thereof |
| CN112625026B (zh) * | 2019-09-24 | 2022-09-09 | 药捷安康(南京)科技股份有限公司 | Tam家族激酶抑制剂的喹啉衍生物 |
-
2020
- 2020-01-02 CA CA3125559A patent/CA3125559A1/en not_active Abandoned
- 2020-01-02 EP EP20701499.4A patent/EP3906234A1/en not_active Withdrawn
- 2020-01-02 WO PCT/IB2020/050009 patent/WO2020141470A1/en not_active Ceased
- 2020-01-02 TW TW109100070A patent/TWI745824B/zh not_active IP Right Cessation
- 2020-01-02 MX MX2021008136A patent/MX2021008136A/es unknown
- 2020-01-02 CR CR20210364A patent/CR20210364A/es unknown
- 2020-01-02 PH PH1/2021/551590A patent/PH12021551590A1/en unknown
- 2020-01-02 US US16/732,733 patent/US20200216416A1/en not_active Abandoned
- 2020-01-02 UY UY0001038536A patent/UY38536A/es not_active Application Discontinuation
- 2020-01-02 KR KR1020217024137A patent/KR20210110664A/ko not_active Withdrawn
- 2020-01-02 AU AU2020205035A patent/AU2020205035A1/en not_active Abandoned
- 2020-01-02 SG SG11202106897XA patent/SG11202106897XA/en unknown
- 2020-01-02 MA MA054656A patent/MA54656A/fr unknown
- 2020-01-02 BR BR112021012956-1A patent/BR112021012956A2/pt not_active Application Discontinuation
- 2020-01-02 CN CN202080007931.8A patent/CN113302188A/zh active Pending
- 2020-01-02 JP JP2021538367A patent/JP2022515880A/ja active Pending
- 2020-01-03 PY PY202002000386A patent/PY2000386A/es unknown
-
2021
- 2021-06-29 CO CONC2021/0008535A patent/CO2021008535A2/es unknown
- 2021-07-01 IL IL284570A patent/IL284570A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SG11202106897XA (en) | 2021-07-29 |
| CN113302188A (zh) | 2021-08-24 |
| PH12021551590A1 (en) | 2022-04-18 |
| CO2021008535A2 (es) | 2021-07-19 |
| MA54656A (fr) | 2022-04-06 |
| JP2022515880A (ja) | 2022-02-22 |
| IL284570A (en) | 2021-08-31 |
| CA3125559A1 (en) | 2020-07-09 |
| EP3906234A1 (en) | 2021-11-10 |
| TWI745824B (zh) | 2021-11-11 |
| US20200216416A1 (en) | 2020-07-09 |
| UY38536A (es) | 2020-08-31 |
| TW202039465A (zh) | 2020-11-01 |
| WO2020141470A1 (en) | 2020-07-09 |
| PY2000386A (es) | 2021-07-26 |
| BR112021012956A2 (pt) | 2021-10-26 |
| AU2020205035A1 (en) | 2021-07-22 |
| KR20210110664A (ko) | 2021-09-08 |
| MX2021008136A (es) | 2021-08-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PH12013501197B1 (en) | Indeno-fused ring compounds | |
| EA201791271A1 (ru) | ТИАЗОЛЫ, ЗАМЕЩЕННЫЕ КАРБОКСАМИДОМ ИЛИ СУЛЬФОНАМИДОМ, И РОДСТВЕННЫЕ ПРОИЗВОДНЫЕ В КАЧЕСТВЕ МОДУЛЯТОРОВ ДЛЯ ОРФАННОГО ЯДЕРНОГО РЕЦЕПТОРА RORγ | |
| CL2017001675A1 (es) | Derivados de quinazolina utilizados para tratar el vih | |
| CR20140464A (es) | Compuestos de heterociclilo | |
| MX385357B (es) | Compuestos de tetrahidroquinolinona sustituidos como moduladores de ror gamma | |
| RU2016126503A (ru) | Аналоги кортистатина, их синтез и применения | |
| EA201791782A1 (ru) | 4,6-диаминопиридо[3,2-d]пиримидиновые соединения, модулирующие toll-подобные рецепторы | |
| EA201071329A1 (ru) | Диамидные производные адамантана и их применение | |
| EA029499B9 (ru) | Ингибиторы rorc2 и способы их применения | |
| MX388300B (es) | Proceso para la preparación de derivados de ácidos biliares de sulfonil carbamato | |
| MX2011006132A (es) | Imidazol carboxamidas fusionadas como moduladores de trpv3. | |
| IN2015DN02930A (es) | ||
| MX2018007774A (es) | Compuestos heterociclicos como inmunomoduladores. | |
| UY34314A (es) | Derivados de anilina, su preparación y su aplicación terapéutica. | |
| EA201992679A1 (ru) | N-замещенные индольные производные | |
| MX2020003495A (es) | Derivados de acido boronico y sintesis de los mismos. | |
| MX386586B (es) | Cristal de base libre de derivados benzofurano y método de preparación. | |
| MX2011006821A (es) | Derivados de imidazol fusionados como antagonistas de trpv3. | |
| EA201791600A1 (ru) | Производные гидроксиалкилпиперазина в качестве модуляторов cxcr3 рецептора | |
| BR112022001866A2 (pt) | Derivados de amida híbridos de anfotericina b | |
| MX373162B (es) | Piridopirimidinonas y utilización de las mismas como moduladores de receptores de n-metil-d-aspartato (nmda). | |
| BR112019001035A2 (pt) | beenato de rotigotina, e método de preparação e uso do mesmo | |
| TR201901977T4 (tr) | Cxcr3 reseptörü modülatörleri olarak (r)-2-metil-piperazin türevleri. | |
| MX2021007511A (es) | Procedimiento para la preparacion de anilinas sustituidas. | |
| FR2981933B1 (fr) | Derives d'oxoazetidine, leur procede de preparation et leur utilisation en medecine humaine ainsi qu'en cosmetique |