CR20210366A - Formulación de fármaco de liberación retardada que comprende una capa externa con un polímero degradable enzimáticamente, su composición, y su método de fabricación - Google Patents
Formulación de fármaco de liberación retardada que comprende una capa externa con un polímero degradable enzimáticamente, su composición, y su método de fabricaciónInfo
- Publication number
- CR20210366A CR20210366A CR20210366A CR20210366A CR20210366A CR 20210366 A CR20210366 A CR 20210366A CR 20210366 A CR20210366 A CR 20210366A CR 20210366 A CR20210366 A CR 20210366A CR 20210366 A CR20210366 A CR 20210366A
- Authority
- CR
- Costa Rica
- Prior art keywords
- core
- delayed release
- drug formulation
- release drug
- enzymaticyally
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2893—Tablet coating processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
- A61K31/606—Salicylic acid; Derivatives thereof having amino groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
- A61K9/2846—Poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2886—Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4891—Coated capsules; Multilayered drug free capsule shells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Un método para producir un núcleo revestible para una formulación farmacéutica de liberación retardada para la administración oral de la entrega de un fármaco en el colon. El método comprende la formación de un núcleo que comprende un fármaco. Una preparación de revestimiento de capa externa se forma al combinar una primera preparación acuosa de un polímero degradable enzimáticamente que se puede degradar mediante enzimas bacterianas del colon; una segunda preparación acuosa de un polímero entérico que forma una película con un umbral de pH de alrededor de pH 6 o superior; y un agente orgánico antiadherente. El núcleo entonces se reviste con la preparación de revestimiento de capa externa para formar un núcleo recubierto de capa externa.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18211152.6A EP3662901B1 (en) | 2018-12-07 | 2018-12-07 | Delayed release drug formulation comprising an outerlayer with an enzymatically degradable polymer, its composition and its method of manufacturing |
| PCT/EP2019/083910 WO2020115255A1 (en) | 2018-12-07 | 2019-12-05 | Delayed release drug formulation comprising an outerlayer with an enzymaticyally degradable polymer, its composition and its method of manufacturing |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CR20210366A true CR20210366A (es) | 2021-11-23 |
Family
ID=64661233
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CR20210366A CR20210366A (es) | 2018-12-07 | 2019-12-05 | Formulación de fármaco de liberación retardada que comprende una capa externa con un polímero degradable enzimáticamente, su composición, y su método de fabricación |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US12370146B2 (es) |
| EP (2) | EP3662901B1 (es) |
| JP (1) | JP7391966B2 (es) |
| KR (1) | KR102802080B1 (es) |
| CN (1) | CN113226292A (es) |
| AR (1) | AR117681A1 (es) |
| AU (2) | AU2019392854B2 (es) |
| BR (1) | BR112021010914A2 (es) |
| CA (2) | CA3281153A1 (es) |
| CL (1) | CL2021001472A1 (es) |
| CO (1) | CO2021008683A2 (es) |
| CR (1) | CR20210366A (es) |
| EA (1) | EA202191597A1 (es) |
| ES (1) | ES3002632T3 (es) |
| GE (1) | GEP20247608B (es) |
| IL (1) | IL283718B1 (es) |
| JO (1) | JOP20210136A1 (es) |
| MA (1) | MA54374A (es) |
| MX (2) | MX2021006603A (es) |
| PH (1) | PH12021551292A1 (es) |
| SG (1) | SG11202105691RA (es) |
| TW (1) | TWI865473B (es) |
| UA (1) | UA128938C2 (es) |
| WO (1) | WO2020115255A1 (es) |
| ZA (1) | ZA202103676B (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20240041779A1 (en) * | 2020-12-08 | 2024-02-08 | Triastek, Inc. | Delayed sustained-release oral drug dosage forms of a janus kinase (jak) inhibitor and methods of use |
| US20250319027A1 (en) * | 2022-07-01 | 2025-10-16 | Vitakey Inc. | Nutraceutical particles |
| JP2026513283A (ja) * | 2023-03-31 | 2026-04-23 | トリアステック，インコーポレーテッド | 結腸送達のための経口薬物剤形ならびにその使用および製造方法 |
| CN118948789B (zh) * | 2024-08-05 | 2025-04-01 | 山东丰金生物医药有限公司 | 一种稳定的美沙拉秦结肠定位释放组合物及其制备方法 |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8812490D0 (en) | 1988-05-26 | 1988-06-29 | Agricultural & Food Res | Delayed release formulations |
| GB8926639D0 (en) | 1989-11-24 | 1990-01-17 | Agricultural & Food Res | Delayed release formulations |
| US5422121A (en) | 1990-11-14 | 1995-06-06 | Rohm Gmbh | Oral dosage unit form |
| US5656290A (en) | 1993-02-26 | 1997-08-12 | The Procter & Gamble Company | Bisacodyl dosage form with multiple enteric polymer coatings for colonic delivery |
| US5914132A (en) | 1993-02-26 | 1999-06-22 | The Procter & Gamble Company | Pharmaceutical dosage form with multiple enteric polymer coatings for colonic delivery |
| US5482718A (en) | 1994-03-23 | 1996-01-09 | Hoffmann-La Roche Inc. | Colon-targeted delivery system |
| CN1239425A (zh) * | 1996-11-15 | 1999-12-22 | 普罗克特和甘保尔公司 | 供结肠释放的具有多层肠溶聚合物包衣的药剂 |
| GB9722426D0 (en) | 1997-10-23 | 1997-12-24 | Univ London Pharmacy | Controlled release formulations |
| GB9724186D0 (en) | 1997-11-14 | 1998-01-14 | British Tech Group | Low temperature coatings |
| FI20000780L (fi) | 2000-04-03 | 2001-10-04 | Novasso Oy | Peroraalinen lääkemuoto lääkeaineen hallituksi vapauttamiseksi |
| GB2367002A (en) | 2000-09-25 | 2002-03-27 | British Sugar Plc | Coating composition |
| GB0203421D0 (en) | 2002-02-13 | 2002-04-03 | Alizyme Therapeutics Ltd | Composition |
| US7670627B2 (en) | 2002-12-09 | 2010-03-02 | Salvona Ip Llc | pH triggered targeted controlled release systems for the delivery of pharmaceutical active ingredients |
| US9149439B2 (en) | 2005-03-21 | 2015-10-06 | Sandoz Ag | Multi-particulate, modified-release composition |
| DE102005032806A1 (de) | 2005-07-12 | 2007-01-18 | Röhm Gmbh | Verwendung eines teilneutralisierten, anionischen (Meth)acrylat-Copolymers als Überzug für die Herstellung einer Arzneiform mit einer Wirkstofffreisetzung bei erniedrigten pH-Werten |
| FR2899061B1 (fr) | 2006-03-31 | 2009-07-31 | Cid Lines Nv | Composition d'hygiene et/ou comestique et/ou desinfectante contenant au moins un agent anti-parasitaire repulsif et/ou insectifuge. |
| GB0607534D0 (en) * | 2006-04-13 | 2006-05-24 | Univ London Pharmacy | Colonic drug delivery formulation |
| AU2012247013B2 (en) * | 2006-04-13 | 2016-01-14 | University College London | Colonic drug delivery formulation |
| PL2152250T3 (pl) | 2007-05-07 | 2020-06-15 | Evonik Röhm Gmbh | Stałe postaci dawkowania zawierające otoczkę dojelitową o przyspieszonym uwalnianiu leku |
| WO2009105409A2 (en) * | 2008-02-19 | 2009-08-27 | Mc Neil-Ppc, Inc. | Dip coated compositions containing a starch having a high amylose content |
| WO2012129551A1 (en) | 2011-03-23 | 2012-09-27 | Ironshore Pharmaceuticals & Development, Inc. | Methods and compositions for treatment of attention deficit disorder |
| CU24343B1 (es) | 2012-04-30 | 2018-05-08 | Tillotts Pharma Ag | Formulación de fármaco de liberación retardada |
| SI2659881T1 (en) | 2012-04-30 | 2018-03-30 | Tillotts Pharma Ag | Formulation of the delayed release medicinal product |
| EA032504B1 (ru) | 2013-10-29 | 2019-06-28 | Тиллоттс Фарма АГ | Лекарственный препарат с отсроченным высвобождением и его применение для доставки лекарственного средства |
| CN105412904A (zh) | 2014-06-17 | 2016-03-23 | 深圳翰宇药业股份有限公司 | 利那洛肽肠溶缓释微丸胶囊制剂及其制备方法和用途 |
| CN108601744B (zh) | 2016-02-09 | 2022-01-04 | 阿尔比里奥公司 | 口服考来烯胺制剂及其用途 |
| CN105832691B (zh) | 2016-05-31 | 2018-10-02 | 深圳市健元医药科技有限公司 | 一种度拉糖肽结肠定位缓释制剂及其制备方法 |
| EP3257501A1 (en) * | 2016-06-14 | 2017-12-20 | Tillotts Pharma AG | Multiple unit dosage form comprising a core with individual core units covered by a mucoadhesive material, and an enteric core coating |
| WO2018005606A1 (en) | 2016-06-28 | 2018-01-04 | Synthetic Biologics, Inc. | Microbiome protection from oral antibiotics |
| JP7328207B2 (ja) | 2017-08-09 | 2023-08-16 | アルビレオ・アクチボラグ | コレスチラミンペレット、経口コレスチラミン製剤、及びそれらの使用 |
| EP3662902B1 (en) | 2018-12-07 | 2024-07-31 | Tillotts Pharma AG | Colonic drug delivery formulation |
| EP3662900A1 (en) | 2018-12-07 | 2020-06-10 | Tillotts Pharma AG | Colonic drug delivery formulation |
-
2018
- 2018-12-07 ES ES18211152T patent/ES3002632T3/es active Active
- 2018-12-07 EP EP18211152.6A patent/EP3662901B1/en active Active
-
2019
- 2019-12-04 TW TW108144379A patent/TWI865473B/zh active
- 2019-12-05 KR KR1020217020595A patent/KR102802080B1/ko active Active
- 2019-12-05 CR CR20210366A patent/CR20210366A/es unknown
- 2019-12-05 EP EP19816317.2A patent/EP3890710A1/en active Pending
- 2019-12-05 CA CA3281153A patent/CA3281153A1/en active Pending
- 2019-12-05 IL IL283718A patent/IL283718B1/en unknown
- 2019-12-05 JP JP2021532824A patent/JP7391966B2/ja active Active
- 2019-12-05 AU AU2019392854A patent/AU2019392854B2/en active Active
- 2019-12-05 SG SG11202105691RA patent/SG11202105691RA/en unknown
- 2019-12-05 JO JOP/2021/0136A patent/JOP20210136A1/ar unknown
- 2019-12-05 CN CN201980081115.9A patent/CN113226292A/zh active Pending
- 2019-12-05 MA MA054374A patent/MA54374A/fr unknown
- 2019-12-05 US US17/309,554 patent/US12370146B2/en active Active
- 2019-12-05 PH PH1/2021/551292A patent/PH12021551292A1/en unknown
- 2019-12-05 WO PCT/EP2019/083910 patent/WO2020115255A1/en not_active Ceased
- 2019-12-05 UA UAA202103934A patent/UA128938C2/uk unknown
- 2019-12-05 EA EA202191597A patent/EA202191597A1/ru unknown
- 2019-12-05 GE GEAP201915683A patent/GEP20247608B/en unknown
- 2019-12-05 MX MX2021006603A patent/MX2021006603A/es unknown
- 2019-12-05 CA CA3122013A patent/CA3122013A1/en active Pending
- 2019-12-05 BR BR112021010914-5A patent/BR112021010914A2/pt unknown
- 2019-12-09 AR ARP190103588A patent/AR117681A1/es unknown
-
2021
- 2021-05-28 ZA ZA2021/03676A patent/ZA202103676B/en unknown
- 2021-06-03 MX MX2024012397A patent/MX2024012397A/es unknown
- 2021-06-04 CL CL2021001472A patent/CL2021001472A1/es unknown
- 2021-06-30 CO CONC2021/0008683A patent/CO2021008683A2/es unknown
-
2025
- 2025-08-21 AU AU2025220793A patent/AU2025220793A1/en active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX2024012397A (es) | Formulacion de farmaco de liberacion retardada que comprende una capa externa con un polimero degradable enzimaticamente, su composicion, y su metodo de fabricacion | |
| TN2014000442A1 (en) | A delayed release drug formulation | |
| NZ778023A (en) | Colonic drug delivery formulation | |
| WO2017171535A8 (en) | Compositions | |
| WO2008062440A3 (en) | Programmable buoyant delivery technology | |
| MY147639A (en) | Coated tablet formulation and method | |
| WO2005092297A3 (en) | A stable pharmaceutical composition comprising an acid labile drug | |
| JP2017039724A5 (es) | ||
| UA117260C2 (uk) | Лікарський препарат з відстроченим вивільненням | |
| MX2009008197A (es) | Forma de dosificacion de liberacion extendida. | |
| PH12018500304A1 (en) | A delyade release drug formulation | |
| ZA202103678B (en) | Colonic drug delivery formulation | |
| EA202191431A1 (ru) | Композиция для доставки лекарственных средств в толстую кишку | |
| TH2101003180A (th) | สูตรตำรับยาที่ชะลอการปลดปล่อย ที่ประกอบด้วย ชั้นนอกที่มีพอลิเมอร์ที่ย่อยสลายได้ด้วยเอนไซม์, องค์ประกอบของมัน และวิธีการผลิตของมัน | |
| TH2101003181A (th) | สูตรตำรับการนำส่งยาทางลำไส้ใหญ่ | |
| MX2018007681A (es) | Composicion farmaceutica osmotica oral de vildagliptin. | |
| WO2010089772A3 (en) | Chronotherapeutic pharmaceutical composition | |
| ATE535235T1 (de) | Galanthamin-haltiges arzneimittel mit kontrollierter freisetzung | |
| WO2009113090A3 (en) | Process for preparing an oral formulation of an acid-sensitive benzimidazole drug | |
| GEP20207119B (en) | A delayed release drug formulation |