CR20210545A - Formas sólidas de un inhibidor de glyt1 - Google Patents

Formas sólidas de un inhibidor de glyt1

Info

Publication number
CR20210545A
CR20210545A CR20210545A CR20210545A CR20210545A CR 20210545 A CR20210545 A CR 20210545A CR 20210545 A CR20210545 A CR 20210545A CR 20210545 A CR20210545 A CR 20210545A CR 20210545 A CR20210545 A CR 20210545A
Authority
CR
Costa Rica
Prior art keywords
solid forms
inhibitor
glyt1 inhibitor
glyt1
glycine transporter
Prior art date
Application number
CR20210545A
Other languages
English (en)
Inventor
Joe Ju Gao
Peter Sieger
Bing-Shiou Yang
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of CR20210545A publication Critical patent/CR20210545A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Se divulgan formas sólidas de un inhibidor del transportador de glicina-1 (GlyT1). La invención también se refiere a métodos para fabricar estas formas sólidas, composiciones farmacéuticas que comprenden estas formas sólidas y su uso para afecciones médicas que responden al tratamiento con un inhibidor del transportador de glicina-1.
CR20210545A 2019-05-01 2020-04-30 Formas sólidas de un inhibidor de glyt1 CR20210545A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962841401P 2019-05-01 2019-05-01
PCT/US2020/030580 WO2020223419A1 (en) 2019-05-01 2020-04-30 Solid forms of a glyt1 inhibitor

Publications (1)

Publication Number Publication Date
CR20210545A true CR20210545A (es) 2021-12-23

Family

ID=70740812

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20210545A CR20210545A (es) 2019-05-01 2020-04-30 Formas sólidas de un inhibidor de glyt1

Country Status (25)

Country Link
US (2) US11447474B2 (es)
EP (1) EP3962911A1 (es)
JP (2) JP7513349B2 (es)
KR (1) KR20220004174A (es)
CN (1) CN113784966B (es)
AR (1) AR118839A1 (es)
AU (1) AU2020266566B2 (es)
BR (1) BR112021020883A2 (es)
CA (1) CA3138288A1 (es)
CL (2) CL2021002837A1 (es)
CO (1) CO2021014260A2 (es)
CR (1) CR20210545A (es)
DO (1) DOP2021000224A (es)
EA (1) EA202192925A1 (es)
EC (1) ECSP21082195A (es)
IL (1) IL287630A (es)
JO (1) JOP20210295A1 (es)
MA (1) MA55801A (es)
MX (1) MX2021013341A (es)
PE (1) PE20212263A1 (es)
PH (1) PH12021552741A1 (es)
SG (1) SG11202111972YA (es)
TW (1) TW202106680A (es)
UA (1) UA129159C2 (es)
WO (1) WO2020223419A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7930336B2 (en) 2006-12-05 2011-04-19 Altera Corporation Large multiplier for programmable logic device
CR20210545A (es) * 2019-05-01 2021-12-23 Boehringer Ingelheim Int Formas sólidas de un inhibidor de glyt1
KR20220125326A (ko) 2020-01-09 2022-09-14 디스크 메디슨, 인크. 적혈구형성 프로토포르피린증, x-연계된 프로토포르피린증, 또는 선천성 적혈구 조혈포르피린증을 글리신 운반 억제제로 치료하는 방법
CA3188340A1 (en) 2020-08-13 2022-02-17 Boehringer Ingelheim International Gmbh Treatment of cognitive impairement associated with schizophrenia
KR20230088761A (ko) 2020-10-13 2023-06-20 베링거 인겔하임 인터내셔날 게엠베하 재가공하는 방법
WO2025140479A1 (zh) * 2023-12-29 2025-07-03 苏州科睿思制药有限公司 Iclepertin的晶型及其制备方法和用途

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL65843A (en) * 1977-08-11 1986-12-31 American Cyanamid Co Pharmaceutical compositions for the treatment of depression containing 3-aza-bicyclo(3.1.0)hexane derivatives and certain novel compounds of this type
EA009903B1 (ru) * 2003-10-14 2008-04-28 Пфайзер Продактс Инк. Бициклические [3.1.0] производные в качестве ингибиторов переносчиков глицина
BRPI0922787A2 (pt) * 2008-12-04 2017-07-11 Sanofi Sa Formas polimórficas de um derivado da azabiciclo-trifluorometil benzamida
EP2381941A4 (en) * 2008-12-29 2012-08-01 Univ Vanderbilt 3.1.0 BICYCLIC GLYTI INHIBITORS AND METHOD FOR THE PRODUCTION AND USE THEREOF
US9012489B2 (en) 2011-08-03 2015-04-21 Boehringer Ingelheim International Gmbh Phenyl-3-aza-bicyclo[3.1.0]hex-3-yl-methanones and the use thereof as medicament
WO2018199235A1 (ja) 2017-04-27 2018-11-01 武田薬品工業株式会社 複素環化合物
CR20210545A (es) * 2019-05-01 2021-12-23 Boehringer Ingelheim Int Formas sólidas de un inhibidor de glyt1
CA3188340A1 (en) * 2020-08-13 2022-02-17 Boehringer Ingelheim International Gmbh Treatment of cognitive impairement associated with schizophrenia
KR20230088761A (ko) * 2020-10-13 2023-06-20 베링거 인겔하임 인터내셔날 게엠베하 재가공하는 방법

Also Published As

Publication number Publication date
US11447474B2 (en) 2022-09-20
BR112021020883A2 (pt) 2022-04-19
IL287630A (en) 2021-12-01
TW202106680A (zh) 2021-02-16
DOP2021000224A (es) 2021-12-15
NZ781254A (en) 2025-03-28
AU2020266566A1 (en) 2021-11-11
AR118839A1 (es) 2021-11-03
CL2021002837A1 (es) 2022-07-29
UA129159C2 (uk) 2025-01-29
US20200347041A1 (en) 2020-11-05
PH12021552741A1 (en) 2022-07-11
JOP20210295A1 (ar) 2023-01-30
PE20212263A1 (es) 2021-11-29
MA55801A (fr) 2022-03-09
CN113784966B (zh) 2024-07-19
JP2024100792A (ja) 2024-07-26
CA3138288A1 (en) 2020-11-05
KR20220004174A (ko) 2022-01-11
WO2020223419A1 (en) 2020-11-05
EA202192925A1 (ru) 2022-03-23
JP7714727B2 (ja) 2025-07-29
ECSP21082195A (es) 2021-12-30
JP7513349B2 (ja) 2024-07-09
SG11202111972YA (en) 2021-11-29
CL2024000829A1 (es) 2024-09-27
US20220332710A1 (en) 2022-10-20
EP3962911A1 (en) 2022-03-09
CO2021014260A2 (es) 2021-10-29
MX2021013341A (es) 2021-11-17
AU2020266566B2 (en) 2025-11-06
JP2022530630A (ja) 2022-06-30
CN113784966A (zh) 2021-12-10

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