CR20220161A - Procedimiento para preparar ésteres aciloximetílicos del ácido (4s)–(4–ciano–2–metoxifenil)–5–etoxi–2,8–dimetil–1,4–dihidro–1,6–naftiridin–3–carboxílico - Google Patents

Procedimiento para preparar ésteres aciloximetílicos del ácido (4s)–(4–ciano–2–metoxifenil)–5–etoxi–2,8–dimetil–1,4–dihidro–1,6–naftiridin–3–carboxílico

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Publication number
CR20220161A
CR20220161A CR20220161A CR20220161A CR20220161A CR 20220161 A CR20220161 A CR 20220161A CR 20220161 A CR20220161 A CR 20220161A CR 20220161 A CR20220161 A CR 20220161A CR 20220161 A CR20220161 A CR 20220161A
Authority
CR
Costa Rica
Prior art keywords
preparing
naphthyridine
methoxyphenyl
dihydro
ethoxy
Prior art date
Application number
CR20220161A
Other languages
English (en)
Inventor
Kai Lovis
Silja Brady
Johannes Platzek
Martin Alba Hernandez
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of CR20220161A publication Critical patent/CR20220161A/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B57/00—Separation of optically-active compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • C12N9/20—Triglyceride splitting, e.g. by means of lipase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/01—Carboxylic ester hydrolases (3.1.1)
    • C12Y301/01003—Triacylglycerol lipase (3.1.1.3)

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invención se refiere a un procedimiento para preparar ésteres aciloximetílicos del ácido (4S)–(4–ciano–2–metoxifenil)–5–etoxi–2,8–dimetil–1,4–dihidro–1,6–naftiridin–3–carboxílico de la fórmula (IIa) por separación de racematos del compuesto de la fórmula (II) usando una hidrolasa. La invención se refiere también a un procedimiento para preparar (4S)–4–(4–ciano–2–metoxifenil)–5–etoxi–2,8–dimetil–1,4–dihidro–1,6–naftiridin–3–carboxamida de la fórmula (Ia), en donde el procedimiento comprende la separación de racematos del compuesto de la fórmula (II) usando una hidrolasa. Además, la invención también se refiere al uso de una hidrolasa en un procedimiento para preparar un compuesto según la fórmula (IIa). La invención también se refiere al uso de una hidrolasa en un procedimiento para preparar un compuesto según la fórmula (Ia).
CR20220161A 2019-10-17 2020-10-12 Procedimiento para preparar ésteres aciloximetílicos del ácido (4s)–(4–ciano–2–metoxifenil)–5–etoxi–2,8–dimetil–1,4–dihidro–1,6–naftiridin–3–carboxílico CR20220161A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP19203821 2019-10-17
PCT/EP2020/078611 WO2021074077A1 (de) 2019-10-17 2020-10-12 Verfahren zur herstellung von acyloxymethylestern der (4s) -(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridin-3-carbonsäure

Publications (1)

Publication Number Publication Date
CR20220161A true CR20220161A (es) 2022-06-17

Family

ID=68281309

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20220161A CR20220161A (es) 2019-10-17 2020-10-12 Procedimiento para preparar ésteres aciloximetílicos del ácido (4s)–(4–ciano–2–metoxifenil)–5–etoxi–2,8–dimetil–1,4–dihidro–1,6–naftiridin–3–carboxílico

Country Status (16)

Country Link
US (2) US12365679B2 (es)
EP (1) EP4045500A1 (es)
JP (1) JP7757278B2 (es)
KR (1) KR20220084102A (es)
CN (1) CN114555599B (es)
AU (1) AU2020365314A1 (es)
BR (1) BR112022005605A2 (es)
CA (1) CA3157823A1 (es)
CL (1) CL2022000941A1 (es)
CO (1) CO2022004464A2 (es)
CR (1) CR20220161A (es)
IL (1) IL292194B1 (es)
JO (1) JOP20220148A1 (es)
MX (1) MX2022004480A (es)
PE (1) PE20221414A1 (es)
WO (1) WO2021074077A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4045499A1 (de) * 2019-10-17 2022-08-24 Bayer Aktiengesellschaft Verfahren zur herstellung von 2-cyanoethyl (4s)-4-(4-cyano-2-methoxy-phenyl)-5-hydroxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridin-3-carboxylat durch racemat-spaltung mittels diastereomerer weinsäureester
CN114214375B (zh) * 2021-12-27 2024-03-19 江苏威凯尔医药科技有限公司 (r)-3-(4-卤代-1h-吡唑-1-基)-3-环戊基丙酸酯的制备方法
CN115340539B (zh) * 2022-01-19 2024-02-27 奥锐特药业股份有限公司 制备非奈利酮及其中间体的方法
EP4511365A1 (en) 2022-04-18 2025-02-26 Teva Pharmaceuticals International GmbH Processes for the preparation of finerenone
US20250115601A1 (en) * 2022-05-16 2025-04-10 Glenmark Life Sciences Limited Process for the preparation of finerenone and intermediates thereof
CN115322194B (zh) * 2022-08-23 2024-04-09 浙江国邦药业有限公司 一种非奈利酮中间体羧酸拆分方法
CN121949317A (zh) * 2023-01-12 2026-05-01 上海新礼泰药业有限公司 非奈利酮及其中间体的制备方法
CN116218942B (zh) * 2023-03-07 2025-07-25 常州制药厂有限公司 一种非奈利酮关键中间体及成品的制备方法
CN116715664B (zh) * 2023-06-12 2025-01-17 常州制药厂有限公司 一种非奈利酮关键中间体的制备方法
CN117964619B (zh) * 2024-01-30 2025-07-18 浙江神洲药业有限公司 一种非奈利酮及其制备方法以及非奈利酮中间体

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5234821A (en) * 1990-09-01 1993-08-10 Kazuo Achiwa Process for preparing 1,4 dihydropyridine compounds
DE102007009494A1 (de) * 2007-02-27 2008-08-28 Bayer Healthcare Ag Substituierte 4-Aryl-1, 4-dihydro-1,6-naphthyridinamide und ihre Verwendung
KR100848935B1 (ko) * 2007-05-16 2008-07-29 주식회사 대희화학 생체 촉매 효소를 이용한 광학 선택적 가수분해방법
CU20090172A7 (es) 2009-10-09 2011-10-05 Ct De Investigación Y Desarrollo De Medicamentos Sistemas tricíclicos y tetracíclicos con actividad sobre el sistema nervioso central y vascular
ES2828704T3 (es) 2014-08-01 2021-05-27 Bayer Pharma AG Procedimiento para la preparación de (4S)-4-(4-ciano-2-metoxifenil)-5-etoxi-2,8-dimetil-1,4-dihidro-1,6-naftiridin-3-carboxamida y su purificación para su uso como principio activo farmacéutico
RU2715226C2 (ru) * 2015-08-21 2020-02-26 Байер Фарма Акциенгезельшафт Способ получения (4s)-4-(4-циано-2-метоксифенил)-5-этокси-2,8-диметил-1,4-дигидро-1,6-нафтиридин-3-карбоксамида и выделения (4s)-4-(4-циано-2-метоксифенил)-5-этокси-2,8-диметил-1,4-дигидро-1,6-нафтиридин-3-карбоксамида посредством электрохимических методов
RS59055B1 (sr) * 2015-08-21 2019-08-30 Bayer Pharma AG Postupak za proizvodnju (4s)-4-(4-cijano-2-metoksifenil)-5-etoksi-2,8-dimetil-1,4-dihidro-1,6-naftiridin-3-karboksamida i njegovo prečišćavanje u svrhu upotrebe kao farmaceutski aktivne supstance
CN108473488A (zh) * 2015-08-21 2018-08-31 拜耳制药股份公司 (4s)-和(4r)-4-(4-氰基-2-甲氧基苯基)-5-乙氧基-2,8-二甲基-1,4-二氢-1,6-萘啶-3-甲酰胺的代谢物的制备方法及其用途
CN106279000B (zh) 2016-08-15 2019-06-18 哈尔滨商业大学 1,4-二氢-2,6-二甲基-4-（3-硝基苯基）-3,5-吡啶二羧酸单甲酯的制备方法
CN108409731B (zh) * 2018-03-07 2020-11-20 西华大学 芳基取代的1H-吡啶[3,4-b]吲哚-3-羧酸甲酯的手性拆分

Also Published As

Publication number Publication date
CN114555599A (zh) 2022-05-27
US12365679B2 (en) 2025-07-22
BR112022005605A2 (pt) 2022-07-19
CO2022004464A2 (es) 2022-04-29
IL292194A (en) 2022-06-01
US20250326751A1 (en) 2025-10-23
JOP20220148A1 (ar) 2023-01-30
US20240150344A1 (en) 2024-05-09
CL2022000941A1 (es) 2022-11-11
MX2022004480A (es) 2022-05-06
CA3157823A1 (en) 2021-04-22
WO2021074077A1 (de) 2021-04-22
KR20220084102A (ko) 2022-06-21
EP4045500A1 (de) 2022-08-24
PE20221414A1 (es) 2022-09-20
JP7757278B2 (ja) 2025-10-21
AU2020365314A1 (en) 2022-05-12
JP2022553225A (ja) 2022-12-22
CN114555599B (zh) 2024-06-07
IL292194B1 (en) 2026-02-01

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