CR20220178A - Compuestos moduladores de glp-1r - Google Patents

Compuestos moduladores de glp-1r

Info

Publication number
CR20220178A
CR20220178A CR20220178A CR20220178A CR20220178A CR 20220178 A CR20220178 A CR 20220178A CR 20220178 A CR20220178 A CR 20220178A CR 20220178 A CR20220178 A CR 20220178A CR 20220178 A CR20220178 A CR 20220178A
Authority
CR
Costa Rica
Prior art keywords
glp
modulating compounds
compounds
agonists
kits
Prior art date
Application number
CR20220178A
Other languages
English (en)
Inventor
Daniel G Shore
Chao-I Hung
Rhiannon Thomas-Tran
Zheng-Yu Yang
Suzanne M Szewczyk
James G Taylor
Jeromy J Cottell
Stephen E Ammann
Michael Graupe
Kavoos Kolahdouzan
Scott D Schroeder
Nathan D Shapiro
Gediminas J Brizgys
James S Cassidy
Elbert Chin
Chienhung Chou
Nathan E Wright
Sheila M Zipfel
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of CR20220178A publication Critical patent/CR20220178A/es

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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
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    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
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    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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  • Chemical & Material Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
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  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente divulgación proporciona agonistas de GLP-1R y composiciones, métodos y kits de los mismos. Dichos compuestos son generalmente útiles para tratar una enfermedad o afección mediada por GLP-1R en un ser humano
CR20220178A 2019-10-25 2020-10-22 Compuestos moduladores de glp-1r CR20220178A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962926270P 2019-10-25 2019-10-25
US202063028187P 2020-05-21 2020-05-21
PCT/US2020/056867 WO2021081207A1 (en) 2019-10-25 2020-10-22 Glp-1r modulating compounds

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CR20220178A true CR20220178A (es) 2022-06-15

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US (2) US11702404B2 (es)
EP (1) EP4048664A1 (es)
JP (2) JP7558267B2 (es)
KR (2) KR102872874B1 (es)
CN (2) CN114630823B (es)
AU (3) AU2020369568B2 (es)
BR (1) BR112022007627A2 (es)
CA (1) CA3157525A1 (es)
CL (2) CL2022001030A1 (es)
CO (1) CO2022005077A2 (es)
CR (1) CR20220178A (es)
DO (3) DOP2022000087A (es)
IL (1) IL292399A (es)
MX (2) MX2022004874A (es)
PE (1) PE20221040A1 (es)
PH (1) PH12022550932A1 (es)
TW (3) TWI790492B (es)
UA (1) UA130060C2 (es)
WO (1) WO2021081207A1 (es)

Families Citing this family (86)

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Publication number Priority date Publication date Assignee Title
LT3860998T (lt) 2018-10-05 2024-06-25 Annapurna Bio Inc. Junginiai ir kompozicijos, skirti gydyti būkles, susijusias su apj receptoriaus aktyvumu
EA202191432A1 (ru) 2018-11-22 2021-10-14 Цилу Регор Терапьютикс Инк. Агонисты glp-1r и их применения
AU2020256647B2 (en) * 2019-04-12 2025-07-31 Qilu Regor Therapeutics Inc. GLP-1R agonists and uses thereof
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