CR20220478A - Derivados de benzodiazepinas como pam de gaba a gamma 1 - Google Patents

Derivados de benzodiazepinas como pam de gaba a gamma 1

Info

Publication number
CR20220478A
CR20220478A CR20220478A CR20220478A CR20220478A CR 20220478 A CR20220478 A CR 20220478A CR 20220478 A CR20220478 A CR 20220478A CR 20220478 A CR20220478 A CR 20220478A CR 20220478 A CR20220478 A CR 20220478A
Authority
CR
Costa Rica
Prior art keywords
sup
gamma1
pams
gaba
benzodiazepine derivatives
Prior art date
Application number
CR20220478A
Other languages
English (en)
Inventor
Eoin Cornelius O`Connor
Luca Gobbi
Giuseppe Cecere
Frédéric Knoflach
Michael Reutlinger
Morales Andres Miguel Olivares
Andrea Koblet
Nicolas Zorn
Maria-Clemencia Hernandez
Cusulin Jaclyn Ivy Wamsteeker
Valerie Runtz-Schmitt
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CR20220478A publication Critical patent/CR20220478A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La invención proporciona compuestos novedosos que tienen la fórmula general (I) en donde R<sup>1</sup>, R<sup>2</sup>, R<sup>3</sup>, R<sup>4</sup>, R<sup>5 </sup>y X son como se describe en la presente, en donde las composiciones incluyen los compuestos y métodos de uso de los compuestos.
CR20220478A 2020-03-31 2021-03-29 Derivados de benzodiazepinas como pam de gaba a gamma 1 CR20220478A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP20167239 2020-03-31
PCT/EP2021/058063 WO2021198124A1 (en) 2020-03-31 2021-03-29 Benzodiazepine derivatives as gaba a gamma1 pams

Publications (1)

Publication Number Publication Date
CR20220478A true CR20220478A (es) 2022-10-27

Family

ID=70110167

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20220478A CR20220478A (es) 2020-03-31 2021-03-29 Derivados de benzodiazepinas como pam de gaba a gamma 1

Country Status (23)

Country Link
US (2) US11739095B2 (es)
EP (1) EP4126869B1 (es)
JP (2) JP7648645B2 (es)
KR (1) KR20220161307A (es)
CN (1) CN115380034A (es)
AR (1) AR121676A1 (es)
AU (1) AU2021246833A1 (es)
BR (1) BR112022018828A2 (es)
CA (1) CA3167543A1 (es)
CL (1) CL2022002661A1 (es)
CO (1) CO2022013856A2 (es)
CR (1) CR20220478A (es)
ES (1) ES2986407T3 (es)
IL (1) IL294350B1 (es)
MX (1) MX2022011708A (es)
PE (1) PE20230440A1 (es)
PH (1) PH12022552288A1 (es)
PT (1) PT4126869T (es)
SA (1) SA522440731B1 (es)
TW (1) TWI878507B (es)
UA (1) UA129503C2 (es)
WO (1) WO2021198124A1 (es)
ZA (1) ZA202207383B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20230440A1 (es) * 2020-03-31 2023-03-08 Hoffmann La Roche Derivados de benzodiazepinas como pam de gaba a gamma1
CN118019742A (zh) 2021-09-29 2024-05-10 豪夫迈·罗氏有限公司 作为GABA A γ1 PAM的新颖苯并二氮杂䓬衍生物
CA3232152A1 (en) 2021-10-06 2023-04-13 F. Hoffman-La Roche Ag Benzodiazepine derivatives as positive allosteric modulators of the gaba a gamma1 receptor
EP4518910A1 (en) 2022-05-03 2025-03-12 F. Hoffmann-La Roche AG Pet tracers for visualizing gabaa gamma1 receptors
US20260033761A1 (en) 2022-07-29 2026-02-05 Hoffmann-La Roche Inc. Characterisation of neurological dysfunction
WO2025114404A1 (en) 2023-11-30 2025-06-05 F. Hoffmann-La Roche Ag Solid forms of a pharmaceutically active compound

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3987052A (en) * 1969-03-17 1976-10-19 The Upjohn Company 6-Phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepines
US3681343A (en) * 1971-05-11 1972-08-01 Upjohn Co 6-phenyl-s-triazolo{8 4,3-a{9 {8 1,4{9 {0 benzodiazepines
US3734922A (en) * 1971-05-11 1973-05-22 Upjohn Co Certain 4h-s-triazolo(4,3-a)(1,4)benzodiazepines
US4201712A (en) 1975-07-16 1980-05-06 Boehringer Ingelheim Gmbh Process for preparation of 6-aryl-4H-s-triazolo-[3,4-c]-thieno-[2,3-e]-1,4-diazepines
JPS5283498A (en) * 1976-01-01 1977-07-12 Hoffmann La Roche Benzodiazepine derivative
DE3435973A1 (de) * 1984-10-01 1986-04-10 Boehringer Ingelheim KG, 6507 Ingelheim Diazepine enthaltende pharmazeutische zusammensetzungen mit paf-antagonistischer wirkung
PH30676A (en) 1986-07-22 1997-09-16 Boehringer Ingelhein Kg Hetrazepine compounds which have useful pharmaceutical utility
DE4101146A1 (de) 1991-01-16 1992-07-23 Boehringer Ingelheim Kg Neue in 6-position substituierte diazepine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE60319812T2 (de) 2002-03-28 2009-04-23 Wisys Technology Foundation, Inc., Madison Angstlösende wirkstoffe mit verminderten beruhigenden und ataktischen nebenwirkungen
US9006233B2 (en) * 2011-04-28 2015-04-14 Uwm Research Foundation, Inc. Gabaergic receptor subtype selective ligands and their uses
EP3160969B1 (en) 2014-06-26 2023-09-13 The Johns Hopkins University Peripherally restricted gaba positive allosteric modulators for the treatment of irritable bowel syndrome and other ailments of the peripheral nervous system
JP7013446B2 (ja) * 2016-08-16 2022-02-15 ユーダブリューエム・リサーチ・ファウンデーション，インコーポレーテッド Ｇａｂａ（ａ）受容体モジュレーター、及び、喘息における気道過敏及び炎症を抑制するための方法
WO2020198275A1 (en) 2019-03-25 2020-10-01 President And Fellows Of Harvard College Compositions and methods for reducing tactile dysfunction, anxiety, and social impairment
JP7621289B2 (ja) * 2019-06-28 2025-01-24 ウェストチャイナホスピタル、スーチョワンユニバーシティ ベンゾジアゼピン系化合物及びその製造方法並びに医薬における作用
PE20230440A1 (es) * 2020-03-31 2023-03-08 Hoffmann La Roche Derivados de benzodiazepinas como pam de gaba a gamma1

Also Published As

Publication number Publication date
JP2023521572A (ja) 2023-05-25
CL2022002661A1 (es) 2023-03-31
UA129503C2 (uk) 2025-05-14
US20210309664A1 (en) 2021-10-07
PH12022552288A1 (en) 2024-01-22
JP7648645B2 (ja) 2025-03-18
CN115380034A (zh) 2022-11-22
AR121676A1 (es) 2022-06-29
CA3167543A1 (en) 2021-10-07
US11739095B2 (en) 2023-08-29
ES2986407T3 (es) 2024-11-11
AU2021246833A1 (en) 2022-07-21
JP2025090659A (ja) 2025-06-17
PE20230440A1 (es) 2023-03-08
IL294350A (en) 2022-08-01
EP4126869B1 (en) 2024-06-05
TWI878507B (zh) 2025-04-01
SA522440731B1 (ar) 2025-05-12
PT4126869T (pt) 2024-07-29
BR112022018828A2 (pt) 2022-11-22
CO2022013856A2 (es) 2022-10-11
ZA202207383B (en) 2023-04-26
IL294350B1 (en) 2026-03-01
US20240002393A1 (en) 2024-01-04
EP4126869A1 (en) 2023-02-08
WO2021198124A1 (en) 2021-10-07
MX2022011708A (es) 2022-10-07
KR20220161307A (ko) 2022-12-06
TW202200585A (zh) 2022-01-01

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