CR20230331A - Derivados de pirazolamida - Google Patents

Derivados de pirazolamida

Info

Publication number
CR20230331A
CR20230331A CR20230331A CR20230331A CR20230331A CR 20230331 A CR20230331 A CR 20230331A CR 20230331 A CR20230331 A CR 20230331A CR 20230331 A CR20230331 A CR 20230331A CR 20230331 A CR20230331 A CR 20230331A
Authority
CR
Costa Rica
Prior art keywords
sup
pyrazoleamide
derivatives
formula
present
Prior art date
Application number
CR20230331A
Other languages
English (en)
Inventor
Anthony Richard Bradley
Luke Green
Andrew Simon Bell
Wolfgang Haap
Jérémy BESNARD
Andreas Kuglstatter
Xavier Lucas
Claus Riemer
Hoorn Willem Paul Van
Patrizio Mattei
Buelent Kocer
Dmitry Mazunin
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CR20230331A publication Critical patent/CR20230331A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

La presente invención proporciona compuestos de fórmula I o II: <img alt="" src="data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAf8AAAGBCAYAAABo2bgPAAAgAElEQVR4Ae2cjbIlpwpG8/4vfVJmwpxvs7VF7T91WXVLVEBY7JZJbpJ/fhgQgAAEIAABCGxF4J+tsiVZCEAAAhCAAAR+aP78CCAAAQhAAAKbEaD5b1Zw0oUABCAAAQjQ/PkNQAACEIAABDYjQPPfrOCkCwEIQAACEKD58xuAAAQgAAEIbEaA5r9ZwUkXAhCAAAQgQPPnNwABCEAAAhDYjADNf7OCky4EIAABCECA5s9vAAIQgAAEILAZAZr/ZgUnXQhAAAIQgADNn98ABCAAAQhAYDMCNP/NCk66EIAABCAAAZo/vwEIQAACEIDAZgRo/psVnHQhAAEIQAACNH9+AxCAAAQgAIHNCND8Nys46UIAAhCAAARo/vwGIAABCEAAApsRoPlvVnDShQAEIAABCND8+Q1AAAIQgAAENiNA89+s4KQLgSsI/PPPPz+5/11xFz4hAIFxAjT/cYZ4gMCWBHLNvra3JSiShsALCdD8X1gUQoLA2wnUmnzp/O15ER8EdiFA89+l0uQJgRMIlJp66/4JoeACAhAYIEDzH4CHKQR2I3DU5HMsWvVzPtiDAATOJ0DzP58pHiGwJIHeRl6yWxISSUFgEgI0/0kKRZgQeJqAb+It8XhbW7f4QBcCEDiPAM3/PJZ4gsDSBKxh29yarNnp3OoDfQhA4BwCNP9zOOIFAksT0Iad5N5xlp/e+7GDAAT+EOj/iiEIAQhsQ+Cspn2Wn23AkygELiJA878ILG4hsBKBM5v2mb5WYvzWXLReb42RuNoJ0PzbmWEBga0I6OOf5NFxtr/ReLA/JqD1OtbkdCYC41/yTNkSKwQg0ExAH3+afzO+6Q20/tMnQwJ/CdD8/6JAgAAEcgT08af55wituefrfkbt1yQ1Z1Y0/znrRtQQuI2AbwKjF5/tbzQe7L8J+BrZ+luTnVkJ0PxnrRxxQ+AmAvbw2zx6rfmxedQf9ucSsLrk5nNvwtuTBGj+T9LnbghMQMA3gdGQz/Y3Gg/2nwR8fXT9qclqZgI0/5mrR+wQuIGAPv5JHh1n+xuNB/tPAlYf27X1GbU3n8zPExj/kp/PgQggAIELCejjf0YDONvfhalv6drXWOu1JZBFk6b5L1pY0oLAWQT08feNoeeOs/31xIBNnIDWK26F5tsJ0PzfXiHig8DDBPTxN3kkJPNh84gvbK8nYHVKM2MdAlRznVqSCQQuI6ANYKQJeD8jvi5LFscfBLRmHwcspiZA85+6fAQPgXsIaAMYadhn+bkna25JBLRmEFmHAM1/nVqSCQQuI6ANwOSey8zW5h4f2NxLwGqVZsY6BKjmOrUkEwhcSkCbQGsj8La2vjRgnJ9CwGrVWvNTLsfJZQRo/pehxTEE1iKgTUDlSJaqb3LEDp3nCVi90sxYhwDVXKeWZAKBSwloE1C5dqnqqlyz4/wdBKjZO+pwdhQ0/7OJ4g8CCxPQRjAiL4xoudS0zsslt3FCNP+Ni0/qEOghoM2gR+65E5vnCGiNn4uCm88mQPM/myj+ILAJAW0KUTmCRn1F9NG5lgD1uJbvU95p/k+R514ILEBAG8OR3JKq99Nii+75BLQe53vH41MEaP5PkedeCECgSEAbTpIZfwh4Lj3rVpZ6R6st+u8lwFf13toQGQS2JaANx+RtYUjixmJ0FpdVUe+qKqMwDQGa/zSlIlAI7EVAm06SGZ//qV3Pp3Ud5al+ozbovZ8AX9T7a0SEENiWgDYek7eF4f47+8ajd96ZI7n//ND8+RVAAAKvJZBrbK8N9obAPI/old7O1lF79NYjQPNfr6ZkBIHlCFizsnm5BIMJWf42B83+qpmdzn8PEbYiQPPfqtwkC4E5CWizMnnOTMaittxtbvVmdjq3+kB/DQI0/zXqSBYQmIpAT/NRG5OnSvqEYC1vm1tdmp3OrT7QX4MAzX+NOpIFBKYi0Nt81M7kqRIfDNZytrnVndnp3OoD/TUI0PzXqCNZQGAqAtp8ktwyRmxb7nmj7mju3r6V/RuZEFMfgbavru8OrCAAAQh8EfCN6EvhYGPE9sDt649G8/b2ac3YkwCV37PuZA2BVxDwzSgalLfbpYn5vKO8kp633YVZC6OddGn+O1WbXCHwQgK+KUVD9HY7NDOfc42V19d1zZbztQnQ/NeuL9lB4PUEtCGZHA3a9HWO2s6op3mOyjPmT8znEaD5n8cSTxCAwAAB38yirrxdWq86crn27K3Kh7ziBNb9SuIM0IQABF5AwDexlpBGbFvueVrX59mzfjoH7n8HAZr/O+pAFBCAQOYfSotCyTXBqO1Merk8o3sz5Ums1xOg+V/PmBsgAIEGArlmFjX3tlG7WfSi+Xk9W8+SJ3FeT4Dmfz1jboAABBoJWLOyOWpu+jpHbWfQ07ySfDS8bk3/yBdn6xE4/vWsly8ZQQACkxDwzSsatrdbqen53GpMvP5KLGq5c35MgOZ/zIdTCEDgIQIjjWvE9qF0Q9f6vGpGXt/WNTvO1ydA81+/xmQIgWkJWLPSOZqM2pgctX2rnuVhczRO09c5aovemgRo/mvWlawgsAwBbVgmR5MzfZujdk/qHcVqZzZH4zR9naO26K1JgOa/Zl3JCgJLEdCmleTo8HYtttE7ztLzseb8RnQidm/mkIufvfMJxL+i8+/GIwQgAIEwgdUan8/Hr3NgIjo5u7TnbdOasS8Bqr9v7ckcAlMRGGleI7ZnQsrFUdrL3et1czqlPW9r65I++2sToPmvXV+yg8ByBKxp2RxN0PR1jtr26uldEbl2j/dR0/fn3j6tGXsSoPJ71p2sITAtgZEG5m2vguDvqa2jcXg/UTvT8/a2tnPmfQjQ/PepNZlCYBkC1rR0jianNiZHbXN65qNlzvmJ7Pk7IjZex/tIa8Z+BKj6fjUnYwgsQaC3ifXa5aDlfJX2cvate953q73pez9pzdiLABXfq95kC4GlCIw0MW9bA+P1a+uaP84h8CQBmv+T9LkbAhAYJuCbcNSht0vr3MjplfZy9uxB4I0E8r/2N0ZKTBCAAAQyBHKNOKOW3fK2puT3a2uzY4bALARo/rNUijghAIEigVxzLiq7g5xtbc+5YAmB6QjQ/KcrGQFDAAI5ArmGndPTvZxNaU/tkCEwOwGa/+wVJH4IQOAvgVzj/nv4v5DTye15O9YQWIkAzX+lapILBCDw9d+w90hyjV73vD5rCKxIgOa/YlXJCQKbE9BmbrIhsbXNts8MgZ0I0Px3qja5QmATAtbYdU6p6zrJDAjsSoBf/66VJ28ILE7AN/rcenEEpAeBIgGafxENBxCAwOwEcg3f9mbPjfghMEKA5j9CD1sIQOD1BKzZ+/n1gRMgBC4kQPO/EC6uIQCBdxHQPwC8KzKigcC9BGj+9/LmNghA4EECNP8H4XP1qwjQ/F9VDoKBAASuIkDjv4osfmckQPOfsWrEDAEINBOg+Tcjw2BhAjT/hYtLahCAwC8Bmv8vCyQI0Pz5DUAAAlsQsOa/RbIkCYEKAZp/BRDHEIDAGgRo/mvUkSzOIUDzP4cjXiAAgRcTsMafZgYEIPDzw5fwkl8Bj9NLCkEYSxLg+1qyrCQ1QIDmPwBv1FQfpJI8egf2ENidgP+2dudB/hBIBGj+D/0O/IN0tH4oRK6FwBIE9NtaIiGSgMAJBGj+J0DscaEPUk3u8Y8NBCDwh4B+XzCBAAT+/y4AcT8BfYySnBsRnZwdexCAwCcB/ZY+T1hBYF8C+c6zL49bMo88RqqTZAYEINBHQL+lPg9YQWA9AnSVB2oafYyieg+kwJUQmIKAfkNJZkAAAn8I8DU88EvQB+no+q (***)
CR20230331A 2021-01-29 2022-01-27 Derivados de pirazolamida CR20230331A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP21154295 2021-01-29
PCT/EP2022/051823 WO2022162034A1 (en) 2021-01-29 2022-01-27 Pyrazoleamide derivatives

Publications (1)

Publication Number Publication Date
CR20230331A true CR20230331A (es) 2023-09-01

Family

ID=74418268

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20230331A CR20230331A (es) 2021-01-29 2022-01-27 Derivados de pirazolamida

Country Status (17)

Country Link
US (1) US20230382911A1 (es)
EP (1) EP4284797A1 (es)
JP (1) JP2024504788A (es)
KR (1) KR20230141787A (es)
CN (1) CN116867782A (es)
AR (1) AR124720A1 (es)
AU (1) AU2022212487A1 (es)
CA (1) CA3209599A1 (es)
CL (1) CL2023002052A1 (es)
CO (1) CO2023010155A2 (es)
CR (1) CR20230331A (es)
IL (1) IL304189A (es)
MX (1) MX2023008562A (es)
PE (1) PE20231387A1 (es)
TW (1) TW202246259A (es)
WO (1) WO2022162034A1 (es)
ZA (1) ZA202306694B (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024151112A1 (ko) * 2023-01-11 2024-07-18 주식회사 티움바이오 사이클린 의존성 키나아제 9 저해제로서의 피라졸로피리미딘 유도체

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2951172B1 (fr) * 2009-10-13 2014-09-26 Pf Medicament Derives pyrazolopyridines en tant qu'agent anticancereux
WO2014207213A1 (en) * 2013-06-28 2014-12-31 Medizinische Universität Innsbruck Novel inhibitors of protein kinase c epsilon signaling
TWI698435B (zh) 2015-04-10 2020-07-11 英屬開曼群島商百濟神州有限公司 作為吲哚胺２,３-二加氧酶和/或色氨酸２,３-二加氧酶抑制劑之新穎之５或８-取代之咪唑並［１，５－ａ］吡啶
CN106146493A (zh) 2015-04-21 2016-11-23 中国科学院上海药物研究所 吡唑并[3,4-b]吡啶类和吲唑类化合物的制备方法和用途

Also Published As

Publication number Publication date
AU2022212487A1 (en) 2023-07-13
WO2022162034A1 (en) 2022-08-04
JP2024504788A (ja) 2024-02-01
IL304189A (en) 2023-09-01
ZA202306694B (en) 2024-03-27
CN116867782A (zh) 2023-10-10
AU2022212487A9 (en) 2024-09-26
EP4284797A1 (en) 2023-12-06
PE20231387A1 (es) 2023-09-12
MX2023008562A (es) 2023-08-08
CA3209599A1 (en) 2022-08-04
CL2023002052A1 (es) 2023-12-22
KR20230141787A (ko) 2023-10-10
TW202246259A (zh) 2022-12-01
CO2023010155A2 (es) 2023-09-08
US20230382911A1 (en) 2023-11-30
AR124720A1 (es) 2023-04-26

Similar Documents

Publication Publication Date Title
MX2022015886A (es) Derivados de amidopirimidona.
MX2023001379A (es) Derivados de piperidin-1-il-n-piridina-3-il-2-oxoacet amida utiles para el tratamiento de canceres deficientes en mtap y/o que acumulan mt a.
CR20200488A (es) Péptidos macrocíclicos contra actinetobacter baumannii
MX2025000642A (es) Compuestos macrociclicos para el tratamiento de cancer
WO2021147236A9 (zh) 取代氨基丙酸酯类化合物在治疗SARS-CoV-2感染中的应用
PH12022552056A1 (en) Heterocyclic glp-1 agonists
PH12021551256A1 (en) Pantetheine derivatives and uses thereof
MX2022010520A (es) Macrociclos peptidicos contra acinetobacter baumannii.
TNSN03110A1 (en) Azaindoles.
NO20051265L (no) Anvendelse av og noen nye imidazopyridiner
NZ793536A (en) Imidazolidinone derivatives and medical use thereof
SE0202429D0 (sv) Novel Compounds
MX2022016263A (es) Derivados de ciclobutil-urea.
MX2023004033A (es) Espiro derivados de alfa-d-galactopiranosidos.
MX2024009177A (es) Compuestos y metodos de uso
WO2020247298A3 (en) 1-pyrazolyl, 5-, 6- disubstituted indazole derivatives as lrrk2 inhibitors, pharmaceutical compositions, and uses thereof
MXPA05011176A (es) Derivados de carboxamida como agentes antidiabeticos.
MY195576A (en) Novel Amino-Imidazopyridine Derivatives as Janus Kinase Inhibitors and Pharmaceutical use Thereof
MX2022007518A (es) Derivados bencimidazol.
MX2023009954A (es) Compuestos de aminopirimidina y métodos de uso de estos.
MX2025010256A (es) Derivados de hidroquinazolina para el tratamiento de una enfermedad o un trastorno
MX2023006176A (es) Nuevos derivados de indazol acetileno.
SA523442503B1 (ar) مشتقات سبيروبيبريدينيل مستبدل بأريل غير متجانس واستخدامات صيدلانية لها
MX2023008562A (es) Derivados de pirazolamida.
MX2025010952A (es) Derivados de amida para inhibir el gen nlrp3 y usos de los mismos