CR20230452A - Composiciones que contienen análogos de incretina y usos de estas - Google Patents

Composiciones que contienen análogos de incretina y usos de estas

Info

Publication number
CR20230452A
CR20230452A CR20230452A CR20230452A CR20230452A CR 20230452 A CR20230452 A CR 20230452A CR 20230452 A CR20230452 A CR 20230452A CR 20230452 A CR20230452 A CR 20230452A CR 20230452 A CR20230452 A CR 20230452A
Authority
CR
Costa Rica
Prior art keywords
containing compositions
incretin analog
incretin
dyslipidemia
obesity
Prior art date
Application number
CR20230452A
Other languages
English (en)
Inventor
Ganapathy Gopalrathnam
Christopher Sears Minie
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of CR20230452A publication Critical patent/CR20230452A/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/26Glucagons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/08Solutions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Dermatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Se proporciona una composición que incluye un análogo de incretina con actividad en cada uno de los receptores de polipéptido insulinotrópico dependiente de glucosa (GIP), de péptido similar al glucagón tipo 1 (GLP-1) y de glucagón (GCG) (es decir, agonista triple de receptores) y uno o más agentes adicionales como un agente de tonicidad y un conservante. También se proporcionan métodos para tratar enfermedades como la diabetes mellitus tipo 2, la dislipidemia, el síndrome metabólico, la enfermedad de hígado graso no alcohólica, la esteatohepatitis no alcohólica y la obesidad con la composición.
CR20230452A 2021-03-23 2022-03-22 Composiciones que contienen análogos de incretina y usos de estas CR20230452A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202163164702P 2021-03-23 2021-03-23
PCT/US2022/021309 WO2022204117A1 (en) 2021-03-23 2022-03-22 Incretin analog-containing compositions and uses thereof

Publications (1)

Publication Number Publication Date
CR20230452A true CR20230452A (es) 2023-10-11

Family

ID=81580297

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20230452A CR20230452A (es) 2021-03-23 2022-03-22 Composiciones que contienen análogos de incretina y usos de estas

Country Status (21)

Country Link
US (1) US20240173250A1 (es)
EP (1) EP4312982A1 (es)
JP (1) JP2024513754A (es)
KR (1) KR20230146645A (es)
CN (1) CN117042754A (es)
AR (1) AR125086A1 (es)
AU (2) AU2022246002B2 (es)
BR (1) BR112023016083A2 (es)
CA (1) CA3213230A1 (es)
CL (1) CL2023002808A1 (es)
CO (1) CO2023012373A2 (es)
CR (1) CR20230452A (es)
DO (1) DOP2023000200A (es)
EC (1) ECSP23071867A (es)
IL (1) IL305688A (es)
JO (1) JOP20230224A1 (es)
MX (1) MX2023011278A (es)
PE (1) PE20240238A1 (es)
TW (2) TWI837615B (es)
UA (1) UA129418C2 (es)
WO (1) WO2022204117A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102812908B1 (ko) * 2019-08-19 2025-05-28 일라이 릴리 앤드 캄파니 인크레틴 유사체의 제조 방법
CN119978101B (zh) * 2024-07-30 2025-10-10 四川普康药业有限公司 多肽化合物及其应用
WO2026059846A1 (en) 2024-09-13 2026-03-19 Eli Lilly And Company Dissolving microneedle patch for transdermal delivery of a peptide

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080200383A1 (en) * 2005-04-08 2008-08-21 Amylin Pharmaceuticals, Inc. Pharmaceutical Formulations Comprising Incretin Peptide and Aprotic Polar Solvent
UA101304C2 (ru) * 2006-09-13 2013-03-25 Смитклайн Бичам Корпорейшн Способы введения гипогликемических средств продленного действия
TWI430806B (zh) * 2006-09-13 2014-03-21 Smithkline Beecham Corp 用於投與長效降血糖藥劑之方法
ES2548275T3 (es) 2010-03-01 2015-10-15 Eli Lilly And Company Dispositivo de inyección automático con mecanismo de retardo que incluye un elemento de empuje de funcionamiento doble
CA2808978A1 (en) * 2010-08-23 2012-03-01 Shmuel Ben-Sasson Compositions for gastric delivery of active agents
BR112014014898A2 (pt) * 2011-12-22 2020-10-27 Pfizer Inc. processo para purificar uma amostra de anticorpo h38c2, ou variante do mesmo, e composição compreendendo o referido h38c2
JP2015533483A (ja) * 2012-09-07 2015-11-26 サノフイ メタボリックシンドロームを治療するための融合タンパク質
WO2018096460A1 (en) * 2016-11-22 2018-05-31 Biocon Research Limited Pharmaceutical compositions of glp-1 analogues
GB201621987D0 (en) * 2016-12-22 2017-02-08 Archer Virgil L See Archer Sheri A Arecor Ltd Novel composition
WO2018213151A1 (en) * 2017-05-18 2018-11-22 Merck Sharp & Dohme Corp. Pharmaceutical formulation comprising incretin-insulin conjugates
TWI767095B (zh) 2017-12-21 2022-06-11 美商美國禮來大藥廠 腸促胰島素(incretin)類似物及其用途
AR113486A1 (es) * 2017-12-21 2020-05-06 Lilly Co Eli Análogos de incretina y sus usos
KR20240051304A (ko) * 2018-07-23 2024-04-19 일라이 릴리 앤드 캄파니 Gip/glp1 공효능제 화합물

Also Published As

Publication number Publication date
CA3213230A1 (en) 2022-09-29
TW202423476A (zh) 2024-06-16
AU2025238025A1 (en) 2025-10-23
ECSP23071867A (es) 2023-11-30
US20240173250A1 (en) 2024-05-30
AU2022246002A1 (en) 2023-08-24
JOP20230224A1 (ar) 2023-09-19
IL305688A (en) 2023-11-01
CO2023012373A2 (es) 2023-09-29
EP4312982A1 (en) 2024-02-07
TWI837615B (zh) 2024-04-01
AR125086A1 (es) 2023-06-07
DOP2023000200A (es) 2023-10-15
PE20240238A1 (es) 2024-02-16
MX2023011278A (es) 2023-10-04
BR112023016083A2 (pt) 2023-10-03
AU2022246002B2 (en) 2025-06-26
JP2024513754A (ja) 2024-03-27
UA129418C2 (uk) 2025-04-16
KR20230146645A (ko) 2023-10-19
CL2023002808A1 (es) 2024-06-21
WO2022204117A1 (en) 2022-09-29
TW202302139A (zh) 2023-01-16
CN117042754A (zh) 2023-11-10

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