CR20240344A - Inhibidores de apol1 y métodos de uso - Google Patents

Inhibidores de apol1 y métodos de uso

Info

Publication number
CR20240344A
CR20240344A CR20240344A CR20240344A CR20240344A CR 20240344 A CR20240344 A CR 20240344A CR 20240344 A CR20240344 A CR 20240344A CR 20240344 A CR20240344 A CR 20240344A CR 20240344 A CR20240344 A CR 20240344A
Authority
CR
Costa Rica
Prior art keywords
apol1
inhibitors
methods
yz8vxxx
yxfsleeps
Prior art date
Application number
CR20240344A
Other languages
English (en)
Inventor
Patrick Sang Tae Lee
Christopher Joseph Sinz
Todd Jonathan August Ewing
Victoria Anne Assimon
David John Morgans Jr
Maarten Hoek
Chris Ziebenhaus
Alexander Wayne Schammel
Adam Neil Reid
Birong Zhang
Sarah M Bronner
Original Assignee
Maze Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Maze Therapeutics Inc filed Critical Maze Therapeutics Inc
Priority claimed from PCT/US2023/060787 external-priority patent/WO2023141432A2/en
Publication of CR20240344A publication Critical patent/CR20240344A/es

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  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

En este documento se proporcionan compuestos de fórmula (II): <img src="data:image/png;base64,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 (***)
CR20240344A 2022-01-18 2023-01-17 Inhibidores de apol1 y métodos de uso CR20240344A (es)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US202263300592P 2022-01-18 2022-01-18
US202263311668P 2022-02-18 2022-02-18
US202263332553P 2022-04-19 2022-04-19
US202263400359P 2022-08-23 2022-08-23
US202263442341P 2022-11-03 2022-11-03
PCT/US2023/060787 WO2023141432A2 (en) 2022-01-18 2023-01-17 Apol1 inhibitors and methods of use

Publications (1)

Publication Number Publication Date
CR20240344A true CR20240344A (es) 2024-12-09

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Family Applications (1)

Application Number Title Priority Date Filing Date
CR20240344A CR20240344A (es) 2022-01-18 2023-01-17 Inhibidores de apol1 y métodos de uso

Country Status (1)

Country Link
CR (1) CR20240344A (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4465982A4 (en) * 2022-01-18 2025-11-26 Maze Therapeutics Inc APOL1 INHIBITORS AND METHODS OF USE

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4465982A4 (en) * 2022-01-18 2025-11-26 Maze Therapeutics Inc APOL1 INHIBITORS AND METHODS OF USE

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