CR20250257A - Análogos de ácidos nucleicos bicíclicos abásicos y compuestos oligoméricos preparados a partir de estos - Google Patents

Análogos de ácidos nucleicos bicíclicos abásicos y compuestos oligoméricos preparados a partir de estos

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Publication number
CR20250257A
CR20250257A CR20250257A CR20250257A CR20250257A CR 20250257 A CR20250257 A CR 20250257A CR 20250257 A CR20250257 A CR 20250257A CR 20250257 A CR20250257 A CR 20250257A CR 20250257 A CR20250257 A CR 20250257A
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Costa Rica
Prior art keywords
abasic
nucleic acids
bicyclic nucleic
analogues
compounds prepared
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CR20250257A
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English (en)
Inventor
Dongxu Shu
Pengcheng Patrick Shao
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Shanghai Argo Biopharmaceutical Co Ltd
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Application filed by Shanghai Argo Biopharmaceutical Co Ltd filed Critical Shanghai Argo Biopharmaceutical Co Ltd
Publication of CR20250257A publication Critical patent/CR20250257A/es

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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
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    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
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    • A61K47/545—Heterocyclic compounds
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    • A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
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Abstract

La presente invención se refiere a análogos de ácidos nucleicos bicíclicos abásicos y a compuestos oligoméricos preparados a partir de estos y, más particularmente, a un análogo de ácidos nucleicos bicíclicos abásicos y a un compuesto monomérico análogo de ácidos nucleicos bicíclicos abásicos que puede usarse para ser incorporado en uno o dos extremos de un compuesto oligomérico. El compuesto oligomérico se administra <em>in vivo</em> a las células que requieren una orientación específica y, además de a los tejidos relacionados con el hígado, el compuesto oligomérico también se puede administrar a tejidos extrahepáticos, como células diana oftálmicas y del SNC.
CR20250257A 2022-12-02 2023-12-01 Análogos de ácidos nucleicos bicíclicos abásicos y compuestos oligoméricos preparados a partir de estos CR20250257A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN202211534279 2022-12-02
PCT/CN2023/135759 WO2024114776A1 (zh) 2022-12-02 2023-12-01 双环脱碱基核酸类似物以及由它们制备的寡聚化合物

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CR20250257A true CR20250257A (es) 2025-08-28

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CR20250257A CR20250257A (es) 2022-12-02 2023-12-01 Análogos de ácidos nucleicos bicíclicos abásicos y compuestos oligoméricos preparados a partir de estos

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EP (1) EP4628583A1 (es)
JP (1) JP2025539467A (es)
KR (1) KR20250116697A (es)
CN (1) CN120225676A (es)
AU (1) AU2023404700A1 (es)
CL (1) CL2025001598A1 (es)
CO (1) CO2025008331A2 (es)
CR (1) CR20250257A (es)
DO (1) DOP2025000126A (es)
IL (1) IL321125A (es)
JO (1) JOP20250131A1 (es)
MX (1) MX2025006436A (es)
PE (1) PE20251853A1 (es)
TW (1) TW202440920A (es)
WO (1) WO2024114776A1 (es)

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WO2026021467A1 (en) * 2024-07-23 2026-01-29 Shanghai Argo Biopharmaceutical Co., Ltd. Stereospecific linkages double stranded rna agents and compositions

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