CR20250269A - Compuestos cíclicos fusionados y uso de los mismos - Google Patents

Compuestos cíclicos fusionados y uso de los mismos

Info

Publication number
CR20250269A
CR20250269A CR20250269A CR20250269A CR20250269A CR 20250269 A CR20250269 A CR 20250269A CR 20250269 A CR20250269 A CR 20250269A CR 20250269 A CR20250269 A CR 20250269A CR 20250269 A CR20250269 A CR 20250269A
Authority
CR
Costa Rica
Prior art keywords
cyclic compounds
fused cyclic
zrgdmfwvtptnr
xgdo
urrddjjaubih
Prior art date
Application number
CR20250269A
Other languages
English (en)
Inventor
Wei Long
Hao Zhang
Runze Li
Yanping Wang
Cunbo Ma
Hongwei Yang
Panliang Gao
Huifeng Han
Peng Wang
Xiaoyu Liu
Original Assignee
Jacobio Pharmaceuticals Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jacobio Pharmaceuticals Co Ltd filed Critical Jacobio Pharmaceuticals Co Ltd
Publication of CR20250269A publication Critical patent/CR20250269A/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/22Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/16Peri-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La invención se refiere a compuestos cíclicos fusionados, una composición que contiene los mismos y el uso de los mismos. <img src="data:image/png;base64,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 (***)
CR20250269A 2022-12-07 2023-12-06 Compuestos cíclicos fusionados y uso de los mismos CR20250269A (es)

Applications Claiming Priority (12)

Application Number Priority Date Filing Date Title
CN2022137156 2022-12-07
CN2023071719 2023-01-10
CN2023084883 2023-03-29
CN2023088433 2023-04-14
CN2023101375 2023-06-20
CN2023116529 2023-09-01
CN2023119147 2023-09-15
CN2023124703 2023-10-16
CN2023129225 2023-11-02
CN2023131834 2023-11-15
CN2023135192 2023-11-29
PCT/CN2023/136747 WO2024120433A1 (en) 2022-12-07 2023-12-06 Fused cyclic compounds and use thereof

Publications (1)

Publication Number Publication Date
CR20250269A true CR20250269A (es) 2025-11-20

Family

ID=91378592

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20250269A CR20250269A (es) 2022-12-07 2023-12-06 Compuestos cíclicos fusionados y uso de los mismos

Country Status (12)

Country Link
EP (1) EP4630429A1 (es)
JP (1) JP2025540269A (es)
KR (1) KR20250120376A (es)
CN (1) CN120322440A (es)
AU (1) AU2023388747A1 (es)
CL (1) CL2025001678A1 (es)
CO (1) CO2025009073A2 (es)
CR (1) CR20250269A (es)
IL (1) IL321332A (es)
MX (1) MX2025006678A (es)
TW (1) TW202440594A (es)
WO (1) WO2024120433A1 (es)

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Publication number Priority date Publication date Assignee Title
KR20210006356A (ko) 2018-04-04 2021-01-18 아비나스 오퍼레이션스, 인코포레이티드 단백질분해 조절제 및 연관된 사용 방법
CN114867726B (zh) 2019-10-28 2023-11-28 默沙东有限责任公司 Kras g12c突变体的小分子抑制剂
US12479834B2 (en) 2019-11-29 2025-11-25 Taiho Pharmaceutical Co., Ltd. Phenol compound or salt thereof
CN121419983A (zh) 2023-01-26 2026-01-27 阿尔维纳斯运营股份有限公司 基于小脑蛋白的kras降解protac及其相关用途
CN120882725A (zh) * 2023-04-11 2025-10-31 吉利德科学公司 Kras调节化合物
WO2024230734A1 (en) * 2023-05-08 2024-11-14 Jacobio Pharmaceuticals Co., Ltd. K-ras inhibitors and use thereof
IL326136A (en) 2023-08-07 2026-03-01 Revolution Medicines Inc RMC-6291 for use in the treatment of a disease or disorder associated with the RAS protein
AU2024337913A1 (en) 2023-09-08 2026-03-26 Gilead Sciences, Inc. Pyrimidine-containing polycyclic derivatives as kras g12d modulating compounds
US20250154171A1 (en) 2023-10-12 2025-05-15 Revolution Medicines, Inc. Ras inhibitors
WO2025085748A1 (en) 2023-10-20 2025-04-24 Merck Sharp & Dohme Llc Small molecule inhibitors of kras proteins
WO2025146194A1 (en) * 2024-01-05 2025-07-10 Jacobio Pharmaceuticals Co., Ltd. Fused tetracyclic compounds and use thereof
WO2025171296A1 (en) 2024-02-09 2025-08-14 Revolution Medicines, Inc. Ras inhibitors
WO2025240847A1 (en) 2024-05-17 2025-11-20 Revolution Medicines, Inc. Ras inhibitors
US20250375445A1 (en) 2024-06-07 2025-12-11 Revolution Medicines, Inc. Methods of treating a ras protein-related disease or disorder
WO2025265060A1 (en) 2024-06-21 2025-12-26 Revolution Medicines, Inc. Therapeutic compositions and methods for managing treatment-related effects
WO2026006747A1 (en) 2024-06-28 2026-01-02 Revolution Medicines, Inc. Ras inhibitors
WO2026015796A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Methods of treating a ras related disease or disorder
WO2026015825A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Use of ras inhibitor for treating pancreatic cancer
WO2026015801A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Methods of treating a ras related disease or disorder
WO2026015790A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Methods of treating a ras related disease or disorder
WO2026021459A1 (zh) * 2024-07-25 2026-01-29 上海和誉生物医药科技有限公司 一种具有kras抑制活性的化合物及其在药学上的应用
WO2026050446A1 (en) 2024-08-29 2026-03-05 Revolution Medicines, Inc. Ras inhibitors
WO2026061466A1 (en) * 2024-09-20 2026-03-26 Jacobio Pharmaceuticals Co., Ltd. Fused tetracyclic compounds and use thereof
WO2026072904A2 (en) 2024-09-26 2026-04-02 Revolution Medicines, Inc. Compositions and methods for treating lung cancer

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WO2018206539A1 (en) * 2017-05-11 2018-11-15 Astrazeneca Ab Heteroaryl compounds that inhibit g12c mutant ras proteins
CA3210167A1 (en) * 2021-02-09 2022-08-18 Genentech, Inc. Tetracyclic oxazepine compounds and uses thereof
WO2022188729A1 (en) * 2021-03-07 2022-09-15 Jacobio Pharmaceuticals Co., Ltd. Fused ring derivatives useful as kras g12d inhibitors
EP4310091A4 (en) * 2021-03-17 2025-04-16 Genfleet Therapeutics (Shanghai) Inc. Pyrimidine-fused cyclic compound, preparation method therefor and use thereof
CN117083281A (zh) * 2021-03-24 2023-11-17 南京明德新药研发有限公司 嘧啶并杂环类化合物及其应用
CN116113632B (zh) * 2021-03-30 2025-08-29 浙江海正药业股份有限公司 杂环类衍生物、其制备方法及其医药上的用途
CN117255793A (zh) * 2021-06-21 2023-12-19 江苏恒瑞医药股份有限公司 稠合四环类化合物、其制备方法及其在医药上的应用
KR20240029051A (ko) * 2021-07-02 2024-03-05 상하이 드 노보 파마테크 컴퍼니 리미티드 Kras g12d 억제제 및 이의 용도
CN117677624A (zh) * 2021-07-19 2024-03-08 上海艾力斯医药科技股份有限公司 新型吡啶并嘧啶衍生物
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CN118019746A (zh) * 2021-09-27 2024-05-10 北京加科思新药研发有限公司 多环稠环衍生物及其用途

Also Published As

Publication number Publication date
WO2024120433A1 (en) 2024-06-13
JP2025540269A (ja) 2025-12-11
KR20250120376A (ko) 2025-08-08
CN120322440A (zh) 2025-07-15
TW202440594A (zh) 2024-10-16
IL321332A (en) 2025-08-01
AU2023388747A1 (en) 2025-07-10
EP4630429A1 (en) 2025-10-15
CO2025009073A2 (es) 2025-07-28
MX2025006678A (es) 2025-08-01
CL2025001678A1 (es) 2025-11-07

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