CR6306A - 1,2,3,4-tetrahidroquinlinas 2-sustituidas 4-amino sustituidas - Google Patents

1,2,3,4-tetrahidroquinlinas 2-sustituidas 4-amino sustituidas

Info

Publication number
CR6306A
CR6306A CR6306A CR6306A CR6306A CR 6306 A CR6306 A CR 6306A CR 6306 A CR6306 A CR 6306A CR 6306 A CR6306 A CR 6306A CR 6306 A CR6306 A CR 6306A
Authority
CR
Costa Rica
Prior art keywords
substituted
inhibitors
tetrahydroquinlines
plasma
amino
Prior art date
Application number
CR6306A
Other languages
English (en)
Inventor
Paul Deninno Michael
Tetteh Magnus-Aryitey George
Benjamin Ruggeri Roger
Thure Wester Ronald
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of CR6306A publication Critical patent/CR6306A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • C07D215/46—Nitrogen atoms attached in position 4 with hydrocarbon radicals, substituted by nitrogen atoms, attached to said nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/16—Ring systems of three rings containing carbocyclic rings other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Vascular Medicine (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

INHIBIDORES DE LA PROTEINA DE TRANSFERENCIA DE COLESTERIL ESTER, COMPOSICIONES FARMACEUTICAS QUE CONTIENEN TALES INHIBIDORES Y EL USO DE TALES INHIBIDORES PARA ELEVAR CIERTOS NIVELES DE LIPIDOS EN PLASMA, INCLUYENDO COLESTEROL DE LIPOPROTEINAS DE ALTA DENSIDAD Y PARA REDUCIR CIERTOS OTROS NIVELES DE LIPIDOS EN PLASMA, TALES COMO EL COLESTEROL LDL Y LOS TRIGLICERIDOS Y, POR CONSIGUIENTE PARA TRATAR ENFERMEDADES QUE SE EXACERBAN POR LOS BAJOS NIVELES DE COLESTEROL HDL Y/O ALTOS NIVELES DE COLESTEROL LDL Y TRIGLICERIDOS, TALES COMO LAS ATEROSCLEROSIS Y ENFERMEDADES CARDIOVASCULARES EN ALGUNOS MAMIFEROS, INCLUYENDO LOS SERES HUMANOS.
CR6306A 1998-09-17 2001-02-14 1,2,3,4-tetrahidroquinlinas 2-sustituidas 4-amino sustituidas CR6306A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10092798P 1998-09-17 1998-09-17

Publications (1)

Publication Number Publication Date
CR6306A true CR6306A (es) 2003-08-28

Family

ID=22282246

Family Applications (1)

Application Number Title Priority Date Filing Date
CR6306A CR6306A (es) 1998-09-17 2001-02-14 1,2,3,4-tetrahidroquinlinas 2-sustituidas 4-amino sustituidas

Country Status (50)

Country Link
US (2) US6140343A (es)
EP (1) EP1114032B1 (es)
JP (1) JP3561474B2 (es)
KR (1) KR100422286B1 (es)
CN (2) CN1318057A (es)
AP (1) AP1345A (es)
AR (1) AR030523A1 (es)
AT (1) ATE268324T1 (es)
AU (1) AU747715B2 (es)
BG (1) BG65101B1 (es)
BR (1) BR9913855A (es)
CA (1) CA2344248C (es)
CO (1) CO5290250A1 (es)
CR (1) CR6306A (es)
CU (1) CU23053A3 (es)
CZ (1) CZ2001954A3 (es)
DE (1) DE69917790T2 (es)
DK (1) DK1114032T3 (es)
DZ (1) DZ2891A1 (es)
EA (1) EA005761B1 (es)
EE (1) EE200100167A (es)
ES (1) ES2221420T3 (es)
GC (1) GC0000108A (es)
GE (1) GEP20032973B (es)
GT (1) GT199900147A (es)
HK (1) HK1039938A1 (es)
HR (1) HRP20010200B1 (es)
HU (1) HUP0103512A3 (es)
ID (1) ID27838A (es)
IL (1) IL141388A0 (es)
IS (1) IS2278B (es)
MA (1) MA26689A1 (es)
MY (1) MY121405A (es)
NO (1) NO319781B1 (es)
NZ (1) NZ509837A (es)
OA (1) OA11651A (es)
PA (1) PA8481201A1 (es)
PE (1) PE20001054A1 (es)
PL (1) PL198124B1 (es)
PT (1) PT1114032E (es)
SI (1) SI1114032T1 (es)
SK (1) SK3532001A3 (es)
SV (1) SV1999000150A (es)
TN (1) TNSN99170A1 (es)
TR (1) TR200100780T2 (es)
TW (1) TW502022B (es)
UA (1) UA70960C2 (es)
WO (1) WO2000017165A1 (es)
YU (1) YU18101A (es)
ZA (1) ZA200101745B (es)

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