CR6559A - HETEROARYL REPLACED BICYCLE COMPOUNDS AS INTEGRINE ANTAGONISTS - Google Patents

HETEROARYL REPLACED BICYCLE COMPOUNDS AS INTEGRINE ANTAGONISTS

Info

Publication number
CR6559A
CR6559A CR6559A CR6559A CR6559A CR 6559 A CR6559 A CR 6559A CR 6559 A CR6559 A CR 6559A CR 6559 A CR6559 A CR 6559A CR 6559 A CR6559 A CR 6559A
Authority
CR
Costa Rica
Prior art keywords
integrine
antagonists
heteroaryl replaced
het
saturated
Prior art date
Application number
CR6559A
Other languages
Spanish (es)
Inventor
Edward Clark David
Robert Eastwood Paul
Victor Harris Neil
Mccarthy Clive
David Morly Andrew
Dennis Pickett Stephen
Original Assignee
Aventis Pharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Ltd filed Critical Aventis Pharma Ltd
Publication of CR6559A publication Critical patent/CR6559A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La invencion es dirigida a compuestos fisiologicamente activos de la formula general (i) R1Z1 -Het-L1-Ar1-L2-Y en donde Het es un anillo biciclico sustituible de manera opcional, saturado, parcialmente saturado, o completamente saturado de 8 a 10 miembros que contiene al menos un heteroatromo seleccionado de O, S O N; R1 es aryl, heteroaryl, alkyl, alkenyl, alkynyl, cycloalkyl o heterocicloalkyl sustituido de manera opcional; Z1 representa una union directa, una cadena de alkylene, NR4, O o S(O)n.The invention is directed to physiologically active compounds of the general formula (i) R1Z1 -Het-L1-Ar1-L2-Y wherein Het is an optionally replaceable, saturated, partially saturated, or fully saturated bicyclic ring from 8 to 10 members containing at least one heteroatrome selected from O, SON; R1 is aryl, heteroaryl, alkyl, alkenyl, alkynyl, cycloalkyl or heterocycloalkyl optionally substituted; Z1 represents a direct bond, an alkylene chain, NR4, O or S (O) n.

CR6559A 1999-04-12 2002-01-23 HETEROARYL REPLACED BICYCLE COMPOUNDS AS INTEGRINE ANTAGONISTS CR6559A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9908355.2A GB9908355D0 (en) 1999-04-12 1999-04-12 Chemical compounds
US14147999P 1999-06-29 1999-06-29

Publications (1)

Publication Number Publication Date
CR6559A true CR6559A (en) 2008-11-25

Family

ID=10851398

Family Applications (1)

Application Number Title Priority Date Filing Date
CR6559A CR6559A (en) 1999-04-12 2002-01-23 HETEROARYL REPLACED BICYCLE COMPOUNDS AS INTEGRINE ANTAGONISTS

Country Status (6)

Country Link
JP (1) JP4864206B2 (en)
CR (1) CR6559A (en)
EA (1) EA200101067A1 (en)
GB (1) GB9908355D0 (en)
YU (1) YU71501A (en)
ZA (1) ZA200108302B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006056830A (en) * 2004-08-20 2006-03-02 Dai Ichi Seiyaku Co Ltd 2-arylaminobenzoxazole derivative

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5786373A (en) * 1992-10-14 1998-07-28 Merck & Co., Inc. Fibrinogen receptor antagonists
JPH08504194A (en) * 1992-12-01 1996-05-07 メルク エンド カンパニー インコーポレーテッド Fibrinogen receptor antagonist
IL123164A (en) * 1995-08-30 2001-03-19 Searle & Co Meta-guanidine urea thiourea or azacyclic amino benzoic acid derivatives and pharmaceutical compositions containing them
IL125033A0 (en) * 1995-12-29 1999-01-26 Smithkline Beecham Corp Vitronectin receptor antagonists
JP4373497B2 (en) * 1996-06-19 2009-11-25 ローン−プーラン・ロレ・リミテツド Substituted azabicyclo compounds and their use as inhibitors of TNF and cyclic AMP phosphodiesterase production
JP2001509176A (en) * 1997-01-17 2001-07-10 メルク エンド カンパニー インコーポレーテッド Integrin antagonist
KR20010042614A (en) * 1998-04-10 2001-05-25 윌리암스 로저 에이 Heterocyclic glycyl beta-alanine derivatives as vitronectin antagonists
WO2000049005A1 (en) * 1999-02-16 2000-08-24 Aventis Pharma Limited Bicyclic compounds and their use as integrin receptor ligands
GB9910394D0 (en) * 1999-05-05 1999-07-07 Rhone Poulenc Rorer Ltd Chemical compounds

Also Published As

Publication number Publication date
ZA200108302B (en) 2003-03-26
GB9908355D0 (en) 1999-06-09
YU71501A (en) 2005-07-19
EA200101067A1 (en) 2002-04-25
JP2002541257A (en) 2002-12-03
JP4864206B2 (en) 2012-02-01

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Legal Events

Date Code Title Description
FA Abandonment or withdrawal (granting procedure)