CR7201A - 2,5- DIARILPIRAZINAS, 2,5- DIARILPIRIDINAS AND 2,5- DIARILPIRIMIDINAS AS MODULATORS OF THE CRF1 RECEPTOR - Google Patents

2,5- DIARILPIRAZINAS, 2,5- DIARILPIRIDINAS AND 2,5- DIARILPIRIMIDINAS AS MODULATORS OF THE CRF1 RECEPTOR

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Publication number
CR7201A
CR7201A CR7201A CR7201A CR7201A CR 7201 A CR7201 A CR 7201A CR 7201 A CR7201 A CR 7201A CR 7201 A CR7201 A CR 7201A CR 7201 A CR7201 A CR 7201A
Authority
CR
Costa Rica
Prior art keywords
compounds
disorders
diarilpirimidinas
diarilpiridinas
diarilpirazinas
Prior art date
Application number
CR7201A
Other languages
Spanish (es)
Inventor
Huang Jianhua
Hodgetts Kevin
Doller Dario
Ge Ping
Yamaguchi Yasuchika
Original Assignee
Neurogen Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurogen Corp filed Critical Neurogen Corp
Priority to CR7201A priority Critical patent/CR7201A/en
Publication of CR7201A publication Critical patent/CR7201A/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Se describen compuestos de diarilpirazina, selectivos de receptores de CRF1. Estos compuestos son utiles en el tratamiento de una diversidad de trastornos del CNS y perifericos, particularmente tension, ansiedad, depresion, trastornos cardiovasculares y trastornos de la alimentacion. Tambien se proporcionan metodos de tratamiento de tales trastornos, tambien como composiciones farmaceuticas empacadas. Los compuestos de formula I tambien son utiles como sondas para la localizacion de receptores de CRF y como estandares en analisis para enlace de receptor CRF. Se proporcionan metodos para usar los compuestos en estudios de localizacion del receptor.Diarylpyrazine compounds, selective for CRF1 receptors, are described. These compounds are useful in the treatment of a variety of CNS and peripheral disorders, particularly stress, anxiety, depression, cardiovascular disorders and eating disorders. Methods of treating such disorders are also provided, also as packaged pharmaceutical compositions. The compounds of formula I are also useful as probes for the location of CRF receptors and as standards in analysis for CRF receptor binding. Methods for using the compounds in receptor location studies are provided.

CR7201A 2003-12-12 2003-12-12 2,5- DIARILPIRAZINAS, 2,5- DIARILPIRIDINAS AND 2,5- DIARILPIRIMIDINAS AS MODULATORS OF THE CRF1 RECEPTOR CR7201A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CR7201A CR7201A (en) 2003-12-12 2003-12-12 2,5- DIARILPIRAZINAS, 2,5- DIARILPIRIDINAS AND 2,5- DIARILPIRIMIDINAS AS MODULATORS OF THE CRF1 RECEPTOR

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CR7201A CR7201A (en) 2003-12-12 2003-12-12 2,5- DIARILPIRAZINAS, 2,5- DIARILPIRIDINAS AND 2,5- DIARILPIRIMIDINAS AS MODULATORS OF THE CRF1 RECEPTOR

Publications (1)

Publication Number Publication Date
CR7201A true CR7201A (en) 2004-03-24

Family

ID=44839147

Family Applications (1)

Application Number Title Priority Date Filing Date
CR7201A CR7201A (en) 2003-12-12 2003-12-12 2,5- DIARILPIRAZINAS, 2,5- DIARILPIRIDINAS AND 2,5- DIARILPIRIMIDINAS AS MODULATORS OF THE CRF1 RECEPTOR

Country Status (1)

Country Link
CR (1) CR7201A (en)
  • 2003

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Legal Events

Date Code Title Description
FA Abandonment or withdrawal (granting procedure)