CR7747A - NEW COMPOUNDS DERIVED FROM ISOXAZOL AS INHIBITORS OF THE TRANSFORMING GROWTH FACTOR (TGF) - Google Patents
NEW COMPOUNDS DERIVED FROM ISOXAZOL AS INHIBITORS OF THE TRANSFORMING GROWTH FACTOR (TGF)Info
- Publication number
- CR7747A CR7747A CR7747A CR7747A CR7747A CR 7747 A CR7747 A CR 7747A CR 7747 A CR7747 A CR 7747A CR 7747 A CR7747 A CR 7747A CR 7747 A CR7747 A CR 7747A
- Authority
- CR
- Costa Rica
- Prior art keywords
- tgf
- growth factor
- transforming growth
- new compounds
- inhibitors
- Prior art date
Links
- 102000009618 Transforming Growth Factors Human genes 0.000 title abstract 5
- 108010009583 Transforming Growth Factors Proteins 0.000 title abstract 5
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title abstract 2
- AXLOCHLTNQDFFS-BESJYZOMSA-N azastene Chemical compound C([C@H]1[C@@H]2CC[C@@]([C@]2(CC[C@@H]1[C@@]1(C)C2)C)(O)C)C=C1C(C)(C)C1=C2C=NO1 AXLOCHLTNQDFFS-BESJYZOMSA-N 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- -1 derivatives thereof Chemical compound 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000003176 fibrotic effect Effects 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- ZLTPDFXIESTBQG-UHFFFAOYSA-N isothiazole Chemical compound C=1C=NSC=1 ZLTPDFXIESTBQG-UHFFFAOYSA-N 0.000 abstract 1
- CTAPFRYPJLPFDF-UHFFFAOYSA-N isoxazole Chemical compound C=1C=NOC=1 CTAPFRYPJLPFDF-UHFFFAOYSA-N 0.000 abstract 1
- 230000007170 pathology Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 230000011664 signaling Effects 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Se describen nuevos compuestos de isotiazol e isoxazol, incluyendo derivados de los mismos, intermedios para prepararlos, composiciones farmaceuticas que los contienen y su uso medicinal. Los componenetes de la presente invencion son potentes inhibidores de la ruta de senalizacion del factor de crecimiento transformador ("TGF"). Son utiles en el tratamiento de diversas patologias relacionadas con TGF icluyendo por ejemplo, cancer, y enfermedades fibroticas.New compounds of isothiazole and isoxazole, including derivatives thereof, intermediates for preparing them, pharmaceutical compositions containing them and their medicinal use are described. The components of the present invention are potent inhibitors of the signaling path of transforming growth factor ("TGF"). They are useful in the treatment of various pathologies related to TGF including, for example, cancer, and fibrotic diseases.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41213102P | 2002-09-18 | 2002-09-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CR7747A true CR7747A (en) | 2005-06-15 |
Family
ID=36926891
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CR7747A CR7747A (en) | 2002-09-18 | 2005-03-16 | NEW COMPOUNDS DERIVED FROM ISOXAZOL AS INHIBITORS OF THE TRANSFORMING GROWTH FACTOR (TGF) |
Country Status (4)
| Country | Link |
|---|---|
| CR (1) | CR7747A (en) |
| GT (1) | GT200300202A (en) |
| TN (1) | TNSN05081A1 (en) |
| ZA (1) | ZA200502277B (en) |
-
2003
- 2003-09-17 GT GT200300202A patent/GT200300202A/en unknown
-
2005
- 2005-03-16 CR CR7747A patent/CR7747A/en not_active Application Discontinuation
- 2005-03-17 ZA ZA200502277A patent/ZA200502277B/en unknown
- 2005-03-18 TN TNP2005000081A patent/TNSN05081A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GT200300202A (en) | 2004-04-19 |
| ZA200502277B (en) | 2006-02-22 |
| TNSN05081A1 (en) | 2007-05-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal (granting procedure) |