CR8435A - PROCESS FOR THE PREPARATION OF TUBULIN INHIBITORS - Google Patents

PROCESS FOR THE PREPARATION OF TUBULIN INHIBITORS

Info

Publication number
CR8435A
CR8435A CR8435A CR8435A CR8435A CR 8435 A CR8435 A CR 8435A CR 8435 A CR8435 A CR 8435A CR 8435 A CR8435 A CR 8435A CR 8435 A CR8435 A CR 8435A
Authority
CR
Costa Rica
Prior art keywords
preparation
tubulin inhibitors
tubulin
inhibitors
triazolopyrimidine
Prior art date
Application number
CR8435A
Other languages
Spanish (es)
Inventor
Wu Yanzhong
Schmid Jean
Thomas Afragola Jay
Michael Blum David
Ayral-Kaloustian Semiramis
Original Assignee
Wyeth Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Llc filed Critical Wyeth Llc
Publication of CR8435A publication Critical patent/CR8435A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Steroid Compounds (AREA)

Abstract

La presente invencion suministra un proceso para la preparacion de sal de acido 6-(fenilo(sustituido))-triazolopirimidina dicarboxilico y como una sal hidratada que tiene la formula estructural (1)The present invention provides a process for the preparation of acid salt 6- (phenyl (substituted)) - dicarboxylic triazolopyrimidine and as a hydrated salt having the structural formula (1)

CR8435A 2003-12-08 2006-06-06 PROCESS FOR THE PREPARATION OF TUBULIN INHIBITORS CR8435A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US52793103P 2003-12-08 2003-12-08

Publications (1)

Publication Number Publication Date
CR8435A true CR8435A (en) 2007-06-08

Family

ID=34676796

Family Applications (1)

Application Number Title Priority Date Filing Date
CR8435A CR8435A (en) 2003-12-08 2006-06-06 PROCESS FOR THE PREPARATION OF TUBULIN INHIBITORS

Country Status (28)

Country Link
US (1) US7396835B2 (en)
EP (1) EP1692137B1 (en)
JP (1) JP2007513185A (en)
KR (1) KR20060094984A (en)
CN (1) CN1890245A (en)
AR (1) AR046939A1 (en)
AT (1) ATE356128T1 (en)
AU (1) AU2004297244A1 (en)
BR (1) BRPI0417422A (en)
CA (1) CA2546899A1 (en)
CO (1) CO5700827A2 (en)
CR (1) CR8435A (en)
DE (1) DE602004005239T2 (en)
DK (1) DK1692137T3 (en)
EC (1) ECSP066606A (en)
ES (1) ES2281850T3 (en)
GT (1) GT200400248A (en)
IL (1) IL175775A0 (en)
MY (1) MY179926A (en)
NO (1) NO20062492L (en)
NZ (1) NZ547471A (en)
PA (1) PA8619401A1 (en)
PE (1) PE20050593A1 (en)
PL (1) PL1692137T3 (en)
RU (1) RU2006117023A (en)
TW (1) TW200522963A (en)
WO (1) WO2005056560A1 (en)
ZA (1) ZA200604680B (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6255309B1 (en) * 1999-03-19 2001-07-03 American Cyanomid Co. Fungicidal trifluoromethylalkylamino-triazolopyrimidines
US7419982B2 (en) * 2003-09-24 2008-09-02 Wyeth Holdings Corporation Crystalline forms of 5-chloro-6-{2,6-difluoro-4-[3-(methylamino)propoxy]phenyl}-N-[(1S)-2,2,2-trifluoro-1-methylethyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine salts
TW200800959A (en) 2005-06-10 2008-01-01 Wyeth Corp Piperazine-piperidine antagonists and agonists of the 5-HT1a receptor
TW200808730A (en) * 2006-06-09 2008-02-16 Wyeth Corp Process for synthesizing piperazine-piperidine compounds
CN101600350A (en) * 2007-01-08 2009-12-09 巴斯夫欧洲公司 Use of azolopyrimidine in preventing and controlling phytopathogenic harmful fungi
EP3219207A1 (en) 2012-09-19 2017-09-20 The Trustees Of The University Of Pennsylvania Heterocyclic compounds and their use for the treatment of neurodegenerative tauopathies
US11623927B2 (en) 2018-03-02 2023-04-11 The Trustees Of The University Of Pennsylvania Substituted [1,2,4]triazolo[1,5-a]pyrimidines for stabilizing microtubules
CN116178375B (en) * 2023-02-24 2024-09-20 重庆文理学院 Triazolopyrimidine compound and synthetic method and application thereof

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5593996A (en) * 1991-12-30 1997-01-14 American Cyanamid Company Triazolopyrimidine derivatives
TW224044B (en) 1991-12-30 1994-05-21 Shell Internat Res Schappej B V
JP2794510B2 (en) * 1992-03-27 1998-09-10 富士写真フイルム株式会社 Silver halide photographic material
TW258648B (en) * 1993-03-04 1995-10-01 Shell Internat Res Schappej Bv
IL108747A (en) 1993-03-04 1999-03-12 Shell Int Research Fungicidal compositions containing 6-substituted-5,7-dihalo-1,2,4-triazolo Ú1,5-a¾pyrimidine derivatives certain new such derivatives and their preparation
RU2147584C1 (en) * 1995-10-27 2000-04-20 Американ Цианамид Компани Method of synthesis of dihaloidazolopyrimidines and method of synthesis of dihydroxyazolopyrimidines
US5817663A (en) * 1996-10-07 1998-10-06 American Cyanamid Company Pentafluorophenylazolopyrimidines
US5750766A (en) * 1997-03-18 1998-05-12 American Cyanamid Company Process for the preparation of arylmalonates
WO1998041496A1 (en) 1997-03-18 1998-09-24 American Cyanamid Company Process for the preparation of arylmalonates
TW460476B (en) 1997-04-14 2001-10-21 American Cyanamid Co Fungicidal trifluoromethylalkylamino-triazolopyrimidines
TWI252231B (en) 1997-04-14 2006-04-01 American Cyanamid Co Fungicidal trifluorophenyl-triazolopyrimidines
US6117876A (en) * 1997-04-14 2000-09-12 American Cyanamid Company Fungicidal trifluorophenyl-triazolopyrimidines
US5948783A (en) * 1997-04-14 1999-09-07 American Cyanamid Company Fungicidal trifluoromethylalkylamino-triazolopyrimidines
US5994360A (en) * 1997-07-14 1999-11-30 American Cyanamid Company Fungicidal 5-alkyl-triazolopyrimidines
US5986153A (en) * 1997-09-30 1999-11-16 Phillips Petroleum Company Olefin color stabilization
US6020338A (en) * 1998-02-11 2000-02-01 American Cyanamid Company Fungicidal 7-alkyl-triazolopyrimidines
EA003281B1 (en) * 1998-03-23 2003-04-24 Америкэн Цианамид Компани 6-(2-halo-4-alkoxyphenyl) triazolopyrimidines with fungicidal effect
US5981534A (en) * 1998-09-25 1999-11-09 American Cyanamid Company Fungicidal 6-(2,6-difluoro-4-alkoxyphenyl)-triazolopyrimidines
US6242451B1 (en) * 1998-09-25 2001-06-05 Klaus-Juergen Pees Fungicidal trihalophenyl-triazolopyrimidines
US5985883A (en) * 1998-09-25 1999-11-16 American Cyanamid Company Fungicidal trichlorophenyl-triazolopyrimidines
US5986135A (en) 1998-09-25 1999-11-16 American Cyanamid Company Fungicidal trifluoromethylalkylamino-triazolopyrimidines
JP2000103790A (en) 1998-09-25 2000-04-11 American Cyanamid Co Bactericidal and fungicidal trihalophenyl- triazopyrimidines
CA2413802A1 (en) 2000-06-30 2002-01-10 Mark R. Schmitt Substituted-triazolopyrimidines as anticancer agents
KR20060098368A (en) * 2003-09-24 2006-09-18 와이어쓰 홀딩스 코포레이션 6-[(substituted) phenyl] triazolopyrimidine as anticancer agent
CN101193884A (en) * 2005-06-13 2008-06-04 惠氏公司 Tubulin inhibitor and its preparation method

Also Published As

Publication number Publication date
GT200400248A (en) 2005-09-14
DE602004005239T2 (en) 2007-12-20
MY179926A (en) 2020-11-19
WO2005056560A1 (en) 2005-06-23
US20050124635A1 (en) 2005-06-09
US7396835B2 (en) 2008-07-08
CO5700827A2 (en) 2006-11-30
ES2281850T3 (en) 2007-10-01
TW200522963A (en) 2005-07-16
NZ547471A (en) 2009-03-31
DK1692137T3 (en) 2007-04-30
IL175775A0 (en) 2006-09-05
PA8619401A1 (en) 2005-08-04
AR046939A1 (en) 2006-01-04
PL1692137T3 (en) 2007-06-29
RU2006117023A (en) 2008-01-20
EP1692137A1 (en) 2006-08-23
EP1692137B1 (en) 2007-03-07
NO20062492L (en) 2006-07-03
BRPI0417422A (en) 2007-03-13
AU2004297244A1 (en) 2005-06-23
ATE356128T1 (en) 2007-03-15
CN1890245A (en) 2007-01-03
ZA200604680B (en) 2009-04-29
ECSP066606A (en) 2006-10-25
CA2546899A1 (en) 2005-06-23
KR20060094984A (en) 2006-08-30
HK1090377A1 (en) 2006-12-22
PE20050593A1 (en) 2005-09-27
DE602004005239D1 (en) 2007-04-19
JP2007513185A (en) 2007-05-24

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Legal Events

Date Code Title Description
FA Abandonment or withdrawal (granting procedure)