CR8492A - B-HYDROXI OPTICALLY ACTIVE HETEROAROMATIC ESTERS, PROCESSES FOR THE PREPARATION OF B-CETO ESTERES AND PROCESSES FOR THE PREPARATION OF SUCH B-CETO ESTERES - Google Patents

B-HYDROXI OPTICALLY ACTIVE HETEROAROMATIC ESTERS, PROCESSES FOR THE PREPARATION OF B-CETO ESTERES AND PROCESSES FOR THE PREPARATION OF SUCH B-CETO ESTERES

Info

Publication number
CR8492A
CR8492A CR8492A CR8492A CR8492A CR 8492 A CR8492 A CR 8492A CR 8492 A CR8492 A CR 8492A CR 8492 A CR8492 A CR 8492A CR 8492 A CR8492 A CR 8492A
Authority
CR
Costa Rica
Prior art keywords
esteres
ceto
processes
preparation
optically active
Prior art date
Application number
CR8492A
Other languages
Spanish (es)
Inventor
Platzek Johannes
Zorn Ludwig
Buchmann Bern
Skuballa Werner
Petrov Orlin
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of CR8492A publication Critical patent/CR8492A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D215/14—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C12P17/12—Nitrogen as only ring hetero atom containing a six-membered hetero ring
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/14—Nitrogen or oxygen as hetero atom and at least one other diverse hetero ring atom in the same ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

La presente invencion se refiere a B-hidroxiesteres heteroatomicos opticamente activos utiles en la sintesis de derivados de epotilona, a ciertos compuestos utilizados para producir tales intermediarios, asi como a procedimientos para su produccion.The present invention relates to optically active heteroatomic B-hydroxiesters useful in the synthesis of epothilone derivatives, to certain compounds used to produce such intermediates, as well as to methods for their production.

CR8492A 2003-12-31 2006-06-28 B-HYDROXI OPTICALLY ACTIVE HETEROAROMATIC ESTERS, PROCESSES FOR THE PREPARATION OF B-CETO ESTERES AND PROCESSES FOR THE PREPARATION OF SUCH B-CETO ESTERES CR8492A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10361794A DE10361794B3 (en) 2003-12-31 2003-12-31 Optically active heteroaromatic β-hydroxy esters and processes for their preparation and their use as intermediates in the epothilone total synthesis

Publications (1)

Publication Number Publication Date
CR8492A true CR8492A (en) 2007-03-08

Family

ID=34716267

Family Applications (1)

Application Number Title Priority Date Filing Date
CR8492A CR8492A (en) 2003-12-31 2006-06-28 B-HYDROXI OPTICALLY ACTIVE HETEROAROMATIC ESTERS, PROCESSES FOR THE PREPARATION OF B-CETO ESTERES AND PROCESSES FOR THE PREPARATION OF SUCH B-CETO ESTERES

Country Status (16)

Country Link
EP (1) EP2113031A1 (en)
JP (1) JP2007516999A (en)
KR (1) KR20070029641A (en)
CN (1) CN100510098C (en)
AU (1) AU2004309076A1 (en)
BR (1) BRPI0418254A (en)
CA (1) CA2546981A1 (en)
CR (1) CR8492A (en)
DE (1) DE10361794B3 (en)
EC (1) ECSP066740A (en)
IL (1) IL175908A0 (en)
MX (1) MXPA06007564A (en)
NO (1) NO20063477L (en)
RU (1) RU2006127553A (en)
WO (1) WO2005064006A1 (en)
ZA (1) ZA200606293B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104328152A (en) * 2014-10-13 2015-02-04 青岛科技大学 Method for catalytically producing cyclohexylidene enol by utilizing candida utilis
CN108118004B (en) * 2017-12-15 2021-06-25 北京工商大学 Application of Pichia pastoris in the control of postharvest fruit diseases
CN111689982B (en) * 2019-03-15 2023-04-07 博瑞生物医药（苏州）股份有限公司 Eribulin intermediate and preparation method thereof
CN110283733B (en) * 2019-06-20 2020-10-27 浙江工业大学 Saturn wheel head yeast ZJPH1807 and its application

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU7257096A (en) * 1995-10-04 1997-04-28 Fmc Corporation Herbicidal 6-heterocyclic indazole derivatives
US5942644A (en) * 1997-05-27 1999-08-24 Biocatalytics, Inc. Precursors for the production of chiral vicinal aminoalcohols
US6211412B1 (en) * 1999-03-29 2001-04-03 The University Of Kansas Synthesis of epothilones
PE20010116A1 (en) * 1999-04-30 2001-02-15 Schering Ag 6-ALKENYL-, 6-ALKINYL- AND 6-EPOXY-EPOTILONE DERIVATIVES, PROCEDURES FOR THEIR PREPARATION
JP2001213874A (en) * 1999-07-22 2001-08-07 Mercian Corp Production of isocoumarin derivatives and intermediates therefor
DE10041470A1 (en) * 2000-08-18 2002-02-28 Schering Ag New 6-substituted 12,13-(cyclopropyl or azacyclopropyl)-epothilone derivatives, useful as cell division regulators for treating e.g. malignant tumors, psoriasis or arthritis
WO2003029195A1 (en) * 2001-09-28 2003-04-10 Sumika Fine Chemicals Co., Ltd. Intermediates for epothilone derivative and process for producing these
JP4432315B2 (en) * 2002-03-19 2010-03-17 三菱化学株式会社 Process for producing optically active 3-hydroxy-3- (2'-thienyl) propionic acid ester derivative

Also Published As

Publication number Publication date
RU2006127553A (en) 2008-02-10
WO2005064006A1 (en) 2005-07-14
CN100510098C (en) 2009-07-08
EP2113031A1 (en) 2009-11-04
CA2546981A1 (en) 2005-07-14
MXPA06007564A (en) 2006-12-14
ECSP066740A (en) 2006-10-31
IL175908A0 (en) 2006-10-05
AU2004309076A1 (en) 2005-07-14
JP2007516999A (en) 2007-06-28
BRPI0418254A (en) 2007-04-17
HK1097000A1 (en) 2007-06-15
ZA200606293B (en) 2009-08-26
KR20070029641A (en) 2007-03-14
NO20063477L (en) 2006-08-23
DE10361794B3 (en) 2005-10-06
CN1902322A (en) 2007-01-24

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CR8492A (en) B-HYDROXI OPTICALLY ACTIVE HETEROAROMATIC ESTERS, PROCESSES FOR THE PREPARATION OF B-CETO ESTERES AND PROCESSES FOR THE PREPARATION OF SUCH B-CETO ESTERES

Legal Events

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