CR9178A - DERIVATIVES OF PIRAZOL FUSIONADO AND METHODS OF TREATMENT OF DISORDERS RELATED TO METABOLISM - Google Patents
DERIVATIVES OF PIRAZOL FUSIONADO AND METHODS OF TREATMENT OF DISORDERS RELATED TO METABOLISMInfo
- Publication number
- CR9178A CR9178A CR9178A CR9178A CR9178A CR 9178 A CR9178 A CR 9178A CR 9178 A CR9178 A CR 9178A CR 9178 A CR9178 A CR 9178A CR 9178 A CR9178 A CR 9178A
- Authority
- CR
- Costa Rica
- Prior art keywords
- inhibitors
- present
- compounds
- metabolism
- treatment
- Prior art date
Links
- 230000004060 metabolic process Effects 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 3
- 239000003112 inhibitor Substances 0.000 abstract 3
- UUUHXMGGBIUAPW-UHFFFAOYSA-N 1-[1-[2-[[5-amino-2-[[1-[5-(diaminomethylideneamino)-2-[[1-[3-(1h-indol-3-yl)-2-[(5-oxopyrrolidine-2-carbonyl)amino]propanoyl]pyrrolidine-2-carbonyl]amino]pentanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-3-methylpentanoyl]pyrrolidine-2-carbon Chemical compound C1CCC(C(=O)N2C(CCC2)C(O)=O)N1C(=O)C(C(C)CC)NC(=O)C(CCC(N)=O)NC(=O)C1CCCN1C(=O)C(CCCN=C(N)N)NC(=O)C1CCCN1C(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C1CCC(=O)N1 UUUHXMGGBIUAPW-UHFFFAOYSA-N 0.000 abstract 2
- 102000004270 Peptidyl-Dipeptidase A Human genes 0.000 abstract 2
- 108090000882 Peptidyl-Dipeptidase A Proteins 0.000 abstract 2
- 239000003623 enhancer Substances 0.000 abstract 2
- 208000001072 type 2 diabetes mellitus Diseases 0.000 abstract 2
- YYGNTYWPHWGJRM-UHFFFAOYSA-N (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCCC=C(C)CCC=C(C)CCC=C(C)C YYGNTYWPHWGJRM-UHFFFAOYSA-N 0.000 abstract 1
- ZOBPZXTWZATXDG-UHFFFAOYSA-N 1,3-thiazolidine-2,4-dione Chemical compound O=C1CSC(=O)N1 ZOBPZXTWZATXDG-UHFFFAOYSA-N 0.000 abstract 1
- 201000001320 Atherosclerosis Diseases 0.000 abstract 1
- 229940123208 Biguanide Drugs 0.000 abstract 1
- 208000032928 Dyslipidaemia Diseases 0.000 abstract 1
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 abstract 1
- 206010022489 Insulin Resistance Diseases 0.000 abstract 1
- BHEOSNUKNHRBNM-UHFFFAOYSA-N Tetramethylsqualene Natural products CC(=C)C(C)CCC(=C)C(C)CCC(C)=CCCC=C(C)CCC(C)C(=C)CCC(C)C(C)=C BHEOSNUKNHRBNM-UHFFFAOYSA-N 0.000 abstract 1
- 229940123464 Thiazolidinedione Drugs 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 239000003288 aldose reductase inhibitor Substances 0.000 abstract 1
- 229940090865 aldose reductase inhibitors used in diabetes Drugs 0.000 abstract 1
- 150000004283 biguanides Chemical class 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 230000015556 catabolic process Effects 0.000 abstract 1
- 208000029078 coronary artery disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N dodecahydrosqualene Natural products CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 abstract 1
- 229940125753 fibrate Drugs 0.000 abstract 1
- 239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 abstract 1
- 230000003914 insulin secretion Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 229940096701 plain lipid modifying drug hmg coa reductase inhibitors Drugs 0.000 abstract 1
- 150000003217 pyrazoles Chemical class 0.000 abstract 1
- 239000000018 receptor agonist Substances 0.000 abstract 1
- 229940044601 receptor agonist Drugs 0.000 abstract 1
- 239000002464 receptor antagonist Substances 0.000 abstract 1
- 229940044551 receptor antagonist Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229940031439 squalene Drugs 0.000 abstract 1
- TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 abstract 1
- 208000011580 syndromic disease Diseases 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente invencion esta dirigida a ciertos derivados fusionados de pirazole de Formula (Ia), y sales farmaceuticamente aceptables de los mismos, los cuales muestran propiedades farmacologicas utiles, por ejemplo, como agonistas del receptor RUP25. La presente invencion tambien muestra composiciones farmaceuticas que contienen compuestos de la invencion, y metodos de uso de los compuestos y composiciones de la invencion en el tratamiento de desordenes relacionados con el metabolismo, incluyendo dislipidemias, aterosclerosis, enfermedad coronaria del corazon, resistencia a la insulina, diabetes tipo 2, Sindrome X y similares. Ademas, la presente invencion se relaciona con el uso de los compuestos de la invencion en combinacion con otros ingredientes activos tales como aquellos pertenecientes a la clase de inhibidores de la a-glucosidasa, inhibidores de aldosa reductasa, biguanidas, inhibidores de HMG-CoA reductasa, inhibidores de la sintesis de escualeno, fibratos, mejoradores del catabolismo de LDL, inhibidores de las enzimas convertidoras de angiotensina (ACE), mejoradores de la secrecion de insulina, tiazolidinadiona, antagonistas del receptor DP y similares.The present invention is directed to certain fused derivatives of pyrazole of Formula (Ia), and pharmaceutically acceptable salts thereof, which show useful pharmacological properties, for example, as RUP25 receptor agonists. The present invention also shows pharmaceutical compositions containing compounds of the invention, and methods of use of the compounds and compositions of the invention in the treatment of disorders related to metabolism, including dyslipidemias, atherosclerosis, coronary heart disease, insulin resistance , type 2 diabetes, X syndrome and the like. In addition, the present invention relates to the use of the compounds of the invention in combination with other active ingredients such as those belonging to the class of a-glucosidase inhibitors, aldose reductase inhibitors, biguanides, HMG-CoA reductase inhibitors , squalene synthesis inhibitors, fibrates, LDL catabolism enhancers, angiotensin converting enzyme (ACE) inhibitors, insulin secretion enhancers, thiazolidinedione, DP receptor antagonists and the like.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63866804P | 2004-12-23 | 2004-12-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CR9178A true CR9178A (en) | 2007-10-23 |
Family
ID=38938221
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CR9178A CR9178A (en) | 2004-12-23 | 2007-06-12 | DERIVATIVES OF PIRAZOL FUSIONADO AND METHODS OF TREATMENT OF DISORDERS RELATED TO METABOLISM |
Country Status (4)
| Country | Link |
|---|---|
| CN (1) | CN101087765A (en) |
| CR (1) | CR9178A (en) |
| UA (1) | UA90878C2 (en) |
| ZA (1) | ZA200705147B (en) |
-
2005
- 2005-12-22 CN CN 200580044454 patent/CN101087765A/en active Pending
- 2005-12-22 UA UAA200708375A patent/UA90878C2/en unknown
-
2007
- 2007-06-12 CR CR9178A patent/CR9178A/en not_active Application Discontinuation
- 2007-06-21 ZA ZA200705147A patent/ZA200705147B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN101087765A (en) | 2007-12-12 |
| ZA200705147B (en) | 2008-10-29 |
| UA90878C2 (en) | 2010-06-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal (granting procedure) |