CR9477A - Numero de copias del gen del receptor del factor de crecimiento epidermico - Google Patents

Numero de copias del gen del receptor del factor de crecimiento epidermico

Info

Publication number
CR9477A
CR9477A CR9477A CR9477A CR9477A CR 9477 A CR9477 A CR 9477A CR 9477 A CR9477 A CR 9477A CR 9477 A CR9477 A CR 9477A CR 9477 A CR9477 A CR 9477A
Authority
CR
Costa Rica
Prior art keywords
growth factor
epidermal growth
gen
copies number
factor receiver
Prior art date
Application number
CR9477A
Other languages
English (en)
Inventor
Salvatore Siena
Mauro Moroni
Alberto Bardelli
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of CR9477A publication Critical patent/CR9477A/es

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • General Engineering & Computer Science (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cell Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Se describen los metodos para predecir si un tratamiento con el agente de enlace especifico anti-receptor del factor de crecimiento epidermico (EGFR) sera eficaz en el tratamiento del cancer y los metodos de tratamiento de los pacientes con agentes de enlace especificos anti-EGFR.
CR9477A 2005-04-01 2007-10-26 Numero de copias del gen del receptor del factor de crecimiento epidermico CR9477A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US66782705P 2005-04-01 2005-04-01

Publications (1)

Publication Number Publication Date
CR9477A true CR9477A (es) 2008-03-07

Family

ID=36917385

Family Applications (1)

Application Number Title Priority Date Filing Date
CR9477A CR9477A (es) 2005-04-01 2007-10-26 Numero de copias del gen del receptor del factor de crecimiento epidermico

Country Status (14)

Country Link
US (1) US7635570B2 (es)
EP (1) EP1869220A2 (es)
JP (1) JP2008536493A (es)
KR (1) KR20080014745A (es)
CN (1) CN102007220A (es)
AU (1) AU2006232378A1 (es)
BR (1) BRPI0609615A2 (es)
CA (1) CA2602619A1 (es)
CR (1) CR9477A (es)
EA (1) EA200702143A1 (es)
IL (1) IL186139A0 (es)
MX (1) MX2007012074A (es)
NO (1) NO20074817L (es)
WO (1) WO2006107854A2 (es)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1282443E (pt) * 2000-05-19 2009-12-04 Genentech Inc Análise de detecção génica para melhorar a probabilidade de uma resposta eficaz a uma terapia do cancro com um antagonista de erbb
DE60234094D1 (de) 2001-05-11 2009-12-03 Ludwig Inst For Cancer Res Ltd Spezifische bindungsproteine und ihre verwendung
US20100056762A1 (en) 2001-05-11 2010-03-04 Old Lloyd J Specific binding proteins and uses thereof
KR20080003422A (ko) * 2005-04-14 2008-01-07 메르크 파텐트 게엠베하 종양 조직 내의 ｅｇｆｒ 유전자의 증가된 복제수에 기초한항-ｅｇｆｒ 항체 치료
CA2665567C (en) * 2006-10-06 2012-07-03 Amgen Inc. Stable formulations
CA2666492C (en) * 2006-10-20 2012-07-17 Douglas Rehder Stable polypeptide formulations
CA2676244C (en) 2007-01-25 2017-01-17 Kwok-Kin Wong Use of anti-egfr antibodies in treatment of egfr mutant mediated disease
MX2009009787A (es) 2007-03-13 2009-09-22 Amgen Inc Mutaciones de k-ras y terapia con anticuerpos anti-egfr.
PE20090690A1 (es) * 2007-03-13 2009-06-22 Amgen Inc Mutaciones de k-ras y b-raf y terapia con anticuerpos anti-egfr
CN101688229B (zh) 2007-03-15 2013-06-12 路德维格癌症研究所 包含egfr抗体和src抑制剂的组合物及其在制备用于治疗哺乳动物癌症的药物中的用途
CA2696360C (en) 2007-08-14 2018-11-20 Ludwig Institute For Cancer Research Monoclonal antibody targeting the egfr receptor and uses thereof
WO2009150256A1 (en) * 2008-06-13 2009-12-17 Institut National De La Sante Et De La Recherche Medicale (Inserm) Markers for predicting response and survival in anti-egfr treated patients
US8583380B2 (en) 2008-09-05 2013-11-12 Aueon, Inc. Methods for stratifying and annotating cancer drug treatment options
CN101899504B (zh) * 2010-05-11 2014-12-10 合肥艾迪康临床检验所有限公司 用于检测egfr基因拷贝数和7号染色体倍性的试剂
US9646134B2 (en) * 2010-05-25 2017-05-09 The Regents Of The University Of California Bambam: parallel comparative analysis of high-throughput sequencing data
WO2011149534A2 (en) 2010-05-25 2011-12-01 The Regents Of The University Of California Bambam: parallel comparative analysis of high-throughput sequencing data
CN103228798B (zh) 2010-09-24 2015-12-09 斯坦福大学托管董事会 使用固定的引物直接捕获、扩增及测序靶标dna
DE102010060964A1 (de) * 2010-12-02 2012-06-06 Universitätsklinikum Hamburg-Eppendorf Verfahren zur Prädikation der therapeutischen Wirksamkeit von EGFR-Inhibitoren
AU2012239997A1 (en) 2011-04-07 2013-10-17 Amgen Inc. Novel EGFR binding proteins
BR112014013544A8 (pt) 2011-12-30 2017-06-13 Abbott Molecular Inc materiais e métodos para diagnose, prognose e avaliação do tratamento terapêutico/profilático de câncer da próstata
GB201223025D0 (en) * 2012-12-20 2013-02-06 Medizinische Universitaet Graz Prediction of the treatment response to an anti-EGFR molecule in colorectal cancer patients
WO2014159797A1 (en) * 2013-03-14 2014-10-02 Abbott Molecular Inc. Cell preparations and cell supports and their use in theranosis
KR101776879B1 (ko) 2015-01-19 2017-09-08 주식회사 녹십자 항-egfr 항체를 포함하는 약학 제제
CA3001131A1 (en) 2015-11-02 2017-05-11 Five Prime Therapeutics, Inc. Cd80 extracellular domain polypeptides and their use in cancer treatment
WO2021097464A1 (en) * 2019-11-15 2021-05-20 Institute For Cancer Research Compositions and methods for regulating egfr amplification in cancer cells for improving egfr-targeted anti-cancer agent
CN113215236A (zh) * 2020-01-21 2021-08-06 东曜药业有限公司 一种检测细胞遗传稳定性的引物探针组合物及其应用
CN112430646A (zh) * 2020-12-11 2021-03-02 南京求臻基因科技有限公司 一种基于数字pcr平台的egfr基因扩增的检测方法
CN112646893A (zh) * 2021-01-08 2021-04-13 北京泛生子基因科技有限公司 一种egfr基因拷贝数检测试剂盒及检测方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CU22545A1 (es) 1994-11-18 1999-03-31 Centro Inmunologia Molecular Obtención de un anticuerpo quimérico y humanizado contra el receptor del factor de crecimiento epidérmico para uso diagnóstico y terapéutico
US20040132097A1 (en) * 2002-06-19 2004-07-08 Bacus Sarah S. Method for predicting response to epidermal growth factor receptor-directed therapy
JP2007506442A (ja) 2003-05-30 2007-03-22 ゲノミック ヘルス， インコーポレイテッド Ｅｇｆｒ阻害薬への応答に関する遺伝子発現マーカー
ES2553264T3 (es) * 2004-05-27 2015-12-07 The Regents Of The University Of Colorado Métodos para la predicción del resultado clínico para inhibidores del receptor del factor de crecimiento epidérmico para pacientes de cáncer
KR20080003422A (ko) * 2005-04-14 2008-01-07 메르크 파텐트 게엠베하 종양 조직 내의 ｅｇｆｒ 유전자의 증가된 복제수에 기초한항-ｅｇｆｒ 항체 치료
EP1913157B2 (en) 2005-06-28 2016-10-26 Genentech, Inc. Egfr and kras mutations for prediction of patient response to egfr inhibitor treatment

Also Published As

Publication number Publication date
MX2007012074A (es) 2007-11-21
BRPI0609615A2 (pt) 2010-04-27
CA2602619A1 (en) 2006-10-12
US7635570B2 (en) 2009-12-22
CN102007220A (zh) 2011-04-06
IL186139A0 (en) 2008-01-20
US20070087394A1 (en) 2007-04-19
JP2008536493A (ja) 2008-09-11
WO2006107854A2 (en) 2006-10-12
EP1869220A2 (en) 2007-12-26
KR20080014745A (ko) 2008-02-14
AU2006232378A1 (en) 2006-10-12
NO20074817L (no) 2007-12-28
EA200702143A1 (ru) 2008-06-30
WO2006107854A3 (en) 2007-01-11

Similar Documents

Publication Publication Date Title
CR9477A (es) Numero de copias del gen del receptor del factor de crecimiento epidermico
MX2009006779A (es) Antagonistas especificos para terapia con adyuvantes y neo-adyuvantes y el tratamiento de tumores en etapa temprana.
CR10147A (es) "ligandos que tienen especificidad de enlace para vegf y/o egfr y métodos de uso de los mismos"
CY1111622T1 (el) Ανθρωποποιημενοι ανταγωνιστες anti-cmet
WO2007092433A3 (en) Osteoporosis associated markers and methods of use thereof
SG170793A1 (en) Anti-mn antibodies and methods of using same
WO2006138729A3 (en) Receptor antagonists for treatment of metastatic bone cancer
TW200501960A (en) Synergistic kits and compositions for treating cancer
TW200612918A (en) Lonidamine analogs
NO20070052L (no) Fremgangsmate for behandling av multippel sklerose
MX2022009759A (es) El uso de 1-(4-ciano-3-trifluorometil-fenil)-3-[7-(4-ciano-3-trifl uorometil-fenil)-6-tioxo-5-p-tolilo-5,7-diazaespiro[3.4]oct-8-ili deno]-tiourea.
CY1119112T1 (el) K-ras μεταλλαξεις και θεραπεια anti-egfr αντισωματος
NO20082386L (no) Ligander som har bindingsspesifisitet for EGFR og/eller VEGF og fremgangsmater for anvendelse derav
IL179095A0 (en) Methods for treating cancer using anti-wnt2 monoclonal antibodies and sirna
IL244803A0 (en) Human anti-beta7 antibodies and their use
TWI372628B (en) Methods of modulating cytokine activity; related reagents
NZ593474A (en) Compositions and methods for treatment of celiac disease
PH12013500826A1 (en) Means and methods for treating dlbcl
ZA200606620B (en) Methods of modulating IL-23 activity ; related reagents
MX2008012754A (es) Composiciones de anticuerpos y metodos para tratamiento de enfermedad neoplastica.
ZA200709780B (en) Anti-EGFR antibody therapy based on an increased copy number of the EGFR gene in tumor tissues
MXPA04011550A (es) Tratamiento de carcinoma renal utilizando anticuerpos contra el receptor del factor de crecimiento epidermico.
BRPI0514721A (pt) uso de compostos de peptìdeos para tratar dor de cáncer ósseo, dor induzida por quimioterapia e nucleosìdeo
EA200970884A1 (ru) Способы лечения рака путем введения комбинаций человеческого интерлейкина ил-18
PH12022553333A1 (en) Markers for use in methods for treating cancers with antibody drug conjugates (adc)

Legal Events

Date Code Title Description
FA Abandonment or withdrawal (granting procedure)