CR9823A - AN ANTIGEN-SPECIFIC CA6 CYTOTOXIC CONJUGATE AND METHODS TO USE THE SAME - Google Patents
AN ANTIGEN-SPECIFIC CA6 CYTOTOXIC CONJUGATE AND METHODS TO USE THE SAMEInfo
- Publication number
- CR9823A CR9823A CR9823A CR9823A CR9823A CR 9823 A CR9823 A CR 9823A CR 9823 A CR9823 A CR 9823A CR 9823 A CR9823 A CR 9823A CR 9823 A CR9823 A CR 9823A
- Authority
- CR
- Costa Rica
- Prior art keywords
- methods
- cytotoxic
- antigen
- specific
- same
- Prior art date
Links
- 231100000433 cytotoxic Toxicity 0.000 title abstract 3
- 230000001472 cytotoxic effect Effects 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 239000011230 binding agent Substances 0.000 abstract 2
- 239000012634 fragment Substances 0.000 abstract 2
- 241001529936 Murinae Species 0.000 abstract 1
- 229940127089 cytotoxic agent Drugs 0.000 abstract 1
- 239000002254 cytotoxic agent Substances 0.000 abstract 1
- 231100000599 cytotoxic agent Toxicity 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000017095 negative regulation of cell growth Effects 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Landscapes
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Abstract
Se describen conjugados citotoxicos que comprenden un agente de enlace celular y un agente citotoxico, composiciones terapeuticas que comprenden el conjugado, metodos para usar los conjugados en la inhibicion del crecimiento celular y el tratamiento de la enfermedad, y un equipo que comprende el conjugado citotoxico en todas las modalidades de la invencion. En particular, el agente de enlace celular es un anticuerpo monoclonal, y fragmentos de enlace de epitope del mismo, que reconoce y enlaza el glicotopo CA6. La presente invencion tambien esta dirigida a versiones humanizadas o recubiertas de DS6, un anticuerpo monoclonal anti-CA6 murino, y fragmentos de enlace de epitope del mismo.Cytotoxic conjugates comprising a cell binding agent and a cytotoxic agent, therapeutic compositions comprising the conjugate, methods for using the conjugates in the inhibition of cell growth and the treatment of the disease, and a kit comprising the cytotoxic conjugate are described in all modalities of the invention. In particular, the cell binding agent is a monoclonal antibody, and epitope binding fragments thereof, which recognizes and binds the CA6 glyotope. The present invention is also directed to humanized or coated versions of DS6, a murine anti-CA6 monoclonal antibody, and epitope binding fragments thereof.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CR9823A CR9823A (en) | 2008-03-24 | 2008-03-24 | AN ANTIGEN-SPECIFIC CA6 CYTOTOXIC CONJUGATE AND METHODS TO USE THE SAME |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CR9823A CR9823A (en) | 2008-03-24 | 2008-03-24 | AN ANTIGEN-SPECIFIC CA6 CYTOTOXIC CONJUGATE AND METHODS TO USE THE SAME |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CR9823A true CR9823A (en) | 2008-07-24 |
Family
ID=44839418
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CR9823A CR9823A (en) | 2008-03-24 | 2008-03-24 | AN ANTIGEN-SPECIFIC CA6 CYTOTOXIC CONJUGATE AND METHODS TO USE THE SAME |
Country Status (1)
| Country | Link |
|---|---|
| CR (1) | CR9823A (en) |
-
2008
- 2008-03-24 CR CR9823A patent/CR9823A/en not_active Application Discontinuation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |