CR9941A - PHARMACEUTICAL TRAINING OF ORAL ABSORPTION AND ITS METHOD OF ADMINISTRATION - Google Patents
PHARMACEUTICAL TRAINING OF ORAL ABSORPTION AND ITS METHOD OF ADMINISTRATIONInfo
- Publication number
- CR9941A CR9941A CR9941A CR9941A CR9941A CR 9941 A CR9941 A CR 9941A CR 9941 A CR9941 A CR 9941A CR 9941 A CR9941 A CR 9941A CR 9941 A CR9941 A CR 9941A
- Authority
- CR
- Costa Rica
- Prior art keywords
- micelle
- pharmaceutical
- polyoxypropylene
- aerosol
- administration
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 238000010521 absorption reaction Methods 0.000 title 1
- -1 alkali metal alkyl sulfate Chemical class 0.000 abstract 4
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 4
- 102000004877 Insulin Human genes 0.000 abstract 2
- 108090001061 Insulin Proteins 0.000 abstract 2
- 239000000443 aerosol Substances 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 238000009472 formulation Methods 0.000 abstract 2
- 229940125396 insulin Drugs 0.000 abstract 2
- 239000000693 micelle Substances 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 229920001451 polypropylene glycol Polymers 0.000 abstract 2
- ZORQXIQZAOLNGE-UHFFFAOYSA-N 1,1-difluorocyclohexane Chemical compound FC1(F)CCCCC1 ZORQXIQZAOLNGE-UHFFFAOYSA-N 0.000 abstract 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 235000012054 meals Nutrition 0.000 abstract 1
- 210000002200 mouth mucosa Anatomy 0.000 abstract 1
- 239000008177 pharmaceutical agent Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 229940035049 sorbitan monooleate Drugs 0.000 abstract 1
- 235000011069 sorbitan monooleate Nutrition 0.000 abstract 1
- 239000001593 sorbitan monooleate Substances 0.000 abstract 1
Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Una formulacion farmaceutica para absorber por la mucosa oral que incluye una cantidad efectiva de (a) un agente farmaceutico en forma de micela combinada, (b) al menos un compuesto formador de micela seleccionado del grupo de sulfato alquilo de metal alcalino y monooleato de sorbitan polioxipropileno, (c) un compolimero bloque de polioxietileno y polioxipropileno, (d) al menos un compuesto formador de micela adicional y (e) un disolvente adecuado. La invencion proporciona ademas un dispensador de dosis graduado (aerosol y no aerosol) que contienene la presente formulacion y un metodo de adminsitracion de insulina con un dispensador de dosis graduado que incluye administrar dosis multiples de una formulacion que contiene insulina antes y despues de cada comida.A pharmaceutical formulation for absorbing by the oral mucosa that includes an effective amount of (a) a pharmaceutical agent in the form of a combined micelle, (b) at least one micelle forming compound selected from the group of alkali metal alkyl sulfate and sorbitan monooleate polyoxypropylene, (c) a block compolymer of polyoxyethylene and polyoxypropylene, (d) at least one additional micelle-forming compound and (e) a suitable solvent. The invention also provides a graduated dose dispenser (aerosol and non-aerosol) containing the present formulation and an insulin administration method with a graduated dose dispenser that includes administering multiple doses of an insulin-containing formulation before and after each meal. .
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CR9941A CR9941A (en) | 2008-04-28 | 2008-04-28 | PHARMACEUTICAL TRAINING OF ORAL ABSORPTION AND ITS METHOD OF ADMINISTRATION |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CR9941A CR9941A (en) | 2008-04-28 | 2008-04-28 | PHARMACEUTICAL TRAINING OF ORAL ABSORPTION AND ITS METHOD OF ADMINISTRATION |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CR9941A true CR9941A (en) | 2008-07-29 |
Family
ID=44839425
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CR9941A CR9941A (en) | 2008-04-28 | 2008-04-28 | PHARMACEUTICAL TRAINING OF ORAL ABSORPTION AND ITS METHOD OF ADMINISTRATION |
Country Status (1)
| Country | Link |
|---|---|
| CR (1) | CR9941A (en) |
-
2008
- 2008-04-28 CR CR9941A patent/CR9941A/en not_active Application Discontinuation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal (granting procedure) |