CS136191A3 - Pharmaceutical - Google Patents

Pharmaceutical Download PDF

Info

Publication number: CS136191A3
Authority: CS; Czechoslovakia
Prior art keywords: biologically active; derivatives; pharmaceutical composition; analogs; administration
Prior art date: 1990-05-10

Application number

CS911361A

Other languages

Czech (cs)

English (en)

Inventor

Erik Bechgaard

Sveinbjorn Gizurarson

Rolf Kuhlman Hjortkjaer

Original Assignee

Novo Nordisk As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-05-10

Filing date

1991-05-08

Publication date

1992-04-15

1990-05-10 Priority claimed from DK117090A external-priority patent/DK117090D0/da

1990-08-30 Priority claimed from DK207590A external-priority patent/DK207590D0/da

1991-05-08 Application filed by Novo Nordisk As filed Critical Novo Nordisk As

1992-04-15 Publication of CS136191A3 publication Critical patent/CS136191A3/cs

Links

239000008194 pharmaceutical composition Substances 0.000 claims abstract description 31
241000124008 Mammalia Species 0.000 claims abstract description 13
238000000034 method Methods 0.000 claims abstract description 7
239000000203 mixture Substances 0.000 claims description 110
239000013543 active substance Substances 0.000 claims description 40
DGBIGWXXNGSACT-UHFFFAOYSA-N clonazepam Chemical compound C12=CC([N+](=O)[O-])=CC=C2NC(=O)CN=C1C1=CC=CC=C1Cl DGBIGWXXNGSACT-UHFFFAOYSA-N 0.000 claims description 32
229960003120 clonazepam Drugs 0.000 claims description 31
-1 DADLE Chemical class 0.000 claims description 27
239000003795 chemical substances by application Substances 0.000 claims description 27
LYCAIKOWRPUZTN-UHFFFAOYSA-N ethylene glycol Substances OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 27
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims description 26
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AAOVKJBEBIDNHE-UHFFFAOYSA-N diazepam Chemical compound N=1CC(=O)N(C)C2=CC=C(Cl)C=C2C=1C1=CC=CC=C1 AAOVKJBEBIDNHE-UHFFFAOYSA-N 0.000 claims description 17
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DIWRORZWFLOCLC-HNNXBMFYSA-N (3s)-7-chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-1,4-benzodiazepin-2-one Chemical compound N([C@H](C(NC1=CC=C(Cl)C=C11)=O)O)=C1C1=CC=CC=C1Cl DIWRORZWFLOCLC-HNNXBMFYSA-N 0.000 claims description 9
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BBBFJLBPOGFECG-VJVYQDLKSA-N calcitonin Chemical compound N([C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(N)=O)C(C)C)C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1 BBBFJLBPOGFECG-VJVYQDLKSA-N 0.000 claims description 4
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QQJLHRRUATVHED-UHFFFAOYSA-N tramazoline Chemical compound N1CCN=C1NC1=CC=CC2=C1CCCC2 QQJLHRRUATVHED-UHFFFAOYSA-N 0.000 description 1
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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Oil, Petroleum & Natural Gas (AREA)
Bioinformatics & Cheminformatics (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Endocrinology (AREA)
Immunology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Otolaryngology (AREA)
Diabetes (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Saccharide Compounds (AREA)

CS911361A 1990-05-10 1991-05-08 Pharmaceutical CS136191A3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DK117090A DK117090D0 (da)	1990-05-10	1990-05-10	Composition for intranasal administration of biol ogically active benzodiazepine compounds
DK207590A DK207590D0 (da)	1990-08-30	1990-08-30	Farmaceutisk praeparat

Publications (1)

Publication Number	Publication Date
CS136191A3 true CS136191A3 (en)	1992-04-15

Family

ID=26065326

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CS911361A CS136191A3 (en)	1990-05-10	1991-05-08	Pharmaceutical

Country Status (14)

Country	Link
US (2)	US5428006A (de)
EP (1)	EP0532546B1 (de)
JP (1)	JP3219096B2 (de)
CN (1)	CN1056812A (de)
AT (1)	ATE164080T1 (de)
AU (3)	AU7880991A (de)
CS (1)	CS136191A3 (de)
DE (1)	DE69129110T2 (de)
DK (1)	DK0532546T3 (de)
ES (1)	ES2117642T3 (de)
IE (1)	IE911577A1 (de)
IL (1)	IL98089A0 (de)
PT (1)	PT97610A (de)
WO (1)	WO1991016929A1 (de)

Families Citing this family (152)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE164080T1 (de) *	1990-05-10	1998-04-15	Bechgaard Int Res	Pharmazeutische zubereitung enthaltend n- glykofurole und n-äthylenglykole
ATE202261T1 (de)	1991-12-19	2001-07-15	Univ Saskatchewan	Desikkation von gymnosperm somatischen embryonen
GB2267435A (en) *	1992-06-01	1993-12-08	British Tech Group	Factor VIII
ES2107051T3 (es) *	1992-09-21	1997-11-16	Upjohn Co	Formulaciones de proteinas de liberacion sostenida.
US5970973A (en) *	1993-01-29	1999-10-26	Aradigm Corporation	Method of delivering insulin lispro
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- 1991-05-08 PT PT97610A patent/PT97610A/pt not_active Application Discontinuation
- 1991-05-09 CN CN91103023.9A patent/CN1056812A/zh active Pending
- 1991-05-09 IE IE157791A patent/IE911577A1/en not_active IP Right Cessation
- 1991-05-09 AU AU76435/91A patent/AU654950B2/en not_active Ceased
- 1991-05-09 IL IL98089A patent/IL98089A0/xx unknown
1993
- 1993-11-15 US US08/151,802 patent/US5428006A/en not_active Expired - Lifetime
1995
- 1995-02-27 AU AU13586/95A patent/AU687496B2/en not_active Ceased
- 1995-02-28 US US08/395,838 patent/US5693608A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP0532546B1 (de)	1998-03-18
CN1056812A (zh)	1991-12-11
WO1991016929A1 (en)	1991-11-14
IE911577A1 (en)	1991-11-20
AU654950B2 (en)	1994-12-01
DE69129110T2 (de)	1998-12-10
JP3219096B2 (ja)	2001-10-15
JPH05507085A (ja)	1993-10-14
AU7880991A (en)	1991-11-27
AU7643591A (en)	1991-11-14
AU687496B2 (en)	1998-02-26
US5428006A (en)	1995-06-27
US5693608A (en)	1997-12-02
EP0532546A1 (de)	1993-03-24
DK0532546T3 (da)	1998-12-28
ES2117642T3 (es)	1998-08-16
DE69129110D1 (de)	1998-04-23
IL98089A0 (en)	1992-06-21
AU1358695A (en)	1995-06-01
PT97610A (pt)	1992-01-31
ATE164080T1 (de)	1998-04-15

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