CS167912B2 - - Google Patents
Info
- Publication number
- CS167912B2 CS167912B2 CS140674A CS140674A CS167912B2 CS 167912 B2 CS167912 B2 CS 167912B2 CS 140674 A CS140674 A CS 140674A CS 140674 A CS140674 A CS 140674A CS 167912 B2 CS167912 B2 CS 167912B2
- Authority
- CS
- Czechoslovakia
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
- C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB697870A GB1309692A (en) | 1970-02-13 | 1970-02-13 | N-substituted lactams |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CS167912B2 true CS167912B2 (en) | 1976-05-28 |
Family
ID=9824325
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CS987A CS167911B2 (en) | 1970-02-13 | 1971-02-10 | |
| CS140674A CS167912B2 (en) | 1970-02-13 | 1971-12-10 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CS987A CS167911B2 (en) | 1970-02-13 | 1971-02-10 |
Country Status (15)
| Country | Link |
|---|---|
| JP (2) | JPS535301B1 (en) |
| BE (1) | BE762728R (en) |
| CH (1) | CH530395A (en) |
| CS (2) | CS167911B2 (en) |
| DE (1) | DE2106418C2 (en) |
| DK (1) | DK137451B (en) |
| ES (1) | ES388135A2 (en) |
| FI (1) | FI54916C (en) |
| FR (1) | FR2081508B2 (en) |
| GB (1) | GB1309692A (en) |
| MY (1) | MY7400072A (en) |
| NL (1) | NL168830C (en) |
| SU (2) | SU508185A3 (en) |
| YU (2) | YU34876B (en) |
| ZA (1) | ZA71877B (en) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1045043B (en) * | 1975-08-13 | 1980-04-21 | Isf Spa | PYROLIDINE DERIVATIVES |
| GB1583871A (en) | 1976-10-19 | 1981-02-04 | Ucb Sa | Anti-aggregants |
| BE864269A (en) * | 1977-03-03 | 1978-06-16 | Parke Davis & Co | NEW N- (AMINOALKYL SUBSTITUTE) -2-OXO-1-PYRROLIDINE-ACETAMIDES AND METHODS FOR PRODUCING THEM |
| ATE27T1 (en) * | 1978-05-08 | 1981-04-15 | Ucb Sa | LACTAM-N-ACETIC ACIDS AND THEIR AMIDES, PROCESS FOR THEIR PREPARATION AND MEDICINES CONTAINING THEM |
| IT1141287B (en) * | 1979-06-13 | 1986-10-01 | Nattermann A & Cie | PYROLIDIN ACIDS AMIDS- (2) -ON- (1) -ILALKYL-CARBOXYLS, PROCEDURE FOR THEIR PREPARATION AND MEDICINAL PRODUCTS CONTAINING THEM |
| FR2515179A1 (en) * | 1981-07-24 | 1983-04-29 | Hoffmann La Roche | PYRROLIDINE DERIVATIVES, PROCESS FOR THEIR PREPARATION, INTERMEDIATES FOR THEIR SYNTHESIS AND THEIR THERAPEUTIC APPLICATION |
| EP0089900B1 (en) * | 1982-03-24 | 1985-12-27 | Prodes S.A. | New n-((2-oxo-1-pyrrolidinyl)acetyl)piperazines, the methods of producing such new compounds and their salts as well as pharmaceutical preparations for therapeutic use containing these compounds or salts |
| GB8412358D0 (en) * | 1984-05-15 | 1984-06-20 | Ucb Sa | Pharmaceutical composition |
| GB8412357D0 (en) * | 1984-05-15 | 1984-06-20 | Ucb Sa | Pharmaceutical composition |
| DE3420193A1 (en) * | 1984-05-30 | 1985-12-05 | Boehringer Ingelheim KG, 6507 Ingelheim | NEW SUBSTITUTED PYRROLIDINONES, METHOD FOR THEIR PRODUCTION AND MEDICINAL PRODUCTS |
| US4804400A (en) * | 1986-09-12 | 1989-02-14 | Ciba-Geigy Corporation | N-phenyl-maleimides and herbicidal and plant growth regulating methods of use thereof |
| GB8827389D0 (en) * | 1988-11-23 | 1988-12-29 | Ucb Sa | Process for preparation of(s)alpha-ethyl-2-oxo-1-pyrrolidineacetamide |
| AR020115A1 (en) * | 1998-08-06 | 2002-04-10 | Daiichi Seiyaku Co | THERAPEUTIC OR PREVENTIVE AGENT FOR REBEL EPILEPSIES AND USE OF THE COMPOUND FOR THE SAME PRODUCTION |
| GB0004297D0 (en) | 2000-02-23 | 2000-04-12 | Ucb Sa | 2-oxo-1 pyrrolidine derivatives process for preparing them and their uses |
| US6686477B2 (en) | 2000-09-29 | 2004-02-03 | Eastman Chemical Company | Highly enantiomerically pure lactam-substituted propanoic acid derivatives and methods of making and using same |
| EP1395560A1 (en) | 2001-05-23 | 2004-03-10 | Ucb, S.A. | 2-oxo-piperidinyl- and 2-oxo-azepanyl alkanoic acid derivativ es for the treatment of epilepsy and other neurological disorders |
| ES2314090T3 (en) | 2001-08-10 | 2009-03-16 | Ucb Pharma S.A. | OXOPIRROLIDINE COMPOUNDS, PREPARATION OF SUCH COMPOUNDS AND USE OF THE SAME IN THE MANUFACTURE OF LEVETIRACETAM AND ITS ANALOGS. |
| US20040242671A1 (en) * | 2001-10-08 | 2004-12-02 | Renee Grimee | Use of 2-oxo-1-pyrrolidine derivatives for the preparation of a drug |
| CN1802352A (en) | 2003-02-03 | 2006-07-12 | 特瓦制药工业有限公司 | Process for preparing levetiracetam |
| ES2214147B1 (en) | 2003-02-28 | 2005-10-01 | Farma-Lepori S.A. | PROCEDURE FOR OBTAINING AN ANTIEPILEPTIC AGENT. |
| US7531673B2 (en) | 2004-02-18 | 2009-05-12 | Dr. Reddy's Laboratories Limited | Preparation of amino acid amides |
| CA2488325C (en) | 2004-11-22 | 2010-08-24 | Apotex Pharmachem Inc. | Improved process for the preparation of (s)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide and (r)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide |
| WO2006095362A1 (en) * | 2005-03-10 | 2006-09-14 | Rubamin Limited | Process for preparing levetiracetam |
| JP2008542323A (en) | 2005-06-01 | 2008-11-27 | ユセベ ファルマ ソシエテ アノニム | 2-Oxo-1-pyrrolidine derivatives, process for producing the same and use thereof |
| EP2147911A1 (en) | 2008-07-24 | 2010-01-27 | ZaCh System S.p.A. | Process for the preparation of levetiracetam |
| EP3260118B1 (en) | 2008-10-16 | 2021-03-24 | The Johns Hopkins University | Methods and compositions for improving cognitive function |
| US8785661B2 (en) | 2009-05-13 | 2014-07-22 | Nektar Therapeutics | Oligome-containing pyrrolidine compounds |
| US7939676B2 (en) | 2009-09-17 | 2011-05-10 | Zach System S.P.A. | Process for the preparation of levetiracetam |
| US20110212928A1 (en) | 2010-02-09 | 2011-09-01 | The Johns Hopkins University | Methods and compositions for improving cognitive function |
| WO2014078568A1 (en) | 2012-11-14 | 2014-05-22 | The Johns Hopkins University | Methods and compositions for treating schizophrenia |
| WO2014144663A1 (en) | 2013-03-15 | 2014-09-18 | The Johns Hopkins University | Methods and compositions for improving cognitive function |
| EP2968220B1 (en) | 2013-03-15 | 2021-05-05 | Agenebio, Inc. | Methods and compositions for improving cognitive function |
| LT3431106T (en) | 2014-01-21 | 2021-02-10 | Janssen Pharmaceutica Nv | Combinations comprising positive allosteric modulators of metabotropic glutamatergic receptor subtype 2 and their use |
| KR102414246B1 (en) | 2014-01-21 | 2022-06-27 | 얀센 파마슈티카 엔.브이. | Combinations comprising positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic receptor subtype 2 and their use |
| CN104059010A (en) * | 2014-06-12 | 2014-09-24 | 浙江华海药业股份有限公司 | Preparation method of 2-(2-oxopyrrolidine-1-yl)-butyrate |
| CN106591179B (en) * | 2016-12-05 | 2018-07-03 | 长兴制药股份有限公司 | Methyl packing bacterium and its prepare the application on (S)-α-ethyl -2- oxygen -1- pyrrolidine acetic acid salt in selective fractionation |
| RU2663899C1 (en) * | 2017-07-19 | 2018-08-13 | Федеральное государственное унитарное предприятие "Государственный научный центр "Научно-исследовательский институт органических полупродуктов и красителей" | Process for the preparation of 1-carbamoylmethyl-4-phenyl-2-pyrrolidone |
| US12559456B2 (en) | 2021-02-03 | 2026-02-24 | Suzhou Brighthope Pharma Tech Co., Ltd | Method for preparing levetiracetam and intermediates thereof |
| US11384050B1 (en) | 2021-02-03 | 2022-07-12 | Vitaworks Ip, Llc | Method for preparing levetiracetam and intermediates thereof |
| CN113979911A (en) * | 2021-11-12 | 2022-01-28 | 汤斌 | Method for extracting etiracetam from giant salamander peptide |
| US20240132513A1 (en) | 2022-08-19 | 2024-04-25 | Agenebio, Inc. | Benzazepine derivatives, compositions, and methods for treating cognitive impairment |
| US12590059B2 (en) | 2023-03-28 | 2026-03-31 | Suzhou Brighthope Pharmatech Co., Ltd | Process for the production of levetiracetam |
| US12528770B2 (en) | 2023-06-12 | 2026-01-20 | Suzhou Brighthope Pharmatech Co., Ltd. | Process for the production of levetiracetam and intermediates thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1039113A (en) * | 1964-08-06 | 1966-08-17 | Ucb Sa | New n-substituted lactams |
-
1970
- 1970-02-13 GB GB697870A patent/GB1309692A/en not_active Expired
-
1971
- 1971-02-08 FR FR7104195A patent/FR2081508B2/fr not_active Expired
- 1971-02-09 NL NLAANVRAGE7101697,A patent/NL168830C/en not_active IP Right Cessation
- 1971-02-10 BE BE762728A patent/BE762728R/en active
- 1971-02-10 YU YU306/71A patent/YU34876B/en unknown
- 1971-02-10 DK DK59571AA patent/DK137451B/en not_active IP Right Cessation
- 1971-02-10 ES ES388135A patent/ES388135A2/en not_active Expired
- 1971-02-10 FI FI383/71A patent/FI54916C/en active
- 1971-02-10 CS CS987A patent/CS167911B2/cs unknown
- 1971-02-11 ZA ZA710877A patent/ZA71877B/en unknown
- 1971-02-11 CH CH200171A patent/CH530395A/en not_active IP Right Cessation
- 1971-02-11 DE DE2106418A patent/DE2106418C2/en not_active Expired
- 1971-02-12 SU SU1621307A patent/SU508185A3/en active
- 1971-02-12 JP JP612471A patent/JPS535301B1/ja active Pending
- 1971-02-12 SU SU1893858A patent/SU508186A3/en active
- 1971-12-10 CS CS140674A patent/CS167912B2/cs unknown
-
1974
- 1974-12-31 MY MY197472A patent/MY7400072A/en unknown
-
1977
- 1977-11-07 JP JP13335277A patent/JPS53130656A/en active Granted
-
1978
- 1978-06-19 YU YU01445/78A patent/YU144578A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| YU34876B (en) | 1980-04-30 |
| DE2106418C2 (en) | 1983-12-22 |
| FR2081508B2 (en) | 1975-06-06 |
| DK137451C (en) | 1978-07-24 |
| YU144578A (en) | 1982-10-31 |
| ES388135A2 (en) | 1973-05-01 |
| FI54916B (en) | 1978-12-29 |
| CH530395A (en) | 1972-11-15 |
| GB1309692A (en) | 1973-03-14 |
| JPS535301B1 (en) | 1978-02-25 |
| NL168830C (en) | 1982-05-17 |
| NL7101697A (en) | 1971-08-17 |
| JPS53130656A (en) | 1978-11-14 |
| MY7400072A (en) | 1974-12-31 |
| BE762728R (en) | 1971-08-10 |
| ZA71877B (en) | 1971-10-27 |
| SU508186A3 (en) | 1976-03-25 |
| CS167911B2 (en) | 1976-05-28 |
| JPS5420491B2 (en) | 1979-07-23 |
| DE2106418A1 (en) | 1971-08-19 |
| SU508185A3 (en) | 1976-03-25 |
| DK137451B (en) | 1978-03-06 |
| FR2081508A2 (en) | 1971-12-03 |
| YU30671A (en) | 1979-10-31 |
| NL168830B (en) | 1981-12-16 |
| FI54916C (en) | 1979-04-10 |