CS194191A3 - Process for preparing substituted acyclic nucleosides and intermediates obtained in the process - Google Patents

Process for preparing substituted acyclic nucleosides and intermediates obtained in the process

Info

Publication number
CS194191A3
CS194191A3 CS911941A CS194191A CS194191A3 CS 194191 A3 CS194191 A3 CS 194191A3 CS 911941 A CS911941 A CS 911941A CS 194191 A CS194191 A CS 194191A CS 194191 A3 CS194191 A3 CS 194191A3
Authority
CS
Czechoslovakia
Prior art keywords
preparing substituted
intermediates obtained
substituted acyclic
acyclic nucleosides
nucleosides
Prior art date
Application number
CS911941A
Other languages
English (en)
Inventor
Gerhard Dr Jahne
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of CS194191A3 publication Critical patent/CS194191A3/cs

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D473/00Heterocyclic compounds containing purine ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/10Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C323/11Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/12Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00Ethers; Compounds having groups, groups or groups
    • C07C43/30Compounds having groups
    • C07C43/315Compounds having groups containing oxygen atoms singly bound to carbon atoms not being acetal carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D473/00Heterocyclic compounds containing purine ring systems
    • C07D473/40Heterocyclic compounds containing purine ring systems with halogen atoms or perhalogeno-alkyl radicals directly attached in position 2 or 6
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/30Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
    • C07F9/32Esters thereof
    • C07F9/3258Esters thereof the ester moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/3264Esters with hydroxyalkyl compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/38Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40Esters thereof
    • C07F9/4003Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006Esters of acyclic acids which can have further substituents on alkyl

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
CS911941A 1990-06-27 1991-06-25 Process for preparing substituted acyclic nucleosides and intermediates obtained in the process CS194191A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4020481A DE4020481A1 (de) 1990-06-27 1990-06-27 Verfahren zur herstellung von substituierten acyclischen nukleosiden und dabei auftretende zwischenprodukte

Publications (1)

Publication Number Publication Date
CS194191A3 true CS194191A3 (en) 1992-03-18

Family

ID=6409198

Family Applications (1)

Application Number Title Priority Date Filing Date
CS911941A CS194191A3 (en) 1990-06-27 1991-06-25 Process for preparing substituted acyclic nucleosides and intermediates obtained in the process

Country Status (17)

Country Link
US (1) US5225550A (cs)
EP (1) EP0464511A3 (cs)
JP (1) JP3156235B2 (cs)
KR (1) KR920000782A (cs)
CN (1) CN1057652A (cs)
AU (1) AU642504B2 (cs)
CA (1) CA2045730A1 (cs)
CS (1) CS194191A3 (cs)
DE (1) DE4020481A1 (cs)
FI (1) FI913102A7 (cs)
HU (1) HU209307B (cs)
IE (1) IE912235A1 (cs)
IL (1) IL98619A0 (cs)
NO (1) NO912509L (cs)
NZ (1) NZ238686A (cs)
PT (1) PT98095A (cs)
ZA (1) ZA914922B (cs)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE59310344D1 (de) * 1992-09-24 2003-07-24 Hoechst Ag N1-Substituierte 1H-1,2,3-Triazolo[4,5-d]pyrimidine, Verfahren zu ihrer Herstellung sowie ihre Verwendung als antivirale Mittel
US5631202A (en) * 1993-09-24 1997-05-20 Montell Technology Company B.V. Stereospecific metallocene catalysts with stereolocking α-CP substituents
US6160072A (en) * 1997-05-02 2000-12-12 Ewen; John A. Process for polymerizing tactioselective polyolefins in condensed phase using titanocenes

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4347360A (en) * 1980-09-16 1982-08-31 Ens Bio Logicals Inc. Ring open nucleoside analogues
AU569462B2 (en) * 1981-08-11 1988-02-04 Wellcome Foundation Limited, The Antiviral purine derivatives
US4816447A (en) * 1981-08-26 1989-03-28 Merck & Co., Inc. Anti-viral guanine compounds
US4803271A (en) * 1982-02-01 1989-02-07 Syntex (U.S.A.) Inc. Process for preparing guanine derivatives
US5059604A (en) * 1982-10-14 1991-10-22 Burroughs Wellcome Co. 2-amino purine derivatives
ES8403904A1 (es) * 1983-02-25 1984-04-01 Ind Farma Especial Un procedimiento para la preparacion de acicloguanosina.
US4897479A (en) * 1983-09-30 1990-01-30 Merck & Co., Inc. Arylsulfonyloxy purine intermediates
US4621140A (en) * 1984-02-23 1986-11-04 Syntex (U.S.A.) Inc. Process for preparing 2,6-substituted-9-(1,3-dihydroxy-2-propoxymethyl)-purines and certain derivatives
US4801710A (en) * 1984-10-26 1989-01-31 Merck & Co., Inc. Regioselective synthesis of 9-substituted purine acyclonucleoside derivatives
US4826981A (en) * 1984-12-22 1989-05-02 Krka Process for preparing 9-(2-hydroxyethoxymethyl)-guanine
DE3627024A1 (de) * 1985-09-24 1987-04-02 Hoechst Ag In 6- und 9-stellung substituierte 2-aminopurine, ihre verwendung, diese purine enthaltende arzneimittel und verfahren zur herstellung der purine
US4931575A (en) * 1987-03-13 1990-06-05 The Board Of Governors For Higher Education, State Of Rhode Island And Providence Plantations Chiral glycerol derivatives
US4965270A (en) * 1987-05-30 1990-10-23 Beecham Group P.L.C. Purine derivatives
GB8817607D0 (en) * 1988-07-23 1988-09-01 Beecham Group Plc Novel process
AU618436B2 (en) * 1988-12-19 1991-12-19 Wellcome Foundation Limited, The Antiviral cytosine and guanine derivatives
DE4009327A1 (de) * 1990-03-23 1991-09-26 Metallgesellschaft Ag Verfahren zur herstellung von katalysatoren und traenkloesungen

Also Published As

Publication number Publication date
KR920000782A (ko) 1992-01-29
JP3156235B2 (ja) 2001-04-16
HU912157D0 (en) 1991-12-30
ZA914922B (en) 1992-03-25
NZ238686A (en) 1993-10-26
US5225550A (en) 1993-07-06
AU7929791A (en) 1992-01-02
CN1057652A (zh) 1992-01-08
IE912235A1 (en) 1992-01-01
HUT61023A (en) 1992-11-30
AU642504B2 (en) 1993-10-21
FI913102A7 (fi) 1991-12-28
FI913102A0 (fi) 1991-06-25
NO912509L (no) 1991-12-30
JPH04356487A (ja) 1992-12-10
NO912509D0 (no) 1991-06-26
PT98095A (pt) 1992-06-30
DE4020481A1 (de) 1992-01-02
CA2045730A1 (en) 1991-12-28
EP0464511A2 (de) 1992-01-08
HU209307B (en) 1994-04-28
EP0464511A3 (en) 1992-07-15
IL98619A0 (en) 1992-07-15

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