CS202097B2 - Způsob přípravy analogů somatostatinu - Google Patents

Způsob přípravy analogů somatostatinu Download PDF

Info

Publication number: CS202097B2
Authority: CS; Czechoslovakia
Prior art keywords: phe; lys; thr; trp; cys
Prior art date: 1977-04-21

Application number

CS782581A

Other languages

Czech (cs)

English (en)

Inventor

James E Shields

Isung-Min Lin

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1977-04-21

Filing date

1978-04-21

Publication date

1980-12-31

1978-04-21 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

1980-12-31 Publication of CS202097B2 publication Critical patent/CS202097B2/cs

Links

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JCCNYMKQOSZNPW-UHFFFAOYSA-N loratadine Chemical compound C1CN(C(=O)OCC)CCC1=C1C2=NC=CC=C2CCC2=CC(Cl)=CC=C21 JCCNYMKQOSZNPW-UHFFFAOYSA-N 0.000 description 1
ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 description 1
239000001095 magnesium carbonate Substances 0.000 description 1
229910000021 magnesium carbonate Inorganic materials 0.000 description 1
235000019359 magnesium stearate Nutrition 0.000 description 1
239000000594 mannitol Substances 0.000 description 1
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238000004519 manufacturing process Methods 0.000 description 1
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125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
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PSZYNBSKGUBXEH-UHFFFAOYSA-N naphthalene-1-sulfonic acid Chemical compound C1=CC=C2C(S(=O)(=O)O)=CC=CC2=C1 PSZYNBSKGUBXEH-UHFFFAOYSA-N 0.000 description 1
230000003472 neutralizing effect Effects 0.000 description 1
150000007524 organic acids Chemical class 0.000 description 1
230000001590 oxidative effect Effects 0.000 description 1
125000006503 p-nitrobenzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1[N+]([O-])=O)C([H])([H])* 0.000 description 1
238000010647 peptide synthesis reaction Methods 0.000 description 1
AHWALFGBDFAJAI-UHFFFAOYSA-N phenyl carbonochloridate Chemical compound ClC(=O)OC1=CC=CC=C1 AHWALFGBDFAJAI-UHFFFAOYSA-N 0.000 description 1
COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 description 1
NMHMNPHRMNGLLB-UHFFFAOYSA-N phloretic acid Chemical compound OC(=O)CCC1=CC=C(O)C=C1 NMHMNPHRMNGLLB-UHFFFAOYSA-N 0.000 description 1
239000008363 phosphate buffer Substances 0.000 description 1
230000001766 physiological effect Effects 0.000 description 1
229920001184 polypeptide Polymers 0.000 description 1
229920002223 polystyrene Polymers 0.000 description 1
235000015497 potassium bicarbonate Nutrition 0.000 description 1
229910000028 potassium bicarbonate Inorganic materials 0.000 description 1
239000011736 potassium bicarbonate Substances 0.000 description 1
TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
102000004196 processed proteins & peptides Human genes 0.000 description 1
125000001501 propionyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 description 1
238000000746 purification Methods 0.000 description 1
239000012264 purified product Substances 0.000 description 1
210000001187 pylorus Anatomy 0.000 description 1
UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
238000002601 radiography Methods 0.000 description 1
239000000376 reactant Substances 0.000 description 1
230000001172 regenerating effect Effects 0.000 description 1
230000002040 relaxant effect Effects 0.000 description 1
239000012266 salt solution Substances 0.000 description 1
239000002002 slurry Substances 0.000 description 1
210000002460 smooth muscle Anatomy 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
238000010532 solid phase synthesis reaction Methods 0.000 description 1
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150000003460 sulfonic acids Chemical class 0.000 description 1
239000000725 suspension Substances 0.000 description 1
150000003512 tertiary amines Chemical class 0.000 description 1
150000003573 thiols Chemical group 0.000 description 1
JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
125000000430 tryptophan group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12 0.000 description 1
231100000397 ulcer Toxicity 0.000 description 1
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239000004474 valine Substances 0.000 description 1
238000005303 weighing Methods 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
- C07K14/6555—Somatostatins at least 1 amino acid in D-form
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Biophysics (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Biochemistry (AREA)
Toxicology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Endocrinology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)

CS782581A 1977-04-21 1978-04-21 Způsob přípravy analogů somatostatinu CS202097B2 (cs)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US78947377A	1977-04-21	1977-04-21

Publications (1)

Publication Number	Publication Date
CS202097B2 true CS202097B2 (cs)	1980-12-31

Family

ID=25147751

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CS782581A CS202097B2 (cs)	1977-04-21	1978-04-21	Způsob přípravy analogů somatostatinu

Country Status (5)

Country	Link
BE (1)	BE866166A (fr)
CS (1)	CS202097B2 (fr)
PH (1)	PH16886A (fr)
PL (1)	PL206279A1 (fr)
ZA (1)	ZA782246B (fr)

1978
- 1978-04-19 PH PH21028A patent/PH16886A/en unknown
- 1978-04-19 ZA ZA00782246A patent/ZA782246B/xx unknown
- 1978-04-20 BE BE1008849A patent/BE866166A/fr not_active IP Right Cessation
- 1978-04-21 PL PL20627978A patent/PL206279A1/xx unknown
- 1978-04-21 CS CS782581A patent/CS202097B2/cs unknown

Also Published As

Publication number	Publication date
BE866166A (fr)	1978-10-20
PH16886A (en)	1984-04-02
ZA782246B (en)	1979-12-27
PL206279A1 (pl)	1979-06-04

Publication	Publication Date	Title
US4093574A (en)	1978-06-06	Somatostatin analogs and intermediates thereto
FI64576C (fi)	1983-12-12	Foerfarande foer framstaellning av en terapeutiskt anvaendbar somatostatinanalog
US4087390A (en)	1978-05-02	Somatostatin analogs and intermediates thereto
CA1148146A (fr)	1983-06-14	Cyclopeptides et preparations pharmaceutiques les contenant et aussi procede de preparation
US4316890A (en)	1982-02-23	Peptides and processes for the manufacture thereof
KR20130127985A (ko)	2013-11-25	글루코스-의존 인슐린 친화성 펩티드 유사체
US4490364A (en)	1984-12-25	CCK Agonists II
NO803757L (no)	1981-06-15	Nye acylpeptider og farmasoeytiske preparater herav, samt deres fremstilling og anvendelse
IE44532B1 (en)	1981-12-30	Somatostatin analogues
EP0226217B1 (fr)	1994-01-26	Peptides ayant des groupes ester-sulfate
PT87537B (pt)	1992-09-30	Processo para preparacao de peptidos ciclicos anticoagulantes
EP0283956B1 (fr)	1992-11-11	Peptides atriaux natriurétiques contenant du fluor
EP0417217A1 (fr)	1991-03-20	Peptides a groupes d'ester de sulfate
GB1574492A (en)	1980-09-10	D-ala2,d-lys4-somatostatin
CS202097B2 (cs)	1980-12-31	Způsob přípravy analogů somatostatinu
EP0021585A1 (fr)	1981-01-07	Analogues tronqués de la somatostatine et leurs intermédiaires, procédés pour les préparer et compositions pharmaceutiques contenant les analogues
US4061607A (en)	1977-12-06	Somatostatin analogs and intermediates thereto
IE910648A1 (en)	1991-08-28	"Vasoactive vasotocin derivatives"
US4076659A (en)	1978-02-28	L-Val10 -somatostatin and intermediates thereto
KR810000692B1 (ko)	1981-06-22	소마토스타틴(Somatostatin) 동족체의 제조방법
FI64575C (fi)	1983-12-12	Foerfarande foer framstaellning av en terapeutiskt anvaendbar somatostatinanalog
US4202802A (en)	1980-05-13	Peptides related to somatostatin
KR850000151B1 (ko)	1985-02-28	소마토스타틴 동족체의 제조방법
US5502164A (en)	1996-03-26	Peptide compounds having therapeutic activity
GB1577414A (en)	1980-10-22	Somatostatin analogues