CS209518B2 - Způsob výroby nových derivátů benzimidazolu - Google Patents

Způsob výroby nových derivátů benzimidazolu Download PDF

Info

Publication number: CS209518B2
Authority: CS; Czechoslovakia
Prior art keywords: formula; weight; parts; halogen; compound
Prior art date: 1977-04-12

Application number

CS782367A

Other languages

Czech (cs)

English (en)

Inventor

Ernst Aufderhaar

Jean J Gallay

Manfred Kuehne

Alfred Meyer

Oswald Rechsteiner

Max Schellenbaum

Jean-Paul Fumeux

Original Assignee

Ciba Geigy Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1977-04-12

Filing date

1978-04-11

Publication date

1981-12-31

1978-04-11 Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag

1980-06-04 Priority to CS803943A priority Critical patent/CS209519B2/cs

1980-06-04 Priority to CS803944A priority patent/CS209520B2/cs

1981-12-31 Publication of CS209518B2 publication Critical patent/CS209518B2/cs

Links

238000004519 manufacturing process Methods 0.000 title description 2
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150000001875 compounds Chemical class 0.000 claims description 29
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-1 methylthio, methylsulfonyl Chemical group 0.000 claims description 10
239000000203 mixture Substances 0.000 claims description 10
229910052736 halogen Chemical group 0.000 claims description 9
150000002367 halogens Chemical group 0.000 claims description 9
238000000034 method Methods 0.000 claims description 8
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235000013379 molasses Nutrition 0.000 description 1
239000005645 nematicide Substances 0.000 description 1
239000003921 oil Substances 0.000 description 1
235000019198 oils Nutrition 0.000 description 1
210000000056 organ Anatomy 0.000 description 1
229960004454 oxfendazole Drugs 0.000 description 1
BEZZFPOZAYTVHN-UHFFFAOYSA-N oxfendazole Chemical compound C=1C=C2NC(NC(=O)OC)=NC2=CC=1S(=O)C1=CC=CC=C1 BEZZFPOZAYTVHN-UHFFFAOYSA-N 0.000 description 1
125000004430 oxygen atom Chemical group O* 0.000 description 1
229950007337 parbendazole Drugs 0.000 description 1
239000006072 paste Substances 0.000 description 1
239000000575 pesticide Substances 0.000 description 1
229950000688 phenothiazine Drugs 0.000 description 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
230000000704 physical effect Effects 0.000 description 1
230000002035 prolonged effect Effects 0.000 description 1
QZWHWHNCPFEXLL-UHFFFAOYSA-N propan-2-yl n-[2-(1,3-thiazol-4-yl)-3h-benzimidazol-5-yl]carbamate Chemical compound N1C2=CC(NC(=O)OC(C)C)=CC=C2N=C1C1=CSC=N1 QZWHWHNCPFEXLL-UHFFFAOYSA-N 0.000 description 1
102000004169 proteins and genes Human genes 0.000 description 1
108090000623 proteins and genes Proteins 0.000 description 1
229960005134 pyrantel Drugs 0.000 description 1
YSAUAVHXTIETRK-AATRIKPKSA-N pyrantel Chemical compound CN1CCCN=C1\C=C\C1=CC=CS1 YSAUAVHXTIETRK-AATRIKPKSA-N 0.000 description 1
UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
238000010992 reflux Methods 0.000 description 1
150000003839 salts Chemical class 0.000 description 1
238000003307 slaughter Methods 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
239000002904 solvent Substances 0.000 description 1
241000894007 species Species 0.000 description 1
238000003756 stirring Methods 0.000 description 1
238000010254 subcutaneous injection Methods 0.000 description 1
239000007929 subcutaneous injection Substances 0.000 description 1
125000001424 substituent group Chemical group 0.000 description 1
239000003826 tablet Substances 0.000 description 1
239000000454 talc Substances 0.000 description 1
229910052623 talc Inorganic materials 0.000 description 1
235000012222 talc Nutrition 0.000 description 1
238000012360 testing method Methods 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
229960004546 thiabendazole Drugs 0.000 description 1
WJCNZQLZVWNLKY-UHFFFAOYSA-N thiabendazole Chemical compound S1C=NC(C=2NC3=CC=CC=C3N=2)=C1 WJCNZQLZVWNLKY-UHFFFAOYSA-N 0.000 description 1
235000010296 thiabendazole Nutrition 0.000 description 1
239000004308 thiabendazole Substances 0.000 description 1
230000001988 toxicity Effects 0.000 description 1
231100000419 toxicity Toxicity 0.000 description 1
230000002110 toxicologic effect Effects 0.000 description 1
231100000723 toxicological property Toxicity 0.000 description 1
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
239000011782 vitamin Substances 0.000 description 1
229940088594 vitamin Drugs 0.000 description 1
229930003231 vitamin Natural products 0.000 description 1
235000013343 vitamin Nutrition 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/28—Sulfur atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Tropical Medicine & Parasitology (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

CS782367A 1977-04-12 1978-04-11 Způsob výroby nových derivátů benzimidazolu CS209518B2 (cs)

Priority Applications (2)

Application Number	Priority Date	Filing Date	Title
CS803943A CS209519B2 (cs)	1977-04-12	1980-06-04	Způsob výroby nových derivátů benzimidazolu
CS803944A CS209520B2 (cs)	1977-04-12	1980-06-04	Způsob výroby nových derivátů benzimidazolu

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
LU77122A LU77122A1 (de)	1977-04-12	1977-04-12

Publications (1)

Publication Number	Publication Date
CS209518B2 true CS209518B2 (cs)	1981-12-31

Family

ID=19728529

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CS782367A CS209518B2 (cs)	1977-04-12	1978-04-11	Způsob výroby nových derivátů benzimidazolu

Country Status (3)

Country	Link
CS (1)	CS209518B2 (de)
LU (1)	LU77122A1 (de)
SU (3)	SU944503A3 (de)

1977
- 1977-04-12 LU LU77122A patent/LU77122A1/xx unknown
1978
- 1978-04-11 CS CS782367A patent/CS209518B2/cs unknown
- 1978-04-11 SU SU782601449A patent/SU944503A3/ru active
1980
- 1980-03-26 SU SU802897053A patent/SU915801A3/ru active
- 1980-03-26 SU SU802896950A patent/SU904520A3/ru active

Also Published As

Publication number	Publication date
SU944503A3 (ru)	1982-07-15
LU77122A1 (de)	1979-01-18
SU915801A3 (en)	1982-03-23
SU904520A3 (ru)	1982-02-07

Publication	Publication Date	Title
US4197307A (en)	1980-04-08	2-Alkylthio-, 2-alkylsulphinyl- and 2-alkylsulfonyl-6-phenylbenzimidazoles as anthelmintic agents
US3743738A (en)	1973-07-03	Substituted benzimidazoles as anthelmintic agents
US4512998A (en)	1985-04-23	Anthelmintic benzimidazole carbamates
PL85278B1 (de)	1976-04-30
EP0015124A1 (de)	1980-09-03	Parasitizide heterocyclische Ätherderivate, Verfahren zu ihrer Herstellung und ihre Zusammensetzungen
US3336191A (en)	1967-08-15	Anthelmintic 2-amidobenzimidazoles
DE69712608T2 (de)	2002-08-29	Protonenpumpinhibitoren
US4205077A (en)	1980-05-27	Benzimidazole sulphides as anthelmintic agents
EP0192180A1 (de)	1986-08-27	5-(Azolyloxyphenylcarbamoyl)barbitursäure-derivate als Wirkstoffe für Anthelmintika
US3759938A (en)	1973-09-18	Thiazolidine derivatives
US3686110A (en)	1972-08-22	1-oxybenzimidazoles
US4086336A (en)	1978-04-25	Phosphonothioureide anthelmintics
PL101396B1 (pl)	1978-12-30	Sposob wytwarzania estrow fenylowych kwasu 2-karboalkoksyaminobenzimidazolilo-5 /6/-sulfonowego
CS209518B2 (cs)	1981-12-31	Způsob výroby nových derivátů benzimidazolu
US3987181A (en)	1976-10-19	Certain 2-trifluoromethylbenzimidazoles as anthelmintics
US3705174A (en)	1972-12-05	Polyhaloalkyl benzimidazoles
CS209520B2 (cs)	1981-12-31	Způsob výroby nových derivátů benzimidazolu
CS197255B2 (en)	1980-04-30	Method of producing basicly substituted 2-alkoxycarbonyl-amino-benzimidazol-5/6/-ylphenyl esters and ketones
US3538108A (en)	1970-11-03	Water - soluble 2 - substituted benzimidazole methanesulfonic acid salts
US3984549A (en)	1976-10-05	Substituted pyrido-triazines as anthelmintics
US4062952A (en)	1977-12-13	Substituted benzenedisulfonamides as anthelmintics
US4303666A (en)	1981-12-01	5-Phenylseleno-2-benzimidazole carbamates
CA1085297A (en)	1980-09-09	Anthelmintic therapy
SI7810857A8 (sl)	1994-12-31	Postopek za pripravo novih benzimidazolovih derivatov
US4093731A (en)	1978-06-06	Methyl-6-n-propoxybenzothiazole-2-carbamate and anthelmintic pharmaceutical compositions thereof