CS216226B2 - Method of making the forms of hydrochloride 2-+l 4-+l2-furoyl+p-piperazin-1-yl+p-4-amino-6,7-dimethoxychinazoline - Google Patents

Method of making the forms of hydrochloride 2-+l 4-+l2-furoyl+p-piperazin-1-yl+p-4-amino-6,7-dimethoxychinazoline Download PDF

Info

Publication number: CS216226B2
Authority: CS; Czechoslovakia
Prior art keywords: hydrochloride; furoyl; amino; piperazin; water
Prior art date: 1980-02-26

Application number

CS811167A

Other languages

Czech (cs)

English (en)

Inventor

Pekka J Kairisalo

Heinrich Thaler

Erkki J Honkanen

Original Assignee

Orion Yhtymae Oy

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1980-02-26

Filing date

1981-02-18

Publication date

1982-10-29

1981-02-18 Application filed by Orion Yhtymae Oy filed Critical Orion Yhtymae Oy

1982-10-29 Publication of CS216226B2 publication Critical patent/CS216226B2/cs

Links

238000004519 manufacturing process Methods 0.000 title claims description 3
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 title 1
YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims description 21
WFXFYZULCQKPIP-UHFFFAOYSA-N prazosin hydrochloride Chemical compound [H+].[Cl-].N=1C(N)=C2C=C(OC)C(OC)=CC2=NC=1N(CC1)CCN1C(=O)C1=CC=CO1 WFXFYZULCQKPIP-UHFFFAOYSA-N 0.000 claims description 14
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 11
238000000034 method Methods 0.000 claims description 7
239000013078 crystal Substances 0.000 claims description 3
238000009835 boiling Methods 0.000 claims description 2
-1 2-furoyl Chemical group 0.000 claims 2
239000007858 starting material Substances 0.000 claims 1
229960002386 prazosin hydrochloride Drugs 0.000 description 11
229960001289 prazosin Drugs 0.000 description 3
IENZQIKPVFGBNW-UHFFFAOYSA-N prazosin Chemical compound N=1C(N)=C2C=C(OC)C(OC)=CC2=NC=1N(CC1)CCN1C(=O)C1=CC=CO1 IENZQIKPVFGBNW-UHFFFAOYSA-N 0.000 description 3
238000010533 azeotropic distillation Methods 0.000 description 2
239000012535 impurity Substances 0.000 description 2
239000002904 solvent Substances 0.000 description 2
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
230000036772 blood pressure Effects 0.000 description 1
229910052799 carbon Inorganic materials 0.000 description 1
125000004432 carbon atom Chemical group C* 0.000 description 1
238000006243 chemical reaction Methods 0.000 description 1
238000000354 decomposition reaction Methods 0.000 description 1
229940079593 drug Drugs 0.000 description 1
239000003814 drug Substances 0.000 description 1
230000002349 favourable effect Effects 0.000 description 1
238000002329 infrared spectrum Methods 0.000 description 1
239000000203 mixture Substances 0.000 description 1
239000003960 organic solvent Substances 0.000 description 1
238000002360 preparation method Methods 0.000 description 1
238000001228 spectrum Methods 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

CS811167A 1980-02-26 1981-02-18 Method of making the forms of hydrochloride 2-+l 4-+l2-furoyl+p-piperazin-1-yl+p-4-amino-6,7-dimethoxychinazoline CS216226B2 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FI800556A FI64367C (fi)	1980-02-26	1980-02-26	Foerfarande foer framstaellning av alfa-form av prazosinhydroklorid

Publications (1)

Publication Number	Publication Date
CS216226B2 true CS216226B2 (en)	1982-10-29

Family

ID=8513276

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CS811167A CS216226B2 (en)	1980-02-26	1981-02-18	Method of making the forms of hydrochloride 2-+l 4-+l2-furoyl+p-piperazin-1-yl+p-4-amino-6,7-dimethoxychinazoline

Country Status (11)

Country	Link
CS (1)	CS216226B2 (de)
DD (1)	DD156532A5 (de)
DK (1)	DK157548C (de)
ES (1)	ES499796A0 (de)
FI (1)	FI64367C (de)
HU (1)	HU182297B (de)
NO (1)	NO154461C (de)
PL (1)	PL128350B1 (de)
PT (1)	PT72511B (de)
SE (1)	SE431873B (de)
SU (1)	SU980621A3 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FI79107C (fi) *	1984-06-25	1989-11-10	Orion Yhtymae Oy	Foerfarande foer framstaellning av stabil -form av prazosinhydroklorid.
DE69630799T2 (de) *	1995-09-06	2004-08-12	Kowa Co., Ltd., Nagoya	Pyrimidinderivate

1980
- 1980-02-26 FI FI800556A patent/FI64367C/fi not_active IP Right Cessation
1981
- 1981-02-16 PT PT72511A patent/PT72511B/pt not_active IP Right Cessation
- 1981-02-18 CS CS811167A patent/CS216226B2/cs unknown
- 1981-02-20 NO NO810590A patent/NO154461C/no unknown
- 1981-02-23 DD DD81227817A patent/DD156532A5/de not_active IP Right Cessation
- 1981-02-25 PL PL1981229865A patent/PL128350B1/pl unknown
- 1981-02-25 ES ES499796A patent/ES499796A0/es active Granted
- 1981-02-25 HU HU81460A patent/HU182297B/hu not_active IP Right Cessation
- 1981-02-25 DK DK084581A patent/DK157548C/da not_active IP Right Cessation
- 1981-02-25 SU SU813247560A patent/SU980621A3/ru active
- 1981-02-26 SE SE8101265A patent/SE431873B/sv not_active IP Right Cessation

Also Published As

Publication number	Publication date
FI64367B (fi)	1983-07-29
HU182297B (en)	1983-12-28
DD156532A5 (de)	1982-09-01
ES8201577A1 (es)	1981-12-16
SE431873B (sv)	1984-03-05
NO154461C (no)	1986-09-24
PL128350B1 (en)	1984-01-31
PL229865A1 (de)	1981-10-30
PT72511B (en)	1983-02-01
SU980621A3 (ru)	1982-12-07
ES499796A0 (es)	1981-12-16
DK84581A (da)	1981-08-27
DK157548C (da)	1990-06-11
DK157548B (da)	1990-01-22
NO154461B (no)	1986-06-16
NO810590L (no)	1981-08-27
FI800556A7 (fi)	1981-08-27
PT72511A (en)	1981-03-01
SE8101265L (sv)	1981-08-27
FI64367C (fi)	1986-08-05

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