CS221404B1 - Method of stabilization of polyolefine for attaining the increased resistance against biological degradation of the organism - Google Patents
Method of stabilization of polyolefine for attaining the increased resistance against biological degradation of the organism Download PDFInfo
- Publication number
- CS221404B1 CS221404B1 CS973781A CS973781A CS221404B1 CS 221404 B1 CS221404 B1 CS 221404B1 CS 973781 A CS973781 A CS 973781A CS 973781 A CS973781 A CS 973781A CS 221404 B1 CS221404 B1 CS 221404B1
- Authority
- CS
- Czechoslovakia
- Prior art keywords
- organism
- tocopherol
- parts
- stabilization
- increased resistance
- Prior art date
Links
- 229920000098 polyolefin Polymers 0.000 title claims description 10
- 238000000034 method Methods 0.000 title claims description 7
- 230000015556 catabolic process Effects 0.000 title description 5
- 238000006731 degradation reaction Methods 0.000 title description 5
- 230000006641 stabilisation Effects 0.000 title description 2
- 238000011105 stabilization Methods 0.000 title description 2
- 239000000203 mixture Substances 0.000 claims description 6
- 230000000087 stabilizing effect Effects 0.000 claims description 4
- WGVKWNUPNGFDFJ-DQCZWYHMSA-N β-tocopherol Chemical compound OC1=CC(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C WGVKWNUPNGFDFJ-DQCZWYHMSA-N 0.000 claims description 4
- 239000011732 tocopherol Substances 0.000 claims description 3
- 229960001295 tocopherol Drugs 0.000 claims description 3
- 229940066595 beta tocopherol Drugs 0.000 claims description 2
- 235000010382 gamma-tocopherol Nutrition 0.000 claims description 2
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 2
- 229920000642 polymer Polymers 0.000 claims description 2
- 239000011590 β-tocopherol Substances 0.000 claims description 2
- 235000007680 β-tocopherol Nutrition 0.000 claims description 2
- 239000002478 γ-tocopherol Substances 0.000 claims description 2
- QUEDXNHFTDJVIY-DQCZWYHMSA-N γ-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1 QUEDXNHFTDJVIY-DQCZWYHMSA-N 0.000 claims description 2
- GZIFEOYASATJEH-VHFRWLAGSA-N δ-tocopherol Chemical compound OC1=CC(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1 GZIFEOYASATJEH-VHFRWLAGSA-N 0.000 claims 2
- GZIFEOYASATJEH-UHFFFAOYSA-N D-delta tocopherol Natural products OC1=CC(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 GZIFEOYASATJEH-UHFFFAOYSA-N 0.000 claims 1
- 238000006065 biodegradation reaction Methods 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 235000010389 delta-tocopherol Nutrition 0.000 claims 1
- 239000003381 stabilizer Substances 0.000 claims 1
- 239000002446 δ-tocopherol Substances 0.000 claims 1
- 239000007943 implant Substances 0.000 description 6
- 238000000265 homogenisation Methods 0.000 description 5
- 239000004033 plastic Substances 0.000 description 5
- 229920003023 plastic Polymers 0.000 description 5
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 4
- -1 polyethylene Polymers 0.000 description 4
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 4
- 239000004698 Polyethylene Substances 0.000 description 2
- 239000004743 Polypropylene Substances 0.000 description 2
- 238000010171 animal model Methods 0.000 description 2
- CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 description 2
- 235000013539 calcium stearate Nutrition 0.000 description 2
- 239000008116 calcium stearate Substances 0.000 description 2
- 238000002513 implantation Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 229920000573 polyethylene Polymers 0.000 description 2
- 229920001155 polypropylene Polymers 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 229930003799 tocopherol Natural products 0.000 description 2
- 235000010384 tocopherol Nutrition 0.000 description 2
- 206010067484 Adverse reaction Diseases 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
- 229940087168 alpha tocopherol Drugs 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000000711 cancerogenic effect Effects 0.000 description 1
- 230000000747 cardiac effect Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000006735 deficit Effects 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 239000002530 phenolic antioxidant Substances 0.000 description 1
- 150000002989 phenols Chemical class 0.000 description 1
- 229920001083 polybutene Polymers 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 229960000984 tocofersolan Drugs 0.000 description 1
- 235000004835 α-tocopherol Nutrition 0.000 description 1
- 239000002076 α-tocopherol Substances 0.000 description 1
Landscapes
- Compositions Of Macromolecular Compounds (AREA)
Description
Vynález se týká způsobu stabilizace poilyoleifinů, kterým se dosahu je zvýšení odolnosti proti biologické degradaci při implantaci v organismu ,a zvýšení snášenlivosti 8 organismem.The present invention relates to a method for stabilizing poilyolefins, the effect of which is to increase resistance to biological degradation upon implantation in an organism, and to enhance tolerance by the organism.
Polyolefiny (například polyethylen), se používají v humánní medicíně jako implantáty například ve formě kloubových protéz, mamárních protéz, izolací kardiostimulačních elektrod aj. V průběhu expozice těchto implantátů v organismu dochází k degradaci polymerního materiálu, které se projevuje postupným zhoršováním užitkových vlastností implantátu. Snižuje se spolehlivost funkce implantátu, případně dochází k jeho porušení.Polyolefins (for example polyethylene) are used in human medicine as implants, for example in the form of articulated prostheses, mammary prostheses, cardiac pacemaker electrode isolation, etc. During exposure of these implants in the body, the polymeric material degrades, resulting in gradual deterioration of the implant's performance. Impairment of implant function decreases, eventually its failure.
V důsledku toho je nutné provádět reimplantace, které vždy představují větší nebo menší ohrožení zdraví pacienta.As a result, reimplantations must always be performed which always present a greater or lesser risk to the patient's health.
Doposud není znám účinný způsob stabilizace polyolefinů proti biologické degradaci vyvolávané působením fyziologického prostředí organismu. V literatuře je popsáno pouze snížení degradace polypropylenu stabilizovaného· fenolickými antioxidanty nebo jejich směsí se synergickou přísadou při implantaci v pokusných zvířatech. Deriváty fenolů jsou většinou látky zdravotně závadné a ve styku s živou tkání vyvolávají nepříznivé reakce. Některé z těchto látek mají karcinogenní účinky.To date, there is no known effective method of stabilizing polyolefins against biological degradation induced by the physiological environment of an organism. Only a reduction in degradation of polypropylene stabilized by phenolic antioxidants or mixtures thereof with a synergistic additive when implanted in experimental animals is described in the literature. Phenol derivatives are usually harmful substances and cause adverse reactions in contact with living tissue. Some of these substances have carcinogenic effects.
Uvedené nedostatky jsou odstraněny při použití polyolefinů stabilizovaných podle vynálezu, jehož podstatou je přísada 0,01 až 5 % tokoferolu do polyolefinů.These drawbacks are overcome by the use of the polyolefins stabilized according to the invention, which is based on the addition of 0.01 to 5% tocopherol to the polyolefins.
Stabilizace· polyolefinů tokoferolem zvyšuje jejich odolnost proti degradaci při působení fyziologického prostředí organismu. Zvyšuje spolehlivost funkce a několikanásobně prodlužuje životnost implantátů z těchto· materiálů ve srovnání s polyolefiny nestabilizovanými. Podle vynálezu stabilizované polyolefiny jsou zdravotně nezávadné, nevyvolávají nepříznivé reakce tkání v okolí implantátu a příznivě působí na vhojovací proces.Stabilization of polyolefins with tocopherol increases their resistance to degradation under the influence of the physiological environment of the organism. It improves the reliability of function and extends the lifetime of implants of these materials several times compared to non-stabilized polyolefins. According to the invention, the stabilized polyolefins are harmless to health, do not cause adverse tissue reactions in the vicinity of the implant and have a beneficial effect on the healing process.
Způsob stabilizace polyolefinů vyplývá z těchto příkladů.The method for stabilizing polyolefins results from these examples.
Příklad 1Example 1
1,00' hmot. dílů polyethylenu se smísí s 0,1 hmot. dílů d,l-alfa-tokoferolu. Po dokonalé homogenizaci se dále zpracovává technologiemi obvyklými pro zpracování plastů. Příklad 21.00 'wt. parts of polyethylene are mixed with 0.1 wt. parts of d, l-alpha-tocopherol. After perfect homogenization, it is further processed by technologies common for plastics processing. Example 2
100 hmot, dílů polybutenu.— 1 se smísí s 0,2 hmot. díly d,l-alfa-tokofer©lu a s 0i,0l4 hmot. díly stearátu vápenatého. Po· dokonalé homogenizaci se dále zpracovává technologiemi obvyklými pro zpracování plastů.100 parts by weight of polybutene. parts by weight of d, l-alpha-tocopherol; parts of calcium stearate. After perfect homogenization, it is further processed by technologies common for plastics processing.
Příklad 3Example 3
100 hmot. dílů polypropylenu se· smísí s 0,04 hmot. díly stearátu vápenatého a s 0,3 hmot. díly gama-tokoferolu. Po dokonalé homogenizaci se směs dále zpracovává technologiemi obvyklými pro zpracování plastů.100 wt. parts of polypropylene are mixed with 0.04 wt. parts of calcium stearate and with 0.3 wt. parts of gamma-tocopherol. After perfect homogenization, the mixture is further processed by technologies common for plastics processing.
Příklad 4Example 4
100 hmot. dílů pol-4-methylpentenu se smísí s 0,4 hmot. díly beta-tokoferolu. Po dokonalé homogenizaci se směs dále zpracovává technologiemi obvyklými pro· zpracování plastů.100 wt. parts of pol-4-methylpentene are mixed with 0.4 wt. parts of beta-tocopherol. After perfect homogenization, the mixture is further processed by conventional plastics processing techniques.
Příklad 5Example 5
100 hmot. dílů kopolymeru ethylenu s propylenem se smísí s 0,2 hmot. díly alfa-tokoferolu. Po dokonalé homogenizaci se směs dále· zpracovává technologiemi obvyklými pro zpracování plastů.100 wt. 0.2 parts by weight of ethylene-propylene copolymer are mixed with 0.2 wt. parts of alpha-tocopherol. After perfect homogenization, the mixture is further processed by technologies common to plastics processing.
Uvedené směsi vykázaly při subkutánmí implantaci v pokusných zvířatech 5- až 6násobně delší životnost než polymery nestahilizované.Said compositions showed a 5 to 6-fold longer lifetime than non-downloadable polymers at subcutaneous implantation in experimental animals.
Claims (2)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CS973781A CS221404B1 (en) | 1981-12-23 | 1981-12-23 | Method of stabilization of polyolefine for attaining the increased resistance against biological degradation of the organism |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CS973781A CS221404B1 (en) | 1981-12-23 | 1981-12-23 | Method of stabilization of polyolefine for attaining the increased resistance against biological degradation of the organism |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CS221404B1 true CS221404B1 (en) | 1983-04-29 |
Family
ID=5446307
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CS973781A CS221404B1 (en) | 1981-12-23 | 1981-12-23 | Method of stabilization of polyolefine for attaining the increased resistance against biological degradation of the organism |
Country Status (1)
| Country | Link |
|---|---|
| CS (1) | CS221404B1 (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000049079A1 (en) * | 1999-02-17 | 2000-08-24 | Bone Support Ab | A method for the preparation of uhmwpe doped with an antioxidant and an implant made thereof |
| WO2016169536A1 (en) | 2015-04-21 | 2016-10-27 | Ustav Makromolekularni Chemie Av Cr, V.V.I. | Composition for stabilization of polyethylene, polyethylene, method of preparation thereof, polyethylene implants |
-
1981
- 1981-12-23 CS CS973781A patent/CS221404B1/en unknown
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000049079A1 (en) * | 1999-02-17 | 2000-08-24 | Bone Support Ab | A method for the preparation of uhmwpe doped with an antioxidant and an implant made thereof |
| WO2016169536A1 (en) | 2015-04-21 | 2016-10-27 | Ustav Makromolekularni Chemie Av Cr, V.V.I. | Composition for stabilization of polyethylene, polyethylene, method of preparation thereof, polyethylene implants |
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