CS228527B2 - Process for the production of 3-/pyrid-3-or-4-y alkyl/indolic derivates - Google Patents

Process for the production of 3-/pyrid-3-or-4-y alkyl/indolic derivates Download PDF

Info

Publication number
CS228527B2
CS228527B2 CS819343A CS934381A CS228527B2 CS 228527 B2 CS228527 B2 CS 228527B2 CS 819343 A CS819343 A CS 819343A CS 934381 A CS934381 A CS 934381A CS 228527 B2 CS228527 B2 CS 228527B2
Authority
CS
Czechoslovakia
Prior art keywords
formula
alkyl
indole
group
pyridylmethyl
Prior art date
Application number
CS819343A
Other languages
Czech (cs)
English (en)
Inventor
Peter E Cross
Roger P Dickinson
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of CS228527B2 publication Critical patent/CS228527B2/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
CS819343A 1980-12-15 1981-12-15 Process for the production of 3-/pyrid-3-or-4-y alkyl/indolic derivates CS228527B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8040081 1980-12-15

Publications (1)

Publication Number Publication Date
CS228527B2 true CS228527B2 (en) 1984-05-14

Family

ID=10517993

Family Applications (1)

Application Number Title Priority Date Filing Date
CS819343A CS228527B2 (en) 1980-12-15 1981-12-15 Process for the production of 3-/pyrid-3-or-4-y alkyl/indolic derivates

Country Status (22)

Country Link
US (1) US4363912A (fr)
EP (1) EP0054417B1 (fr)
JP (1) JPS57181082A (fr)
KR (1) KR830007552A (fr)
AR (1) AR229110A1 (fr)
AU (1) AU525296B2 (fr)
CA (1) CA1143737A (fr)
CS (1) CS228527B2 (fr)
DD (1) DD202290A5 (fr)
DE (1) DE3167879D1 (fr)
DK (1) DK552581A (fr)
ES (1) ES8308872A1 (fr)
FI (1) FI814003L (fr)
GR (1) GR76355B (fr)
IE (1) IE51949B1 (fr)
IL (1) IL64534A0 (fr)
NO (1) NO814264L (fr)
PH (1) PH17576A (fr)
PL (1) PL133634B1 (fr)
PT (1) PT74123B (fr)
YU (1) YU293481A (fr)
ZA (1) ZA818665B (fr)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CS229934B2 (en) * 1981-07-07 1984-07-16 Pfizer Production method subst.indolylacryte acid derivative
US4460777A (en) * 1981-11-19 1984-07-17 Ciba-Geigy Corporation N-Substituted-2-pyridylindoles
US4478842A (en) * 1981-11-19 1984-10-23 Ciba-Geigy Corporation N-Substituted-2-pyridylindoles
US4511573A (en) * 1983-05-17 1985-04-16 Ciba-Geigy Corporation 3-Substituted-2-(heteroaryl) indoles
US4536505A (en) * 1983-05-17 1985-08-20 Ciba-Geigy Corporation Certain N-(pyridyl) indoles
GB8524157D0 (en) * 1984-10-19 1985-11-06 Ici America Inc Heterocyclic amides
US4609733A (en) * 1984-12-27 1986-09-02 Ciba-Geigy Corporation 3-keto-substituted-N-pyridylindoles
GB8609175D0 (en) * 1986-04-15 1986-05-21 Ici America Inc Heterocyclic carboxamides
US6214991B1 (en) * 1998-03-31 2001-04-10 The Institute For Pharmaceutical Discovery, Inc. Substituted indolealkanoic acids
TNSN99224A1 (fr) * 1998-12-01 2005-11-10 Inst For Pharm Discovery Inc Methodes de reduction des niveaux de glucose et triglyceride en serum et pour suppression de l'antigenese utilisant les acides la indolealkanoique
WO2001051489A2 (fr) * 2000-01-14 2001-07-19 The Institutes For Pharmaceutical Discovery, Llc Procedes pour abaisser les niveaux d'acide urique
CA2509170A1 (fr) * 2002-12-10 2004-06-24 Wyeth Derives substitues de l'acide acetique de 3-alkyle et 3-arylalkyle 1h-indol-1-yle en tant qu'inhibiteurs de l'inhibiteur des activateurs du plasminogene (pai-1)
GB0324763D0 (en) * 2003-10-23 2003-11-26 Oxagen Ltd Use of compounds in therapy
CA2658496A1 (fr) 2006-07-22 2008-01-31 Oxagen Limited Derives d'acide acetique 2-(5-fluoro-2-methyl-3-{2-(phenylsulfonyl)benzyl et esters de ceux-ci ayant une activite antagoniste crth2
BRPI0817397A2 (pt) * 2007-09-24 2015-04-07 Allergan Inc Compostos indol contendo grupos arila ou heteroarila com atividade biológica do receptor de esfingosina-1-fosfato (sip)
US7750027B2 (en) * 2008-01-18 2010-07-06 Oxagen Limited Compounds having CRTH2 antagonist activity
CA2712017C (fr) * 2008-01-18 2016-08-09 Oxagen Limited Composes presentant une activite antagoniste de crth2
EP2265581A1 (fr) * 2008-01-22 2010-12-29 Oxagen Limited Composés présentant une activité antagoniste du récepteur crth2
JP2011509991A (ja) * 2008-01-22 2011-03-31 オキサジェン リミテッド Ｃｒｔｈ２アンタゴニスト活性を有する化合物
GB201322273D0 (en) 2013-12-17 2014-01-29 Atopix Therapeutics Ltd Process
GB201407807D0 (en) 2014-05-02 2014-06-18 Atopix Therapeutics Ltd Polymorphic form
GB201407820D0 (en) 2014-05-02 2014-06-18 Atopix Therapeutics Ltd Polymorphic form

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR5173M (fr) * 1966-02-11 1967-06-19
FR7337M (fr) * 1968-01-11 1969-10-13
GB2045244B (en) 1979-03-07 1983-01-26 Pfizer Ltd 3-1-(imidazolylalkyl) indoles
US4322533A (en) * 1980-03-17 1982-03-30 Lesher George Y 1H-Indole-2,3-dione derivatives

Also Published As

Publication number Publication date
PT74123B (en) 1983-12-19
ES507960A0 (es) 1983-10-01
DK552581A (da) 1982-06-16
DD202290A5 (de) 1983-09-07
NO814264L (no) 1982-06-16
EP0054417B1 (fr) 1984-12-19
PL234253A1 (en) 1983-05-23
ZA818665B (en) 1982-10-27
PT74123A (en) 1982-01-01
IL64534A0 (en) 1982-03-31
ES8308872A1 (es) 1983-10-01
EP0054417A1 (fr) 1982-06-23
DE3167879D1 (en) 1985-01-31
FI814003A7 (fi) 1982-06-16
IE51949B1 (en) 1987-04-29
KR830007552A (ko) 1983-10-21
US4363912A (en) 1982-12-14
YU293481A (en) 1984-10-31
CA1143737A (fr) 1983-03-29
IE812928L (en) 1982-06-15
AR229110A1 (es) 1983-06-15
FI814003L (fi) 1982-06-16
GR76355B (fr) 1984-08-06
PL133634B1 (en) 1985-06-29
PH17576A (en) 1984-10-01
AU7848881A (en) 1982-06-24
JPS57181082A (en) 1982-11-08
AU525296B2 (en) 1982-10-28

Similar Documents

Publication Publication Date Title
CS228527B2 (en) Process for the production of 3-/pyrid-3-or-4-y alkyl/indolic derivates
US4496572A (en) Benzo-fused thromboxane synthetase inhibitors
US4551468A (en) Heterocyclic thromboxane synthetase inhibitors and pharmaceutical compositions containing them
SU1277894A3 (ru) Способ получени 3-/1-имидазолилалкил/индолов или их фармацевтически приемлемых кислотно-аддитивных солей
HU184227B (en) Process for preparing imidazole derivatives
CS216517B2 (en) Method of making the substituted n-+l phenoxyalcyl + p- imidazol derivatives
JP2007506772A (ja) Ｐａｉ−１としてのヘテロサイクリックまたはアリールオキシ、−チオまたは−アミノ置換インドール−２−カルボン酸またはエステル
EP0035863B1 (fr) Dérivés d'imidazole, procédé pour leur préparation et leurs compositions pharmaceutiques
CS229934B2 (en) Production method subst.indolylacryte acid derivative
JPS5841875A (ja) インド−ルトロンボキサンシンセタ−ゼ抑制剤類、それらの製造法、およびそれらを含有する製薬的組成物
AU702406B2 (en) Imidazole derivatives and medicinal composition thereof
GB2118552A (en) Thromboxane synthetase inhibitors
US4599336A (en) Derivatives of (E)-3-(4-oxo-4H-quinazolin-3-yl)-2-propenamide
NO171211B (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive 1,3-dioksaner
GB2102795A (en) Indole derivatives
HU209471B (en) Process for producing substituted 1-(alkoxy-iminoalkyl)-imidazole derivatives and pharmaceutical preparations containing them
GB2101115A (en) Thromboxane synthetase inhibitors
JPS6022711B2 (ja) トランス−デカハイドロキノリン誘導体，その製造法，及びそれを含む医薬
MXPA97006585A (en) Derivatives of imidazol and medicinal composition of mis
JPWO1996026927A1 (ja) イミダゾール誘導体及びその医薬組成物