CS252055B1 - Process for recovering 2-propanol lost in the production of D, L-threo-2-amino-1- (4-nitrophenyl) -1,3-propanediol hydrochloride - Google Patents
Process for recovering 2-propanol lost in the production of D, L-threo-2-amino-1- (4-nitrophenyl) -1,3-propanediol hydrochloride Download PDFInfo
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- CS252055B1 CS252055B1 CS837273A CS727383A CS252055B1 CS 252055 B1 CS252055 B1 CS 252055B1 CS 837273 A CS837273 A CS 837273A CS 727383 A CS727383 A CS 727383A CS 252055 B1 CS252055 B1 CS 252055B1
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Abstract
Způsob regenerace 2-propanolu při výrobě hydrochloridu D-L-threo-2-§oetamido-l- -(4-nitrofenyl)-l,3-propanolu. Řešení se týká regenerace 2-propanolu užívaného na promýv&ní produktu. Rozpuštěné balasty se odstraňují účinkem zásad.Method for the regeneration of 2-propanol in the production of D-L-threo-2-acetamido-1-(4-nitrophenyl)-1,3-propanol hydrochloride. The solution relates to the regeneration of 2-propanol used for washing the product. Dissolved ballasts are removed by the action of alkalis.
Description
Při výrobě hydrochloridu D,L-threo-2-amino-l-(4-nitrofenyl)-l,5-propandiol (I) odpadá velké množství 2-propanolu.In the preparation of D, L-threo-2-amino-1- (4-nitrophenyl) -1,5-propanediol (I) hydrochloride, a large amount of 2-propanol is eliminated.
Ve vodném 2-propanolu se provádí např. deacetylace D,L-threo-2-acetamido-l-(4-nitrofenyl)-l,3~propandiolu (II). Vodným i bezvodým 2-propanolem se produkt, tj. hydrochlorid I, promývá.In aqueous 2-propanol, for example, deacetylation of D, L-threo-2-acetamido-1- (4-nitrophenyl) -1,3-propanediol (II) is carried out. Both aqueous and anhydrous 2-propanol wash the product, i.e., hydrochloride I.
Je popsána řada postupů zpracování odpadajícího 2-propanolu. Obvykle se odpadající 2-propanol zpracuje absolutizací.Numerous processes for treating 2-propanol are described. Usually, the 2-propanol which is removed is treated by absolutization.
Z hlediska rozpustnosti hydrochloridu I je výhodné tento produkt promýt 2-propanolem. Po promytí hydrochloridu I obsahuje 2-propanol vedle kyselin řadu různých balastů organické i anorganické povahy a 30 až 50 % hmot, · vody. Značný obsah vody znemožňuje absolutizací. Balastni látky komplikují oddestilování azeotropni směsi a vody (88 % 2-propanolu), protože zanáší destilační zařízení. Z těchto důvodů se promývaoí 2-propanol kanalizoval. Tím se z výroby ztráoí 20 až 5θ % 2-propanolu.In view of the solubility of hydrochloride I, it is preferable to wash this product with 2-propanol. After washing the hydrochloride I, in addition to the acids, the 2-propanol contains a number of different ballasts of organic and inorganic nature and 30 to 50% by weight of water. A considerable water content makes it impossible by absolutisation. Ballasts complicate the distillation of the azeotropic mixture and water (88% 2-propanol) because it clogs the distillation apparatus. For this reason, the 2-propanol wash was drained. As a result, 20 to 5% of 2-propanol is lost from production.
Uvedené nedostatky a ztrátu 2-propanolu odstraňuje postup podle předkládaného vynálezu.Said drawbacks and loss of 2-propanol are eliminated by the process of the present invention.
Podle vynálezu se promývací 2-propanol zbaví většiny kyselin neutralizací přidáním zásady, např. hydroxidu sodného. Potom se oddestiluje vodný 2-propanol s obsahem vody 10 až 12 % hmot.' Během destilace se vyloučí balastni látky v takové formě, kterou lze z vařáku snadno odstranit.According to the invention, the washing 2-propanol is freed of most acids by neutralization by addition of a base, e.g. sodium hydroxide. Aqueous 2-propanol with a water content of 10 to 12% by weight is then distilled off. During the distillation, ballasts in a form that can be easily removed from the digester are deposited.
Uvedeným postupem, tj.regenerací promývacího 2-propanolu, lze vrátit do výroby 20 až 50 % hmot,. 2-propanolu. Další výhoda, kterou vynález přináší, spočívá ve zlepšeni stavu odpadních vod.By this process, i.e. regeneration of the 2-propanol wash, 20 to 50 wt. Of 2-propanol. A further advantage of the invention is the improvement of the wastewater condition.
Vynález a jeho účinky-jsou blíže osvětleny na následujícím příkladu pr ovesní.The invention and its effects are illustrated in more detail in the following example.
PříkladExample
Do 2 litrové baňky opatřené topným hnízdem a sestupným chladičem s teploměrem bylo vneseno 1000 ml roztoku 2-propanolu o složení -30 % hmot. vody, 6 % hmot· kyseliny chlorovodíkové a, octové a 15 % hmot. balastů. Směs byla zneutralizována přidáním 30 g hydroxidu sodného. Potom bylo oddestilováno 450 ml destilátu o složení 90 % hmot. 3r*propanolu, 8 % hmot; vody a 2 % hmot. nečistot. Teplota par dosáhla 82 °C.A 2 liter flask equipped with a heating nest and a descending condenser with a thermometer was charged with 1000 ml of a -30 wt.% 2-propanol solution. water, 6 wt.% and hydrochloric acid, acetic acid, and 15 wt. ballasts. The mixture was neutralized by the addition of 30 g of sodium hydroxide. Thereafter, 450 ml of a 90% by weight distillate were distilled off. 3% propanol, 8 wt%; water and 2 wt. impurities. The vapor temperature reached 82 ° C.
- 2 PfiEDMÉT VYNÁLEZU- 2 SCOPE OF THE INVENTION
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CS837273A CS252055B1 (en) | 1983-10-05 | 1983-10-05 | Process for recovering 2-propanol lost in the production of D, L-threo-2-amino-1- (4-nitrophenyl) -1,3-propanediol hydrochloride |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CS837273A CS252055B1 (en) | 1983-10-05 | 1983-10-05 | Process for recovering 2-propanol lost in the production of D, L-threo-2-amino-1- (4-nitrophenyl) -1,3-propanediol hydrochloride |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CS727383A1 CS727383A1 (en) | 1987-01-15 |
| CS252055B1 true CS252055B1 (en) | 1987-08-13 |
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ID=5421560
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CS837273A CS252055B1 (en) | 1983-10-05 | 1983-10-05 | Process for recovering 2-propanol lost in the production of D, L-threo-2-amino-1- (4-nitrophenyl) -1,3-propanediol hydrochloride |
Country Status (1)
| Country | Link |
|---|---|
| CS (1) | CS252055B1 (en) |
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1983
- 1983-10-05 CS CS837273A patent/CS252055B1/en unknown
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| Publication number | Publication date |
|---|---|
| CS727383A1 (en) | 1987-01-15 |
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