CS252927B1 - Cosmetic product for hair and scalp treatment - Google Patents

Abstract

Cosmetic product in the form of a solution suitable for long-term use due to its non-irritating properties, contains myrrh tincture, witch hazel extract, 3-carboxy-4-hydroxybenzene sulfonic acid, sodium alkoxymacrogol sulfonate, sodium macrogol sulfosuccinate, macrogol 9,000 glycerol oleocan, macrogol 4,000 lanolin, substances ensuring the stability of the product, antimicrobial resistance and pleasant aroma of the product. The product is used for cosmetic purposes in regular hair and scalp care as a shampoo, especially before using the recommended hair product /according to Czechoslovak AO 244 38 7/.

Description

The invention relates to the composition of a new cosmetic preparation for regular treatment of hair and scalp. The preparation is in the form of a clear solution of surfactants and contains active substances from witch hazel, myrrh, 3-carboxy-4-hydroxy-benzene sulfonic acid, as well as auxiliary substances reducing excessive degreasing of hair and scalp - macrogol 4,000 lanolin and macrogol 9,000 glyceryl oleoyl. The preparation smells pleasantly /S. M. Kaplan: Selecting fragr.ances for hair preparations, Cosmet. Toilet., 94, 33-35 /1979/ and does not sensitize the skin.

A number of works are devoted to the issues of hair loss, hair growth, scalp and hair oiliness, dandruff formation and hair cosmetics, the most important of which are:

OUTSIDE. Robinson: A Study of damaged hair - J. Soc. Cosmetics. Chem., 27, 155-161 /1976/; F.A.O. Thiele: Clinical Aspects of Hair Loss and its Cosmètological significance - Brit.

0. Dermatol., 92, 355-358 Ú1975/; F. 0. Ebling: Hair - 0.

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Invest. Dermatol., 67, 98-105 /1976/; U.-F. Haustein: Seborrhea, Koptschuppung, Haarausfall - Med. world,

340-341 /19 /; H. Zaun: Diagnostik und Therapie bei totalen Haarausfall - Dtsch. Copper. Wochenschr., 103, 997-998 /1978/; V. H. Price: Testosterone Metabolism in the Skin - Arch. Dermatol., 111, 1496-1502 /1975/; M. L. Garcia,

J. Diaz: Compatibility Measurements on Human Hair - J. Soc. Cosmetics. Chem., 27, 379-378 /1976/; R. Kubba, A. Rook: Congenital triangular alopecia - Brit. 3. Dermatol*,

95, 657-659 /1979/; G. Frentez: Topical Treatment of Extended Alopecia - Dermatologica, 155, 147-154 /1977/;

R.Z. Shah, 3.K. Sugden: Some Aspects of the role of Pityrosporum ovale in dandruff - Pharm. Acta Helv., 51, 209-211 /1986/.

3e I am aware of a large number of inventions and applications for inventions that state the composition and/or method of preparing hair and scalp care products /Czechoslovak. author's certificate 211 937, Czechoslovak. author's certificate 213 265, U.S. Patent 4 033 895, B.R.D. Offenlegungsschrift 1 904 159, U.S. Patent 3 236 733, U.S. Patent 3 313 734, U.S. Patent 3 816 616, U.S. Patent 3 156 656, U.S. Patent

697,655, U.S. Pat. U.S. Patent 3,671,634 U.S. Patent 3,809,329 Patent 3 808 311, Eur. Pat. Appl. 0108517, U.S. U.S. Patent 3,055,836 U.S. Patent 3,947,382 Patent

048 338, U.S. Patent 3 950 417, B.R.D. Offenlegungsschrift 2 244 830, B.R.D. Offenlegungsschrift 1 901 029, Canad. Patent 905 299, Canad. Patent 909 774/, but to ensure the antimicrobial effect against dermatophytes they use /report/ substances that are very rapidly acting and therefore unsuitable for regular and frequent use. Active substances

D type Captan /N-trichloromethylthio-3,6,7,8-tetrahydrophthal p

imide/ and selenium disulfide /Selsun/ are highly toxic

252 927 or allergenic and there are a number of justified objections against them, the same applies to parabens in higher concentrations, similar to sorbic acid. Also, the use of quaternary ammonium compounds, which are cationic and in combination with anionic or amphoteric surfactants, is not a suitable solution. With long-term use, the vehicle of the cosmetic product becomes more important, when the appropriate selection of excipients and their optimal combination can achieve a targeted effect.

The above-mentioned shortcomings and problems are eliminated by the fact that the preparation according to the invention uses substances exactly used in pharmacy and that their well-defined properties are taken as a basis, which allows the final effect of the preparation to be predicted with certainty. Each substance has been carefully checked and tested before use.

The preparation contains a combination of myrrh tincture in an amount of 0.1 to 5% by weight, witch hazel extract in an amount of 0.1 to 5% by weight, 3-carboxy-4-hydroxybenzene sulfonic acid in an amount of 0.1 to 2% by weight, sodium alkoxymacrogolsulfonate in an amount of 10 to 75% by weight, sodium macrogol sulfosuccinate in an amount of 10 to 75% by weight, macrogol 9,000 glycerol oleoan in an amount of 1 to 10% by weight, macrogol 4,000 lanolin in an amount of 0.5 to 5% by weight, substances ensuring the stability of the preparation, antimicrobial resistance, a pleasant aroma and propylene glycol.

This composition mainly achieves the following advantages: a powerful and reliable effect against dermatophytes is ensured, a mild anti-inflammatory effect is ensured, the surfactant mixture has a suitable size of WAS 22.5 /Washing Active Agents/

252 927 and the over-greasy ingredients do not allow rapid degreasing of the scalp and hair, thus preventing hair breakage or the rebound effect of increased sebum secretion on the head.

The perfume is stabilized against decomposition and thus against the usual penetrating increase in irritation or sensitization with a food antioxidant - butylhydroxytoluene. Stability is also positively influenced by the sodium salt of ethylenediaminetetraacetic acid. The antimicrobial preservative effect is ensured by

2-bromo-2-nitro-l,3-propanediol. The pleasant color of the preparation comes from dyes of natural origin from witch hazel extract and myrrh tincture, and therefore synthetic irritating dyes from the series of aniline dyes are not necessary. The preparation is indicated for seborrhoea oleosa in combination with another preparation - hair activator manufactured according to CS AO 244 387, which contains a combination of myrrh tincture in an amount of 0.1 to 5.0% by weight, witch hazel extract 0.1 to 5.0% by weight, chamomile extract 0.2 to 5.0% by weight, panthenol 0.1 to 2.0% by weight, corn oil extract with an unsaponifiable fraction 0.1 to 1.0% by weight. substances ensuring mild irritation of the scalp and ensuring a pleasant scent of the product: This composition achieves the following advantages in particular: an anti-inflammatory effect, a disinfectant effect, a sufficient supply of the necessary panthenol and vitamin E to the hair follicles, which combines an anti-inflammatory effect and a nourishing effect for the hair follicle. The vehicle is mildly irritating and thus ensures blood circulation to the scalp, without the need to use significantly more toxic substances serving to irritate and blood circulation to the scalp, such as nicotinates. The fatty components of the vehicle do not allow rapid degreasing of the scalp by the ethyl alcohol present. The perfume is resistant to decomposition and thus to the usual

AND

252 927 to a penetrating increase in irritation or sensitization stabilized by a food antioxidant - butylhydroxytoluene. A suitable combination of propylene glycol, water and ethanol allows the preparation to be produced without having to be protected against microbial attack by chemical preservatives. The pleasant color of the preparation is ensured by dyes of natural origin from witch hazel extract and myrrh tincture, and therefore there is no need to choose synthetic irritating dyes from the range of aniline dyes.

The subject matter of the invention is further illustrated by two examples without being limited to these.

Example No. 1

Witch hazel extract 0.25 % wt. Myrrh tincture 1.25 % wt. 3-Carboxy-4-hydroxybenzene acid sulfonic 1.20 % by weight Alkoxymacrogolsufonate sodium /28% solution/ 50.00 % by weight Sodium sulfosuccinate macrogol /30% solution/ 25.00 % by weight Macrogol 9,000 Glyceryl oleate /70% solution/ 5.20 % by weight Macrogol 4,000 lanolin /50% solution/ 4.00 % by weight 2-Bromo-2-nitro-1,3-propanediol 0.02 % by weight Disodium salt of ethylenediaminetetraacetic acid 0.03 % by weight Quebracho perfume 0.70 % by weight 1,2-propanediol to 100.00 % by weight

Example No. 1 - Preparation method

Into a homogenizing device equipped with a stirrer,

252 927 is charged with heating to 50°C sodium alkoxymacrogol sulfonate, sodium macrogol sulfosuccinate, macrogol 9,000 glyceryl oleoyl, macrogol 4,000 lanolin, sodium salt of ethylenediaminetetraacetic acid and 3-carboxy-4-hydroxybenzene sulfinic acid. The mixture is stirred until a homogeneous solution is formed, then cooled to room temperature. Gradually add myrrh tincture, witch hazel extract, 2-bromo-2nitro-1,3-propanediol is added dissolved in three times

1,2-propandiol, add the remaining 1,2-propanediol and perfume. After thorough homogenization, the preparation is poured. Store at a temperature of 15 - 25 C /CsL 3/ in the absence of light.

Example No. 2

Mixture according to Example No. 1 60% by weight.

Fluorochlorocarbon F-12 40% by weight

Example No. 2 - Preparation method

The mixture according to example no. 1 and prepared according to the preparation method ad 1 is filled into pressure containers, which, after being screwed with a continuous valve, are filled with propellant gas /F-12/ to the desired weight. The preparation is stored at a temperature of 15 -25 °C and under conditions for storing pressure packages.

Tincture of myrrh /ČsL 1/

It is produced by dissolving myrrh gum resin in ethanol and filtering. The resin is obtained from the myrrh tree /Commiphora abyssinica, Engl./ from the Bursetaceae family. The resin contains essential oil /about 10%/, bitumen /about 30-40%/ and mucilaginous substances /50-60%/. The effect is due to the substances contained, mainly terpenic hydrocarbons -ponene, and d,l-limonene. Furthermore, eugenol, cresol, cuminaldehyde, cinnamic aldehyde, myrhol, myrholic acid and aliphatic hydrocarbons, mainly m-nonacosane. The drug and tincture smell of cinnamic aldehyde. The tincture has a mainly astringent, disinfectant and deodorant effect. The antimicrobial effect has already been used in the past in the form of smoke (burning gum resin) during fumigation.

Extractum hamamelidis fluidum /ČsL 2/

It is prepared by percolating witch hazel leaves with 50% alcohol. The leaves are provided by Hamamelis virginiana L. from the Hamamelidaceae family. The extract contains tannins, especially - hamamelitanin, flavone glycosides, gallic acid and saponins /P.H. List, L. Hórhammer: Hagers Handbuch der PHARMAZEUTISCHEN PRAXIS, A. Ausg., Springer-Verlag Berlin, Heidelberg, New York 1980/. The effect is astringent and anti-inflammatory /B. Hlava, F. Starý, F. Pospíšil: Rastliny v kozmetike, Příroda - Bratislava 1982; H. Gabler: Arzneipflanzen in Medizin und Pharmazie, Verlag Muller + Steinicke, Munich 1982/. Due to decades of use in pharmacy and cosmetics, the extract has not been subjected to any other special tests.

Acidum 5-carboxy-4-hydroxybenzene sulfonicum /USP XXI /RS/,

2. AB-DDR /RE/

Previously, this acid was used as an antirheumatic drug (oral) in the form of its sodium salt. In combination with samarium

252 927 is used as a local antiphlogistic. Due to its excellent antifungal effect, it is suitable for preparations targeting dermatophytes. It does not irritate or cause allergies to the skin.

Pharmacology of the preparation according to the invention

Determination of acute toxicity - experiments were performed on mice of both sexes with an average weight of 25 g. Housing was under constant conditions and the animals were fed a standard diet and water ad libitum. LD^g was determined after oral application by the Litchfield-Wilcoxon method with at least a five-dose procedure. The result on female mice was 15.0 /12.0 to 18.75/ ml/kg. Local irritation on the oral mucosa of golden hamsters, kept under standard conditions, was also determined. 0.2 ml was applied to each animal in the respective group by a probe into the oral sac twice a day. The application was always performed only on one side, the other side served as a comparative control. At the same time, distilled water was applied to the control group. In the same experimental series, the preparation Neomukoseptonex nasal drops was applied, which thus served as a second control. The preparation was tested both after one-day application, when the animals were killed and samples were taken for histological examination, and after five-day application under the same conditions and also with the taking of samples for histological examination. All samples were also assessed macroscopically, the color of the mucosa, its blood supply and integrity /erosion/ were monitored. There were always five animals in each of the groups. At the end of the study, it was stated that the preparation does not irritate the mucosa.

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Clinical experience with the product according to the invention

The product was tested in a controlled clinical trial. It was tested in three ways: patch tests, external application and microscopic examination of epilated hair. It was tested in a total of one hundred patients.

Patch tests - in undiluted form, the samples were tested with standard Testoplast on the back skin of 100 patients. The results were evaluated 0.5 hours after removing the patch /after 48 hours of application/ and checked for another 24 hours. None of the hundred patients tested developed a toxic reaction or showed any signs of allergy. All patch test results were negative.

External application - foaming, burning or itching of the skin after application, washing and degreasing ability, hair combability, perfumery and consumption of the product were monitored.

The following results were obtained - very good foaming, no burning or itching of the skin occurred during or after washing, for excessively oily hair it is necessary to use two shampoo baths. For more frequent hair washing /about 4 days/ one bath is enough. The combability of the hair is very good. The perfume is rated as excellent.

Microscopic evaluation of epilated hair - a decrease in the number of telogen hairs is not a normal finding /30%/, which occurs during and after washing the hair. The product is indicated for seborrhoea olesa, where the use of another product - a hair activator according to AO 244 387 leads to an increase in the effect, as has also been proven.

Determination of biological activity of a preparation sample

Overview of effective dilution of the preparation according to the invention

252,927 for selected microorganisms:

Microorganism

Effective dilution /1

Staphylococcus aureus 771 480 Staphylococcus epidermidis kk 120 Streptococcus pyogenes A kk 2 000 Streptococcus faecium kk 40 Escherichia coli 185/59 60 Proteus mirabilis Mi 60 Pseudomonas aeruginosa kk 40 Bacillus cereus kk 100 Candida albicans Ca 1 128 Saccharomyces cerevisiae Sc/Fu-2 384 Branhamella catarrhalis 1 1 000 Branhamella catarrhalis 2 2,000 Klebsiella pneumoniae kk 40 /kk - strains isolated from clinical materials/

Microorganism Dilution preparation at title Fungicidal Fungicidal action action /1 : / /1 : / Trichophyton tonsurans 80 6 Trichophyton violaceum 3 840 640 Trichophyton megnii 480 40 Trichophyton floccosum 240 16 Trichophyton schoenleinii 2 560 480 Microsporon gypseum 30 4 Mentagrophytes interdigitale 40 2 Trichophytes interdigitalis 80 10 Microsporum 480 480 Microsporon audouini 20 2

Claims (1)

SUBJECT OF THE INVENTION 252 927 Cosmetic preparation for the treatment of hair and scalp in the form of a solution, emulsion, suspension, gel or spray, containing a combination of myrrh tincture in an amount of 0,1 to 5% by weight, witch hazel extract 0,1 to 5% by weight, sodium alkoxymacrogoisulfonate in an amount 10 to 75% by weight of sodium sulfosuccinate macrogol in an amount of 10 to 75% by weight of macrogol 9000 glycerollojane in an amount of 1 to 10% by weight, macrogol 4000 lanolin in an amount of 0.5 to 5% by weight, agents providing stability of the preparation, antimicrobial resistance, pleasant odor of the preparation and propylene glycol, characterized in that it contains 3-carboxy-4-hydroxybenzene sulfonic acid in 0.1 to 2% by weight.