CS258001B1 - Method of ergotamine production - Google Patents
Method of ergotamine production Download PDFInfo
- Publication number
- CS258001B1 CS258001B1 CS794080A CS794080A CS258001B1 CS 258001 B1 CS258001 B1 CS 258001B1 CS 794080 A CS794080 A CS 794080A CS 794080 A CS794080 A CS 794080A CS 258001 B1 CS258001 B1 CS 258001B1
- Authority
- CS
- Czechoslovakia
- Prior art keywords
- ergotamine
- tul
- production
- ibp
- lav lav
- Prior art date
Links
- OFKDAAIKGIBASY-VFGNJEKYSA-N ergotamine Chemical compound C([C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@@](C(N21)=O)(C)NC(=O)[C@H]1CN([C@H]2C(C3=CC=CC4=NC=C([C]34)C2)=C1)C)C1=CC=CC=C1 OFKDAAIKGIBASY-VFGNJEKYSA-N 0.000 title claims 4
- 229960004943 ergotamine Drugs 0.000 title claims 4
- XCGSFFUVFURLIX-UHFFFAOYSA-N ergotaminine Natural products C1=C(C=2C=CC=C3NC=C(C=23)C2)C2N(C)CC1C(=O)NC(C(N12)=O)(C)OC1(O)C1CCCN1C(=O)C2CC1=CC=CC=C1 XCGSFFUVFURLIX-UHFFFAOYSA-N 0.000 title claims 4
- 238000004519 manufacturing process Methods 0.000 title claims 2
- 238000000034 method Methods 0.000 title claims 2
- HEEACTTWORLLPM-UHFFFAOYSA-N 2-(1h-imidazol-5-yl)ethanol Chemical compound OCCC1=CNC=N1 HEEACTTWORLLPM-UHFFFAOYSA-N 0.000 claims description 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical class N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical class [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 238000010564 aerobic fermentation Methods 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 239000001963 growth medium Substances 0.000 claims 1
- 229910052500 inorganic mineral Chemical class 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 239000002609 medium Substances 0.000 claims 1
- 239000011707 mineral Chemical class 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 241000221751 Claviceps purpurea Species 0.000 description 5
- 241000221760 Claviceps Species 0.000 description 2
- XGZRAKBCYZIBKP-UHFFFAOYSA-L disodium;dihydroxide Chemical compound [OH-].[OH-].[Na+].[Na+] XGZRAKBCYZIBKP-UHFFFAOYSA-L 0.000 description 2
- HEMHJVSKTPXQMS-UHFFFAOYSA-M sodium hydroxide Inorganic materials [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 2
- WUBBRNOQWQTFEX-UHFFFAOYSA-N 4-aminosalicylic acid Chemical compound NC1=CC=C(C(O)=O)C(O)=C1 WUBBRNOQWQTFEX-UHFFFAOYSA-N 0.000 description 1
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
- 241000368779 Asota Species 0.000 description 1
- 101100120289 Drosophila melanogaster Flo1 gene Proteins 0.000 description 1
- 229910005390 FeSO4-7H2O Inorganic materials 0.000 description 1
- 229910005444 FeSO4—7H2O Inorganic materials 0.000 description 1
- 101150096418 Mepe gene Proteins 0.000 description 1
- 206010037549 Purpura Diseases 0.000 description 1
- 241001672981 Purpura Species 0.000 description 1
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 1
- CSNNHWWHGAXBCP-UHFFFAOYSA-L magnesium sulphate Substances [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 1
- 235000019341 magnesium sulphate Nutrition 0.000 description 1
Landscapes
- Crystals, And After-Treatments Of Crystals (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Description
J HA3BAHHE H30EPETEHHflCnocoO nonyMeHHH sproTaMHHaOGíiaCTb ΠΡΗΜΘΗΘΗΗΗ Η3θ6ρβΤβΗΗΗ ΗβοδρβτβΗΗβ KacaeTca cnocoGa nonyHeHHH sproTaMHHa.J HA3BAHHE H30EPETEHHflCnocoO nonyMeHHH sproTaMHHaOGiiaCTb ΠΡΗΜΘΗΘΗΗΗ Η3θ6ρβΤβΗΗΗ ΗβοδρβτβΗΗβ KacaeTca cnocoGa nonyHeHHH sproTaMHHa.
CpeflH. Bfcinie 50 λο chx nop HSBecTHux πρηροαηηχ anxanoHflOB cjiopmhh npeACTaBHTe-JIH ΠβΠΤΗβΗΟή rpynntl HM6I0T Oonbtnoe 3HaWeHHe B MeAHUHHe. Han8onee H3BeCTHb!MHnpeflCTaBHTejIHMH HBJIHIOTCH aprOTaMHH, aprOKOPHHH, SprOKpHnTHM H ŠprOKpHCTHH, , OproTaMWi npexfle Bcero noBumaeT AaBjienne xpoBH, ycmiHBaeT n ycKopxeT koht-paKium mhtkh h bjihhmt Ha τορΜοχβΗΗβ aApeH3prHvecxHx HepBHbtx bojiokoh. 3prora-mhh ripuMenaeTCH b rHHexonorHH.h Tepánu». Hapany c sthm cymecTeyeT bo3mo«-hoctb aacTHHHo-cHHTeTHMecKoro M3MeHeHHB ocoĎeHHo pfin noncKa hobmx noxaaaHHň. f .CpeflH. Bfcinie 50 λο chx nop HSBecTHux πρηροαηηχ anxanoHflOB cjiopmhh npeACTaBHTe-JIH ΠβΠΤΗβΗΟή rpynntl HM6I0T Oonbtnoe 3HaWeHHe B MeAHUHHe. Han8onee H3BeCTHb! MHnpeflCTaBHTejIHMH HBJIHIOTCH aprOTaMHH, aprOKOPHHH, SprOKpHnTHM ŠprOKpHCTHH H,, OproTaMWi npexfle Bcero noBumaeT AaBjienne xpoBH, ycmiHBaeT ycKopxeT Koht n-paKium mhtkh h bjihhmt Ha τορΜοχβΗΗβ aApeH3prHvecxHx HepBHbtx bojiokoh. 3prora-mhh ripuMenaeTCH b rHHexonorHH.h Tepán ». Hapany c sthm cymecTeyeT bo3mo «-hoctb aacTHHHo-cHHTeTHMecKoro M3MeHeHHB ochoHHo pfin noncKa hobmx noxaaaHHn. f.
XapaKTepHCTHxa HSBecTHbix TexHHvecxHX pemeHHň B HacToamee BpeMH tph cnocoGa onpeflejijnoT ypoeeHb TexHHKH canpo<J>HTHvecxorononyveHHH sproTaMHHa.XapaKTepHCTHxa HSBecTHbix TexHHvecxHX B HacToamee BpeMH tph cnocoGa onpeflejijnoT ypoeeHb TexHHKH canpo <J> HTHvecxorononyveHHH sproTaMHHa.
IttraMM Claviceps purpúrea (Fr.) Tul, ATCC 15383 oGpaayeT 900-1450 μκγ 3pro-TaMHHa Ha mji cycneiismi xynbTypu,IttraMM Claviceps purpúrea (Fr.) Tul, ATCC 15383 oGpaayeT 900-1450 μκγ 3pro-TaMHHa Ha mji cycneiismi xynbTypu
AnKanoHflbí (sproTaMHH; 3proTaMHHHH) xax npH stom cnocoGe, Tax η npH ocTanb-Hbix oCcyxnaeMbK cnocoGax HaxoflHTCH xax h b cycneHSHH· xynbTypw, Tak h b mh-uejine (DE-AS 1 210 128), ΠρΗ flpyroM cnocoGe c πομοπιβιο nrraMMa Claviceps purpurea FI 32/17 oCpasyeTCflCMecb anxajioHAOB na sproTaMHHa η βργοκρηπτηηβ ηπη hx HSOMepos 3ργοτβμηηηη3h aproxpunTHHHHa b xojnraecTBax ot 1200 ao 3800 μκγ anxanoHAa Ha ηπ cycneH-3hh xyjibTypu, npHveM o6a anxaJioHAa oGpasoBajiHCb b npHGjuoHTenbHo OAHHaxoBuxxojiHHecTBax (DE-OS 1 792' 038), ΙΙΙτβΜΜ Claviceps purpurea OKI 56/70 oGpaayeT . b canpotfiHTHHecxoft xynbType Me«-K K ax ax K K K K K K K K K K K st K K K K K K K lav lav lav lav lav lav lav lav lav lav lav lav lav lav lav lav lav / 17 oCpasyeTCflCMecb anxajioHAOB to sproTaMHHa η βργοκρηπτηηβ ηπη hx HSOMepos 3ργοτβμηηηη3h aproxpunTHHHHa b xojnraecTBax ot 1200 and 3800 μκγ anxanoHAa Ha ηπ cycneH-3HH xyjibTypu, OELs o6a anxaJioHAa oGpasoBajiHCb b npHGjuoHTenbHo OAHHaxoBuxxojiHHecTBax (DE-OS 1 792 '038) ΙΙΙτβΜΜ Claviceps purpurea OKI 56 / 70 oGpaayeT. b canpotfiHTHHecxoft xynbType Me «-
Ay 1300 η 1850 μκγ anxanoHAOB Ha mji cycneHSHH KynbTypw, cpeAH xotopmx 80% cocTaBJiHK»T sproTaMHH/aproTakHHHH (BeHrepcxHň naTeíiT 161 654). 258001 2Ay 1300 η 1850 μκγ anxanoHAOB Ha mji cycneHSHH KynbTypw, cpeAH xotopmx 80% cocTaBJiHK T T sproTaMHH / aproTakHHHH (BeHrepcxHn 161 161 65 65 161 654). 258001 2
Bce cnocofibi ΗΜβιοτ tot ιιε,ηοοτβτοκ, ντο fljiH BbifleneHHH ajiKanoHflOB Ha«o o6pa6a-TUBaTb Bcm cycneH3Hio KyjibTypbi. B Heo6xoflHMOcTH 3KCTpaKimn anKanoHflOB Kax hsnHTaTeíibHoň cpe^u, Tax h H3 MHyenn aaxnmaeTCB TexHMvecKHň Ηβ,ςοοτβτοκ 3thxcnoco6oB. Bo ΒτοροΜ H3 HasBaHHbix cnocoSoB HMeeTca eme o^hh Ηβ,ροοτβτοκ - Ha-níme AByx poflCTBenHbix nermmuwx anKanoHHOB, aproTaMHH η βργοκρηπτηη, b OflU“HaxoBbix xojnraecTBax, Tax ντο HeoĎxoflHMo ncnojib3OBaTb TpyjjoeMKne cnoco6bi pa3-fleneHHH.Bce cnocofibi ΗΜβιοτ tot ιιε, ηοοτβτοκ, ντο fljiH BbifleneHHH ajiKanoHflOB Ha «o6pa6a-TUBaTb Bcm cycneH3Hio KyjibTypbi. B Heo6xoflHMOcTH 3KCTpaKimn anCanoHflOB Kax hSnHTaTeíibHo cpe ^ u, Tax h H3 MHyenn aaxnmaeTCB TexHMvecKHn Ηβ, ςοοτβτοκ 3thxcnoco6oB. Bo ΒτοροΜ H3 HasBaHHbix cnocoSoB HMeeTca eme o ^ hh Ηβ, ροοτβτοκ - Ha-Nim AByx poflCTBenHbix nermmuwx anKanoHHOB, aproTaMHH η βργοκρηπτηη b OflU "HaxoBbix xojnraecTBax, Tax ντο HeoĎxoflHMo ncnojib3OBaTb TpyjjoeMKne cnoco6bi PO3-fleneHHH.
Uejib Η3ο6ρετβΗΗΗUejib Η3ο6ρετβΗΗΗ
Uejibio H3o6peTenna HBnaeTca^ nonyueHHe anKanoHfla aproTaMHHa no BbiroflHOMycnocoCy h TaxHM o6pa3OM eró npeflocTaBnenne pjin ycnneHHoro ηρΗΜβΗβΗΗΗ b Me-AHitHHe. H3JI0«eHHe CymHOCTH Η3θ6ρβΤβΗΗΛ B ocHOBy Η3ο6ρβτεΗΗΗ nonojKeHa sanana. paaBHTb cnocoC nonyneHna sproTaMHHa,npn κοτοροΜ BbwenenHe ajucajionfla ocymécTBJíHeTca τοηβκο «3 nHTaTejibHOň cpeflbíh KOTopbiň ne TpeSyeT TpyfloeMKoro OTfleneHHa poflCTBeHHbix πβπτΗΑΗΜΧ ajiKanoH-AOB. Pflst 3Toro Hago BbmejinTb tnTaMMbi, KOTOpbie: 1 . B COCTOHHHH lf CanpO<J)HTHVeCKH O6pa3OBaTb 3prOT3MHH, KOTOpblíi ΠΟΗΤΗ CBO·SofleH ot noSouHbix βηκβηοΗβΟΒ nenTHflHoň rpynnbl, 2, o6pa3OBaBniHecH ajiKanoHflbí BbwejiHWT b oRpyTKaramyio nnTaTenbHyioe cpeny Sonb-me ueM Ha 95%, 3. OTJnwaioTCH CTaSunbuocTbio, xopomefl npoflyKHHeň ajmcajioHgoB m SnaronpŘHT-HblMH CBOflcTBBMH φβρΜβΗΤβμΗΗ. • CornacHo Η3θ6ρβτβΗΗΚ> pjin npoH3BOflCTBa 3proTaMHHa Hcnojib3yeTCH niTaMM Clavi-ceps purpuréa (Fr.) Tul. IBP 74, ero MyTaHTbi hjih β3ρηβητμ·Uejibio H3o6peTenna HBnaeTca ^ nonyueHHe anCanoHfla aproTaMHHa no BbiroflHOMycnocoCy h TaxHM o6pa3OM ero npeflocTaBnenne pjin ycnneHHoro ηρΗΜβΗβΗΗΗb Me-AHitHHe. H3JI0 «eHHe CymHOCTH Η3θ6ρβΤβΗΗΛ B ocHOBy Η3ο6ρβτεΗΗΗ nonojKeHa sanana. paaBHTb cnocoC nonyneHna sproTaMHHa, npn κοτοροΜ BbwenenHe ajucajionfla ocymécTBJíHeTca τοηβκο «3 nHTaTejibhoň cpeflbíh KOTopbni ne TpeSyeT TpyfloeMKoro OTfleneHHa poflCTBeHHbix πβπτΗΑΗΜΧ ajiKanoH-AOB. Pflst 3Toro Hago BbmejinTb tnTaMMbi, KOTOpbie: 1. B COCTOHHHH CanpO lf <J) HTHVeCKH O6pa3OBaTb 3prOT3MHH, KOTOpblíi ΠΟΗΤΗ CBO rev · SofleH noSouHbix βηκβηοΗβΟΒ nenTHflHoň rpynnbl, 2 o6pa3OBaBniHecH ajiKanoHflbí BbwejiHWT b oRpyTKaramyio nnTaTenbHyioe sonb cPen Me Ha UEM 95% 3. OTJnwaioTCH CTaSunbuocTbio, xopomefl npoflyKHHeň ajmcajioHgoB m SnaronpŘHT- HblMH CBOflcTBBMH φβρΜβΗΤβμΗΗ. • CornacHo Η3θ6ρβτβΗΗΚ> pjin npoH3BOflCTBa 3proTaMHHa Hcnojib3yeTCH niTaMM Clavi-ceps purpurea (Fr.) Tul. IBP 74, ero MyTaHTbi hjih β3ρηβητμ ·
Ho b bifl ηιτβΜΜ Claviceps pUrpurea (Fr.) Tul. IBP 74 no« Η33βηηη@μ IMET PA 135nenoHHpOBan b UenTpaJibHOM HHCTHTyTe mhkpoShojiothh h 3KcnepHMeHTanbH‘oň Tepa-πηη AKafleMHH Hayx ΓβΡ b ňene. Oh oSpaayeT oSmyro cMecb anKanoHfloB (πρη6πη3Η-TenbHO 900 - 1500 μκγ Ha mji KyjibTypHoro pacTBopa), H3 κοτοροϋ Ηβ MeHbme50% anKajioHflOB BbrrpHXHBaeMbi b opraHHvecKHň pacTBopHTejib, H3 κοτορωχ Sojiee75 “ 80% COCTHBJIHeT napa H3OMepOB-3prOTaMHH/3prOTaMHHHH.Ho b bifl ηιτβΜΜ Claviceps pUrpurea (Fr.) Tul. IBP 74 no «β33βηηη @ μ IMET PA 135nHHpOBan b UenTpaJibHOM HHCTHTyTe mhkpoShojiothh h 3KcnepHMeHTanbH‘oň Tepa-πηη AKafleMHH Hayx ΓβΡ b ňene. Oh oSpaayeT oSmyro cMecb anKanoHfloB (πρη6πη3Η-TenbHO 900-1500 μκγ Ha vk KyjibTypHoro pacTBopa) H3 κοτοροϋ Ηβ MeHbme50% anKajioHflOB BbrrpHXHBaeMbi b opraHHvecKHň pacTBopHTejib, H3 κοτορωχ Sojiee75 "80% COCTHBJIHeT Napa H3OMepOB-3prOTaMHH / 3prOTaMHHHH.
Kax conyTCTByronme anxajioHflbí b CMecu coflepxcaTca:Kax conyTCTByronme anxajioHflb b CMecu coflepxcaTca:
XaHOKJiaBHH 10—15% BbrrpaXHBaeMoň flOJiH aproMeTpHH 5-6% 3ΡΓΟ3ΗΗ CJieflbl 4% 3ΡΓΟΚΡΗΠΤΗΗ 5% flpyrne KjiaBHHbí vacTHUHo cjieflu. B nnTaTejibHbix cpeflax ocTaeTcn nocne βμτρηχηβηηηη cpeflu flpyrnx h nuseprmtOBanKHcnoTa. Ha nuTaTenhHbix pacTBopoB ajiKajioHgbi H3OJiHpyroTCH ηββθοτηημ nyTeM.Bosmowho npeepamenHe ofliioro anKajioHflHoro H3OMepa b npyroft.XaHOKJiaBHH 10—15% BbrrpaXHBaeMoň flOJiH aproMeTpHH 5-6% 3ΡΓΟ3ΗΗ CJieflbl 4% 3ΡΓΟΚΡΗΠΤΗΗ 5% flpyrne KjiaBHHbí vacTHUHo cjieflu. B nnTaTejibHbix cpeflax ocTaeTcn nocne βμτρηχηβηηηη flpyrnx h nuseprmtOBanKHcnoTa. Ha nuTaTenhHbix pacTBopoB ajiKajioHgbi H3OJiHpyroTCH ηββθοτηημ nyTeM.Bosmowho npeepamenHe ofliioro anKajioHflHoro H3OMepa b npyroft.
HoBbiň ιπτβΜΜ oTJiHuaeTca TeM, ντο oh flaeT 6ojibme 95% o6pa3OBaHHhix ajixajioHflOBb oKpyxcawmyK) nHTaTejibiiyio cpejjy h conyrcTBywiHHe ajixanoHflbí Jierxo OTflejineMbi,HoBbien ιπτβΜΜ oTJiHuaeTca TeM ντο oh flaeT 6ojibme 95% o6pa3OBaHHhix ajixajioHflOBb oKpyxcawmyK) nHTaTejibiiyio cpejjy h conyrcTBywiHHe ajixanoHflbí Jierxo OTflejineMbi,
í KyJibTHBaipHO fljin xapaxTepHCTHKH Claviceps purpuréa (Fr.) Tul. IBP 74, IMET PA 135 npoBOflHJiH na hjih b cpe^ax, npHBefleHHbixvB . TaSjínue 1. HoBbrit πιτβμμ ημθ- βτ cJieflyranHe MaxpocKonHvecKHe h MHKpocKonHvecKHe ceoflcTBa: 258001 3Ky KyJibTHBaipHO fljin xapaxTepHCTHKH Claviceps purpuréa (Fr.) Tul. IBP 74, IMET PA 135 npoBOflHJiH on hjih b cpe ^ ax, npHBefleHHbixvB. TaSjínue 1. HoBbrit πιτβμμ ημθ- βτ cJieflyranHe MaxpocKonHvecKHe h MHKpocKonHvecKHe ceoflcTBa: 258001 3
MaKpocKontraecKHft buk: BO3pacT KyjibTyp:arap NL 126: arap NL 829: 3 Helenu nnoCKHň,CBeTnO“KopHHHeBblft ΠΟΚΡΟΒ, nyWHCTbtíi, KOpHH“HeBbift, CKJiafl^íaTbiň; oTflenbHbie kojiohhh: (6 0,8-1,3 cm, οστρο orpaHHweH-ΗΜβ,ϋΒβΤΠΟ-ΚΟρΗΗΗβΒΜβ, nymHCTwe.MaKpocKontraecKHft buk: BO3pacT KyjibType: arap NL 126: arap NL 829: 3 Helen nnoCKHn, CBeTnO “KopHHeBblft ΠΟΚΡΟΒ, nyWHCTbti, KOpHH” HeBbift, CKJiafl ^ iTbien; oTflenbHbie kojiohhh: (6 0.8-1.3 cm, οστρο orpaHHweH-β, ϋΒβΤΠΟ-ΚΟρΗΗΗβΒΜβ, nymHCTwe.
CnaQan guiioopecHeHiiHH b yxibTpa4>HoneTOBOM CBere. MOJHHMň, CHHbltO CKJiaflHaTblft ΠΟΚΡΟΒ,CnaQan guiioopecHeHiiHH b yxibTpa4> HoneTOBOM CBere. MOJHHMň, CHHbltO CKJiaflHaTblft ΠΟΚΡΟΒ,
BepxHHn eropoHa cépo-KopHHHeBaa,οοτρο orpamweH-Hbtň Kpaft. OTflenbHbie kojiohhh: ¢( 0,8-1,3 cm, bmcotb no 1 cm.KoHycoBHAHbie, ocTpo orpaHHqeHHbie,BepxHHn eropoHa cépo-KopHHHeBaa, οοτρο orpamweH-Hbtň Kpaft. OTflenbHbie kojiohhh: ¢ (0.8-1.3 cm, bmcotb no 1 cm.KoHycoBHAHbie, ocTpo orpaHHqeHHbie,
BepxHHH cTopona cepo-KopH«tHeBaa, ,· ttnxHaa eropoHa: Mono^ue kojiohhh «βπτο-κορΗΗΗβΒΜβ^ crapbie kojiohhh cpeflHe-KOHHHHeBbie., «bnioopecueHijHH b ΥΦ-οββτβ. MHKpOCKQIHWeCKHft BHflj ΠβρΒΗΗΗβΗ KynbTypa NL 849:BepxHHH cTopona cepo-KopH «HeeBaa,, · ttnxHaa eropoHa: Mono ^ ue kojiohhh« βπτο-κορΗΗΗβΒΜβ ^ crapbie kojiohhh cpeflHe-KOHHHHeBbie., «BnioopecueHijHH b ΥΦ-οββτβ. MHKpOCKQIHWeCKHft BHflj ΠβρΒΗΗΗβΗ KynbTypa NL 849:
BoapacT 3 ρρχ . - οτηοοητβπβηο κοροτκκβ, cwibHo pasBeTBJteHHbie ΓΗ(>1. Γκφω 6onee ηπη MeHee CHuibHo paapeneHHbie, cnnbHosepHHCTbie, 3epHncTbie c nyabipqaTbiMH yronmeHHííMH,oTflenbHbie apTpocnopw. flnHHa γηΦοβ 50-200 μκγ, ny-3bipnaTbie yTonmeHHH 10 mkm.BoapacT 3 ρρχ. - οτηοοητβπβηο κοροτκκβ, cwibHo pasBeTBJteHHbie ΓΗ (> first Γκφω 6onee ηπη MeHee CHuibHo paapeneHHbie, cnnbHosepHHCTbie, 3epHncTbie c nyabipqaTbiMH yronmeHHííMH, oTflenbHbie apTpocnopw. FlnHHa γηΦοβ μκγ 50-200, NY-3bipnaTbie yTonmeHHH 10 mkm.
PnaBHaa KynbTypa NL 833:PnaBHaa KynbTypa NL 833:
BoapacT 7 flHeň - Mrajenna c ajihhhwmh', pasBeTBJíeHHWMHi γηΦβμη. CTeH-BoapacT 7 flHeň - Mrajenna c ajihhhwmh ', pasBeTBJíeHHWMHi γηΦβμη. CTeH-
Ka γηΦοβ HopMajibHaa, He ocoCeHHÓ BbiflejiHiomaaca,pa3fleJieHHaH,: ΓηΦμ "aepHHCTwe". iinasMa ueHTpajibHaH ηπη npHCTeHOMHaa.Ka γηΦοβ HopMajibHaa, He ocoCeHHÓ BbiflejiHiomaaca, pa3fleJieHHaH ,: ΓηΦμ "aepHHCTwe". iinasMa ueHTpajibHaH ηπη npHCTeHOMHaa.
Ilyswp.HaTbie yTonmeHHH name Bcero y kohijob γηΦοβ.OTAenbHhie cnopw/xnaMHflo-HnH apTpocnopw/, 0- γη-Φοβ: 5-7 mkm, <t> ny3bipMaTbtx yTonmeHHii: 8-10 mkm,Ilyswp.HaTbie yTonmeHHH name Bcero y kohijob γηΦοβ.OTAenbHhie cnopw / xnaMHflo-HnH apTpocnopw /, 0- γη-Φοβ: 5-7 mkm, <t> ny3bipMaTbtx yTonmeHHii: 8-10 mkm,
Bo3pacT l4 flHeň - MHpenna c απηηημμη, pasBeTBneHHWMH γηΦβμη, cHntb- ho pa3flejieHHbie. ILnaaMa peHTpanbHaH hjih npHCTeHOHHaH· & γηΦοβ: 5-7 mkmBo3pacT l4 flHen - MHpenna c απηηημμη, pasBeTBneHHWMH γηΦβμη, cHntb- ho pa3flejieHHbie. ILnaaMa peHTpanbHaH hjih npHCTeHOHHaH · & γηΦοβ: 5-7 mkm
IlysupnaTbie yTOjiqeHHH 8-12 mkm. OTAejibHbie apTpocnopbi.IlysupnaTbie yTOjiqeHHH 8-12 mkm. OTAejibHbie apTpocnopbi.
Mnnenna coflepatHT nHnHniibie KanjiH, flojia KOTopwx ocoóeHHo BbicoKa b KyjihTypax,oCpaaywniHX anKanoHflw. 1Mnnenna coflepatHT nHnHniibie KanjiH, flojia KOTopwx ocoóeHHo BbicoKa b KyjihTypax, oCpaaywniHX anKanoHflw. 1
KyjibTHBaiXHio npoBoflHHH npH 24íl°C. KyjibTypw HHKyCHpoBajiH Ha Kpyrnwx BCTpHXH-iBaranHxcH cTOjiax řípu 24.0 o6/mhh.KyjibTHBa1HiOnpoBoflHHH npH 24l ° C. KyjibTypw HHKyCHpoBajiH Ha Kpyrnwx BCTpHXH-iBaranHxcH cTOjiax ripple 24.0 o6 / mhh.
Uejiecoo6pa3HO npoBopHTb aapoOHyio φβρΜβΗτβμκιο rpnCKa ajih nponsBOflCTBa b jkha- khx nHTaTejibHbix cpeflax b noBepxHocTHoň h/hjih rny0HHHoň KyjibType. IlHTaTenbHwe cpepw coflepxcaT ycBoaeMbiň hctomhhk yrnepona, κβκ HanpHMep caxaposy, rnioKosy,Uejiecoo6pa3HO npoBopHTb aapoOHyio φβρΜβΗτβμκιο rpnCKa ajih nponsBOflCTBa b jkha- khx nHTaTejibHbix cpeflax b noBepxHocTHoň h / hjih rny0HHHon KyjibType. IlHTaTenbHwe cpepw coflepxcaT ycBoaeMbiň hctomhhk yrnepona, κβκ HanpHMep caxaposy, rnioKosy,
MaHHHT, COp0HT, ΓΠΗΙΙβρΗΗ, JIHMOHHyiO HJIH HHTapHy» KHCJIOTbl} yCBOHeMWft HCTOHHHK asoTa, xax HanpHMep 3μμηηκ,' . acnaparnH, πθπτοη, rHaponnaaT xaseHHa ηπη conn 258001 βμμοηηη, a TaKwe MHHepaAbHbie cojih, ΦερΜβΗτβΑΗΐο mojkho npoBOAHTb b xonOax4>epH6axa, EpneHMeňepa, nnocKOflOHHbix xon6ax hah b φβρΜβΗΤορβ.MaHHHT, COp0HT, ΓΠΗΙΙβρΗΗ, JIHMOHHyiO HJIH HHTapHy »KHCJIOTbl} yCBOHeMWft HCTOHHHK asoTa, xax HanpHMep 3μμηηκ, '. acnaparnH, πθπτοη, rHaponnaaT xaseHHa ηπη conn 258001 βμμοηηη, and TaKwe MHHepaAbHbie cojih, ΜερΜβΗτβΑΗΐο mykpo npoBOAHTb b xonOax4> epH6axa, EpneHMenepa, nnocKOflOHHbix xon6ax hah b φβρΜβΗΤορβ.
UenecooOpasHo npoBOAHTb φβρΜβΗτβΑΗΐο b ’οαηοΠ ao Tpex , CTyneHeň. Βμγοαηο ecAHnepBiPtHaH xynbTypa ΗΜββτ BO3pacT ot 4 po 14. ppeň, ň npHBHBOHHoe cooTHonteMuenepBHHHoň xyjibTypu: rjiaBHoft xynbTypbi ρβΒΗΗβτβπ 1:5 po 1:20, Γααβηηη xyjibTy-pa BbtaepxHBaeTca 7-20 AHeň. 3havenue pH Μοχβτ xojie6aTbc« Μβ»ΑΥ 4,0 h 6,2, aTeMnepaTypa Me»Ay 20 h 30°C. OnTHMaAbHoň ΗΒΑΗβτβΗ φβρΜβΗτβΑΗΗ npH 22-25°Ch pH » 5,2-5,9. A . UIthmm coxpaHHeTCH οΘμηηΜμ cnocoCoM c noMombio προβκροκ, ηπη xynbTHBaiXHH προτο-nnačTOB hah xpaHeHHGM npH hhskhx TeMnepaTypax επρΗΜβκβΗΗβΜ saotHTHbtx koaaoh-Aob, xax HanpHMep 60% pacTBopa caxaposbi: cHHToe moaoko 2:1. ΠρΗΜβρΜ OCymeCTBneHHft H3O6peTeHHH .UenecooOpasHo npoBOAHTb φβρΜβΗτβΑΗΐο b 'οαηοΠ and Tpex, CTyneHen. AHμγοαηο ecAHnepBiPtHaH xynbTypa ΗΜββτ BO3pacT ot 4 after 14.ppn, npHBHBOHHoe cooTHonteMuenepBHHHo xyjibTypu: rjiaBHoft xynbTypbi ρβΒΗΗβτβπ 1: 5 after 1:20, xααβηηη xyjibTy-pa BbtaepxHBaeTca 7-20 AHen. 3havenue pH Υοχβτ xojie6aTbc «»β» ΑΥ 4.0 h 6.2, aTeMnepaTypa Me »Ay 20 h 30 ° C. OnTHMaAbHoň ΗΒΑΗβτβΗ φβρΜβΗτβΑΗΗ npH 22-25 ° Ch pH »5.2-5.9. A. UIthmm coxpaHHeTCH οΘμηηΜμ cnocoCoM c noMombio προβκροκ, ηπη xynbTHBaiXHH προτο-nnačTOB hah xpaHeHHGM npH hhskhx TeMnepaTypax επρΗΜβκβΗΗβΜ saotHTHbtx koaaoh-Aob, xax HanpHMep 60% pacTBopa caxaposbi: cHHToe moaoko 2: 1. ΠρΗΜβρΜ OCymeCTBneHHft H3O6peTeHHH.
CoeffytoiQHe ηρΗΜβρω πρηβοαητch c nenbio ο6έηοηθηηη η3ο6ρθτθηηη.CoeffytoiQHe ηρΗΜβρω πρηβοαητch c nenbio ο6έηοηθηηη η3ο6ρθτθηηη.
KcnonbsoBaHHbie nHTaTenbHbie pacTBopu πρκΒβΑβΗΗ b τββπΗΑβ 1,KcnonbsoBaHHbie nHTaTenbHbie pacTBopu πρκΒβΑβΗΗ b τββπΗΑβ 1,
I ΠρΗΜβρ 1:I ΠρΗΜβρ 1:
Hcxoah H3 KOHcepBOB nrraMMa Clavícepe purpuřea (Fr.) Tul. IBP 74 aaceanH nep-BHHHbie xynbTypbi b 100 μπ cpeAbt NL 849 b nnocKOAOHHbix KonCax Ha 500 ma. Koa-6m BbiAepKHBanHCb 7 AHeň πρκ TeMnepaType 24+1°C h 240 o6/mhh. 10% ot nony-neHHbix xyjibTyp cnyxcHno aah τογο, Ητοβω aaceHTb κοπ6η Ha 500 ma c 100 ma cpe-AM NL 833 b xaKAoft· ílocne 14 ppeft HHKyOauHH npH onHcaHHbix ycnoBHHX KynbTypwcoAepatanH 1450 μκγ/μπ. anKanoHAa KynbTypHoro patíTBopa BbnneHaSBaHHoro cocTaBa.ΠρΗΜβρ 2:Hcxoah H3 KOHcepBOB nrraMMa Clamorepe purpura (Fr.) Tul. IBP 74 aaceanH non-BHHHbie xynbTypbi b 100 μπ cpeAbt NL 849 b nnocKOAOHHbix KonCax Ha 500 ma. Koa-6m BbiAepKHBanHCb 7 AHen πρκ TeMnepaType 24 + 1 ° C h 240 o6 / mhh. 10% ot nony-neHHbix xyjibType cnyxcHno aah τογο, Ητοβω aaceHTb κοπ6η Ha 500 m and c 100 m and cpe-AM NL 833 b xaKAoft · lloc 14 ppeft HHKyOauHH npH onHcaHHbix ycnoBHHX KynbTypwcoAepatanH 1450 μκγ / μπ. anKanoHAa KynbTypHoro patíTBopa BbnneHaSBaHHoro cocTaBa.ΠρΗΜβρ 2:
Hcxoah H3 HaaBaHHoň b npHMepe lt nepBHHHoň KynbTypbi b NL 849 aaceanH BTopyionepBHAHyio xyAbTypy b Ty κβ cpeAý. Η b stot paa npHBHBOHHoe cooTHomeHHe coc-TaBHAO 1:10. ΠοβΑβ 7 AHeň KynbTHBHpoBaHHH pasBOAKAH HHKySauHOHHbiň MaTepHanΗ ΠρΗΒΗΒ3ΑΗ ΑΠΗ HHKy6HpOBaHHH φβρΜβΗΤΟρβ C 2,0 A NL 833 B βΟΟΤΗΟΠΙβΗΗΗ 1:103THMH BTOpHHHblMH ΠρβΑΒβρΗΤβΑΒΗΗΜΗ KyAfcTypaMH.Hcxoah H3 HaaBaHHoň b npHMepe lt nepBHHHoon KynbTypbi b NL 849 aaceanH BTopyionepBHAHyio xyAbTypes b Ty κβ cpeAý. St b stot paa npHBHBOHHoe 1:10. ΠοβΑβ 7 AHen KynbTHBHpoBaHHH pasBOAKAH HHKySauHOHHbien MaTepHanΗ ΠρΗΒΗΒ3ΑΗ ΑΠΗ HHKy6HpOBaHHH φβρΜβΗΤΟρβ C 2,0 A NL 833 B βΟΟΤΗΟΠΙβΗΗΗ 1: 103THMH BTOpHHHblMH ΠρβΑΒβρΗΤβΑΒΗΗΜΗ KyAfcTypaMH.
TeMnepaTypa 24°CTeMnepaTyp 24 ° C
CxopocTb nepeMeuiHBaHHH: 280-450 o6/mhh., KoneSneTCH no pone npHpocTa. Ποτοκ BO3Ayxa: 0,2-0,65 a/mhh., b aaBHCHMocTH οτ παοτηοοτη.BMpocmeň MHAennbi. Ποοπβ 12 A«eň o6pa3OBanocb 900 μκγ oS^ero anKanoHAa Ha ma xynbTypHoro pacT-sopa. ΠρΗΜβρ 3: fljIH ΗΑβΉΤΗφΗΚβΑΗΗ aAKHAOHAOB ΠΟΑΠξβΛβΑΗΒβΙΟΤ 1 “5 MA ΠΗΤβΤβΑΒΗΟΓΟ paCTBOpa ΗτρΗ pasa SKCTparHpyioT χηοροφορΜΟΜ. 3κοτρβκτ BbicymHBawT, αο6ββπηιοτ Manoe Ko-AHuecTBO χποροφορΜΗ η ρ33ΑβΑΗΐοτ· c noMombio npenapaTHBHOň CAoňnoň xpoMaTofpa-|Φηη Ha cHAHKarene c φΑίοορβεηβΗΤΗΜΜΗ HHAHKaTopaMH. B xanecTBe cncTeMbi pacT-BopHTeneň ynoTpeSnnioT χηοροφορΜ: sthhoa (9:1). AnKanoHAHbie 3ohm CHHMaiOT cnAacTHHKH h npHHHMawTCH CMecbw boam:MeTaHOAa:AeAHHoň yxcycHoň khcaotm(45:45:10), ομθιπηβηκτ c peaxTHBOM βηη Ypxa b οοοτηοπιθηηη 2:4 h oSnyvawT'xBapAeBoň AaMnoň b TeneHHe 5 MHHyT, ΑβΗτρΗφνΓΗρνιοτ η οπρβΑβΑΗΐοτ skcthhkahw .B φΟΤΟΜβΤρβ, KOAHHeCTBO 3ΑΚ3ΛΟΗΑθΒ ΟΠρβΑβΑΗΙΟΤ ΠΟ KaAHČpOBOMHblM KpHBblM. H3napaAAeAbHbtx npo6 npenapaTHBHOň CAoňHoň χροΜβτοΓρβφΗΗ moucho οταθαβηο bmmm—BaTb npnnHcaHHbie aproTaMHHy hah sproTaMHHHHy 3OHbi h noAaBaTb· hx απη α^ΠΒ-Heňmeň ΗΑβΗΤΗφΗκβΑΗΗ. Οοο6θηηο ποαχοαητ: 258001 5CxopocTb nepeMeuiHBaHHH: 280-450 o6 / mhh. Ποτοκ BO3Ayxa: 0.2-0.65 a / mhh., AaBHCHMocTH οτ παοτηοοτη.BMpocmeň MHAennbi. Ποοπβ 12 A «e o6pa3OBanocb 900 μκγ oS ^ ero anKanoHAa Ha ma xynbTypHoro pacT-sopa. 3: fljIH ΗΑβΉΤΗφΗβΑΗΗ aAKHAOHAOB ΠΟΑΠξβΛβΑΗΒβΙΟΤ 1 “5 MA ΠΗΤβΤβΑΒΗΟΓΟ paCTBOpa ΗτρΗ pasa SKCTparHpyioT χηοροφορΜΟΜ. Κ η oe b oe oe oe oe oe oe oe oe oe oe oe oe oe oe oe oe oe oe oe oe oe oe oe oe oe oe oe oe oe oe oe oe oe oe oe oe oe oe oe oe B xanecTBe cncTeMbi pacT-BopHTenne ynoTpeSnnioT χηοροφορΜ: sthhoa (9: 1). AnKanoHAHbie 3ohm CHHMaiOT cnAacTHHKH h npHHHMawTCH CMecbw boam: MeTaHOAa: AeAHHoň yxcycHoň khcaotm (45:45:10) ομθιπηβηκτ c peaxTHBOM βηη Ypxa b οοοτηοπιθηηη 2: 4 h oSnyvawT'xBapAeBoň AaMnoň b TeneHHe 5 MHHyT, ΑβΗτρΗφνΓΗρνιοτ η οπρβΑβΑΗΐοτ skcthhkahw φΟΤΟΜβΤρβ .B. KOAHHeCTBO 3ΑΚ3ΛΟΗΑθΒ ΟΠρβΑβΑΗΙΟΤ ΠΟ KaAHČpOBOMHblM KpHBblM. H3napaAAeAbHbtx npo6 npenapaTHBHOň CAoňHoň χροΜβτοΓρβφΗΗ moucho οταθαβηο bmmm — BaTb npnnHcaHHbie aproTaMHHy hah sproTaMHHHHy 3OHbi h noAaBaTb · hx απη α ^ ΠΒ-Heňmen ΗΑβΗΤΗφΗκβΑΗΗ. 001οο6θηηο ποαχοαητ: 258001 5
Macc-cneicrpoMeTpHa (m)e: 581 (M+), 314, 296, 286, 271, 267, 244, 223, 221,215, 180, 167, 153, 131, 125, ΪΦ-, HK- h ΗΜΡ-αιεκτροεκοηΗΗ, χροΜβτοΓρβφκ-uecKHe MeTOAbi, a Taxxe KHCJibiň rHflpojiHs h AOxasaTenbCTBO xapaxTepHUX hmhho-KHCJIOT “ npOJIHH Η (fceHHJiajiaHHH . řípu meJIOMHOM ΓΗΑΡΟΠΗ3β MOXHO flOKa3aTb ΗβΛΗ-ΗΗβ JIHSeprHHOBOft KHCJIOTbl (H9 SprOTaMHHa) ΚΠΗ H3OJIH9eprHHOBOft KHCJIOTbl («3Maccne-cicMpoTpHa (m) e: 581 (M < + >), 314, 296, 286, 271, 267, 244, 223, 221, 215, 180, 167, 153, 131, 125, < - > -uecKHe MeTOAbi and taxxi KHCJibiň rHflpojiHs h AOxasaTenbCTBO xapaxTepHUX hmhho-KHCJIOT "npOJIHH Η (fceHHJiajiaHHH. Rip meJIOMHOM ΓΗΑΡΟΠΗ3β Moxhe flOKa3aTb ΗβΛΗ-ΗΗβ JIHSeprHHOBOft KHCJIOTbl (H9 SprOTaMHHa) ΚΠΗ H3OJIH9eprHHOBOft KHCJIOTbl (« 3
SprOTaMHHHBia) .SprOTaMHHHBia).
Ta0jinqa 1: Coctsb HCnonbsyeMMX πκτβτβπΒΗΜΧ cpejn (tfaHHbie b γ/λ) - ----η. NL 849 | NL 720 j NL 833 | NL 126 | NL 829 Caxaposa 300,0 200,0 300,0 100,0 CHHTOe MOJI OK o 100 mji - * - - nHBHoe cycno i - - - 150 Mn - AHTpaT aMMOHHB 10,0 15,0 20,0 1,0 acnapariiH - - 10,0 . ΑΡΟΧΧβΒΟΑ BKCTp. - - 5,0 0,5 Ca(NO,)2 - i,o 1*0 - 1,0 KH,PO4 0,25 0,25 0,25 - 0,25 (ΝΗ4),ΗΡ0+ i - - - 5,0 - MgSO4·7H,0 , 0,8 0,3 0,3 0,25 FeSO4-7H2O 0,01 0,01 - 0,02 ZnS04.7H.,0 •M 0,0308 0,0308 - 0,02 KC1 0,1 - - flHCT. BO«a Pfi 1 ji 1 n 1 JI 1 ji 1 Ji arap-arap - - - 30,0 30,0 pH nepea cTepHJiHsaijKeft 5,4 5,8-6,0 5,4 6,0 5,4 ··. ycTaHOBxa pH c nOMombw NaOH NaOH NaOH NaOH NaOH - aBTOKjiaBupoBaHHe Anta Bcex cpefl 30 MHHyt ttpH 110"C Ta&nmja4 1: Coctqb HcnonbsyeMbix nHTaTejibHbix cpen (aarnibie b r «a ji) ___________________] NL0** | NL | NLM | Ní?16 | NL**5Ta0jinqa 1: Coctsb HCnonbsyeMMX πκτβτβπΒΗΜΧ cpejn (tfaHHbie b γ / λ) - ---- η. NL 849 | NL 720 j NL 833 | NL 126 | NL 829 Caxaposa 300.0 200.0 300.0 100.0 CHHTOe MY OK o 100 mji - * - - nHBHoe cycno i - - - 150 Mn - AHTpaT aMMOHHB 10.0 15.0 20.0 1.0 acnapariiH - - 10.0. ΑΡΟΧΧβΒΟΑ BKCTp. - - 0,5 0,5 Ca (NO) 2 - i, o 1 * 0 - 1,0 KH, PO4 0,25 0,25 0,25 - 0,25 (ΝΗ4), ΗΡ0 + i - - - 5.0 - MgSO4 · 7H, 0, 0.8 0.3 0.3 0.25 FeSO4-7H2O 0.01 0.01 - 0.02 ZnS04.7H .0 • M 0.0308 0.0308 - 0.02 KC1 0.1 - - flHCT. BO «a Pfi 1 ji 1 n 1 JI 1 ji 1 Ji arap-arap - - - 30.0 30.0 pH nepea cTepHJiHsaijKeft 5.4 5.8-6.0 5.4 6.0 5.4 ·· . ycTaHOBxa pH c nOMombw NaOH NaOH NaOH NaOH NaOH - aBTOKjiaBupoBaHHe Anta Bcex cpefl 30 MHHyt ttpH 110 "C Ta & nmja4 1: Coctqb HcnonbsyeMbix nHTaTejibHbix cpen (aarnibie br« and her) ___________________] NL0 ** | NL | NL ** 5
Caxaposa 300,0 200,0 300,0 - 100,1 CHíITOe MOJIOKO 100 mji · - - , - nHBHoe cyeno - - - 150 mji - HHTpaT 8MMOHHH 10,0 15,0 20,0 1,0 - acnaparuH - «Μ ! - - - 10,0 Apoxxesoň 3KCTp. - • i. - · ' 5,0 0,5 HHTpaT KaJIbHHH - 1,0 1,0 - 1,0 ΑΗΓΗβρΟΓβΗφοέφβΤ KaJIHH 0,25 0,25 0,25 - ,· 0,25 ΓΗΑρΟΓΘΗφοεφβΤ aMMOHHH - - - 5,0 ΟΤΠΒφβΤ ΜΒΓΗΗΗ (7 HiP) 0,8' . 0,3 0,3 a» 0,25 ογ/ΐΒφβτ xenesa (7 Η-χΟ) - 0,01 0,01 - 0,02 ογπΒφβτ uHHxa (7 H^O) - 0,0308 0,0308 - 0,02 ΧΠΟΡΗΑ KQJIHH _ - 0,1 - - - AHCT. BOfla flO 1 ji 1 ji 1 ji 1 ji 1 ji arap-arap - 30,0 30,0 pH nepefl cTepHJiHsauHefl 5, V 5,8-6,0 5,4 6,0 5,4 ycraHOBKa pH C ΠΟΜΟΠφΙΟ ΗβΤρΗβΒΟΟ ntanotiH» aBTOKJiaBHpoBaHHe AJiH Bcex cpefl 30 mhh npH 110 C 258001Caxaposa 300,0 200,0 300,0 - 100,1 CHÍITOe MOJIOKO 100 mji · - -, - nHBHoe cyeno - - - 150 mji - HHTpaT 8MMOHHH 10,0 15,0 20,0 1,0 - acnaparuH - «Μ ! - - - 10.0 Apoxxesoň 3KCTp. - • i. - · 5.0 5.0 HHTpaT KaJIbHHH - 1.0 1.0 - 1.0 ΑΗΓΗβρΟΓβΗφοέφβΤ KaJIHH 0.25 0.25 0.25 -, · 0.25 ΓΗΑρΟΓΘΗφοεφβΤ aMMOHHH - - - 5, 0 ΟΤΠΒφβΤ ΜΒΓΗΗΗ (7 HiP) 0.8.. 0.3 0.3 and 0.25 ογ / ΐΒφβτ xenesa (7 Η-χΟ) - 0.01 0.01 - 0.02 ογπΒφβτ uHHxa (7 H ^ O) - 0.0308 0.0308 - 0, 02 QΠΟΡΗΑ KQJIHH _ - 0,1 - - - AHCT. BOfla flO 1 ji 1 ji 1 ji 1 ji 1 ji arap-arap - 30.0 30.0 pH nepefl cTepHJiHsauHefl 5, V 5.8-6.0 5.4 6.0 5.4 ycraHOBKa pH C ΠΟΜΟΠφΙΟ ΗβΤρΗβΒΟΟ ntanotiH »ABTOKJiaBHpoBaHHe AJiH Bcex cpefl 30 mhh npH 110 C 258001
(PopMyjia HsoCpeTeHHH 1. Cnoco6 npoHSBOflcTBa aproTaMHHa, oTJiHwaionmňCH τβΜ, ντο nrraMM Clavicepspurpurea (Fr.) Tul. IBP 74, IMET PA 135, ero. MyTaHTbi h BapnaiiTbi, KynbTM-BHpywT nyTeM aapotitioft φβρΜεΗτβηΗΗ b «ηηκοή nHTaTenbHoft cpene, κοτορεπcoflep»ijT ycBOBeMbiň hctovhhk ymepofla, a3OTa h MHHepajibHbix coneň, b no- , BepxHocTHoň h/hjih rnyOHHHoft KynbType npw TeMnepaType 20-30°C κ SHaveHHHpH 4,0 flo 6,2 b τβΜβΗΗβ οτ 7 no 35 flHefl h oCpaaoBaHHbiň sproTaMHH/aproTa-MHHHH HBOJIHpyeTCH H3 nHTaTeJIbHOft CpenbI HSBeCTHblM nyTeM. 2. Cnocoč no nynKTy 1, OTjiinawmHňcH τβΜ, ντο φβρΜεΗτβιχΗΗ npoBOflHTCH npn(PopMyjia HsoCpeTeHHH first Cnoco6 npoHSBOflcTBa aproTaMHHa, oTJiHwaionmňCH τβΜ, ντο nrraMM Clavicepspurpurea (Fr.) Tul. IBP 74 IMET PA 135 ero. MyTaHTbi h BapnaiiTbi, KynbTM-BHpywT rivet aapotitioft φβρΜεΗτβηΗΗ b «ηηκοή nHTaTenbHoft cPen, κοτορεπcoflep» IJT ycBOBeMbiň hctovhhk ymepofla, a3OTa hHhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhHhHhHhHhHhHhhhhHeHHHeHHeHHeHHeHHHHHHHHHHHHHHHHHHHHH nHTaTeJIbHOft CpenbI HSBeCTHblM nyTeM 2. Cnocočn nynKTy 1, OTjiinawmHňcH τβΜ, ντο φβρΜεΗτβιχΗΗ npoBOflHTCH npn
TeMnepaType 22 n° 25°C h 3HaveHHH pH ot 5,2 po 5,9, AHHOTAfflgTeMnepaType 22 n ° 25 ° C h 3 HaveHHH pH ot 5.2 to 5.9, AHHOTAfflg
OnucbiBaeTCB nonyneHne ajiKanonna sproTaMHHa c noMombio nrraMMa Claviceps purpu-rea (Fr.) Tul, IBP 74, IMET PA 135, ero MyTaHTOB h BapnaHTOB, 3tot HOBbiň mTaMM oSpaayeT CMecb ajiKanonflOB ot 900-1500 μκγ Ha μπ ηκτβτβΠΒΗΟ-ro pacTBopa, οτ κοτοροή no κρβήΗβή Mepe 50? ajiKanonflOB BbiTpaxHBaeMbi opraHH-VeCKHMH paCTBOpHTeJIHMH. Πομημο 3proTaMMHa ηπη ero HáOMepa sproTaMHHHHa (BMecTe 6ojiee 75-80? nonyvae-μογο ajiKanoHffa) oOpaayioTCH h xaHOKJiaBHH (10-15?), sproMeTpHH (5-6?), apro-3HH (cneflM - MHKCHMyM 4?), aprOKpHnTHH (5?), ΠΡΗ cnyvae H npyrtie ΚΠβΒΗΗΜ BoveHb Manbix KOJiHnecTBax (cnenw). B nHTaTenbHoň cpene HaxoflHTCH H JiHaeprHHO-ΒβΗ KHCJIOTa,Claviceps purpu-rea (Fr.) Tul, IBP 74, IMET PA 135, ero MyTaHTOB h BapnaHTOB, 3t HOBbI mTaMM oSpaayeT CMecb ajiKanonflOB ot 900-1500 μ μγ Ha κρβήκβή Mepe 50? ajiKanonflOB BbiTpaxHBaeMbi opraHH-VeCKHMH paCTBOpHTeJIHMH. Πομημο 3proTaMMHa ηπη ero HáOMepa sproTaMHHHHa (BMecTe 6ojiee 75-80? Nonyvae-μογο ajiKanoHffa) oOpaayioTCH h xaHOKJiaBHH (10-15?), SproMeTpHH (5-6?); ?), ΠΡΗ cnyvae H npyrtie ΚΠβΒΗΗΜ BoveHb Manbix KOJiHnecTBax (cnenw). B nHTaTenbHoň cpene HaxoflHTCH H JiHaeprHHO-ΒβΗ KHCJIOTa,
UlTaMM KyjibTHBHpyeTCH πγτβΜ aapoOHoň φβρΜβΗΤβηΗΗ B χπηκΗΧ HHTaTejibHbix cpe-nax, KOTopue coflepacaT ycBoneMbie hctovhhkh yrnepona, a3OTa h MHHepajibHbút co-jieň, b ríiyCHHHbix η/ηπη ποβθρχηοοτημχ KyjibTypax npn TeMnepaType ot 20-30°C haHaneHHH pH - ot 4,0 po 6,2 b TeveHHe 7-35 ffHeň.UlTaMM KyjibTHBHpyeTCH πγτβΜ aapoOHoň φβρΜβΗΤβηΗΗ B χπηκΗΧ HHTaTejibHbix CPE nax, KOTopue coflepacaT ycBoneMbie hctovhhkh yrnepona, a3OTa h MHHepajibHbút co-Jien b ríiyCHHHbix η / ηπη ποβθρχηοοτημχ KyjibTypax npn TeMnepaType ot 20-30 ° C haHaneHHH pH - 4.0 rpm at 6, 2 b TeveHHe 7-35 ffHene.
Bonee 95? oCpaayeMbix ajiKanoiwoB BbinejiHioTcn b nHTaTejibHyio cpeny, H3 κοτοροήohh nerKO HSonnpyioTCH. IIpnaHaHo Η3θ6ρβτβΗΗβΜ no peaynbTaTaM 3KcnepTH3bi, ocymecTBnéHHoň BenoMCTBOMno nenaM Η3θβρβτβΗΗή η πβτβπτοΒ TflP. 258001Bonee 95? oCpaayeMbix ajiKanoiwoB BbinejiHioTcn b nHTaTejibHyio cpeny, H3 κοτοροήohh nerKO HSonnpyioTCH. IIpnaHaHo Η3θ6ρβτβΗΗβΜ no peaynbTaTaM 3KcnepTH3bi, ocymecTBnéHHoBenoMCTBOMno nenM Η3θβρβτβΗΗή η πβτβπτοΒ TflP. 258001
Claims (2)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DD21723579A DD234172A3 (en) | 1979-07-16 | 1979-07-16 | PROCESS FOR THE PREPARATION OF ERGOTAMINE |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CS258001B1 true CS258001B1 (en) | 1988-07-15 |
Family
ID=5521316
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CS794080A CS258001B1 (en) | 1979-07-16 | 1980-11-20 | Method of ergotamine production |
Country Status (2)
| Country | Link |
|---|---|
| CS (1) | CS258001B1 (en) |
| DD (1) | DD234172A3 (en) |
-
1979
- 1979-07-16 DD DD21723579A patent/DD234172A3/en unknown
-
1980
- 1980-11-20 CS CS794080A patent/CS258001B1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DD234172A3 (en) | 1986-03-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GB1428793A (en) | Cephalosporins | |
| ES426272A1 (en) | Preparation of cephalosporin compounds | |
| GB1298017A (en) | New phenoxy-hydroxypropylamines and their preparation | |
| GB1490634A (en) | 7-amino-cephem compounds | |
| FR2469281A1 (en) | PROCESS FOR PRODUCING A DECORATIVE LAMINATE PRODUCT HAVING A COLORED PATTERN COINCIDING WITH A RELIEF PATTERN | |
| CA1113872A (en) | ANTIBIOTICS AND DERIVATIVES THEREOF HAVING .beta.-LACTAMASE INHIBITORY ACTIVITY AND PRODUCTION THEREOF | |
| Ajl et al. | Enzymatic fixation of carbon dioxide in α-ketoglutaric acid | |
| Anders | Effect of phenobarbital and 3-methylcholanthrene administration on the in vitro enhancement of microsomal aromatic hydroxylation | |
| US4346041A (en) | Composition and process | |
| EP0462833A3 (en) | Process for the preparation of ascorbic acid-2-phosphate | |
| US3116216A (en) | Production of cephalosporin c by fermentation | |
| GB1457726A (en) | Process for the production of cephamycin type antibiotic substances | |
| US5182206A (en) | Pyrimine-producing bacteria | |
| Pai et al. | Production of aflatoxin M in a liquid medium | |
| US2943023A (en) | Production of spiramycin | |
| US5108924A (en) | Pyrimine-producing bacteria | |
| US3795583A (en) | Process for preparing l-serine | |
| GB1434757A (en) | Method and composition for the control of fertility | |
| USD87574S (en) | Herbert b | |
| USD100485S (en) | Design fob a trailer or | |
| GB1455740A (en) | Benzylpyrimidine derivatives | |
| GB191110635A (en) | Improvements in the Manufacture and Production of Deep Black Water-soluble Colouring Matters from Nigrosines and from Indulines. | |
| GB426982A (en) | Improvements relating to road vehicle wheels | |
| ES406861A1 (en) | Azetitin-2-ores and process for preparing same | |
| USD54366S (en) | Edgar h |