CS264016B1 - Způsob výroby N-oxadiethylenbenzoth5.azolyl-2-sulfonamidu - Google Patents
Způsob výroby N-oxadiethylenbenzoth5.azolyl-2-sulfonamidu Download PDFInfo
- Publication number
- CS264016B1 CS264016B1 CS843719A CS371984A CS264016B1 CS 264016 B1 CS264016 B1 CS 264016B1 CS 843719 A CS843719 A CS 843719A CS 371984 A CS371984 A CS 371984A CS 264016 B1 CS264016 B1 CS 264016B1
- Authority
- CS
- Czechoslovakia
- Prior art keywords
- preparation
- morpholine
- oxadiethylene
- benzothiazol
- sulfonamide
- Prior art date
Links
Landscapes
- Crystals, And After-Treatments Of Crystals (AREA)
Abstract
Způsob výroby N-oxadiethylenbenzothiazolyl-2-sulfenamidu spočívá ve vzájemném působení 2-merkaptobenzothiazolu s morfolinem, použitým v přebytku za přítomnosti peroxidu vodíku. Frooes probíhá za přidávání peroxidu vodíku v morfolinu k smési 2-merkaptobenzothiazolu a morfolinu.
Description
1 264016 ΟΠΗΟΑΗΗΕ Η3ΟΒΡΕΤΕΗΗΉ K ABTOPCKOMY CBHflETEJIbCTBY3aHBJieHo: 09.01.783anBKa Ν’ 2565916/23-04MKHZ C 07 D 277/80, C 08 I 3/24
Abtopm: Π,Α.Πηρογοβ, P.A.AicjypHHa, P.C.JIeBHHa, B.H.ropčyHOB, B.H.IIapaMOHOB,C.K),Ch30b, B.r.UlKonbHbiň, C.A.Ahoumh, Η.Π.ΥτροΒηη, C.B.CyxaHOB,B.K.Pmkob í 3aHBHTejib! aBTopbi .
Haasaime Η3θ6ρετβΗΗ«: OTOCOB nOJIY3EHHJI!N-OKCAflH3TEnEHBEH3THA30JfflJI-2-CyjIb-ΦΕΗΛΜΗβΑ. H3o6peTeHne othochtch k cnocoGy nonyqeHHH N-oKcaflH9THneH0eH3THa3anHJi-2- icynM>eHaMima (cyni4>eHaMHfla Μ) , κοτορΜή Hcno«b3yioT b XHMHnecKoň npoMumneHHoe-íth B xanecTBe ycKopHTena BynKaHHsartHH KayqyxoB 06mero HasHaqeHHH. ; H3BecTeH cnocoS nanyqeHHH cyjib$enaMHfla M, aaKnioqaraiiiHňcH b tom, ίτο CMecb J2-MepKanTo6eH3THa3ona vt ΜορφοπΗΗε noflBepraioT BgaHMoneňcŤBHio c οκκοπΗτεπεΜ brtjpHcyTCTBHH BOflbí £lj. B KanecTse OKHCJiHTeneft HcnoJibsyeTCH xuop, SpoM, ňoflηπη γηποχπορη« mejioHHoro: MeTanna. OKMCJieHHe προβοαητ npH TeMnepaType 25-40 C;B TeHeHHe 10-20 MHHyT. GOQTHODieHHe 2-ΜβρΚΒΠΤθ6βΗ3ΤΗ33ΟΠ í μορΦοπηη paBHO1:(8-10). Bbixoň 94-96%. T.nji. 85°C.
Cnoco6 xapaKTepH3yeTca Hcnonb3OBaHHeM b npouecce ranoreHa, TpyqHOCTHMHpereHepanHH η30μτοηηογο Μορφοπηκη BBuny nonyqeHHfl Ďaňbůůfó KOJiHnecTBa MHHe-panbHbix ccwieň, U6iibio M3o6peTeHHH HanaeTCfl ynpomeHHe τθχηοπογηη nonyneHHH cyju4*eHeMHAa Mh ynymneHne xanecTBa npoflyKTa. llocTaBJíeHHaa nenb flocTHraeTcn cnoco0OM, saKnioqaioiqHMcn b tom, ίτο CMecb2-MepKanTo6eH3THa3ona c μορΦοπηηομ o6pa6araBaioT nepeKHCbio BOflopoaa B Μορφο-jiHite.
Ecjih nepeKHCb BOflOpcwa «oĎaBjíHTb κ cMecH. 2-MepKanŤo0eH3Tna3ona η Μορφο-jiHHa 6e3 npemBapHTanbHoro cMenieHHH ee c μορΦοπηηομ, το neneeoň προηγκτ no·» - 2 - 264016 nynaeTcn c hh3khm BbixonoM (70%, T.nn. 83-84°C). IIpoBefleHHe peaKUHH nepe3npoflyKT B3anMOfleňcTBHH ΜορφοπΗΗβ c nepeKHCbio Boflopofla HCKnranaeT pa# noóon-Hbix peaKujíň, b pe3ynbTaTe uero noBbímaeTCH Bbixofl nponyKTa h ynynmaeTCfl eroKanecTBo (βμχοα 90-94%, T.nn. 86-87°C).
Jlnn npoBefleHHH peaKUHH 2-MepKanTo6eH3THa3on pacTBopnioT b ΜορφοπκΗε (co-OTHomeHHe 2-MepKanTo6eH3THa3on: μορΦοπηη 1:5,6) h floSaBJíaioT κ nonyneHHOMypacTBopy CMecb ΜορφαπΗΗβ h nepeKHCH Bonopona (cooTHomeHHe μορΦοπηη:nepeKHCbBOflopofla 1:(2,7-4) β TeneHHe 5-7 MHHyT, ΜορΦοπηη peraHepHpyioT c bhxqhom 95% Ha kqjiohhb c 3aTonneHHOH HacanKoňb τόκε yrjieKHcnoTbi, KOTopan nHpKynHpyeT b 33MKHyTOM utHicne. ΠρΗΜερ 1. B Tpexropnyio Kon6y εΜκοετωο 350 μπ, cHa6aceHHyio MenianKoň η τερΜΟΜετροΜ,3arpywaioT 20 r (0,12 γ-μοπ) 2-MepKanTO&eH3Tna3OJia h 60 μπ (0,68 γ-μοπ) Mop-φΟΠΗΗε, CMGCb Η3ΓρεΒ3Κ)Τ flO 60°C H BblflGpjKHBaiOT XipH 3TOÍI TGMnepaTypG 10 MHH.IlanyHGHHbiň pacTBop oxnaatflaioT no 20°C η noSaBnnioT CMecb 60 μπ (0,68 γ-μοπ)ΜορφοπΗΗ3 η 15 μπ (0,168 γ~μοπ) nepeKHCH Bonopo,n;a β TeneHHe 5 MHHyT. TeMne-paTypa b peaKHjiOHHofí CMecH noflHHMaeTcn no 75-80°C. IIonynatoT 28,4 r εγπκφεΗ-aMuna M (Bbixofl 94%, cnHTan Ha 2-MepKanTo6eH3THa3on) c T.nn, 87°C. flnn BbmeneHHn cyni^eHaMMna M hs μορΦοπηηοβογο pacTBOpa κ nocnenneMy β τε-qeiffle 10 MHHyT npn TeMnepaType 20-25°C πρΗβεΒππιοτ sony b KónHnecTse, paBHOMKonHnecTBy ΜορφοπΗΗε, κοτοροε ocTaeTcn b peaKnHOHHoft Macce nocne okohhhhhhpeaKUHH oKHcneHHH. IIpnyneHHyio cycneH3Hio οτΦηπβτροβμβηιοτ, npoMbroaioT no pH « = 9 h cyinaT npn t° = 50°C. ΠρΗΜβρ 2. B Tpexropnyro Kon6y, cnaSacenHyro MenianKoň η τερΜΟΜβτροΜ, 3arpyxcaroT 20 r(0,12 γ-μοπ) 2-MepKanTo6eH3Tna3ona h 60 μπ (0,68 γ-μοπ) ΜορφοπΗΗβ, CMecbHarpeBaioT no TeMnepaTypw 60°C h BbtfjepjKHBaioT npn stoh TeMnepaType 10 MHHyT.nonyqenHbiH pacTBop oxnaacnaroT no ,20°C η ηοδβΒΠπιοτ CMecb 40 μπ (0,456 γ/μοπ)ΜθρφθΠΗΗ3 Η 15 ΜΠ (0,168 Γ~ΜΟπ) nepeKHCH BOflOpOfla Β ΤεΠεΗΗΘ 7 MHHyT. Ilony-naioT 27,2 r ογπΒφ6Η3ΜΗη& M, (Bbixon 90%, cnHTan Ha 2-MepKanTo6eH3raa3on),T.nn. 86°C. IIpoflyKT Bb^ennioT, iok onncaHO b npHMepe 1.
HacToaiUHH cnocoč πο3Βοπηθτ οΦορμητβ nponecc b HenpepbiBHOM BapHaHTe, o6ec-nenHBaeT nonyneHHe neneBoro nponyKTa βμοοκογο KanecTBa 0e3 ηοποπΗΗτεπΒΗΟΗohhctkh (T.nn. 86-87°C).
. ΦΟΡΜΥΠΑ H30BPETEHHH
Cnocóó nonyneHHn N-oKcanH3THneH6eH3THa3onHn-2-cyn^eHaMnna B3anMoneňcTBH-fteM 2-MepKanTo6eH3THa3ona c μορΦοπηηομ, β3ητημ β η36ητκθ, β npHcyTcTBHH okhc-πΗτεππ, OTJiHHa»HHftca τβΜ, πτο, c nenbro ynpomenHn τθχηοπογηη ηynynmeHHH KanecTsa nponyKTa, b xanecTBe οκκοπΗτεπη Hcncnb3yioT nepeKHCb bo-ňopofla h nponecc BenyT nyTeM noBaBneHHn nepeKHCH Bonopona β μορΦοηηηθ κ CMe-ch 2-MepKanTo6eH3THa3ona η μορΦοπηϊιη. UCTOHHHKH ΗΗφορΜΗΙξΗΗ, npHHHTbie BO BHHM3HHe ΠρΗ 3KCnepTH3e: 1. ΠβτεΗτ CIHA ...3600398, κπ. 260-306, ony6n. 1971.
P E Φ E P A T
CnOCOB nOJIYHEHHH N-0KCAíai3WinEHBEH3THA30JBtlI-2-CyJII4>EHAMHflA
Cnoco6 nonyneHHH. Ν-0Κ03ηΗ3ΤΗΠβΗ6εΗ3ΤΗ330ΠΗΠ-2-0νΠΒφβΗ3ΜΗη3 3aKnionaeTCH BOB3aHMoneHCTBHH 2~MepKanTo6eH3THa3ona c μορΦοπηηομ, Β3ητημ β H36biTKe β npH-cyTcTBHH nepeKHCH Bonopona. nponecc προΒοηπτ πρη noČaBneHHH nepeKHCH BOflopo-na η ΜορφοπΗΗβ η CMecH 2-MepKanTo6eH3THa3ona η μορΦοπηιμ. - 3 - 264016 ΠρΗ3ΗδΗο Η3ο6ρβτβΗΗβΜ no pesynbTaTaM 3KcnepTH3bi, ocymecTBjíeHHOň FocynapcT-
BeaiWM ΚοΜΗτετοΜ CCCE no flenaM Η30θρβτβΗΗ& η οτκρωτΗβ, ,
Claims (1)
- 264016 - 4 - PŘEDMĚT VYNÁLEZU Způsob výroby N-oxadiethylenbenzothlazolyl^--sulfenamidu reakcí 2-merkaptobenzothlazolu s morfo-línem, použitým v přebytku, za přítomnosti okysličo-vadla, vyznačujíoí se tím, že jako okysllčovadlo sepoužívá peroxid vodíku a reakce se provádí přidávánímperoxidu vodíku v morfolinu do směsi 2-merkaptobenzo-thiazolu a morfolinu.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CS843719A CS264016B1 (cs) | 1984-05-18 | 1984-05-18 | Způsob výroby N-oxadiethylenbenzoth5.azolyl-2-sulfonamidu |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CS843719A CS264016B1 (cs) | 1984-05-18 | 1984-05-18 | Způsob výroby N-oxadiethylenbenzoth5.azolyl-2-sulfonamidu |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CS371984A1 CS371984A1 (en) | 1987-03-12 |
| CS264016B1 true CS264016B1 (cs) | 1989-05-12 |
Family
ID=5378075
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CS843719A CS264016B1 (cs) | 1984-05-18 | 1984-05-18 | Způsob výroby N-oxadiethylenbenzoth5.azolyl-2-sulfonamidu |
Country Status (1)
| Country | Link |
|---|---|
| CS (1) | CS264016B1 (cs) |
-
1984
- 1984-05-18 CS CS843719A patent/CS264016B1/cs unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CS371984A1 (en) | 1987-03-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR850004440A (ko) | 구급시(救急時)의 산소발생방법 | |
| KR850008661A (ko) | 개량된 산화촉매 | |
| ES8503015A1 (es) | Una composicion de organopolisiloxano vulcanizable a la temperatura ambiente. | |
| ATE198214T1 (de) | Polyvinylalkohol-kompositionen | |
| DE3477494D1 (en) | Process for measuring activity of dehydrogenase | |
| ES437541A1 (es) | Procedimiento para la obtencion de composiciones formadoras de espuma. | |
| GB1491560A (en) | Reagent composition and method for determination of glycerol concentrations | |
| ATE69T1 (de) | Verfahren zur herstellung von stereoisomeren n-aralkyl-2,6-dimethylmorpholinen. | |
| JPS5745131A (en) | Manufacture of beta-oxybutyric acid and oligocondensate thereof | |
| CS264016B1 (cs) | Způsob výroby N-oxadiethylenbenzoth5.azolyl-2-sulfonamidu | |
| DE59205154D1 (de) | Verfahren zur Herstellung von Huminaten | |
| ES461389A1 (es) | Un procedimiento para preparar una sal por adicion de acido metanosulfonico. | |
| ATE3027T1 (de) | Verfahren zur hydroxylierung von kuerzerkettigen aliphatischen mono- oder diolefinen. | |
| DK162654C (da) | Fremgangsmaade til fremstilling af kul-vand-blandinger | |
| ATE60092T1 (de) | Verfahren zur herstellung von kaliumnitrat. | |
| DE50100315D1 (de) | Verfahren zur Herstellung von 2,3,5-Trimethyl-p-benzochinon | |
| JPS5626197A (en) | Preparation of l-phenylalanine | |
| JPS5764660A (en) | N-hydroxysulfoalkylaminine derivative and its application | |
| KR790000143B1 (en) | Method for preparation of cyanophenyl carbonate | |
| ATE70269T1 (de) | Verfahren zur herstellung von 2-carboxypyrazin-4- oxiden. | |
| JPS5764683A (en) | 2-(substituted phenyl)-5-alkylthiazolidin-4-one and remedy for pepticulcer containing said compound as active component | |
| JPS5239636A (en) | Synthetic process of dihydrocoenzyme q group compound | |
| DK146181C (da) | Fremgangsmaade til fremstilling af 4-amino-5-chlor-1-phenyl-pyridazon-6 | |
| JPS55122750A (en) | Production of aminonitrile | |
| KR920000700A (ko) | L-n-(1-메틸-2-아세틸-비닐)-아스파트산의 제조방법 |