CS269196B1 - Biokompatibilný kolagénový materiál a spôsob Jeho přípravy - Google Patents

Biokompatibilný kolagénový materiál a spôsob Jeho přípravy Download PDF

Info

Publication number: CS269196B1
Authority: CS; Czechoslovakia
Prior art keywords: collagen; water; collagen material; mass; gel
Prior art date: 1988-05-11

Application number

CS883168A

Other languages

Czech (cs)

English (en)

Other versions

CS316888A1 (en

Inventor

Antonin Ing Csc Galatik

Karel Doc Mudr Csc Kubena

Anton Akademik Blazej

Original Assignee

Galatik Antonin

Kubena Karel

Blazej Anton

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-05-11

Filing date

1988-05-11

Publication date

1990-04-11

1988-05-11 Application filed by Galatik Antonin, Kubena Karel, Blazej Anton filed Critical Galatik Antonin

1988-05-11 Priority to CS883168A priority Critical patent/CS269196B1/sk

1989-09-12 Publication of CS316888A1 publication Critical patent/CS316888A1/cs

1990-04-11 Publication of CS269196B1 publication Critical patent/CS269196B1/sk

Links

239000000463 material Substances 0.000 title claims description 30
238000000034 method Methods 0.000 title claims description 10
238000002360 preparation method Methods 0.000 title claims description 10
229920001436 collagen Polymers 0.000 claims description 77
102000008186 Collagen Human genes 0.000 claims description 76
108010035532 Collagen Proteins 0.000 claims description 76
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 33
CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims description 8
239000002253 acid Substances 0.000 claims description 8
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 7
239000006260 foam Substances 0.000 claims description 7
NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 claims description 6
238000007710 freezing Methods 0.000 claims description 6
230000008014 freezing Effects 0.000 claims description 6
238000004519 manufacturing process Methods 0.000 claims description 6
102000004196 processed proteins & peptides Human genes 0.000 claims description 6
108090000765 processed proteins & peptides Proteins 0.000 claims description 6
AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical class [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 claims description 5
239000007788 liquid Substances 0.000 claims description 5
239000000126 substance Substances 0.000 claims description 5
239000011230 binding agent Substances 0.000 claims description 4
239000001569 carbon dioxide Substances 0.000 claims description 4
229910002092 carbon dioxide Inorganic materials 0.000 claims description 4
229920001184 polypeptide Polymers 0.000 claims description 4
-1 propionase Proteins 0.000 claims description 4
239000011780 sodium chloride Substances 0.000 claims description 4
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 3
108090000631 Trypsin Proteins 0.000 claims description 3
102000004142 Trypsin Human genes 0.000 claims description 3
235000019270 ammonium chloride Nutrition 0.000 claims description 3
239000007864 aqueous solution Substances 0.000 claims description 3
230000015572 biosynthetic process Effects 0.000 claims description 3
239000011575 calcium Substances 0.000 claims description 3
229910052791 calcium Inorganic materials 0.000 claims description 3
230000003366 colagenolytic effect Effects 0.000 claims description 3
239000003814 drug Substances 0.000 claims description 3
238000004108 freeze drying Methods 0.000 claims description 3
239000000203 mixture Substances 0.000 claims description 3
229920006395 saturated elastomer Polymers 0.000 claims description 3
239000012588 trypsin Substances 0.000 claims description 3
WCDDVEOXEIYWFB-VXORFPGASA-N (2s,3s,4r,5r,6r)-3-[(2s,3r,5s,6r)-3-acetamido-5-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,5,6-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@@H]1C[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](C(O)=O)O[C@@H](O)[C@H](O)[C@H]1O WCDDVEOXEIYWFB-VXORFPGASA-N 0.000 claims description 2
102000057297 Pepsin A Human genes 0.000 claims description 2
108090000284 Pepsin A Proteins 0.000 claims description 2
108091005804 Peptidases Proteins 0.000 claims description 2
239000004365 Protease Substances 0.000 claims description 2
102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims description 2
239000013543 active substance Substances 0.000 claims description 2
BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical group NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 claims description 2
150000004697 chelate complex Chemical class 0.000 claims description 2
239000008139 complexing agent Substances 0.000 claims description 2
210000002808 connective tissue Anatomy 0.000 claims description 2
238000001035 drying Methods 0.000 claims description 2
239000004744 fabric Substances 0.000 claims description 2
238000001914 filtration Methods 0.000 claims description 2
229940014041 hyaluronate Drugs 0.000 claims description 2
229910021645 metal ion Inorganic materials 0.000 claims description 2
238000006386 neutralization reaction Methods 0.000 claims description 2
229940111202 pepsin Drugs 0.000 claims description 2
239000000825 pharmaceutical preparation Substances 0.000 claims description 2
WBHQBSYUUJJSRZ-UHFFFAOYSA-M sodium bisulfate Chemical compound [Na+].OS([O-])(=O)=O WBHQBSYUUJJSRZ-UHFFFAOYSA-M 0.000 claims description 2
229910000342 sodium bisulfate Inorganic materials 0.000 claims description 2
230000003319 supportive effect Effects 0.000 claims description 2
238000001356 surgical procedure Methods 0.000 claims description 2
230000035876 healing Effects 0.000 claims 2
159000000000 sodium salts Chemical class 0.000 claims 2
PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 claims 1
238000001816 cooling Methods 0.000 claims 1
238000006073 displacement reaction Methods 0.000 claims 1
238000005755 formation reaction Methods 0.000 claims 1
238000009472 formulation Methods 0.000 claims 1
230000020477 pH reduction Effects 0.000 claims 1
229910052938 sodium sulfate Inorganic materials 0.000 claims 1
235000011152 sodium sulphate Nutrition 0.000 claims 1
239000002594 sorbent Substances 0.000 claims 1
238000000859 sublimation Methods 0.000 claims 1
230000002792 vascular Effects 0.000 claims 1
239000000835 fiber Substances 0.000 description 13
239000000243 solution Substances 0.000 description 12
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 9
230000002163 immunogen Effects 0.000 description 6
238000004132 cross linking Methods 0.000 description 5
230000005847 immunogenicity Effects 0.000 description 5
CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 4
239000012153 distilled water Substances 0.000 description 4
230000004048 modification Effects 0.000 description 4
238000012986 modification Methods 0.000 description 4
235000018102 proteins Nutrition 0.000 description 4
102000004169 proteins and genes Human genes 0.000 description 4
108090000623 proteins and genes Proteins 0.000 description 4
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
230000000890 antigenic effect Effects 0.000 description 3
238000005119 centrifugation Methods 0.000 description 3
239000000501 collagen implant Substances 0.000 description 3
238000000605 extraction Methods 0.000 description 3
239000007943 implant Substances 0.000 description 3
230000008569 process Effects 0.000 description 3
229910001220 stainless steel Inorganic materials 0.000 description 3
239000010935 stainless steel Substances 0.000 description 3
108010059712 Pronase Proteins 0.000 description 2
235000011130 ammonium sulphate Nutrition 0.000 description 2
102000036639 antigens Human genes 0.000 description 2
108091007433 antigens Proteins 0.000 description 2
230000008901 benefit Effects 0.000 description 2
230000015556 catabolic process Effects 0.000 description 2
238000006243 chemical reaction Methods 0.000 description 2
238000010908 decantation Methods 0.000 description 2
238000006731 degradation reaction Methods 0.000 description 2
238000009826 distribution Methods 0.000 description 2
229940079593 drug Drugs 0.000 description 2
230000002255 enzymatic effect Effects 0.000 description 2
239000000284 extract Substances 0.000 description 2
230000001900 immune effect Effects 0.000 description 2
238000001727 in vivo Methods 0.000 description 2
210000003041 ligament Anatomy 0.000 description 2
BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 2
230000000813 microbial effect Effects 0.000 description 2
244000005700 microbiome Species 0.000 description 2
FEMOMIGRRWSMCU-UHFFFAOYSA-N ninhydrin Chemical compound C1=CC=C2C(=O)C(O)(O)C(=O)C2=C1 FEMOMIGRRWSMCU-UHFFFAOYSA-N 0.000 description 2
230000001575 pathological effect Effects 0.000 description 2
238000000746 purification Methods 0.000 description 2
150000003839 salts Chemical class 0.000 description 2
229910000029 sodium carbonate Inorganic materials 0.000 description 2
238000003756 stirring Methods 0.000 description 2
210000001519 tissue Anatomy 0.000 description 2
238000011282 treatment Methods 0.000 description 2
KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 1
VZSRBBMJRBPUNF-UHFFFAOYSA-N 2-(2,3-dihydro-1H-inden-2-ylamino)-N-[3-oxo-3-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)propyl]pyrimidine-5-carboxamide Chemical compound C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)C(=O)NCCC(N1CC2=C(CC1)NN=N2)=O VZSRBBMJRBPUNF-UHFFFAOYSA-N 0.000 description 1
OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 1
241000283690 Bos taurus Species 0.000 description 1
108090000317 Chymotrypsin Proteins 0.000 description 1
ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 description 1
108090000790 Enzymes Proteins 0.000 description 1
102000004190 Enzymes Human genes 0.000 description 1
108010010803 Gelatin Proteins 0.000 description 1
AVXURJPOCDRRFD-UHFFFAOYSA-N Hydroxylamine Chemical compound ON AVXURJPOCDRRFD-UHFFFAOYSA-N 0.000 description 1
PMMYEEVYMWASQN-DMTCNVIQSA-N Hydroxyproline Chemical compound O[C@H]1CN[C@H](C(O)=O)C1 PMMYEEVYMWASQN-DMTCNVIQSA-N 0.000 description 1
ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 description 1
241000322338 Loeseliastrum Species 0.000 description 1
101100345589 Mus musculus Mical1 gene Proteins 0.000 description 1
206010028980 Neoplasm Diseases 0.000 description 1
108010019160 Pancreatin Proteins 0.000 description 1
206010057249 Phagocytosis Diseases 0.000 description 1
239000004952 Polyamide Substances 0.000 description 1
ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 description 1
241000187747 Streptomyces Species 0.000 description 1
QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
HKUQMSGUQQIAGK-UHFFFAOYSA-N [Pb].[Rh] Chemical compound [Pb].[Rh] HKUQMSGUQQIAGK-UHFFFAOYSA-N 0.000 description 1
230000009471 action Effects 0.000 description 1
239000003513 alkali Substances 0.000 description 1
125000003275 alpha amino acid group Chemical group 0.000 description 1
125000000539 amino acid group Chemical group 0.000 description 1
BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 1
229910052921 ammonium sulfate Inorganic materials 0.000 description 1
239000001166 ammonium sulphate Substances 0.000 description 1
239000003242 anti bacterial agent Substances 0.000 description 1
229940088710 antibiotic agent Drugs 0.000 description 1
239000000427 antigen Substances 0.000 description 1
239000012736 aqueous medium Substances 0.000 description 1
238000003556 assay Methods 0.000 description 1
239000000022 bacteriostatic agent Substances 0.000 description 1
239000002585 base Substances 0.000 description 1
239000011324 bead Substances 0.000 description 1
239000012620 biological material Substances 0.000 description 1
235000015895 biscuits Nutrition 0.000 description 1
210000000988 bone and bone Anatomy 0.000 description 1
239000004202 carbamide Substances 0.000 description 1
210000000845 cartilage Anatomy 0.000 description 1
150000001768 cations Chemical class 0.000 description 1
238000004113 cell culture Methods 0.000 description 1
238000007385 chemical modification Methods 0.000 description 1
229960002376 chymotrypsin Drugs 0.000 description 1
238000003776 cleavage reaction Methods 0.000 description 1
238000004737 colorimetric analysis Methods 0.000 description 1
239000000356 contaminant Substances 0.000 description 1
230000006378 damage Effects 0.000 description 1
238000004925 denaturation Methods 0.000 description 1
230000036425 denaturation Effects 0.000 description 1
PMMYEEVYMWASQN-UHFFFAOYSA-N dl-hydroxyproline Natural products OC1C[NH2+]C(C([O-])=O)C1 PMMYEEVYMWASQN-UHFFFAOYSA-N 0.000 description 1
230000002500 effect on skin Effects 0.000 description 1
230000000694 effects Effects 0.000 description 1
230000009483 enzymatic pathway Effects 0.000 description 1
229940088598 enzyme Drugs 0.000 description 1
238000011067 equilibration Methods 0.000 description 1
235000019253 formic acid Nutrition 0.000 description 1
125000002485 formyl group Chemical class [H]C(*)=O 0.000 description 1
239000000499 gel Substances 0.000 description 1
239000008273 gelatin Substances 0.000 description 1
229920000159 gelatin Polymers 0.000 description 1
235000019322 gelatine Nutrition 0.000 description 1
235000011852 gelatine desserts Nutrition 0.000 description 1
230000012010 growth Effects 0.000 description 1
230000002439 hemostatic effect Effects 0.000 description 1
229920002674 hyaluronan Polymers 0.000 description 1
229960003160 hyaluronic acid Drugs 0.000 description 1
XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 1
229960002591 hydroxyproline Drugs 0.000 description 1
230000000984 immunochemical effect Effects 0.000 description 1
230000016784 immunoglobulin production Effects 0.000 description 1
239000003018 immunosuppressive agent Substances 0.000 description 1
238000000338 in vitro Methods 0.000 description 1
229910052500 inorganic mineral Inorganic materials 0.000 description 1
230000002503 metabolic effect Effects 0.000 description 1
239000011707 mineral Substances 0.000 description 1
230000003472 neutralizing effect Effects 0.000 description 1
229910052759 nickel Inorganic materials 0.000 description 1
PXHVJJICTQNCMI-UHFFFAOYSA-N nickel Substances [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 description 1
MGFYIUFZLHCRTH-UHFFFAOYSA-N nitrilotriacetic acid Chemical compound OC(=O)CN(CC(O)=O)CC(O)=O MGFYIUFZLHCRTH-UHFFFAOYSA-N 0.000 description 1
QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
229940055695 pancreatin Drugs 0.000 description 1
231100000915 pathological change Toxicity 0.000 description 1
230000036285 pathological change Effects 0.000 description 1
230000037361 pathway Effects 0.000 description 1
239000008188 pellet Substances 0.000 description 1
230000035699 permeability Effects 0.000 description 1
230000008782 phagocytosis Effects 0.000 description 1
229920002647 polyamide Polymers 0.000 description 1
229920000642 polymer Polymers 0.000 description 1
230000003389 potentiating effect Effects 0.000 description 1
239000013014 purified material Substances 0.000 description 1
230000009257 reactivity Effects 0.000 description 1
230000009467 reduction Effects 0.000 description 1
235000013580 sausages Nutrition 0.000 description 1
210000004761 scalp Anatomy 0.000 description 1
230000007017 scission Effects 0.000 description 1
238000007873 sieving Methods 0.000 description 1
239000004460 silage Substances 0.000 description 1
210000003491 skin Anatomy 0.000 description 1
239000012279 sodium borohydride Substances 0.000 description 1
229910000033 sodium borohydride Inorganic materials 0.000 description 1
ZAWGLAXBGYSUHN-UHFFFAOYSA-M sodium;2-[bis(carboxymethyl)amino]acetate Chemical compound [Na+].OC(=O)CN(CC(O)=O)CC([O-])=O ZAWGLAXBGYSUHN-UHFFFAOYSA-M 0.000 description 1
238000009331 sowing Methods 0.000 description 1
230000007480 spreading Effects 0.000 description 1
238000003892 spreading Methods 0.000 description 1
238000010186 staining Methods 0.000 description 1
239000000758 substrate Substances 0.000 description 1
229910021653 sulphate ion Inorganic materials 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
230000008467 tissue growth Effects 0.000 description 1
FGMPLJWBKKVCDB-UHFFFAOYSA-N trans-L-hydroxy-proline Natural products ON1CCCC1C(O)=O FGMPLJWBKKVCDB-UHFFFAOYSA-N 0.000 description 1
230000009466 transformation Effects 0.000 description 1
238000005406 washing Methods 0.000 description 1

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Materials For Medical Uses (AREA)
Peptides Or Proteins (AREA)

CS883168A 1988-05-11 1988-05-11 Biokompatibilný kolagénový materiál a spôsob Jeho přípravy CS269196B1 (sk)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
CS883168A CS269196B1 (sk)	1988-05-11	1988-05-11	Biokompatibilný kolagénový materiál a spôsob Jeho přípravy

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CS883168A CS269196B1 (sk)	1988-05-11	1988-05-11	Biokompatibilný kolagénový materiál a spôsob Jeho přípravy

Publications (2)

Publication Number	Publication Date
CS316888A1 CS316888A1 (en)	1989-09-12
CS269196B1 true CS269196B1 (sk)	1990-04-11

Family

ID=5370986

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CS883168A CS269196B1 (sk)	1988-05-11	1988-05-11	Biokompatibilný kolagénový materiál a spôsob Jeho přípravy

Country Status (1)

Country	Link
CS (1)	CS269196B1 (sk)

1988
- 1988-05-11 CS CS883168A patent/CS269196B1/sk unknown

Also Published As

Publication number	Publication date
CS316888A1 (en)	1989-09-12

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