CS271891A3 - Diphenyl compounds inhibiting substitution of arachidonic acid and their use in pharmaceuticals - Google Patents

Diphenyl compounds inhibiting substitution of arachidonic acid and their use in pharmaceuticals

Info

Publication number: CS271891A3
Authority: CS; Czechoslovakia
Prior art keywords: pharmaceuticals; arachidonic acid; compounds inhibiting; diphenyl compounds; diseases
Prior art date: 1990-09-05

Application number

CS912718A

Other languages

English (en)

Inventor

Tankred Prof Dr Schefe

Helmut Dr Luther

Dentscho Dr Jordanov

Original Assignee

Ciba Geigy Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-09-05

Filing date

1991-09-04

Publication date

1992-03-18

1991-09-04 Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag

1992-03-18 Publication of CS271891A3 publication Critical patent/CS271891A3/cs

1995-05-17 Publication of CZ279624B6 publication Critical patent/CZ279624B6/cs

Links

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/075—Ethers or acetals
- A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/065—Diphenyl-substituted acyclic alcohols
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
- A61K31/055—Phenols the aromatic ring being substituted by halogen
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
- A61K31/06—Phenols the aromatic ring being substituted by nitro groups
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
- A61K31/10—Sulfides; Sulfoxides; Sulfones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pulmonology (AREA)
Pain & Pain Management (AREA)
Dermatology (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Oncology (AREA)
Neurosurgery (AREA)
Rheumatology (AREA)
Communicable Diseases (AREA)
Immunology (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicinal Preparation (AREA)
Medicines Containing Plant Substances (AREA)

CS912718A 1990-09-05 1991-09-04 Difenilové sloučeniny zabraňující látkové výměně kyseliny arachidonové a jejich použití ve farmaceutických prostředcích CZ279624B6 (cs)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CH287590		1990-09-05

Publications (2)

Publication Number	Publication Date
CS271891A3 true CS271891A3 (en)	1992-03-18
CZ279624B6 CZ279624B6 (cs)	1995-05-17

Family

ID=4243541

Country Status (22)

Country	Link
US (1)	US5185377A (cs)
EP (1)	EP0474597B1 (cs)
JP (1)	JP3264950B2 (cs)
KR (1)	KR100201749B1 (cs)
AT (1)	ATE156353T1 (cs)
AU (1)	AU645599B2 (cs)
CA (1)	CA2050569C (cs)
CZ (1)	CZ279624B6 (cs)
DE (1)	DE59108814D1 (cs)
DK (1)	DK0474597T3 (cs)
ES (1)	ES2106770T3 (cs)
FI (1)	FI914185A7 (cs)
GR (1)	GR3024440T3 (cs)
HU (2)	HUT58998A (cs)
IE (1)	IE913110A1 (cs)
IL (1)	IL99376A (cs)
MX (1)	MX9100917A (cs)
NO (1)	NO913472L (cs)
PT (1)	PT98874B (cs)
RU (1)	RU2060731C1 (cs)
SK (1)	SK279104B6 (cs)
ZA (1)	ZA917005B (cs)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9117140D0 (en) *	1991-08-08	1991-09-25	Unilever Plc	Treatment of periodontitis
US6440395B1 (en)	1992-06-22	2002-08-27	Barry M. Libin	Antiplaque mouth rinse
CH686285A5 (fr) *	1992-08-06	1996-02-29	Beiersdorf Ag	Preparation cosmetique ou pharmaceutique servant a retarder le vieillissement de la peau humaine.
US5880146A (en) *	1995-06-07	1999-03-09	Fuji Immunopharmaceuticals Corporation	Inhibition of IL-12-induced IFN-γ synthesis by specific bis-phenol compounds as a method of immune modulation
EP0839031A1 (de) *	1995-07-20	1998-05-06	JUERGENS, Uwe R.	Verwendung eines nicht-steroidalen antiphlogistikums zur topischen und systemischen behandlung der akuten und chronischen polypoiden rhinosinusitis
AUPN814496A0 (en) *	1996-02-19	1996-03-14	Monash University	Dermal penetration enhancer
US6108850A (en) *	1997-06-03	2000-08-29	Mclaughlin; Gerald	Accelerated method and instrumentation for whitening teeth
DE19834355A1 (de) *	1998-07-30	2000-02-03	Henkel Kgaa	Entzündungshemmende Zahnpflegemittel
US7566740B2 (en) *	1998-10-06	2009-07-28	Bml Pharmaceuticals, Inc.	Method of treating mucositis
WO2001000138A2 (en) *	1999-06-23	2001-01-04	Jawaharlal Nehru Centre For Advanced Scientific Research	Use of hydroxydiphenyl ether class of chemicals, as exemplified by triclosan, as an antimalarial and identification of fatty acid synthesis as its target
RU2200550C2 (ru) *	1999-10-29	2003-03-20	Научно-исследовательская лаборатория иммунохимиотерапии лепры и иммунотропных средств с клиникой и опытно-экспериментальным производством	Новые лекарственные формы димоцифона в терапии лепры, зудящих и аллергодерматозов, герпетиформного дерматита дюринга
WO2002050008A2 (en) *	2000-12-20	2002-06-27	Warner-Lambert Company Llc	Non-halogenated phenoxy and/or benzyloxy phenols and antimicrobial compositions containing them
EP1366763A1 (en) *	2002-05-28	2003-12-03	Ciba SC Holding AG	Hydroxy diphenyl ether compounds as anti-inflammatory agents
US20030229149A1 (en) *	2002-05-28	2003-12-11	Werner Baschong	Anti-inflammatory agents
JP2013532734A (ja) *	2010-08-04	2013-08-19	ユニバーシティオブバージニアパテントファウンデーション	炎症性疾患を治療するための組成物及び方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1199273A (en) *	1982-07-15	1986-01-14	Ctibor Schindlery	Anti-inflammatory composition
GB2148116B (en) *	1983-10-27	1986-07-30	Ciba Geigy Ag	Topical steroid preparations
GB8526093D0 (en) *	1985-10-22	1985-11-27	Beecham Group Plc	Composition
US4735802A (en) *	1986-05-05	1988-04-05	Le Bich N	Topical dermatological composition and method of treatment
US4942029A (en) *	1986-09-19	1990-07-17	Smith & Nephew United, Inc.	Medicated skin preparation
GB8629640D0 (en) *	1986-12-11	1987-01-21	Beecham Group Plc	Composition & method
GB8718026D0 (en) *	1987-07-29	1987-09-03	Smith & Nephew Ass	Pharmaceutical composition
AU610906B2 (en) *	1987-07-31	1991-05-30	Sumitomo Chemical Company, Limited	Method for preventing harm from bloodsucking insects

1991
- 1991-08-27 AT AT91810685T patent/ATE156353T1/de not_active IP Right Cessation
- 1991-08-27 DK DK91810685.7T patent/DK0474597T3/da active
- 1991-08-27 ES ES91810685T patent/ES2106770T3/es not_active Expired - Lifetime
- 1991-08-27 EP EP91810685A patent/EP0474597B1/de not_active Expired - Lifetime
- 1991-08-27 DE DE59108814T patent/DE59108814D1/de not_active Expired - Lifetime
- 1991-09-03 MX MX9100917A patent/MX9100917A/es not_active IP Right Cessation
- 1991-09-03 CA CA002050569A patent/CA2050569C/en not_active Expired - Lifetime
- 1991-09-03 IL IL9937691A patent/IL99376A/en not_active IP Right Cessation
- 1991-09-04 NO NO91913472A patent/NO913472L/no unknown
- 1991-09-04 HU HU912866A patent/HUT58998A/hu unknown
- 1991-09-04 ZA ZA917005A patent/ZA917005B/xx unknown
- 1991-09-04 US US07/754,788 patent/US5185377A/en not_active Expired - Lifetime
- 1991-09-04 KR KR1019910015407A patent/KR100201749B1/ko not_active Expired - Fee Related
- 1991-09-04 RU SU915001448A patent/RU2060731C1/ru active
- 1991-09-04 FI FI914185A patent/FI914185A7/fi unknown
- 1991-09-04 SK SK2718-91A patent/SK279104B6/sk unknown
- 1991-09-04 CZ CS912718A patent/CZ279624B6/cs unknown
- 1991-09-04 IE IE311091A patent/IE913110A1/en not_active IP Right Cessation
- 1991-09-04 AU AU83640/91A patent/AU645599B2/en not_active Ceased
- 1991-09-05 JP JP22563191A patent/JP3264950B2/ja not_active Expired - Lifetime
- 1991-09-05 PT PT98874A patent/PT98874B/pt not_active IP Right Cessation
1995
- 1995-06-21 HU HU95P/P00310P patent/HU211292A9/hu unknown
1997
- 1997-08-13 GR GR970402083T patent/GR3024440T3/el unknown

Also Published As

Publication number	Publication date
PT98874A (pt)	1992-07-31
JPH04257517A (ja)	1992-09-11
PT98874B (pt)	1999-02-26
AU645599B2 (en)	1994-01-20
IE913110A1 (en)	1992-03-11
EP0474597B1 (de)	1997-08-06
KR100201749B1 (ko)	1999-06-15
IL99376A0 (en)	1992-08-18
MX9100917A (es)	1992-05-04
SK279104B6 (sk)	1998-06-03
CA2050569C (en)	2004-01-27
US5185377A (en)	1993-02-09
EP0474597A2 (de)	1992-03-11
IL99376A (en)	1996-01-19
HUT58998A (en)	1992-04-28
NO913472D0 (no)	1991-09-04
HU211292A9 (en)	1995-11-28
NO913472L (no)	1992-03-06
FI914185A0 (fi)	1991-09-04
DK0474597T3 (da)	1997-10-20
ATE156353T1 (de)	1997-08-15
KR920005988A (ko)	1992-04-27
AU8364091A (en)	1992-03-12
JP3264950B2 (ja)	2002-03-11
CZ279624B6 (cs)	1995-05-17
ES2106770T3 (es)	1997-11-16
CA2050569A1 (en)	1992-03-06
RU2060731C1 (ru)	1996-05-27
EP0474597A3 (en)	1992-07-01
ZA917005B (en)	1992-04-29
FI914185A7 (fi)	1992-03-06
GR3024440T3 (en)	1997-11-28
DE59108814D1 (de)	1997-09-11

Publication	Publication Date	Title
AU645599B2 (en)	1994-01-20	Diphenyl compounds which inhibit arachidonic acid metabolism, and their use in pharmaceutical compositions
SE8804036D0 (sv)	1988-11-08	New use of 11,28-dioxa-4-azatricyclo(22.3.1.0?724,9 )octacos-18-ene derivatives and pharmaceutical compositions containing them
DE59307360D1 (de)	1997-10-23	Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
ATE40994T1 (de)	1989-03-15	L-n-n-propylpipekolsaeure-2,6-xylidid und dessen herstellung.
DE3480474D1 (de)	1989-12-21	2-amino-5-hydroxy-4-methylpyrimidine derivatives
BR9810385A (pt)	2000-09-05	Derivados de ácido benzóico 2-(4-bromo ou 4-iodo fenilamino) e sua utilização como inibidores de mek
ATE448194T1 (de)	2009-11-15	Verwendung einer pharmazeutischen zusammensetzung mit einem para-aminophenylessigsäurederivat für die behandlung von entzündlichen erkrankungen des magen-darmtrakts
IT1229570B (it)	1991-09-04	Derivati fluorurati di acidi biliari, loro preparazione e composizioni farmaceutiche che li contengono.
ATE205199T1 (de)	2001-09-15	Quinolin- oder quinazolinderivate, deren herstellung und verwendung
PE42598A1 (es)	1998-08-17	Composiciones farmaceuticas para el tratamiento de la rinitis
ATE21246T1 (de)	1986-08-15	Substituierte imidazol-derivate mit pharmakologischer wirkung sowie ihre herstellung und verwendung.
JPS6490125A (en)	1989-04-06	Drug composition
ES2063578T3 (es)	1995-01-01	Derivados del acido hidroxamico y de n-hidroxiurea inhibidores de la lipoxigenasa.
MX2025002985A (es)	2025-05-02	Compuestos para el tratamiento de procesos inflamatorios
ES2098370T3 (es)	1997-05-01	Derivado del acido epoxisuccinamico.
DE10046728C1 (de)	2001-09-27	Tricyclische mercaptomethylsubstituierte 2,3-Dihydro-chinazolin-5-one und 2,3-Dihydro-benzo[1,2,4,]-thiadiazin-5,5-dioxide als Matrix Metalloproteinase (MMP) Inhibitoren
ES2042994T3 (es)	1993-12-16	Derivados de pirimidina antiulcerantes.
DE69011747D1 (de)	1994-09-29	Beta-lactam-Elastase-Inhibitoren.
IT1199994B (it)	1989-01-05	Derivati dell'acido d-2-(6-metossi-2-naftil)-propionico ad attivita'terapeutica,procedimento per la loro preparazione e composizioni farmaceutiche che li contengono
UY24954A1 (es)	2001-08-27	Compuestos y composiciones para tratar enfermedades asociadas con la actividad de proteasa
ES8307803A1 (es)	1983-08-01	Procedimiento de preparar trimetoxibenzoatos de apovincaminol substituidos con efecto inhibidor de las fosfodiestebasas.
ES2056211T3 (es)	1994-10-01	Derivados de acilsulfonamida de acidos alfa-carbocicliltoluicos usados como antagonistas de leucotrienos.
ATE168683T1 (de)	1998-08-15	Substituierte iminoacetonitrile mit myokardprotektiver wirkung
JPS55162750A (en)	1980-12-18	Purification of 4,4'-bis(dialkylamino)benzophenone
TH48497A3 (th)	2001-11-30	สารประกอบกรดอะมิโนเบนโซอิกชนิดเมท-อะชาไซคลิกและอนุพันธ์ของสารประกอบ