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Application filed by Ustav Organicke Chemie A BiochfiledCriticalUstav Organicke Chemie A Bioch
Priority to CS245289ApriorityCriticalpatent/CS274992B2/en
Publication of CS8902452A1publicationCriticalpatent/CS8902452A1/en
Publication of CS274992B2publicationCriticalpatent/CS274992B2/en
Medicines That Contain Protein Lipid Enzymes And Other Medicines
(AREA)
Peptides Or Proteins
(AREA)
Abstract
The invention solves the production of the prototype of porcine insulin by the condensation reaction of amino acid component and des-Ala <B30> insulin with the initial content of zinc during catalysis by trypsin. The reaction takes place in the medium of 60 percent by volume of hydrous dimethylformamide with pH between 6 and 8, at the temperature between 18 and 20 degrees C for the duration between 10 and 20 hours. The prototype of porcine insulin is fully biologically active and can be used in pharmaceutical industry, especially for treatment of diabetes.
CS245289A1989-04-201989-04-20Method of porcine insulin's analogue preparation
CS274992B2
(en)
Mixed crystals of insulin and insulin derivatives, their process of manufacture, pharmaceutical agents containing them and their use in the treatment of diabetes mellitus
Biophysically derived ascomycetes, schizomycetes and yeast preparation, process for the manufacture thereof and fodder and plant hormones containing this preparation, and use of the preparations for skin treatment and probiotic activation