CS275015B2 - Method of human insulin's analogues preparation - Google Patents

Method of human insulin's analogues preparation

Info

Publication number: CS275015B2
Authority: CS; Czechoslovakia
Prior art keywords: insulin; human insulin; thr; analogues; preparation
Prior art date: 1989-08-24

Application number

CS497489A

Other languages

English (en)

Other versions

CS497489A2 (en

Inventor

Ivo Rndr Svoboda

Tomas Ing Buchvaldek

Alena Hankeova

Jana Rndr Csc Barthova

Tomislav Rndr Drsc Barth

Original Assignee

Ustav Organicke Chemie A Bioch

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-08-24

Filing date

1989-08-24

Publication date

1991-12-17

1989-08-24 Application filed by Ustav Organicke Chemie A Bioch filed Critical Ustav Organicke Chemie A Bioch

1989-08-24 Priority to CS497489A priority Critical patent/CS275015B2/cs

1991-03-12 Publication of CS497489A2 publication Critical patent/CS497489A2/cs

1991-12-17 Publication of CS275015B2 publication Critical patent/CS275015B2/cs

Links

PBGKTOXHQIOBKM-FHFVDXKLSA-N insulin (human) Chemical class C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 PBGKTOXHQIOBKM-FHFVDXKLSA-N 0.000 title abstract 3
238000000034 method Methods 0.000 title abstract 2
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 5
ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 abstract 3
101000976075 Homo sapiens Insulin Proteins 0.000 abstract 2
102000004877 Insulin Human genes 0.000 abstract 2
108090001061 Insulin Proteins 0.000 abstract 2
229940125396 insulin Drugs 0.000 abstract 2
UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 abstract 1
108010005991 Pork Regular Insulin Proteins 0.000 abstract 1
102000004142 Trypsin Human genes 0.000 abstract 1
108090000631 Trypsin Proteins 0.000 abstract 1
HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 abstract 1
230000004071 biological effect Effects 0.000 abstract 1
229910001628 calcium chloride Inorganic materials 0.000 abstract 1
239000001110 calcium chloride Substances 0.000 abstract 1
238000006555 catalytic reaction Methods 0.000 abstract 1
239000000126 substance Substances 0.000 abstract 1
239000012588 trypsin Substances 0.000 abstract 1
239000011701 zinc Substances 0.000 abstract 1
229910052725 zinc Inorganic materials 0.000 abstract 1

Landscapes

Peptides Or Proteins (AREA)

CS497489A 1989-08-24 1989-08-24 Method of human insulin's analogues preparation CS275015B2 (en)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
CS497489A CS275015B2 (en)	1989-08-24	1989-08-24	Method of human insulin's analogues preparation

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CS497489A CS275015B2 (en)	1989-08-24	1989-08-24	Method of human insulin's analogues preparation

Publications (2)

Publication Number	Publication Date
CS497489A2 CS497489A2 (en)	1991-03-12
CS275015B2 true CS275015B2 (en)	1991-12-17

Family

ID=5393680

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CS497489A CS275015B2 (en)	1989-08-24	1989-08-24	Method of human insulin's analogues preparation

Country Status (1)

Country	Link
CS (1)	CS275015B2 (cs)

1989
- 1989-08-24 CS CS497489A patent/CS275015B2/cs unknown

Also Published As

Publication number	Publication date
CS497489A2 (en)	1991-03-12

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