CS276924B6 - Agent preventing the formation of dandruff in the form of emulsion or shampoo - Google Patents

Abstract

Image-forming material is claimed and comprises: a roughened plastic film substrate and, in order transparent resin-, coloured resin-, photosensitive resin- and protective layers. The four layers are designed so, after exposure to active radiation, the unexposed parts are completely removed by dissoln. or swelling during development. Image-formation is also claimed and comprises: exposing the material to active radiation and then developing the exposed material etc.

Description

The present invention relates to an anti-dandruff composition in the form of an emulsion and a shampoo. The emulsion formulation is applied in severe forms of the disease and the shampoo is more commonly used in maintenance treatments or lighter forms of the disease. Both formulations are characterized by high efficacy, especially when combined with each other.

It is an object of the invention to prevent or substantially reduce dandruff by using a combination of an emulsion formulation (which is applied for several hours, preferably overnight to the scalp) and hair shampoo.

In both formulations, high anti-dandruff efficacy is achieved by using a combination of zinc 2-pyridinthiol-i-oxide (hereinafter zinc-pyrithione) and monoethanolamine salt

1-hydroxy-4-methyl-6- (2,4,4-trimethylpetyl) -2 (1H) -pyridone (hereinafter piroctone olamine), which exhibits synergistic effects.

The anti-dandruff agents used hitherto use a wide range of substances such as various tars, selendisulfide, undecylenic acid, salicylic acid, zinc, magnesium and sodium salts.

2-pyridinethiol-1-oxide, monoethanolamine salts of 1-hydrose-4-methyl-6- (2,4,4-trimethylpentyl) -2 (1H) -pyridone and others. The use of these substances is described in the literature of the respective companies producing these substances, such as Olin Chemicals USA, Hoechst Germany, Rewo Germany and others. Further, the use of these substances is described in cosmetic chemistry encyclopedias such as Cosmetics

M.S.Balsama and E.Sagarin (Willex, New York 1972), Handbuch der Kosmetika und Riechstoffe by H. Janistyn (Hüthig Verlag, Heidelberg 1973), Die Kosmetische Praparate by G. A. Nowak (Ziolkowski, Augsbur 1969) and others. None of these publications disclose the simultaneous use of the two agents or a combination of the two anti-drug preparations. The disadvantage of some of these substances is their high toxicity (especially selendisulfide) or relatively low efficacy resulting in the use of high concentrations causing undesirable side effects, in particular increased sebum production.

These drawbacks are overcome by the invention relating to an anti-dandruff composition in the form of an emulsion or shampoo, wherein zinc pyrithione and piroctone olamine are used. According to the results of our research, a synergistic effect is shown and good anti-dull activity is achieved at relatively low concentrations of both active substances. The anti-husk ingredients are part of an oil in water cream and hair shampoo. Practical tests (in 60 cases of focal and diffuse seborrhoea by double blind and compared with placebo) confirmed that the formulations prepared and used according to the invention have surprising efficacy. No adverse allergic reactions or signs of dermal toxicity were observed during the trials (38 volunteers with epiculum testing).

The use of the invention is evident from the following examples.

Example 1: Anti-dandruff emulsion.

A mixture of 6 g of cetyl alcohol, 12 g of glycerol monostearate, 2 g of isopropyl myristate, 10 g of mineral oil, 4 g of ethoxylated lauryl-myristyl alcohol (HLB = 17.3) is heated to 75 ° C. This mixture forms the fat phase of the emulsion formulation. To this mixture is added

2.5 g of 48 wt. % suspension of zinc-pyrithione in water and 0.05 g of 1.5 wt. aqueous solution of a mixture of 5-chloro-2-methyl-4-isothiazolin-3-one and 2-methyl-4-isothiazolin-3-one and 62.85 g of water heated to 75 ° C. After addition and formation of the emulsion, a solution of 0.1 g of piroctone olamine in 1 g of 96% v / v ethanol is added to the hot emulsion. The mixture is stirred under free cooling to 28 ° C to form a soft cream characterized by excellent anti-dandruff effects.

Example 2: Anti-dandruff shampoo.

Mixture 10 g 29% wt. sodium lauryl ether sulphate solution,

1.1 g carboxymethylcellulose, 5 g coconut fatty acid diethanolamide, 0.1 g soluble elastin, 0.05 g 1.5 wt. of an aqueous solution of a mixture of 5-chloro-2-methyl-4-isothiazolin-3-one and 2-methyl-4-isothiazolin-3-one, 1.05 g of 48 wt. a suspension of zinc-pyrithione in water, 0.1 g of the fragrance composition and 0.1 g of piroctone olamine are mixed to form a homogeneous mixture. 71.30 g of water, in which 0.2 g of citric acid and 2 g of sodium chloride are dissolved, are added. The resulting mixture is again mixed to complete homogeneity by adding 9 g of 35 wt. of an alkylamidobetaine solution, resulting in a final increase in viscosity. This shampoo has a very gentle effect on the hair and very good anti-dandruff effect.

The efficacy of both product types was demonstrated by a double blind trial in 38 volunteers.

Claims (1)

PATENT CLAIMS An anti-dandruff composition in the form of an emulsion or shampoo, characterized in that it contains from 0.01 to 5% by weight of said composition. ethanolamine salts of 1-hydroxy-4-methyl-6- (2,4,4-trimethylpentyl-2 (1H) -pyridone and 0.01 to 5% by weight of zinc 2-pyridithiol-1-oxide complexone.