CS276965B6 - Novel lipophilic muramyl peptides and process for preparing thereof - Google Patents

Novel lipophilic muramyl peptides and process for preparing thereof Download PDF

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Publication number
CS276965B6
CS276965B6 CS805262A CS526280A CS276965B6 CS 276965 B6 CS276965 B6 CS 276965B6 CS 805262 A CS805262 A CS 805262A CS 526280 A CS526280 A CS 526280A CS 276965 B6 CS276965 B6 CS 276965B6
Authority
CS
Czechoslovakia
Prior art keywords
formula
alanyl
compound
radical
group
Prior art date
Application number
CS805262A
Other languages
Czech (cs)
English (en)
Other versions
CS526280A3 (en
Inventor
Lajos Dr Tarcsay
Gerhard Dr Baschang
Albert Dr Hartmann
Jaroslav Dr Stanek
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of CS526280A3 publication Critical patent/CS526280A3/cs
Publication of CS276965B6 publication Critical patent/CS276965B6/cs

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure
    • C07K9/005—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure containing within the molecule the substructure with m, n > 0 and m+n > 0, A, B, D, E being heteroatoms; X being a bond or a chain, e.g. muramylpeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CS805262A 1979-07-25 1980-07-25 Novel lipophilic muramyl peptides and process for preparing thereof CS276965B6 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH689379 1979-07-25
AU66581/81A AU6658181A (en) 1979-07-25 1981-01-23 Increasing antibiotic action of antibiotics

Publications (2)

Publication Number Publication Date
CS526280A3 CS526280A3 (en) 1992-06-17
CS276965B6 true CS276965B6 (en) 1992-11-18

Family

ID=34862371

Family Applications (1)

Application Number Title Priority Date Filing Date
CS805262A CS276965B6 (en) 1979-07-25 1980-07-25 Novel lipophilic muramyl peptides and process for preparing thereof

Country Status (27)

Country Link
US (2) US4414204A (el)
EP (1) EP0025495B1 (el)
JP (1) JPS5649397A (el)
KR (1) KR840001617B1 (el)
AU (2) AU541147B2 (el)
CA (1) CA1183129A (el)
CS (1) CS276965B6 (el)
CY (1) CY1381A (el)
DD (1) DD153843A5 (el)
DE (1) DE3068304D1 (el)
DK (1) DK161025C (el)
ES (1) ES493633A0 (el)
FI (1) FI75578C (el)
GR (1) GR69314B (el)
HK (1) HK85787A (el)
HU (1) HU188861B (el)
IE (1) IE50145B1 (el)
IL (1) IL60676A (el)
MX (1) MX9203368A (el)
MY (1) MY8700554A (el)
NO (1) NO157177C (el)
NZ (1) NZ194432A (el)
PL (2) PL131613B1 (el)
PT (1) PT71607A (el)
SG (1) SG38187G (el)
SU (2) SU1277905A3 (el)
ZA (1) ZA804487B (el)

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GB1582884A (en) * 1977-05-19 1981-01-14 Beecham Group Ltd Clavulanic acid derivatives their preparation and use
ZA804670B (en) * 1979-08-03 1981-07-29 Beecham Group Ltd Derivatives of clavulanic acid, a process for their preparation and their use
FI803077A7 (fi) * 1979-10-12 1981-04-13 Ciba Geigy Ag Foerfarande foer framstaellning av myramylpeptider
NZ199061A (en) * 1980-12-09 1984-10-19 Beecham Group Ltd 9-(n-tetrazolyl)-deoxyclavulanic acids,salts,esters,and pharmaceutical compositions
NZ199200A (en) * 1980-12-23 1984-07-31 Beecham Group Ltd Clavulanic acid derivatives and pharmaceutical compositions
EP0056560A1 (de) * 1981-01-19 1982-07-28 Ciba-Geigy Ag Antibiotische Präparate mit gesteigerter Wirksamkeit, Verfahren zu deren Herstellung und Verfahren zur Steigerung der antibiotischen Wirkung von Antibiotika
GR78246B (el) * 1981-01-23 1984-09-26 Ciba Geigy Ag
EP0102319B1 (de) * 1982-07-23 1987-08-19 Ciba-Geigy Ag Verwendung von Muramylpeptiden oder deren Analogen zur Prophylaxe und Therapie von Virusinfektionen
US5189017A (en) * 1982-07-23 1993-02-23 Ciba-Geigy Corporation Use of sugar derivatives for the prophylaxis and treatment of virus infections
EP0099578B1 (de) * 1982-07-23 1986-11-12 Ciba-Geigy Ag Neue Muramylpeptide und Verfahren zu ihrer Herstellung
US5334583A (en) * 1982-07-23 1994-08-02 Ciba-Geigy Corp. Use of sugar derivatives for the prophylaxis and treatment of virus infections
US4746651A (en) * 1983-11-01 1988-05-24 Scripps Clinic And Research Foundation Antimicrobial chemotherapeutic potentiation using substituted nucleoside derivatives
US5171568A (en) * 1984-04-06 1992-12-15 Chiron Corporation Recombinant herpes simplex gb-gd vaccine
FR2564096B1 (fr) * 1984-05-11 1988-02-19 Anvar Derives lipophiles de muramylpeptides ayant des proprietes d'activation des macrophages, compositions les contenant et procede pour les obtenir
ATE45744T1 (de) * 1984-07-25 1989-09-15 Ciba Geigy Ag Phosphatidylverbindungen, verfahren zu ihrer herstellung und ihre verwendung.
EP0174912A3 (de) * 1984-09-13 1986-06-04 Ciba-Geigy Ag Phosphorverbindungen, Verfahren zu ihrer Herstellung und ihre Verwendung
CA1260393A (en) * 1984-10-16 1989-09-26 Lajos Tarcsay Liposomes of synthetic lipids
GB8524001D0 (en) * 1985-09-30 1985-11-06 Glaxo Group Ltd Pharmaceutical composition
US4873322A (en) * 1986-01-24 1989-10-10 Ciba-Geigy Corporation Saccharide derivatives and processes for their manufacture
US4916118A (en) * 1986-08-18 1990-04-10 Board Of Regents, The University Of Texas System Pharmaceutical administration systems containing chemotactic peptides
US5149529A (en) * 1988-04-08 1992-09-22 Board Of Trustees Of Leland Chiron Corporation Compositions and treatment for herpes simplex
US5416070A (en) * 1988-07-08 1995-05-16 Immunotherapeutics, Inc. Composition for macrophage activation
US4950645A (en) * 1988-07-08 1990-08-21 Immunotherapeutics, Inc. Composition for macrophage activation
US4994440A (en) * 1989-02-13 1991-02-19 Creaven Patrick J Method for the treatment of renal cell carcinoma
GB9320820D0 (en) * 1993-10-08 1993-12-01 Biokine Tech Ltd Compounds for medicinal use
US6156319A (en) * 1994-07-25 2000-12-05 The Trustees Of The University Of Pennsylvania Soluble herpesvirus glycoprotein complex vaccine
US6080427A (en) * 1997-04-17 2000-06-27 Bristol-Myers Squibb Company Cefadroxil monohydrate tablet formulation
AUPP059897A0 (en) * 1997-11-27 1998-01-08 Fujisawa Pharmaceutical Co., Ltd. New use of bicozamycin
US20040029842A1 (en) * 2001-12-18 2004-02-12 Gardner Wallace J. Triglyceride lowering, common cold and pneumonia prevention composition comprising tetracycline, and methods of treating or preventing diseases using same
WO2005013918A2 (en) 2003-02-28 2005-02-17 The Trustees Of The University Of Pennsylvania Compositions, methods and kits relating to poxvirus subunit vaccines
US20050079187A1 (en) * 2003-10-14 2005-04-14 Gardner Wallace J. Composition, kit and method for reducing plaque formation, tooth decay and incidence of caries
JP2008522951A (ja) * 2004-07-19 2008-07-03 ベイラー・カレツジ・オブ・メデイシン サイトカインシグナル伝達調節物質の調節および免疫療法のための応用
CN101501055B (zh) * 2005-06-23 2016-05-11 贝勒医学院 负性免疫调节因子的调节和免疫疗法应用
WO2008116347A1 (en) 2007-03-26 2008-10-02 General Regeneratives Limited Methods for promoting protection and regeneration of bone marrow using cxcl9 and anti-cxcl9 antibodies
EP2222344A4 (en) * 2007-11-30 2012-11-07 Baylor College Medicine VACCINATE COMPOSITIONS WITH DENDRITIC CELLS AND THEIR USE
KR101856462B1 (ko) 2009-03-25 2018-05-10 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 병원체에 대한 포유동물의 선천성 면역 저항성의 자극을 위한 조성물
US9808504B2 (en) 2009-09-22 2017-11-07 Yale University Immunogenic epitopes as targets for universal cancer vaccines
CN104203287B (zh) 2011-07-12 2017-07-14 费城健康及教育公司，d/b/a,德雷克塞尔大学医学院 新型艰难梭菌dna疫苗
RU2491922C1 (ru) * 2012-04-26 2013-09-10 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования Курская государственная сельскохозяйственная академия имени профессора И.И. Иванова Способ повышения биоцидного и лечебного действия крема-суспензии с энрофлоксацином
RU2527330C2 (ru) * 2012-07-05 2014-08-27 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования Курская государственная сельскохозяйственная академия имени профессора И.И. Иванова Министерства сельского хозяйства Российской Федерации Способ повышения биоцидного и лечебного действия крема - суспензии с метронидазолом
WO2015116178A1 (en) 2014-01-31 2015-08-06 Thomas Jefferson University Fusion proteins for modulating regulatory and effector t cells
EP2951199A4 (en) 2013-01-31 2016-07-20 Univ Jefferson Fusion proteins for the modulation of regulatory and effector T cells
WO2016044839A2 (en) 2014-09-19 2016-03-24 The Board Of Regents Of The University Of Texas System Compositions and methods for treating viral infections through stimulated innate immunity in combination with antiviral compounds
WO2016138286A1 (en) 2015-02-26 2016-09-01 Stc.Unm Irgm and precision autophagy controls for antimicrobial and inflammatory disease states and methods of detection of autophagy
US10576147B2 (en) 2015-12-15 2020-03-03 Bharat Biotech International Limited Muramyl peptide derivative compound, synthesis and uses thereof
WO2017190145A1 (en) 2016-04-29 2017-11-02 Icahn School Of Medicine At Mount Sinai Targeting the innate immune system to induce long-term tolerance and to resolve macrophage accumulation in atherosclerosis
WO2020140007A1 (en) 2018-12-28 2020-07-02 University Of Rochester Gene therapy for best1 dominant mutations
CN118459539B (zh) 2021-03-19 2026-01-06 生物治疗探索股份有限公司 用于调节训练免疫的化合物及其使用方法
KR20260104103A (ko) 2023-10-31 2026-07-03 무스크 파운데이션 포 리서치 디벨롭먼트 섬유증 치료를 위한 에놀라제 억제제 pomhex의 용도
WO2026015821A1 (en) 2024-07-12 2026-01-15 University Of Rochester Antibiotic alkaloid and methods of generating and use thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4001395A (en) * 1972-06-20 1977-01-04 Agence Nationale De Valorisation De La Recherche (Anvar) Hydrosoluble extracts of mycobacteria
NL7308450A (el) * 1972-06-20 1973-12-27
US4186194A (en) * 1973-10-23 1980-01-29 Agence Nationale De Valorisation De La Recherche (Anvar) Water soluble agents effective as immunological adjuvants for stimulating, in the host the immune response to various antigens and compositions, notably vaccines containing said water soluble agents
CH613709A5 (en) * 1975-12-10 1979-10-15 Ciba Geigy Ag Process for the preparation of glucosamine derivatives
US4082736A (en) * 1976-04-26 1978-04-04 Syntex (U.S.A.) Inc. Novel immunological adjuvant compounds and methods of preparation thereof
US4082735A (en) * 1976-04-26 1978-04-04 Syntex (U.S.A.) Inc. Novel immunological adjuvant compounds and methods of preparation thereof
GB1563561A (en) * 1976-06-23 1980-03-26 Daiichi Seiyaku Co Muramyldipeptide derivatives and process for the preparation thereof
FR2368282A1 (fr) * 1976-10-22 1978-05-19 Anvar Adjuvant immunologique constitue par le p-amino-phenyl de n-acetyl-muramyl-l-alanyl-d-isoglutamine
US4268505A (en) * 1978-04-13 1981-05-19 Kureha Kagaku Kogyo Kabushiki Kaisha Pharmaceutical composition comprising a nitrogen-containing polysaccharide and an antibiotic agent, and a method of treating an infectious disease therewith
FI803077A7 (fi) * 1979-10-12 1981-04-13 Ciba Geigy Ag Foerfarande foer framstaellning av myramylpeptider

Also Published As

Publication number Publication date
NO157177C (no) 1988-02-03
DD153843A5 (de) 1982-02-03
DK319480A (da) 1981-01-26
IL60676A (en) 1984-10-31
MX9203368A (es) 1992-09-01
EP0025495B1 (de) 1984-06-20
PL127481B1 (en) 1983-10-31
MY8700554A (en) 1987-12-31
IE801533L (en) 1981-01-25
US4406890A (en) 1983-09-27
EP0025495A1 (de) 1981-03-25
FI75578C (fi) 1988-07-11
DK161025B (da) 1991-05-21
SG38187G (en) 1988-01-15
US4414204A (en) 1983-11-08
HK85787A (en) 1987-11-27
ES8105971A1 (es) 1981-07-01
PT71607A (de) 1980-08-01
IL60676A0 (en) 1980-09-16
JPS5649397A (en) 1981-05-02
PL131613B1 (en) 1984-12-31
KR840001617B1 (ko) 1984-10-11
NO157177B (no) 1987-10-26
PL225870A1 (el) 1981-05-08
AU6078880A (en) 1981-01-29
NO802200L (no) 1981-01-26
GR69314B (el) 1982-05-14
FI75578B (fi) 1988-03-31
SU1277905A3 (ru) 1986-12-15
CY1381A (en) 1987-12-18
SU1277906A3 (ru) 1986-12-15
NZ194432A (en) 1983-09-02
AU6658181A (en) 1982-11-04
FI802294A7 (fi) 1981-01-26
JPS6356239B2 (el) 1988-11-07
IE50145B1 (en) 1986-02-19
DE3068304D1 (en) 1984-07-26
DK161025C (da) 1991-10-28
KR830003511A (ko) 1983-06-21
HU188861B (en) 1986-05-28
ES493633A0 (es) 1981-07-01
CS526280A3 (en) 1992-06-17
AU541147B2 (en) 1984-12-20
CA1183129A (en) 1985-02-26
ZA804487B (en) 1981-07-29

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Legal Events

Date Code Title Description
IF00 In force as of 2000-06-30 in czech republic
MK4A Patent expired

Effective date: 20000725