CS277517B6 - Spósob čistenia kodeinu připraveného metylizáciou morfínu - Google Patents

Spósob čistenia kodeinu připraveného metylizáciou morfínu Download PDF

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Publication number
CS277517B6
CS277517B6 CS906197A CS619790A CS277517B6 CS 277517 B6 CS277517 B6 CS 277517B6 CS 906197 A CS906197 A CS 906197A CS 619790 A CS619790 A CS 619790A CS 277517 B6 CS277517 B6 CS 277517B6
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CS
Czechoslovakia
Prior art keywords
codeine
aqueous
solution
methylation
morphine
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Application number
CS906197A
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Czech (cs)
English (en)
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CS619790A3 (en
Inventor
Gejza Ing Kmetty
Ivan Ing Varga
Roman Ing Kacina
Juraj Ing Gomory
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Slovakofarma S P
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Application filed by Slovakofarma S P filed Critical Slovakofarma S P
Priority to CS906197A priority Critical patent/CS277517B6/sk
Publication of CS619790A3 publication Critical patent/CS619790A3/cs
Publication of CS277517B6 publication Critical patent/CS277517B6/sk

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Abstract

Vynález rieši přípravu kodeinu v liekopisnej kvalitě bez vediajších látok vznikajúcich pri metylizácii morfínu extrakciou připraveného kodeinu v organickom rozpúšťadle do vodného roztoku anorganické] alebo organickej kyseliny v rozmedzí hodnot pH 7 až 5,4 s výhodou v rozmedzí 6,8 až 6,0, po oddělení vodnej vrstvy jej extrakciou chlórovaným organickým rozpúšťadlom, vyzrážaním kodeinovej bázy, jej rozpuštěním v etanole a kryštalizáciou z vodnoalkoholického roztoku kyseliny fosforečnej vo formě fosforečnanu kodeinu v liekopisnej kvalitě podl’a požiadavky německého liekopisu DAB 9. Oblasťou použitia je farmaceutický priemysel.
CS906197A 1990-12-12 1990-12-12 Spósob čistenia kodeinu připraveného metylizáciou morfínu CS277517B6 (sk)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CS906197A CS277517B6 (sk) 1990-12-12 1990-12-12 Spósob čistenia kodeinu připraveného metylizáciou morfínu

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CS906197A CS277517B6 (sk) 1990-12-12 1990-12-12 Spósob čistenia kodeinu připraveného metylizáciou morfínu

Publications (2)

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CS619790A3 CS619790A3 (en) 1992-08-12
CS277517B6 true CS277517B6 (sk) 1993-02-17

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CS906197A CS277517B6 (sk) 1990-12-12 1990-12-12 Spósob čistenia kodeinu připraveného metylizáciou morfínu

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004037826A3 (en) * 2002-10-21 2004-07-01 Mallinckrodt Inc Preparation of codeine from morphine
US20220154232A1 (en) * 2013-03-15 2022-05-19 The Board Of Trustees Of The Leland Stanford Junor University Benzylisoquinoline Alkaloids (BIA) Producing Microbes, and Methods of Making and Using the Same
US12480131B2 (en) 2019-03-08 2025-11-25 The Board Of Trustees Of The Leland Stanford Junior University Tropane alkaloid (TA) producing non-plant host cells, and methods of making and using the same
US12497638B2 (en) 2015-05-08 2025-12-16 The Board Of Trustees Of The Leland Stanford Junior University Methods of producing epimerases and benzylisoquinoline alkaloids

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100396685C (zh) * 2003-09-25 2008-06-25 中国医药集团总公司四川抗菌素工业研究所 一种由吗啡合成可待因的新方法

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004037826A3 (en) * 2002-10-21 2004-07-01 Mallinckrodt Inc Preparation of codeine from morphine
US20220154232A1 (en) * 2013-03-15 2022-05-19 The Board Of Trustees Of The Leland Stanford Junor University Benzylisoquinoline Alkaloids (BIA) Producing Microbes, and Methods of Making and Using the Same
US12497638B2 (en) 2015-05-08 2025-12-16 The Board Of Trustees Of The Leland Stanford Junior University Methods of producing epimerases and benzylisoquinoline alkaloids
US12480131B2 (en) 2019-03-08 2025-11-25 The Board Of Trustees Of The Leland Stanford Junior University Tropane alkaloid (TA) producing non-plant host cells, and methods of making and using the same

Also Published As

Publication number Publication date
CS619790A3 (en) 1992-08-12

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Legal Events

Date Code Title Description
IF00 In force as of 2000-06-30 in czech republic
MM4A Patent lapsed due to non-payment of fee

Effective date: 20071212