CS291484A2 - Zpusob vyroby 1 l4 l4 lfluoralkylmethylthio nebo sulfonyl pfenoxy pfenyl p 1,3,5 triazin 2,4,6 l1h,3h,5h p trionu - Google Patents

Zpusob vyroby 1 l4 l4 lfluoralkylmethylthio nebo sulfonyl pfenoxy pfenyl p 1,3,5 triazin 2,4,6 l1h,3h,5h p trionu Download PDF

Info

Publication number: CS291484A2
Authority: CS; Czechoslovakia
Prior art keywords: formula; compound; sulfonyl; iii; compounds
Prior art date: 1983-04-23

Application number

CS842914A

Other languages

Czech (cs)

English (en)

Inventor

Axel Dr Haberkorn

Toyohiko Kume

Original Assignee

Bayer Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-04-23

Filing date

1984-04-18

Publication date

1985-08-15

1984-04-18 Application filed by Bayer Ag filed Critical Bayer Ag

1985-08-15 Publication of CS291484A2 publication Critical patent/CS291484A2/cs

Links

125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 title claims description 8
JIHQDMXYYFUGFV-UHFFFAOYSA-N 1,3,5-triazine Chemical compound C1=NC=NC=N1 JIHQDMXYYFUGFV-UHFFFAOYSA-N 0.000 title 1
241001611408 Nebo Species 0.000 title 1
150000001875 compounds Chemical class 0.000 claims description 39
238000000034 method Methods 0.000 claims description 11
238000011282 treatment Methods 0.000 claims description 11
125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims description 9
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 9
150000003839 salts Chemical class 0.000 claims description 9
150000003672 ureas Chemical class 0.000 claims description 5
YNKDRTCJDFVUTJ-UHFFFAOYSA-N carbonyl diisocyanate Chemical compound O=C=NC(=O)N=C=O YNKDRTCJDFVUTJ-UHFFFAOYSA-N 0.000 claims description 4
229910052736 halogen Inorganic materials 0.000 claims description 4
150000002367 halogens Chemical class 0.000 claims description 4
238000004519 manufacturing process Methods 0.000 claims description 4
239000007858 starting material Substances 0.000 claims description 4
125000003545 alkoxy group Chemical group 0.000 claims description 2
125000000217 alkyl group Chemical group 0.000 claims description 2
125000004104 aryloxy group Chemical group 0.000 claims description 2
239000001257 hydrogen Substances 0.000 claims description 2
229910052739 hydrogen Inorganic materials 0.000 claims description 2
125000004432 carbon atom Chemical group C* 0.000 claims 3
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238000010255 intramuscular injection Methods 0.000 description 1
238000010253 intravenous injection Methods 0.000 description 1
ZFSLODLOARCGLH-UHFFFAOYSA-N isocyanuric acid Chemical compound OC1=NC(O)=NC(O)=N1 ZFSLODLOARCGLH-UHFFFAOYSA-N 0.000 description 1
238000002955 isolation Methods 0.000 description 1
NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
239000008101 lactose Substances 0.000 description 1
239000008297 liquid dosage form Substances 0.000 description 1
239000012669 liquid formulation Substances 0.000 description 1
230000004807 localization Effects 0.000 description 1
235000019359 magnesium stearate Nutrition 0.000 description 1
235000009973 maize Nutrition 0.000 description 1
239000000594 mannitol Substances 0.000 description 1
235000010355 mannitol Nutrition 0.000 description 1
235000012054 meals Nutrition 0.000 description 1
WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical compound [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 description 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
239000003094 microcapsule Substances 0.000 description 1
239000011707 mineral Substances 0.000 description 1
235000010755 mineral Nutrition 0.000 description 1
235000010446 mineral oil Nutrition 0.000 description 1
235000013379 molasses Nutrition 0.000 description 1
VBBUFMFZDHLELS-UHFFFAOYSA-N n-(oxomethylidene)carbamoyl chloride Chemical compound ClC(=O)N=C=O VBBUFMFZDHLELS-UHFFFAOYSA-N 0.000 description 1
235000016709 nutrition Nutrition 0.000 description 1
OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
239000002674 ointment Substances 0.000 description 1
239000003960 organic solvent Substances 0.000 description 1
239000007800 oxidant agent Substances 0.000 description 1
239000012188 paraffin wax Substances 0.000 description 1
238000007911 parenteral administration Methods 0.000 description 1
239000002245 particle Substances 0.000 description 1
239000006072 paste Substances 0.000 description 1
230000000144 pharmacologic effect Effects 0.000 description 1
239000003444 phase transfer catalyst Substances 0.000 description 1
150000002989 phenols Chemical class 0.000 description 1
DGTNSSLYPYDJGL-UHFFFAOYSA-N phenyl isocyanate Chemical class O=C=NC1=CC=CC=C1 DGTNSSLYPYDJGL-UHFFFAOYSA-N 0.000 description 1
239000002798 polar solvent Substances 0.000 description 1
229920002647 polyamide Polymers 0.000 description 1
239000001267 polyvinylpyrrolidone Substances 0.000 description 1
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
229910000027 potassium carbonate Inorganic materials 0.000 description 1
239000012286 potassium permanganate Substances 0.000 description 1
230000003389 potentiating effect Effects 0.000 description 1
238000012545 processing Methods 0.000 description 1
230000002035 prolonged effect Effects 0.000 description 1
239000003380 propellant Substances 0.000 description 1
230000000069 prophylactic effect Effects 0.000 description 1
125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
239000000376 reactant Substances 0.000 description 1
235000019204 saccharin Nutrition 0.000 description 1
CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
229940081974 saccharin Drugs 0.000 description 1
239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
239000012266 salt solution Substances 0.000 description 1
239000008299 semisolid dosage form Substances 0.000 description 1
239000004208 shellac Substances 0.000 description 1
ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 description 1
229940113147 shellac Drugs 0.000 description 1
235000013874 shellac Nutrition 0.000 description 1
RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 1
235000012239 silicon dioxide Nutrition 0.000 description 1
210000000813 small intestine Anatomy 0.000 description 1
239000012312 sodium hydride Substances 0.000 description 1
229910000104 sodium hydride Inorganic materials 0.000 description 1
AKHNMLFCWUSKQB-UHFFFAOYSA-L sodium thiosulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=S AKHNMLFCWUSKQB-UHFFFAOYSA-L 0.000 description 1
235000019345 sodium thiosulphate Nutrition 0.000 description 1
239000007892 solid unit dosage form Substances 0.000 description 1
235000012424 soybean oil Nutrition 0.000 description 1
239000003549 soybean oil Substances 0.000 description 1
210000004215 spore Anatomy 0.000 description 1
239000003381 stabilizer Substances 0.000 description 1
239000008117 stearic acid Substances 0.000 description 1
239000008174 sterile solution Substances 0.000 description 1
230000001954 sterilising effect Effects 0.000 description 1
238000010254 subcutaneous injection Methods 0.000 description 1
YBBRCQOCSYXUOC-UHFFFAOYSA-N sulfuryl dichloride Chemical compound ClS(Cl)(=O)=O YBBRCQOCSYXUOC-UHFFFAOYSA-N 0.000 description 1
239000000829 suppository Substances 0.000 description 1
229940095064 tartrate Drugs 0.000 description 1
125000006337 tetrafluoro ethyl group Chemical group 0.000 description 1
YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
229940124597 therapeutic agent Drugs 0.000 description 1
238000011285 therapeutic regimen Methods 0.000 description 1
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 1
239000008158 vegetable oil Substances 0.000 description 1
235000013311 vegetables Nutrition 0.000 description 1
239000000341 volatile oil Substances 0.000 description 1
230000004584 weight gain Effects 0.000 description 1
235000019786 weight gain Nutrition 0.000 description 1
238000009736 wetting Methods 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/30—Only oxygen atoms
- C07D251/34—Cyanuric or isocyanuric esters
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Tropical Medicine & Parasitology (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

CS842914A 1983-04-23 1984-04-18 Zpusob vyroby 1 l4 l4 lfluoralkylmethylthio nebo sulfonyl pfenoxy pfenyl p 1,3,5 triazin 2,4,6 l1h,3h,5h p trionu CS291484A2 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19833314739 DE3314739A1 (de)	1983-04-23	1983-04-23	1-(4-(4-(fluoralkylmethylthio- oder -sulfinyl- oder -sulfonyl-)phenoxy) phenyl)-1,3,5-triazin-2,4,6(1h,3h,5h)-trione, verfahren zu ihrer herstellung und ihre verwendung als coccidiosemittel

Publications (1)

Publication Number	Publication Date
CS291484A2 true CS291484A2 (en)	1985-08-15

Family

ID=6197155

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CS842914A CS291484A2 (en)	1983-04-23	1984-04-18	Zpusob vyroby 1 l4 l4 lfluoralkylmethylthio nebo sulfonyl pfenoxy pfenyl p 1,3,5 triazin 2,4,6 l1h,3h,5h p trionu

Country Status (8)

Country	Link
EP (1)	EP0123217A1 (da)
JP (1)	JPS59196873A (da)
AU (1)	AU2710484A (da)
CS (1)	CS291484A2 (da)
DE (1)	DE3314739A1 (da)
DK (1)	DK203784A (da)
ES (1)	ES531836A0 (da)
ZA (1)	ZA842967B (da)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3408768A1 (de) *	1984-03-09	1985-09-12	Bayer Ag, 5090 Leverkusen	Immunstimulierende mittel
EP0364765A3 (de) *	1988-10-08	1991-07-17	Bayer Ag	Substituierte 1,3,5-Triazintrione, Verfahren zu ihrer Herstellung und ihre Verwendung gegen parasitäre Protozoen
DE10040174A1 (de) *	2000-08-17	2002-02-28	Bayer Ag	Verwendung von Triazintrion-Sulfonen zur Bekämpfung von Coccidiosen
MX2020008816A (es)	2018-02-26	2020-09-28	AlzeCure Pharma AB	Derivados de triazina para el tratamiento de enfermedades relacionadas con neurotrofinas.
GB201810668D0 (en)	2018-06-28	2018-08-15	Stiftelsen Alzecure	New compounds

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2313721A1 (de) *	1973-03-20	1974-10-03	Bayer Ag	Neue 1-phenylsubstituierte 1,3,5triazine, verfahren zu ihrer herstellung, sowie ihre verwendung als arzneimittel
DE2413722C3 (de) *	1974-03-21	1982-04-08	Bayer Ag, 5090 Leverkusen	Neue 1-(4-Phenoxy-phenyl)-1,3,5-triazin-Derivate, ein Verfahren zu ihrer Herstellung sowie ihre Anwendung als Arzneimittel
DE2718799A1 (de) *	1977-04-27	1978-11-09	Bayer Ag	1-(4-phenoxy-phenyl)-1,3,5-triazin- derivate, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel und wachstumsfoerderer

1983
- 1983-04-23 DE DE19833314739 patent/DE3314739A1/de not_active Withdrawn
1984
- 1984-04-12 EP EP84104094A patent/EP0123217A1/de not_active Withdrawn
- 1984-04-18 DK DK203784A patent/DK203784A/da not_active Application Discontinuation
- 1984-04-18 CS CS842914A patent/CS291484A2/cs unknown
- 1984-04-19 ZA ZA842967A patent/ZA842967B/xx unknown
- 1984-04-19 AU AU27104/84A patent/AU2710484A/en not_active Abandoned
- 1984-04-20 JP JP59078720A patent/JPS59196873A/ja active Pending
- 1984-04-23 ES ES531836A patent/ES531836A0/es active Granted

Also Published As

Publication number	Publication date
ES8502102A1 (es)	1984-12-16
JPS59196873A (ja)	1984-11-08
EP0123217A1 (de)	1984-10-31
DE3314739A1 (de)	1984-10-25
DK203784A (da)	1984-10-24
AU2710484A (en)	1984-10-25
DK203784D0 (da)	1984-04-18
ZA842967B (en)	1984-12-24
ES531836A0 (es)	1984-12-16

Publication	Publication Date	Title
US3948893A (en)	1976-04-06	1-Phenyl-substituted 1,3,5-triazines
US3933814A (en)	1976-01-20	1-(4-Phenoxyphenyl)-1,3,5-triazines
US3966725A (en)	1976-06-29	1-(4-Phenoxy-phenyl)-1,3,5-triazines
US4568674A (en)	1986-02-04	Anti-coccidal agents 1-[4-(benzothia- or -oxazol-2-ylthio- or -2-yloxy)phenyl]-1,3,5-triazine-2,4,6-(1H,3H,5H)-trione derivatives, compositions, and method of use thereof
CS291484A2 (en)	1985-08-15	Zpusob vyroby 1 l4 l4 lfluoralkylmethylthio nebo sulfonyl pfenoxy pfenyl p 1,3,5 triazin 2,4,6 l1h,3h,5h p trionu
US2731382A (en)	1956-01-17	Pyrimidine substituted urea complexes and processes for preparing the same
US4348406A (en)	1982-09-07	Novel guanidine derivatives
US3970752A (en)	1976-07-20	Coccidiocidal compositions utilizing 1-phenyl-substituted 1,3,5-triazine
US4173631A (en)	1979-11-06	7-Methyl-8-methylamino-10-(1'-D-ribityl)isoalloxazine
US2731384A (en)	1956-01-17	2-hydroxy pyridine substituted urea complex
US2951010A (en)	1960-08-30	Substituted carbanilide compositions for treating coccidiosis
US2983646A (en)	1961-05-09	Anthelmintic compositions containing substituted carbanilides and methods of using same
US2831795A (en)	1958-04-22	Practice for the raising and protection of animals
JPS624388B2 (da)	1987-01-30
US4764534A (en)	1988-08-16	Anticoccidial naphthalenamines and combinations thereof
US4079069A (en)	1978-03-14	5-Deazariboflavin and its derivatives
DK142617B (da)	1980-12-01	Analogifremgangsmåde til fremstilling af 4-amino-1,3-benzendisulfonamider.
IL42355A (en)	1977-12-30	Phosphonoureido and thioureido compounds their preparation and anthelmintic compositions containing them
US3467653A (en)	1969-09-16	Anticoccidial sulfanilamidothiadiazoles
US2731385A (en)	1956-01-17	3-amino-as-triazine substituted urea complexes and processes for preparing the same
US3859443A (en)	1975-01-07	Composition and methods of treatment employing acrylanilides as anticoccidial agents
US3105797A (en)	1963-10-01	Bis(lower alkyl-thio-carbamoyl)-hydrazine derivatives for regulating gonadotrophin
WO1985001283A1 (en)	1985-03-28	Phenylguanidines
WO1992012707A1 (en)	1992-08-06	A benzoylurea-containing composition for parasite control in animals
JPS5951535B2 (ja)	1984-12-14	２−アミノ−５−メチルピリジン−３−スルホンアミド、およびそれを有効成分とする抗コクシジウム剤