CS29990A3 - Racemic or optically active bis-aza-bicyclic compounds, process forpreparing thereof, intermediates and use - Google Patents

Racemic or optically active bis-aza-bicyclic compounds, process forpreparing thereof, intermediates and use

Info

Publication number
CS29990A3
CS29990A3 CS90299A CS29990A CS29990A3 CS 29990 A3 CS29990 A3 CS 29990A3 CS 90299 A CS90299 A CS 90299A CS 29990 A CS29990 A CS 29990A CS 29990 A3 CS29990 A3 CS 29990A3
Authority
CS
Czechoslovakia
Prior art keywords
aza
racemic
intermediates
optically active
bicyclic compounds
Prior art date
Application number
CS90299A
Other languages
English (en)
Inventor
Kishor Amratral Desai
Gene Michael Bright
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of CS29990A3 publication Critical patent/CS29990A3/cs
Publication of CZ277698B6 publication Critical patent/CZ277698B6/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
CS90299A 1989-01-23 1990-01-22 Racemic or optically active bis-aza-bicyclic compounds, process for preparing thereof, intermediates and use thereof CZ277698B6 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/US1989/000275 WO1990008148A1 (en) 1989-01-23 1989-01-23 Bis-aza-bicyclic anxiolytic agents
PCT/US1989/003811 WO1990008144A1 (en) 1989-01-23 1989-09-01 Bis-aza-bicyclic anxiolytic agents

Publications (2)

Publication Number Publication Date
CS29990A3 true CS29990A3 (en) 1992-11-18
CZ277698B6 CZ277698B6 (en) 1993-03-17

Family

ID=22214801

Country Status (38)

Country Link
US (1) US5122525A (cs)
EP (1) EP0380217B1 (cs)
JP (1) JPH0643427B2 (cs)
KR (1) KR910009289B1 (cs)
CN (1) CN1022186C (cs)
AP (1) AP128A (cs)
AR (1) AR246969A1 (cs)
AT (1) ATE82574T1 (cs)
AU (1) AU614214B2 (cs)
BA (1) BA98302A (cs)
BG (1) BG51046A3 (cs)
CA (1) CA2008108C (cs)
CZ (1) CZ277698B6 (cs)
DD (1) DD291560A5 (cs)
DE (1) DE69000467T2 (cs)
DK (1) DK0380217T3 (cs)
EG (1) EG19306A (cs)
ES (1) ES2053094T3 (cs)
FI (1) FI95381C (cs)
GR (1) GR3006925T3 (cs)
HU (1) HU215154B (cs)
IE (1) IE62670B1 (cs)
IL (1) IL93073A (cs)
IS (1) IS1667B (cs)
MA (1) MA21735A1 (cs)
MX (1) MX19222A (cs)
MY (1) MY104861A (cs)
NO (1) NO175978C (cs)
NZ (1) NZ232168A (cs)
OA (1) OA10041A (cs)
PL (1) PL163836B1 (cs)
PT (1) PT92919B (cs)
RO (1) RO110142B1 (cs)
RU (1) RU2015977C1 (cs)
SK (1) SK279339B6 (cs)
WO (2) WO1990008148A1 (cs)
YU (1) YU47554B (cs)
ZA (1) ZA90430B (cs)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX19222A (es) * 1989-01-23 1993-12-01 Pfizer Agentes ansioliticos bis-aza-biciclicos
WO1992000075A1 (en) * 1990-06-29 1992-01-09 Pfizer Inc. Pyridopyrazine derivatives for treating substance abuse and addiction
DK0569387T3 (da) * 1991-01-31 1995-07-03 Pfizer Optisk adskillelse af trans-2-(2-pyrimidinyl)-7-(hydroxymethyl)octahydro-2H-pyrido/1,2-a/ pyrazin
EP0737683A1 (en) * 1991-02-27 1996-10-16 Pfizer Inc. N-2-(Phthalimido)ethyl trans-piperidine-2,5-dicarboxylates as intermediates in the preparation of perhydro-1H-pyrido[1,2-a]pyrazines
US5185449A (en) * 1991-02-27 1993-02-09 Pfizer Inc. Process and intermediate for certain bis-aza-bicyclic anxiolytic agents
US5157034A (en) * 1991-02-27 1992-10-20 Pfizer Inc. Neuroleptic perhydro-1H-pyrido[1,2-a]pyrazines
US5311195A (en) * 1991-08-30 1994-05-10 Etak, Inc. Combined relative and absolute positioning method and apparatus
DE69215886T2 (de) * 1991-09-25 1997-04-03 Pfizer NEUROLEPTISCH 2-SUBSTITUIERTE PERHYDRO-1H-PYRIDO[1,2-a]PYRAZINE
ES2137986T3 (es) * 1992-06-16 2000-01-01 Pfizer Procedimiento y productos intermedios para agentes ansioliticos bis-aza-biciclicos.
AU5291793A (en) * 1992-09-24 1994-04-12 National Institutes Of Health Aralkyl diazabicycloalkane derivatives for cns disorders
IL104506A (en) * 1993-01-25 1997-11-20 Israel State Fast changing heating- cooling device and method, particularly for cryogenic and/or surgical use
US5637713A (en) * 1993-08-20 1997-06-10 Pfizer Inc. Process for preparing trans-piperidine-2,5-dicarboxylates
US5455350A (en) * 1993-10-13 1995-10-03 Pfizer Inc. Process and intermediate for certain bis-aza-bicyclic anxiolytic agents
IL107460A (en) * 1993-11-01 1999-06-20 Israel State Controlled cryogenic contact system
US5731307A (en) * 1994-09-30 1998-03-24 Pfizer, Inc. Neuroleptic 2,7-disubtituted perhydro-1h-pyrido 1, 2-A!pyrazines
US6231833B1 (en) 1999-08-05 2001-05-15 Pfizer Inc 2,7-substituted octahydro-1H-pyrido[1,2-A]pyrazine derivatives as ligands for serotonin receptors
DE69524241T2 (de) * 1994-09-30 2002-06-13 Pfizer Inc., New York 2,7,-substituierte octahydro-1h-pyrido[1,2-a]pyrazin derivate
WO1997023482A1 (en) * 1995-12-21 1997-07-03 Pfizer Inc. 2,7-substituted octahydro-pyrrolo[1,2-a]pyrazine derivatives
JPH11512751A (ja) * 1996-07-01 1999-11-02 ファイザー・インク （７ｓ，トランス）―２―（２―ピリミジニル）―７―（ヒドロキシメチル）オクタヒドロ―２Ｈ―ピリド［１，２―Ａ］ピラジンの製造
PA8469101A1 (es) * 1998-04-09 2000-09-29 Pfizer Prod Inc Ligandos azabiciclicos de receptores 5ht1
US6251893B1 (en) * 1998-06-15 2001-06-26 Nps Allelix Corp. Bicyclic piperidine and piperazine compounds having 5-HT6 receptor affinity
HN1999000146A (es) * 1998-09-21 2000-11-11 Pfizer Prod Inc Agentes farmaceuticos para el tratamiento de la enfermedad de parkinson, adhd y microadenomas.
US20020016334A1 (en) * 2000-07-31 2002-02-07 Coe Jotham Wadsworth Pharmaceutical composition for the treatment of attention deficit hyperactivity disorder (ADHD)
US6670476B2 (en) 2000-11-29 2003-12-30 Pfizer Inc. Resolution of trans-7-(hydroxy-methyl)octa-hydro-2H-pyrido[1,2-a]pyrazine
PL378749A1 (pl) * 2003-03-12 2006-05-15 Pfizer Products Inc. Azabicykliczne pochodne pirydyloksymetylowe i benzoizoksazolowe
DE602004018637D1 (de) 2003-04-09 2009-02-05 Biogen Idec Inc A2a-adenosinrezeptorantagonisten
EP1689721B1 (en) * 2003-11-26 2010-07-14 Pfizer Products Inc. Aminopyrazole derivatives as gsk-3 inhibitors
MXPA06013762A (es) * 2004-05-27 2007-02-08 Warner Lambert Co Combinacion de atomoxetina y un agonista del receptor 5t1a para el tratamiento de trastorno de hiperactividad con deficit de atencion y otros trastornos.
US7658206B2 (en) 2006-12-05 2010-02-09 Kohler Co. Plumbing valve with stick control handle

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3388128A (en) * 1965-09-03 1968-06-11 Allan R. Day Substituted 1, 4-diazabicyclo [4. 4. 9] decanes
US4182763A (en) * 1978-05-22 1980-01-08 Mead Johnson & Company Buspirone anti-anxiety method
US4339579A (en) * 1980-12-29 1982-07-13 American Home Products Corporation 2,6-Bis-(pyrrolopyrazinyl)pyrazines
US4400511A (en) * 1982-05-07 1983-08-23 American Home Products Corporation 2-Substituted octahydropyrrolo(1,2-A)-pyrazine-3-carboxylic acids
US4414389A (en) * 1982-05-25 1983-11-08 American Home Products Corporation 4-Substituted-piperidino carboxamides
US4517187A (en) * 1982-10-18 1985-05-14 Pennwalt Corporation 1,3,4,6,7-11b-Hexahydro-7-phenyl-2H-pyrazino[2,1-a]isoquinolines methods of preparation, and use as antidepressants
DE3321969A1 (de) * 1983-06-18 1984-12-20 Troponwerke GmbH & Co KG, 5000 Köln 2-pyrimidinyl-1-piperazin-derivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
DE3409440A1 (de) * 1984-03-15 1985-09-26 Bayer Ag, 5090 Leverkusen Imidazo(1,5-a)pyridyl-methan- und imidazo(1,5-b)pyridazinylmethan-derivate, ihre herstellung und sie enthaltende aufzeichnungsmaterialien
IT1204803B (it) * 1986-02-17 1989-03-10 Acraf Composto farmacologicamente attivo e composizioni farmaceutiche che lo contengono,procedimento per prepararlo e intermedio utile in detto procedimento
US4788290A (en) * 1987-12-11 1988-11-29 American Home Products Corporation Serotonergic pyrazine derivatives
JP2668259B2 (ja) * 1988-02-18 1997-10-27 塩野義製薬株式会社 複素環化合物および抗潰瘍剤
MX19222A (es) * 1989-01-23 1993-12-01 Pfizer Agentes ansioliticos bis-aza-biciclicos

Also Published As

Publication number Publication date
NZ232168A (en) 1991-08-27
MA21735A1 (fr) 1990-10-01
PL163836B1 (pl) 1994-05-31
FI913510A0 (fi) 1991-07-22
CA2008108C (en) 1995-08-08
SK279339B6 (sk) 1998-10-07
AU4867990A (en) 1990-07-26
BG51046A3 (bg) 1993-01-15
KR900011774A (ko) 1990-08-02
IE900225L (en) 1990-07-23
NO912863L (no) 1991-07-22
US5122525A (en) 1992-06-16
BA98302A (bs) 2001-09-14
RO110142B1 (ro) 1995-10-30
ES2053094T3 (es) 1994-07-16
MX19222A (es) 1993-12-01
JPH02233681A (ja) 1990-09-17
DD291560A5 (de) 1991-07-04
IE62670B1 (en) 1995-03-08
AP128A (en) 1991-03-20
YU11190A (sh) 1993-05-28
DE69000467D1 (de) 1992-12-24
IS3529A7 (is) 1990-07-24
AR246969A1 (es) 1994-10-31
PT92919A (pt) 1990-07-31
FI95381B (fi) 1995-10-13
MY104861A (en) 1994-06-30
OA10041A (en) 1996-10-14
WO1990008148A1 (en) 1990-07-26
PT92919B (pt) 1995-12-29
NO175978B (no) 1994-10-03
CN1022186C (zh) 1993-09-22
RU2015977C1 (ru) 1994-07-15
EP0380217B1 (en) 1992-11-19
IS1667B (is) 1997-11-14
IL93073A (en) 1994-05-30
CN1044464A (zh) 1990-08-08
DK0380217T3 (da) 1992-12-14
EP0380217A1 (en) 1990-08-01
HU215154B (hu) 2000-09-28
FI95381C (fi) 1996-01-25
DE69000467T2 (de) 1993-04-01
EG19306A (en) 1995-01-31
HUT63163A (en) 1993-07-28
JPH0643427B2 (ja) 1994-06-08
ATE82574T1 (de) 1992-12-15
AP9000158A0 (en) 1990-01-31
NO175978C (no) 1995-01-11
GR3006925T3 (cs) 1993-06-30
YU47554B (sh) 1995-10-03
WO1990008144A1 (en) 1990-07-26
AU614214B2 (en) 1991-08-22
NO912863D0 (no) 1991-07-22
CA2008108A1 (en) 1990-07-23
KR910009289B1 (ko) 1991-11-09
ZA90430B (en) 1991-08-28
CZ277698B6 (en) 1993-03-17

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Legal Events

Date Code Title Description
IF00 In force as of 2000-06-30 in czech republic
MM4A Patent lapsed due to non-payment of fee

Effective date: 20050122