CS305091A3 - Pharmaceutical free of a solvent for per oral administration with delayed liberation of an active component and process for preparing thereof - Google Patents

Pharmaceutical free of a solvent for per oral administration with delayed liberation of an active component and process for preparing thereof

Info

Publication number
CS305091A3
CS305091A3 CS913050A CS305091A CS305091A3 CS 305091 A3 CS305091 A3 CS 305091A3 CS 913050 A CS913050 A CS 913050A CS 305091 A CS305091 A CS 305091A CS 305091 A3 CS305091 A3 CS 305091A3
Authority
CS
Czechoslovakia
Prior art keywords
solvent
preparing
pct
oral administration
active component
Prior art date
Application number
CS913050A
Other languages
Czech (cs)
Inventor
Ulrich Dr Munch
Hans-Jurgen Dr Mika
Bernhard Dr Emschermann
Rainer Dr Schmidt
Bernard Sczepanik
Original Assignee
Sanol Arznei Schwarz Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6415859&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CS305091(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sanol Arznei Schwarz Gmbh filed Critical Sanol Arznei Schwarz Gmbh
Publication of CS305091A3 publication Critical patent/CS305091A3/en
Publication of CZ284923B6 publication Critical patent/CZ284923B6/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1611—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Cardiology (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Organic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

PCT No. PCT/DE91/00791 Sec. 371 Date Apr. 7, 1993 Sec. 102(e) Date Apr. 7, 1993 PCT Filed Oct. 7, 1991 PCT Pub. No. WO92/05774 PCT Pub. Date Apr. 16, 1992.Delayed release pharmaceutical preparations include a solvent free, solidified melt granulate of a pharmaceutical ingredient in admixture with a meltable auxiliary substance which is soluble in the pharmaceutical ingredient at elevated temperatures.
CS913050A 1990-10-08 1991-10-07 Pharmaceutical preparation for peroral administration with delayed release of active substance and process for preparing thereof CZ284923B6 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4031881A DE4031881C2 (en) 1990-10-08 1990-10-08 Solvent-free, oral sustained-release pharmaceutical preparation and process for its preparation

Publications (2)

Publication Number Publication Date
CS305091A3 true CS305091A3 (en) 1992-04-15
CZ284923B6 CZ284923B6 (en) 1999-04-14

Family

ID=6415859

Country Status (24)

Country Link
US (1) US5453283A (en)
EP (1) EP0552227B2 (en)
JP (1) JP3233929B2 (en)
KR (1) KR0166599B1 (en)
AT (1) ATE116843T1 (en)
CA (1) CA2093666C (en)
CZ (1) CZ284923B6 (en)
DE (2) DE4031881C2 (en)
DK (1) DK0552227T4 (en)
ES (1) ES2067250T5 (en)
FI (1) FI108401B (en)
GR (1) GR3015131T3 (en)
HR (1) HRP920960B1 (en)
HU (2) HUT64211A (en)
IE (1) IE76142B1 (en)
LV (1) LV11002B (en)
PL (1) PL167593B1 (en)
PT (1) PT99168B (en)
RU (1) RU2101009C1 (en)
SI (1) SI9111618B (en)
SK (1) SK279446B6 (en)
UA (1) UA26449C2 (en)
WO (1) WO1992005774A1 (en)
YU (1) YU48766B (en)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2151396C (en) * 1992-12-23 2006-08-22 I.M.A. Industria Macchine Automatiche S.P.A. Process for preparing controlled release pharmaceutical forms and the forms thus obtained
NZ260408A (en) 1993-05-10 1996-05-28 Euro Celtique Sa Controlled release preparation comprising tramadol
US5879705A (en) * 1993-07-27 1999-03-09 Euro-Celtique S.A. Sustained release compositions of morphine and a method of preparing pharmaceutical compositions
US5891471A (en) * 1993-11-23 1999-04-06 Euro-Celtique, S.A. Pharmaceutical multiparticulates
KR100354702B1 (en) * 1993-11-23 2002-12-28 유로-셀티크 소시에떼 아노뉨 Manufacturing method and sustained release composition of pharmaceutical composition
US5843480A (en) * 1994-03-14 1998-12-01 Euro-Celtique, S.A. Controlled release diamorphine formulation
DE4418837A1 (en) * 1994-05-30 1995-12-07 Bayer Ag Thermal granulation process
GB9422154D0 (en) 1994-11-03 1994-12-21 Euro Celtique Sa Pharmaceutical compositions and method of producing the same
US5965161A (en) 1994-11-04 1999-10-12 Euro-Celtique, S.A. Extruded multi-particulates
DE19504832A1 (en) * 1995-02-14 1996-08-22 Basf Ag Solid drug preparations
WO1996031197A1 (en) * 1995-04-03 1996-10-10 Abbott Laboratories Homogeneous mixtures of low temperature-melting drugs and additives for controlled release
TW474824B (en) 1996-09-13 2002-02-01 Basf Ag The production of solid pharmaceutical forms
US5851555A (en) * 1997-08-15 1998-12-22 Fuisz Technologies Ltd. Controlled release dosage forms containing water soluble drugs
UA73092C2 (en) * 1998-07-17 2005-06-15 Брістол-Майерс Сквібб Компані Tablets with enteric coating and method for their manufacture
DE19918325A1 (en) 1999-04-22 2000-10-26 Euro Celtique Sa Extruded drug dosage form, e.g. granulate for tableting, comprising an active agent in a polysaccharide-containing matrix, giving a release profile which is controllable by extrusion conditions and/or the inclusion of additives
DE10029201A1 (en) 2000-06-19 2001-12-20 Basf Ag Retarded release oral dosage form, obtained by granulating mixture containing active agent and polyvinyl acetate-polyvinyl pyrrolidone mixture below the melting temperature
JP2004521083A (en) * 2000-10-27 2004-07-15 ニトロメッド，インク． Methods for treating vascular diseases characterized by nitric oxide deficiency
GB0209265D0 (en) 2002-04-23 2002-06-05 Novartis Ag Organic compounds
US20040029959A1 (en) * 2002-08-08 2004-02-12 John Devane Isosorbide mononitrate compositions and methods of their use
RU2267318C1 (en) * 2004-05-25 2006-01-10 Закрытое акционерное общество "ФАРМАПЭК" Prolonged antianginal preparation of isosorbide dinitrate and method for its obtaining
MY148074A (en) * 2005-05-10 2013-02-28 Novartis Ag Pharmaceutical compositions comprising imatinib and a release retardant
US7884136B2 (en) 2005-06-27 2011-02-08 Biovail Laboratories International S.R.L. Modified-release formulations of a bupropion salt
US20090246276A1 (en) 2008-01-28 2009-10-01 Graham Jackson Pharmaceutical Compositions
KR101659983B1 (en) * 2012-12-31 2016-09-26 주식회사 삼양바이오팜 Melt-extruded release controlled pharmaceutical composition and oral dosage form comprising the same
WO2017086835A1 (en) * 2015-11-17 2017-05-26 Общество С Ограниченной Ответственностью "Валента-Интеллект" Pharmaceutical composition exhibiting therapeutic effect with regard to demyelinating diseases (variants)
AU2018360383A1 (en) 2017-11-02 2020-05-21 Natureceuticals Sdn. Bhd. Extract of orthosiphon stamineus, formulations, and uses thereof

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL297357A (en) * 1962-08-31
US3308217A (en) * 1965-02-09 1967-03-07 Lowy Lawrence Method of granulating materials for subsequent forming into tablets
FI53921C (en) * 1971-06-04 1978-09-11 Boehringer Mannheim Gmbh FOERFARANDE FOER GRANULERING AV TABLETTMASSOR I PULVERFORM
FR2581541B1 (en) * 1985-05-09 1988-05-20 Rhone Poulenc Sante NOVEL PHARMACEUTICAL COMPOSITIONS FOR THE EXTENDED RELEASE OF AN ACTIVE INGREDIENT AND THEIR PREPARATION METHOD
US5246714A (en) * 1985-10-11 1993-09-21 Aktiebolaget Hassle Drug preparation
DE3612212A1 (en) * 1986-04-11 1987-10-15 Basf Ag METHOD FOR PRODUCING SOLID PHARMACEUTICAL FORMS
DE3612211A1 (en) * 1986-04-11 1987-10-15 Basf Ag CONTINUOUS TABLET METHOD
IT1200217B (en) * 1986-09-30 1989-01-05 Valducci Roberto MEMBRANE FOR PHARMACEUTICAL AND INDUSTRIAL USE
DE3743945A1 (en) * 1987-09-01 1989-03-09 Lohmann Gmbh & Co Kg DEVICE FOR DELIVERING SUBSTANCES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE
DE3743946A1 (en) * 1987-09-01 1989-03-09 Lohmann Gmbh & Co Kg DEVICE FOR DELIVERING NITROGLYCERIN TO THE SKIN, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE
DE3743947A1 (en) * 1987-09-01 1989-03-09 Lohmann Gmbh & Co Kg DEVICE FOR THE CONTROLLED DELIVERY OF NICOTIN, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE
DE3812567A1 (en) * 1988-04-15 1989-10-26 Basf Ag METHOD FOR PRODUCING PHARMACEUTICAL MIXTURES
DE3812799A1 (en) * 1988-04-16 1989-10-26 Sanol Arznei Schwarz Gmbh ORGANIC PREPARATION FOR THE PURPOSES OF AN ACTUATED ACTIVE INGREDIENTS AND METHOD OF PREPARING THEM
DE3830353A1 (en) * 1988-09-07 1990-03-15 Basf Ag METHOD FOR THE CONTINUOUS PRODUCTION OF SOLID PHARMACEUTICAL FORMS
DK469989D0 (en) * 1989-09-22 1989-09-22 Bukh Meditec PHARMACEUTICAL PREPARATION
US5262173A (en) * 1992-03-02 1993-11-16 American Cyanamid Company Pulsatile once-a-day delivery systems for minocycline

Also Published As

Publication number Publication date
HRP920960B1 (en) 1998-10-31
GR3015131T3 (en) 1995-05-31
SI9111618B (en) 1999-08-31
FI931576A0 (en) 1993-04-07
DK0552227T3 (en) 1995-03-27
CA2093666A1 (en) 1992-04-09
ATE116843T1 (en) 1995-01-15
CZ284923B6 (en) 1999-04-14
IE913592A1 (en) 1992-04-08
ES2067250T5 (en) 1999-02-01
SK279446B6 (en) 1998-11-04
LV11002B (en) 1996-06-20
UA26449C2 (en) 1999-08-30
YU48766B (en) 1999-12-27
SI9111618A (en) 1997-12-31
HU9300995D0 (en) 1993-07-28
US5453283A (en) 1995-09-26
CA2093666C (en) 1998-05-19
IE76142B1 (en) 1997-10-08
PL167593B1 (en) 1995-09-30
JP3233929B2 (en) 2001-12-04
PT99168A (en) 1992-09-30
EP0552227B2 (en) 1998-11-04
DE4031881A1 (en) 1992-04-09
EP0552227B1 (en) 1995-01-11
HRP920960A2 (en) 1995-08-31
HUT64211A (en) 1993-12-28
KR0166599B1 (en) 1999-01-15
DK0552227T4 (en) 1999-07-19
RU2101009C1 (en) 1998-01-10
KR930701963A (en) 1993-09-08
DE4031881C2 (en) 1994-02-24
YU161891A (en) 1994-06-10
ES2067250T3 (en) 1995-03-16
DE59104271D1 (en) 1995-02-23
PT99168B (en) 1999-04-30
WO1992005774A1 (en) 1992-04-16
LV11002A (en) 1996-02-20
HU211845A9 (en) 1995-12-28
JPH06501685A (en) 1994-02-24
FI931576L (en) 1993-04-07
EP0552227A1 (en) 1993-07-28
FI108401B (en) 2002-01-31

Similar Documents

Publication Publication Date Title
CS305091A3 (en) Pharmaceutical free of a solvent for per oral administration with delayed liberation of an active component and process for preparing thereof
KR0173989B1 (en) Preparation of pharmaceutical and other matrix systems by solid-state dissolution
PH31564A (en) Composition for the sustained and controled release of medicamentous substance and a process for preparing the same.
IT1274879B (en) APPARATUS AND METHOD FOR PREPARING SOLID PHARMACEUTICAL FORMS WITH CONTROLLED RELEASE OF THE ACTIVE INGREDIENT.
HU9402675D0 (en) Method for prooucing porous delivery devices
TW223592B (en)
HUT58058A (en) Insecticidal composition and process for producing its active ingredient, 1-phenylimidazole derivatives
GR3023242T3 (en) Process for the preparation of solid sustained release pharmaceutical forms
RU93036959A (en) FREE SOLUBLE MEDICATION WITH SLOW-UP ACTION OF BIOLOGICALLY ACTIVE SUBSTANCES, ASSIGNED FOR RECEPTION INSIDE, THE METHOD OF ITS MANUFACTURE
YU242589A (en) New substituted benzimidazole and process for obtaining thereof
HUT59319A (en) Pharmaceutical compositions with controlled release of active ingredient and process for producing same
BG105570A (en) Pharmaceutical compositions for modified release insulin sensitiser
HUT50844A (en) Process for producing new 2'-halogen methylidene, 2'-ethenylidene and 2'-ethinyladenosine derivatives and pharmaceutical compositions comprising same as active ingredient
HUT59116A (en) Process for producing oxazole derivatives and pharmaceutical compositions comprising oxazole derivatives as active ingredient
ZA87216B (en) A pharmaceutical composition with sustained release of the active component and a process for the preparation thereof
ZA901543B (en) Benzoxazolinone derivatives,process for preparing them and pharmaceutical compositions containing them
HU9302813D0 (en) Pharmaceutical compositions containing new benzimidazole derivatives and process for preparing the active ingredients
DE69102143D1 (en) MEDICINAL PRODUCTS CONTAINING SPIRAMYCIN AND METHOD FOR THE PRODUCTION THEREOF.
HUT49590A (en) Process for producing benzimidazole derivatives and pharmaceutical compositions comprising same as active ingredient
HUT57781A (en) Process for producing cytotoxic bicyclo (7.3.1) tridec-4-ene-2,6-diine derivatives and pharmaceutical compositions comprising such ring system
HUT70840A (en) 2,2-dialkyl-2h-1-benzopiran and 2,2-dialkil-3,4-dihydro-3-hydroxy-2h-1-benzo-pyran derivatives, process for preparing them and pharmaceutical compositions comprising them as an active agents
JO1653B1 (en) Benzimidazole process for its preparation
ITBO920455A0 (en) PROCEDURE FOR PREPARING PHARMACEUTICAL FORMS WITH CONTROLLED DELAYED RELEASE OF THE ACTIVE INGREDIENT AND THE PHARMACEUTICAL FORMS SO OBTAINED.
SG25394G (en) Sustained release pharmaceutical compositions and the preparation of particles for use therein.

Legal Events

Date Code Title Description
IF00 In force as of 2000-06-30 in czech republic
MM4A Patent lapsed due to non-payment of fee

Effective date: 20041007